The DOI matches its Crossref record; 78 of the 78 references it cites were found in a registry or an index.
Non-Canonical Control of Neuronal Energy Status by the Na+ Pump
Open accessAbstract
Neurons have limited intracellular energy stores but experience acute and unpredictable increases in energy demand. To better understand how these cells repeatedly transit from a resting to active state without undergoing metabolic stress, we monitored their early metabolic response to neurotransmission using ion-sensitive probes and FRET sensors in vitro and in vivo. A short theta burst triggered immediate Na+ entry, followed by a delayed stimulation of the Na+/K+ ATPase pump. Unexpectedly, cytosolic ATP and ADP levels were unperturbed across a wide range of physiological workloads, revealing strict flux coupling between the Na+ pump and mitochondria. Metabolic flux measurements revealed a "priming" phase of mitochondrial energization by pyruvate, whereas glucose consumption coincided with delayed Na+ pump stimulation. Experiments revealed that the Na+ pump plays a permissive role for mitochondrial ATP production and glycolysis. We conclude that neuronal energy homeostasis is not mediated by adenine nucleotides or by Ca 2+, but by a mechanism commanded by the Na+ pump.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Indeed, in vitro studies have shown that neuronal ATP levels decrease only under hyperexcitation induced by strong electrical stimulation or exogenous glutamate exposure, or following pharmacological inhibition of mitochondrial ATP production pathways20–22.”
From Energy paradox in REM sleep: balancing supply and consumption in brain metabolism (2026) · cites this paper as [22]
In the citing paper
“Consistent with these findings, in vivo studies have demonstrated that neuronal ATP levels remain stable in response to mild sensory stimuli in mice22, while a marked reduction in ATP levels is observed during epileptic seizure activity3.”
From Energy paradox in REM sleep: balancing supply and consumption in brain metabolism (2026) · cites this paper as [22]
Citations
Cites
AMPK: a nutrient and energy sensor that maintains energy homeostasis
Hardie, D. G., Ross, F. A., & Hawley, S. A. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3311 · Cited by 4,602
Pellerin, L., & Magistretti, P. J. (1994) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.91.22.10625 · Cited by 2,927
Assessing mitochondrial dysfunction in cells
Brand, M. D., & Nicholls, D. G. (2011) · Biochemical Journal · doi:10.1042/bj20110162 · Cited by 2,436
The Respiratory Chain and Oxidative Phosphorylation
Chance, B., & Williams, G. R. (1956) · Advances in enzymology and related areas of molecular biology/Advances in enzymology and related subjects · doi:10.1002/9780470122624.ch2 · Cited by 2,084
Synaptic Energy Use and Supply
Harris, J. J., Jolivet, R., & Attwell, D. (2012) · Neuron · doi:10.1016/j.neuron.2012.08.019 · Cited by 1,747
ScanImage: Flexible software for operating laser scanning microscopes
Pologruto, T. A., Sabatini, B. L., & Svoboda, K. (2003) · BioMedical Engineering OnLine · doi:10.1186/1475-925x-2-13 · Cited by 1,300
Imamura, H., Nhat, K. P. H., Togawa, H., Saito, K., Iino, R., Kato‐Yamada, Y., Nagai, T., & Noji, H. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904764106 · Cited by 1,089
Regulation of mitochondrial dehydrogenases by calcium ions
Denton, R. M. (2009) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2009.01.005 · Cited by 885
Herrero-Mendez, A., Almeida, A., Fernández, E., Maestre, C., Moncada, S., & Bolaños, J. P. (2009) · Nature Cell Biology · doi:10.1038/ncb1881 · Cited by 844
Activity-driven local ATP synthesis is required for synaptic function
Rangaraju, V., Calloway, N., & Ryan, T. A. (2014) · Cell · doi:10.1016/j.cell.2013.12.042 · Cited by 836
Cited by
Sorted by citations
Astrocyte-neuron metabolic cooperation shapes brain activity
Bonvento, G., & Bolaños, J. P. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.07.006 · Cited by 580
Contreras‐Baeza, Y., Sandoval, P. Y., Alarcón, R., Galaz, A., Cortés‐Molina, F., Alegría, K., Baeza‐Lehnert, F., Arce‐Molina, R., Guequén, A., Flores, C. A., et al. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.ra119.009093 · Cited by 218
Self-citationWei, Y., Miao, Q., Zhang, Q., Mao, S., Li, M., Xu, X., Xia, X., Wei, K., Fan, Y., Zheng, X., et al. (2023) · Nature Neuroscience · doi:10.1038/s41593-023-01476-4 · Cited by 153
Vergara, R. C., Jaramillo-Riveri, S., Luarte, A., Moënne‐Loccoz, C., Fuentes, R., Couve, A., & Maldonado, P. (2019) · Frontiers in Computational Neuroscience · doi:10.3389/fncom.2019.00049 · Cited by 149
Oligodendrocyte–axon metabolic coupling is mediated by extracellular K+ and maintains axonal health
Looser, Z. J., Faik, Z., Ravotto, L., Zanker, H. S., Jung, R. B., Werner, H. B., Ruhwedel, T., Möbius, W., Bergles, D. E., Barros, L. F., et al. (2024) · Nature Neuroscience · doi:10.1038/s41593-023-01558-3 · Cited by 130
Self-citation
Metadata
- Authors
- Baeza-Lehnert, F., Saab, A. S., Gutiérrez, R., Larenas, V., Díaz, E., Horn, M., Vargas, M., Hösli, L., Stobart, J., Hirrlinger, J., Weber, B., & Barros, L. F.
- Affiliations
- University of Zurich (CH)
- Austral University of Chile (CL)
- Centro de Estudios Científicos (CL)
- Max Planck Institute of Experimental Medicine (DE)
- Corresponding author
- Barros, L. Felipe
- ORCID
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2019-03
- Volume
- 29
- Issue
- 3
- Pages
- 668-680.e4
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W2904685632
- Cited by
- 126
- References
- 78
- Citations by year
- 2026: 10 · 2025: 19 · 2024: 25 · 2023: 21 · 2022: 12 · 2021: 12 · 2020: 13 · 2019: 14
- FWCI
- 3.47
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Funders
- FONDECYT (1160317)
- University of Zurich
- National Science Foundation
- Centro de Estudios Científicos
- Chilean Government
- CONICYT
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Ion Transport and Channel Regulation
- Keywords
- Na+/K+-ATPase, mitochondrial energization, pyruvate, glycolysis, glucose utilization, ATP production, neurotransmission, theta burst stimulation, FRET biosensor, ion sensitive probe
- MeSH terms
- Sodium-Potassium-Exchanging ATPase, Adenosine Triphosphate, Animals, Astrocytes, Energy Metabolism, Glucose, Glycolysis, Homeostasis, Mice, Inbred C57BL, Mitochondria, Neurons
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
