Autophagy and the hallmarks of aging

Repertoires of Autophagy in the Pathogenesis of Ocular Diseases

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The Hallmarks of Aging

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Aging: a theory based on free radical and radiation chemistry

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Autophagy regulates lipid metabolism

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Suppression of basal autophagy in neural cells causes neurodegenerative disease in mice

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Loss of autophagy in the central nervous system causes neurodegeneration in mice

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TFEB Links Autophagy to Lysosomal Biogenesis

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Cellular Senescence: Defining a Path Forward

Gorgoulis, V., Adams, P. D., Alimonti, A., Bennett, D. C., Bischof, O., Bishop, C., Campisi, J., Collado, M., Evangelou, K., Ferbeyre, G., et al. (2019) · Cell · doi:10.1016/j.cell.2019.10.005 · Cited by 3,225 · see citing works

Functions of Lysosomes

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Biological Functions of Autophagy Genes: A Disease Perspective

Levine, B., & Kroemer, G. (2019) · Cell · doi:10.1016/j.cell.2018.09.048 · Cited by 2,832 · see citing works

Geroscience: Linking Aging to Chronic Disease

Kennedy, B. K., Berger, S. L., Brunet, A., Campisi, J., Cuervo, A. M., Epel, E. S., Franceschi, C., Lithgow, G. J., Morimoto, R. I., Pessin, J. E., et al. (2014) · Cell · doi:10.1016/j.cell.2014.10.039 · Cited by 2,764 · see citing works

The genetics of ageing

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Mechanisms, regulation and functions of the unfolded protein response

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Impairment of starvation-induced and constitutive autophagy in <i>Atg7</i> -deficient mice

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In Vivo Analysis of Autophagy in Response to Nutrient Starvation Using Transgenic Mice Expressing a Fluorescent Autophagosome Marker

Mizushima, N., Yamamoto, A., Matsui, M., Yoshimori, T., & Ohsumi, Y. (2003) · Molecular Biology of the Cell · doi:10.1091/mbc.e03-09-0704 · Cited by 2,323 · see citing works

MTOR: a pharmacologic target for autophagy regulation

Kim, Y. C., & Guan, K.-L. (2015) · Journal of Clinical Investigation · doi:10.1172/jci73939 · Cited by 2,126 · see citing works

Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease

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Induction of autophagy by spermidine promotes longevity

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mTOR is a key modulator of ageing and age-related disease

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Effects of intermittent fasting on health, aging, and disease

de Cabo, R., & Mattson, M. P. (2019) · New England Journal of Medicine · doi:10.1056/nejmra1905136 · Cited by 1,605 · see citing works

Mechanisms of mitophagy in cellular homeostasis, physiology and pathology

Palikaras, K., Lionaki, E., & Tavernarakis, N. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0176-2 · Cited by 1,505 · see citing works

The Biology of Proteostasis in Aging and Disease

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Molecular Chaperone Functions in Protein Folding and Proteostasis

Kim, Y., Hipp, M. S., Bracher, A., Hayer-Hartl, M. K., & Hartl, F. U. (2013) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-060208-092442 · Cited by 1,468 · see citing works

Molecular mechanisms and physiological functions of mitophagy

Onishi, M., Yamano, K., Sato, M., Matsuda, N., & Okamoto, K. (2021) · The EMBO Journal · doi:10.15252/embj.2020104705 · Cited by 1,429 · see citing works

The coming of age of chaperone-mediated autophagy

Kaushik, S., & Cuervo, A. M. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0001-6 · Cited by 1,422 · see citing works

Lysosomal calcium signalling regulates autophagy through calcineurin and TFEB

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Autophagy maintains stemness by preventing senescence

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Telomere dysfunction induces metabolic and mitochondrial compromise

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Autophagy Genes Are Essential for Dauer Development and Life-Span Extension in <i>C. elegans</i>

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Cargo recognition and trafficking in selective autophagy

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Cardioprotection and lifespan extension by the natural polyamine spermidine

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Spermidine in health and disease

Madeo, F., Eisenberg, T., Pietrocola, F., & Kroemer, G. (2018) · Science · doi:10.1126/science.aan2788 · Cited by 1,154 · see citing works

Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities

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Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents

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Autophagy mediates the mitotic senescence transition

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Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila Melanogaster

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A mitochondrial specific stress response in mammalian cells

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Geriatric muscle stem cells switch reversible quiescence into senescence

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The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4.

Kang, C., Xu, Q., Martin, T. D., Li, M. Z., Demaria, M., Aron, L., Lu, T., Yankner, B. A., Campisi, J., & Elledge, S. J. (2015) · Science · doi:10.1126/science.aaa5612 · Cited by 982 · see citing works

A Receptor for the Selective Uptake and Degradation of Proteins by Lysosomes

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Microautophagy of Cytosolic Proteins by Late Endosomes

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Autophagy maintains the metabolism and function of young and old stem cells

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Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles

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Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of <i>Drosophila</i> Pink1 is rescued by Parkin

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Autophagy in the Cellular Energetic Balance

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Regulation of H SF 1 Function in the Heat Stress Response: Implications in Aging and Disease

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Coordination of mitophagy and mitochondrial biogenesis during ageing in C. elegans

Palikaras, K., Lionaki, E., & Tavernarakis, N. (2015) · Nature · doi:10.1038/nature14300 · Cited by 770 · see citing works

A Role for Autophagy in the Extension of Lifespan by Dietary Restriction in C. elegans

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Benefits of Metformin in Attenuating the Hallmarks of Aging

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Identification of a candidate therapeutic autophagy-inducing peptide

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Overexpression of Atg5 in mice activates autophagy and extends lifespan

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Functions of Polyamines in Mammals

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Degradation of lipid droplet-associated proteins by chaperone-mediated autophagy facilitates lipolysis

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Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila

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Enhancement of the gut barrier integrity by a microbial metabolite through the Nrf2 pathway

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Measuring In Vivo Mitophagy

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Genome-wide analysis reveals mechanisms modulating autophagy in normal brain aging and in Alzheimer’s disease

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Age-related decline in chaperone-mediated autophagy

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Early time-restricted feeding improves 24-hour glucose levels and affects markers of the circadian clock, aging, and autophagy in humans

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The autophagy protein Atg7 is essential for hematopoietic stem cell maintenance

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FOXO/4E-BP Signaling in Drosophila Muscles Regulates Organism-wide Proteostasis during Aging

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Collapse of proteostasis represents an early molecular event in <i>Caenorhabditis elegans</i> aging

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Disruption of the beclin 1–BCL2 autophagy regulatory complex promotes longevity in mice

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Caloric Restriction Mimetics against Age-Associated Disease: Targets, Mechanisms, and Therapeutic Potential

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FOXO3A directs a protective autophagy program in haematopoietic stem cells

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Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy

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Activation of Chaperone-mediated Autophagy during Oxidative Stress

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The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans

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Parkinson’s Disease-Related Proteins PINK1 and Parkin Repress Mitochondrial Antigen Presentation

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Sestrin as a feedback inhibitor of TOR that prevents age-related pathologies

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The Chaperone-Mediated Autophagy Receptor Organizes in Dynamic Protein Complexes at the Lysosomal Membrane

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Autophagy is required for glucose homeostasis and lung tumor maintenance

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The TFEB orthologue HLH-30 regulates autophagy and modulates longevity in Caenorhabditis elegans

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Consequences of the selective blockage of chaperone-mediated autophagy

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Restoration of chaperone-mediated autophagy in aging liver improves cellular maintenance and hepatic function

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Protein Misfolding Diseases

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Genetic variation in the murine lifespan response to dietary restriction: from life extension to life shortening

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Regulation of autophagy by cytosolic acetyl-coenzyme A

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Hallmarks of Health

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Aggrephagy: Selective Disposal of Protein Aggregates by Macroautophagy

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The ATG conjugation systems in autophagy

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The LC3-conjugation machinery specifies the loading of RNA-binding proteins into extracellular vesicles

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SIRT1 is downregulated by autophagy in senescence and ageing

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The quest to slow ageing through drug discovery

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Essential role for autophagy in life span extension

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Regulation of intracellular accumulation of mutant Huntingtin by Beclin 1

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Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice

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Drosophila parkin mutants have decreased mass and cell size and increased sensitivity to oxygen radical stress

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AMPK–SKP2–CARM1 signalling cascade in transcriptional regulation of autophagy

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Targeting lysosomal quality control as a therapeutic strategy against aging and diseases

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New insights into the mechanisms and therapeutic strategies of chondrocyte autophagy in osteoarthritis

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Bioinspired engineering ADSC nanovesicles thermosensitive hydrogel enhance autophagy of dermal papilla cells for androgenetic alopecia treatment

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Rubicon in Metabolic Diseases and Ageing

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GTP energy dependence of endocytosis and autophagy in the aging brain and Alzheimer’s disease

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Restoration of LAMP2A expression in old mice leads to changes in the T cell compartment that support improved immune function

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Aging Lung: Molecular Drivers and Impact on Respiratory Diseases—A Narrative Clinical Review

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Mitophagy in the aging nervous system

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Genomic instability and genetic heterogeneity in aging: insights from clonal hematopoiesis (CHIP), monoclonal gammopathy (MGUS), and monoclonal B-cell lymphocytosis (MBL)

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Renal Fibrosis: SIRT1 Still of Value

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Asparagine prevents intestinal stem cell aging via the autophagy‐lysosomal pathway

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The Role of Ginseng and Its Bioactive Compounds in Aging: Cells and Animal Studies

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Nutraceutical and Dietary Strategies for Up-Regulating Macroautophagy

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Metformin protects against vascular calcification through the selective degradation of Runx2 by the p62 autophagy receptor

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Puerarin extends the lifespan of Drosophila melanogaster by activating autophagy

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Autophagy impairment in patients with obstructive sleep apnea modulates intermittent hypoxia-induced oxidative stress and cell apoptosis via hypermethylation of the ATG5 gene promoter region

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Hypoxic State of Cells and Immunosenescence: A Focus on the Role of the HIF Signaling Pathway

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A circadian rhythm-restricted diet regulates autophagy to improve cognitive function and prolong lifespan

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Hydrogen sulfide inhibits skeletal muscle ageing by up‐regulating autophagy through promoting deubiquitination of adenosine 5’‐monophosphate (AMP)‐activated protein kinase α1 via ubiquitin specific peptidase 5

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Research Progress and Potential Applications of Spermidine in Ocular Diseases

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Cellular senescence: from homeostasis to pathological implications and therapeutic strategies

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The emerging importance of lymphangiogenesis in aging and aging-associated diseases

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Novel mediators of idiopathic pulmonary fibrosis

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Lycium barbarum Polysaccharides Regulating miR-181/Bcl-2 Decreased Autophagy of Retinal Pigment Epithelium with Oxidative Stress

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Chaperone-mediated autophagy in neurodegenerative diseases: mechanisms and therapy

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The Role and Application of the AMPK-Sirtuins Network in Cellular Senescence

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Autophagy and metabolic aging: Current understanding and future applications

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Anthraquinones and Aloe Vera Extracts as Potential Modulators of Inflammaging Mechanisms: A Translational Approach from Autoimmune to Onco-Hematological Diseases

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Sex differences in socioemotional behavior and changes in ventral hippocampal transcription across aging in C57Bl/6J mice

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Identification of Four Biomarkers of Human Skin Aging by Comprehensive Single Cell Transcriptome, Transcriptome, and Proteomics

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Bone Marrow Stromal Stem Cell Fate Decision: A Potential Mechanism For Bone Marrow Adipose Increase with Aging-related Osteoporosis

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Epigenetic modification and exosome effects on autophagy in osteoarthritis

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Targeting mitochondrial autophagy for anti-aging

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BECN1F121A mutation increases autophagic flux in aged mice and improves aging phenotypes in an organ-dependent manner

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Autophagy-dependent splicing control directs translation toward inflammation during senescence

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Relating aging and autophagy – a new perspective towards the welfare of human health

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Hallmarks of Aging: An Autophagic Perspective

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Autophagy and Aging

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Agephagy – Adapting Autophagy for Health During Aging

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