The DOI matches its Crossref record; 307 of the 307 references it cites were found in a registry or an index.
Watch What You (Self-) Eat: Autophagic Mechanisms that Modulate Metabolism
Open accessAbstract
Autophagy is an evolutionarily conserved lysosome/vacuole-dependent catabolic pathway in eukaryotes. Autophagy functions basally for cellular quality control and is induced to act as an alternative source of basic metabolites during nutrient-deprivation. These functions of autophagy are intimately connected to the regulation of metabolism, and the metabolic status of the cell in turn controls the nature and extent of autophagic induction. Here we highlight the co-regulation of autophagy and metabolism with a special focus on selective autophagy that, along with bulk autophagy, plays a central role in regulating and rewiring metabolic circuits. We outline the metabolic signals that activate these pathways, the mechanisms involved, and the downstream effects and implications while recognizing yet unanswered questions. We also discuss the role of autophagy in the development and maintenance of adipose tissue, an emerging player in systemic metabolic homeostasis, and describe what is currently known about the complex relationship between autophagy and cancer.
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2 retracted
RETRACTED ARTICLE: Parkin and PINK1 mitigate STING-induced inflammation
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“This includes the Atg8family protein LC3, which modulates immune responses and inflammation by a process known as LC3-associated phagocytosis (Cunha et al., 2018; Martinez et al., 2015).”
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AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1
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Autophagy: Renovation of Cells and Tissues
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“Ubiquitinated proteins are recognized by ubiquitin-binding autophagy adaptors such as OPTN and SQSTM1 which also bind LC3-II, promoting mitochondrial degradation (refer to text for details).”
BackgroundInfluentialAutophagy regulates lipid metabolism
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Cited by
Autophagy in major human diseases
Klionsky, D. J., Petroni, G., Amaravadi, R. K., Baehrecke, E. H., Ballabio, A., Boya, P., Bravo‐San Pedro, J. M., Cadwell, K., Cecconi, F., Choi, A. M. K., et al. (2021) · The EMBO Journal · doi:10.15252/embj.2021108863 · Cited by 1,585
Self-citationControl of satellite cell function in muscle regeneration and its disruption in ageing
Sousa-Victor, P., García-Prat, L., & Muñoz-Cánoves, P. (2022) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-021-00421-2 · Cited by 476
Autophagy and the hallmarks of aging
Kaushik, S., Tasset, I., Arias, E., Pampliega, O., Wong, E., Martinez-Vicente, M., & Cuervo, A. M. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101468 · Cited by 285
Critical role of mitochondrial ubiquitination and the OPTN–ATG9A axis in mitophagy
Yamano, K., Kikuchi, R., Kojima, W., Hayashida, R., Koyano, F., Kawawaki, J., Shoda, T., Demizu, Y., Naito, M., Tanaka, K., et al. (2020) · Journal of Cell Biology · doi:10.1083/jcb.201912144 · Cited by 205
ATG9A protects the plasma membrane from programmed and incidental permeabilization
Claude-Taupin, A., Jia, J., Bhujabal, Z., Garfa-Traoré, M., Kumar, S., da Silva, G. P. D., Javed, R., Gu, Y., Allers, L., Peters, R., et al. (2021) · Nature Cell Biology · doi:10.1038/s41556-021-00706-w · Cited by 92
Metadata
- Authors
- Lahiri, V., Hawkins, W. D., & Klionsky, D. J.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2019-04
- Volume
- 29
- Issue
- 4
- Pages
- 803-826
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W2934208435
- Cited by
- 282
- References
- 307
- FWCI
- 26.83
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Lahiri, V., Hawkins, W. D., & Klionsky, D. J. (2019). Watch What You (Self-) Eat: Autophagic Mechanisms that Modulate Metabolism. Cell Metabolism. https://doi.org/10.1016/j.cmet.2019.03.003
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
