Pearce, Edward J.

Metabolic Competition in the Tumor Microenvironment Is a Driver of Cancer Progression

Chang, C.-H., Qiu, J., O’Sullivan, D., Buck, M. D., Noguchi, T., Curtis, J. D., Chen, Q., Gindin, M., Gubin, M. M., van der Windt, G. J. W., et al. (2015) · Cell

Cancer Immunotherapy and BiomarkersCancer, Hypoxia, and Metabolism

Cited by 3,331

Posttranscriptional Control of T Cell Effector Function by Aerobic Glycolysis

Chang, C.-H., Curtis, J. D., Maggi, L. B., Faubert, B., Villarino, A. V., O’Sullivan, D., Huang, S. C.-C., van der Windt, G. J. W., Blagih, J., Qiu, J., et al. (2013) · Cell

Cancer, Hypoxia, and MetabolismT-cell and B-cell Immunology

Cited by 2,204

Network Integration of Parallel Metabolic and Transcriptional Data Reveals Metabolic Modules that Regulate Macrophage Polarization

Jha, A. K., Huang, S. C.-C., Sergushichev, A., Lampropoulou, V., Ivanova, Y., Loginicheva, E., Chmielewski, K., Stewart, K. M., Ashall, J., Everts, B., et al. (2015) · Immunity

Immune cells in cancerCancer, Hypoxia, and Metabolism

Cited by 2,066

Metabolic Pathways in Immune Cell Activation and Quiescence

Pearce, E. L., & Pearce, E. J. (2013) · Immunity

Immune cells in cancerT-cell and B-cell Immunology

Cited by 1,692

Mitochondrial respiratory capacity is a critical regulator of CD8+ T cell memory development

van der Windt, G. J. W., Everts, B., Chang, C.-H., Curtis, J. D., Freitas, T. C., Amiel, E., Pearce, E. J., & Pearce, E. L. (2012) · Immunity

T-cell and B-cell ImmunologyMitochondrial Function and Pathology

Cited by 1,540

Toll-like receptor–induced changes in glycolytic metabolism regulate dendritic cell activation

Krawczyk, C. M., Holowka, T., Sun, J., Blagih, J., Amiel, E., DeBerardinis, R. J., Cross, J. R., Jung, E., Thompson, C. B., Jones, R. G., et al. (2010) · Blood

Immune Response and InflammationImmunotherapy and Immune Responses

Cited by 1,246

TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKɛ supports the anabolic demands of dendritic cell activation

Everts, B., Amiel, E., Huang, S. C.-C., Smith, A. M., Chang, C.-H., Lam, W. Y., Redmann, V., Freitas, T. C., Blagih, J., van der Windt, G. J. W., et al. (2014) · Nature Immunology

Immune Response and InflammationImmunotherapy and Immune Responses

Cited by 1,064

Memory CD8+ T Cells Use Cell-Intrinsic Lipolysis to Support the Metabolic Programming Necessary for Development

O’Sullivan, D., van der Windt, G. J. W., Huang, S. C.-C., Curtis, J. D., Chang, C.-H., Buck, M. D., Qiu, J., Smith, A. M., Lam, W. Y., DiPlato, L. M., et al. (2014) · Immunity

T-cell and B-cell ImmunologyLipid metabolism and biosynthesis

Cited by 790

Osteopontin Expression Identifies a Subset of Recruited Macrophages Distinct from Kupffer Cells in the Fatty Liver

Remmerie, A., Martens, L., Thoné, T., Castoldi, A., Seurinck, R., Pavie, B., Roels, J., Vanneste, B., De Prijck, S., Vanhockerhout, M., et al. (2020) · Immunity

Liver Disease Diagnosis and TreatmentLiver physiology and pathology

Cited by 592

Commitment to glycolysis sustains survival of NO-producing inflammatory dendritic cells

Everts, B., Amiel, E., van der Windt, G. J. W., Freitas, T. C., Chott, R., Yarasheski, K. E., Pearce, E. L., & Pearce, E. J. (2012) · Blood

Cancer, Hypoxia, and MetabolismImmune Response and Inflammation

Cited by 532

CD8 memory T cells have a bioenergetic advantage that underlies their rapid recall ability

van der Windt, G. J. W., O’Sullivan, D., Everts, B., Huang, S. C.-C., Buck, M. D., Curtis, J. D., Chang, C.-H., Smith, A. M., Ai, T., Faubert, B., et al. (2013) · Proceedings of the National Academy of Sciences

T-cell and B-cell ImmunologyMitochondrial Function and Pathology

Cited by 523

Auto-aggressive CXCR6+ CD8 T cells cause liver immune pathology in NASH

Dudek, M., Pfister, D., Donakonda, S., Filpe, P., Schneider, A., Laschinger, M., Hartmann, D., Hüser, N., Meiser, P., Bayerl, F., et al. (2021) · Nature

Liver Disease Diagnosis and TreatmentLiver Diseases and Immunity

Cited by 518

Microbiota-derived acetate enables the metabolic fitness of the brain innate immune system during health and disease

Erny, D., Dokalis, N., Mezö, C., Castoldi, A., Mossad, O., Staszewski, O., Frosch, M., Villa, M., Fuchs, V., Mayer, A., et al. (2021) · Cell Metabolism

Neuroinflammation and Neurodegeneration MechanismsGut microbiota and health

Cited by 478

Acetate Promotes T Cell Effector Function during Glucose Restriction

Qiu, J., Villa, M., Sanin, D. E., Buck, M. D., O’Sullivan, D., Ching, R., Matsushita, M., Grzes, K. M., Winkler, F., Chang, C.-H., et al. (2019) · Cell Reports

Cancer Immunotherapy and BiomarkersT-cell and B-cell Immunology

Cited by 342

Mitochondrial metabolism coordinates stage-specific repair processes in macrophages during wound healing

Willenborg, S., Sanin, D. E., Jais, A., Ding, X., Ulas, T., Nüchel, J., Popović, M., MacVicar, T., Langer, T., Schultze, J. L., et al. (2021) · Cell Metabolism

Wound Healing and TreatmentsImmune cells in cancer

Cited by 310

Inflammatory macrophage dependence on NAD+ salvage is a consequence of reactive oxygen species–mediated DNA damage

Cameron, A. M., Castoldi, A., Sanin, D. E., Flachsmann, L. J., Field, C. S., Puleston, D. J., Kyle, R. L., Patterson, A. E., Hässler, F., Buescher, J. M., et al. (2019) · Nature Immunology

Sirtuins and Resveratrol in MedicineImmune cells in cancer

Cited by 269

Schistosome-derived omega-1 drives Th2 polarization by suppressing protein synthesis following internalization by the mannose receptor

Everts, B., Hussaarts, L., Driessen, N. N., Meevissen, M. H. J., Schramm, G., van der Ham, A. J., van der Hoeven, B., Scholzen, T., Burgdorf, S., Mohrs, M., et al. (2012) · Journal of Experimental Medicine

Parasites and Host InteractionsImmunotherapy and Immune Responses

Cited by 236

Cutting Edge: IPSE/alpha-1, a Glycoprotein from Schistosoma mansoni Eggs, Induces IgE-Dependent, Antigen-Independent IL-4 Production by Murine Basophils In Vivo

Schramm, G., Mohrs, K., Wodrich, M., Doenhoff, M. J., Pearce, E. J., Haas, H., & Mohrs, M. (2007) · The Journal of Immunology

Parasites and Host InteractionsMast cells and histamine

Cited by 163

GAM: a web-service for integrated transcriptional and metabolic network analysis

Sergushichev, A. A., Loboda, A. A., Jha, A. K., Vincent, E. E., Driggers, E. M., Jones, R. G., Pearce, E. J., & Artyomov, M. N. (2016) · Nucleic Acids Research

Bioinformatics and Genomic NetworksMicrobial Metabolic Engineering and Bioproduction

Cited by 94

Review series on helminths, immune modulation and the hygiene hypothesis: Mechanisms underlying helminth modulation of dendritic cell function

Carvalho, L., Sun, J., Kane, C., Marshall, F., Krawczyk, C., & Pearce, E. J. (2009) · Immunology

Parasites and Host InteractionsImmunotherapy and Immune Responses

Cited by 85

Human Transforming Growth Factor-β Activates a Receptor Serine/Threonine Kinase from the Intravascular ParasiteSchistosoma mansoni

Beall, M. J., & Pearce, E. J. (2001) · Journal of Biological Chemistry

TGF-β signaling in diseasesParasites and Host Interactions

Cited by 67

Memory CD8+ T Cells Use Cell-Intrinsic Lipolysis to Support the Metabolic Programming Necessary for Development

O’Sullivan, D., van der Windt, G. J. W., Huang, S. C.-C., Curtis, J. D., Chang, C.-H., Buck, M. D., Qiu, J., Smith, A. M., Lam, W. Y., DiPlato, L. M., et al. (2018) · Immunity

T-cell and B-cell ImmunologyLipid metabolism and biosynthesis

Cited by 58

Memory CD4 T cells enhance primary CD8 T-cell responses

Krawczyk, C. M., Shen, H., & Pearce, E. J. (2007) · Infection and Immunity

T-cell and B-cell ImmunologyImmunotherapy and Immune Responses

Cited by 48

Treg Cells Survive and Thrive in Inhospitable Environments

Grzes, K. M., Field, C. S., & Pearce, E. J. (2017) · Cell Metabolism

T-cell and B-cell ImmunologyPsoriasis: Treatment and Pathogenesis

Cited by 16