Cited by 283Cancer, Hypoxia, and MetabolismMetabolism, Diabetes, and CancerCancer and biochemical research

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Isotope Tracing of Human Clear Cell Renal Cell Carcinomas Demonstrates Suppressed Glucose Oxidation In Vivo

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Courtney, Kevin D., Bezwada, Divya, Mashimo, Tomoyuki, Pichumani, Kumar, Vemireddy, Vamsidhara, Funk, Alexander M., Wimberly, Jennifer, McNeil, Sarah S., Kapur, Payal, Lotan, Yair, Margulis, Vitaly, Cadeddu, Jeffrey A., Pedrosa, Ivan, DeBerardinis, Ralph J., Malloy, Craig R., Bachoo, Robert M., Maher, Elizabeth A.·2018·Cell Metabolism

DOI 10.1016/j.cmet.2018.07.020PMC PMC6221993

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Abstract

Clear cell renal cell carcinoma (ccRCC) is the most common form of human kidney cancer. Histological and molecular analyses suggest that ccRCCs have significantly altered metabolism. Recent human studies of lung cancer and intracranial malignancies demonstrated an unexpected preservation of carbohydrate oxidation in the tricarboxylic acid (TCA) cycle. To test the capacity of ccRCC to oxidize substrates in the TCA cycle, we infused 13 C-labeled fuels in ccRCC patients and compared labeling patterns in tumors and adjacent kidney. After infusion with [U-13 C]glucose, ccRCCs displayed enhanced glycolytic intermediate labeling, suppressed pyruvate dehydrogenase flow, and reduced TCA cycle labeling, consistent with the Warburg effect. Comparing 13 C labeling among ccRCC, brain, and lung tumors revealed striking differences. Primary ccRCC tumors demonstrated the highest enrichment in glycolytic intermediates and lowest enrichment in TCA cycle intermediates. Among human tumors analyzed by intraoperative 13 C infusions, ccRCC is the first to demonstrate a convincing shift toward glycolytic metabolism.

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Authors: Courtney, K. D., Bezwada, D., Mashimo, T., Pichumani, K., Vemireddy, V., Funk, A. M., Wimberly, J., McNeil, S. S., Kapur, P., Lotan, Y., Margulis, V., Cadeddu, J. A., Pedrosa, I., DeBerardinis, R. J., Malloy, C. R., Bachoo, R. M., & Maher, E. A.
Affiliations: Harold C. Simmons Comprehensive Cancer Center (US)
Children's Medical Center (US)
The University of Texas Southwestern Medical Center (US)
VA North Texas Health Care System (US)
Corresponding author: Courtney, Kevin D.
Maher, Elizabeth A.
ORCID: Courtney, Kevin D.
Bezwada, Divya
Mashimo, Tomoyuki
Vemireddy, Vamsidhara
Funk, Alexander M.
Kapur, Payal
Lotan, Yair
Margulis, Vitaly
DeBerardinis, Ralph J.
Malloy, Craig R.
Bachoo, Robert M.
Maher, Elizabeth A.
Venue: Cell Metabolism
Publisher: Elsevier BV
Published: 2018-11
Volume: 28
Issue: 5
Pages: 793-800.e2
ISSN: 1550-4131 (ISSN-L)
DOI: 10.1016/j.cmet.2018.07.020
PMC: PMC6221993
OpenAlex: W2888708599
Cited by: 280
References: 34
Citations by year: 2026: 26 · 2025: 28 · 2024: 31 · 2023: 49 · 2022: 31 · 2021: 43 · 2020: 35 · 2019: 33 · 2018: 4
FWCI: 8.99
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 370 d)
Locations: Cell Metabolism (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: ACS (IRG-02-196)
NCI (P50CA196516, R01CA154475, R35CA220449)
NIH (P41EB015908, KL2TR001103, R01CA154475, TL1TR001104)
CPRIT (RP160089)
Howard Hughes Medical Institute
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
Keywords: clear cell renal cell carcinoma, cancer metabolism, Warburg effect, glucose oxidation, TCA cycle, pyruvate dehydrogenase, glycolysis, 13C isotope tracing, tumor glucose metabolism
MeSH terms: Adult, Aged, Carbon Isotopes, Carcinoma, Renal Cell, Citric Acid Cycle, Glucose, Glycolysis, Humans, Kidney, Kidney Neoplasms, Middle Aged, Oxidation-Reduction

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Isotope Tracing of Human Clear Cell Renal Cell Carcinomas Demonstrates Suppressed Glucose Oxidation In Vivo

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