The DOI matches its Crossref record; 24 of the 24 references it cites were found in a registry or an index.
Mitochondrial Dynamics in Regulating the Unique Phenotypes of Cancer and Stem Cells
Open accessAbstract
Cancer and stem cells appear to share a common metabolic profile that is characterized by high utilization of glucose through aerobic glycolysis. In the presence of sufficient nutrients, this metabolic strategy provides sufficient cellular ATP while additionally providing important metabolites necessary for the biosynthetic demands of continuous cell proliferation. Recent studies indicate that this metabolic profile is dependent on genes that regulate the fusion and fission of mitochondria. High levels of mitochondrial fission activity are associated with high proliferation and invasiveness in some cancer cells and with self-renewal and resistance to differentiation in some stem cells. These observations reveal new ways in which mitochondria regulate cell physiology, through their effects on metabolism and cell signaling.
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Cites
Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
Vander Heiden, M. G., Cantley, L. C., & Thompson, C. B. (2009) · Science · doi:10.1126/science.1160809 · Cited by 16,197
The emerging hallmarks of cancer metabolism
Pavlova, N. N., & Thompson, C. B. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2015.12.006 · Cited by 5,926 · cited 1×
“Many cancer cells display the Warburg effect, in which cells predominantly rely on glycolysis over oxidative phosphorylation (OXPHOS), even when oxygen is plentiful (Pavlova and Thompson, 2016; Vander Heiden et al., 2009).”
Fission and selective fusion govern mitochondrial segregation and elimination by autophagy
Twig, G., Elorza, A., Molina, A. J. A., Mohamed, H., Wikstrom, J. D., Walzer, G., Stiles, L., Haigh, S. E., Katz, S., Las, G., et al. (2008) · The EMBO Journal · doi:10.1038/sj.emboj.7601963 · Cited by 3,082 · cited 1×
“Although the machineries for fusion and fission are distinct, there is evidence that fission events are temporally coordinated with fusion events (Twig et al., 2008), a collaboration that helps to keep the two processes balanced.”
Chen, H., Detmer, S. A., Ewald, A. J., Griffin, E. E., Fraser, S. E., & Chan, D. C. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200211046 · Cited by 2,601
Self-citationDisruption of Fusion Results in Mitochondrial Heterogeneity and Dysfunction
Chen, H., Chomyn, A., & Chan, D. C. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m503062200 · Cited by 1,376 · cited 9×
“MFN2, or of OPA1 (Chen et al., 2005) results in severe respiratory chain function, which is likely to be critical for cell differentiation.”
InfluentialSelf-citationMitochondrial dynamics and apoptosis
Suen, D.-F., Norris, K. L., & Youle, R. J. (2008) · Genes & Development · doi:10.1101/gad.1658508 · Cited by 1,270 · cited 2×
“Apoptotic pathways also play important roles in cancer biology and are regulated by mitochondrial dynamics, but are beyond the scope of this review and have been extensively discussed elsewhere (Sheridan andMartin, 2010; Suen et al., 2008).”
Mitotic phosphorylation of dynamin-related GTPase Drp1 participates in mitochondrial fission.
Taguchi, N., Ishihara, N., Jofuku, A., Oka, T., & Mihara, K. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m607279200 · Cited by 1,226
Cassidy-Stone, A., Chipuk, J. E., Ingerman, E., Song, C., Yoo, C., Kuwana, T., Kurth, M. J., Shaw, J. T., Hinshaw, J. E., Green, D. R., et al. (2008) · Developmental Cell · doi:10.1016/j.devcel.2007.11.019 · Cited by 1,200
Fusion and fission: interlinked processes critical for mitochondrial health
Chan, D. C. (2012) · Annual Review of Genetics · doi:10.1146/annurev-genet-110410-132529 · Cited by 1,196 · cited 7×
“Aurora A phosphorylates RALA, an RAS-like GTPase.”
BackgroundInfluentialOtera, H., Wang, C., Cleland, M. M., Setoguchi, K., Yokota, S., Youle, R. J., & Mihara, K. (2010) · Journal of Cell Biology · doi:10.1083/jcb.201007152 · Cited by 1,110 · cited 4×
“One important DRP1 receptor is MFF (mitochondrial fission factor), whose depletion leads to dramatic mitochondrial elongation (Gandre-Babbe and van der Bliek, 2008) and reduction of DRP1 on mitochondria (Losón et al., 2013; Otera et al., 2010).”
Influential
Cited by
The role of mitochondria in aging
Jang, J. Y., Blum, A., Liu, J., & Finkel, T. (2018) · Journal of Clinical Investigation · doi:10.1172/jci120842 · Cited by 358
Aging shifts mitochondrial dynamics toward fission to promote germline stem cell loss.
Amartuvshin, O., Lin, C., Hsu, S., Kao, S., Chen, A., Tang, W., Chou, H., Chang, D., Hsu, Y., Hsiao, B., et al. (2020) · Aging Cell · doi:10.1111/acel.13191 · Cited by 75
Therapeutic Effects of Mesenchymal Stromal Cells Require Mitochondrial Transfer and Quality Control
Mukkala, A. N., Jerkic, M., Khan, Z., Szaszi, K., Kapus, A., & Rotstein, O. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242115788 · Cited by 45
Mitochondrial Proteolysis and Metabolic Control
Ahola, S., Langer, T., & MacVicar, T. (2019) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a033936 · Cited by 37
Meshrkey, F., Cabrera Ayuso, A., Rao, R. R., & Iyer, S. (2021) · Stem Cell Research · doi:10.1016/j.scr.2021.102572 · Cited by 24
Metadata
- Authors
- Chen, H., & Chan, D. C.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2017-07
- Volume
- 26
- Issue
- 1
- Pages
- 39-48
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W2714470490
- Cited by
- 451
- References
- 24
- FWCI
- 14.56
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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