Extracellular Vesicle-Contained eNAMPT Delays Aging and Extends Lifespan in Mice

NAD+ Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus

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Adipose-derived circulating miRNAs regulate gene expression in other tissues

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NAD+ and sirtuins in aging and disease

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Nicotinamide Mononucleotide, a Key NAD+ Intermediate, Treats the Pathophysiology of Diet- and Age-Induced Diabetes in Mice

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NAD + in aging, metabolism, and neurodegeneration

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Sleep and Human Aging

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Adipose tissue macrophage-derived exosomal miRNAs can modulate in vivo and in vitro insulin sensitivity

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NAD+ Intermediates: The Biology and Therapeutic Potential of NMN and NR

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Cloning and Characterization of the cDNA Encoding a Novel Human pre-B-Cell Colony-enhancing Factor

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Neuroprotection in Glaucoma: NAD+/NADH Redox State as a Potential Biomarker and Therapeutic Target

Petriti, B., Williams, P. A., Lascaratos, G., Chau, K., & Garway‐Heath, D. F. (2021) · Cells · doi:10.3390/cells10061402 · Cited by 52

Association of Human Whole Blood NAD+ Contents With Aging

Yang, F., Deng, X., Yu, Y., Luo, L., Chen, X., Zheng, J., Qiu, Y., Xiao, F., Xie, X., Zhao, Y., et al. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.829658 · Cited by 47

NF‐κB/IKK activation by small extracellular vesicles within the SASP

Fafián‐Labora, J., & O’Loghlen, A. (2021) · Aging Cell · doi:10.1111/acel.13426 · Cited by 49

Organ Crosstalk in Acute Kidney Injury: Evidence and Mechanisms

Li, X., Yuan, F., & Zhou, L. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11226637 · Cited by 50

The Role of Extracellular Vesicles in Senescence

Oh, C., Koh, D., Jeon, H. B., & Kim, K. M. (2022) · Molecules and Cells · doi:10.14348/molcells.2022.0056 · Cited by 49

The emerging roles of extracellular vesicles as intercellular messengers in liver physiology and pathology

Lee, Y., & Kim, J. (2022) · Clinical and Molecular Hepatology · doi:10.3350/cmh.2021.0390 · Cited by 47

Nicotinamide Adenine Dinucleotide in Aging Biology: Potential Applications and Many Unknowns

Bhasin, S., Seals, D. R., Migaud, M. E., Musi, N., & Baur, J. A. (2023) · Endocrine Reviews · doi:10.1210/endrev/bnad019 · Cited by 50

A systematic review and meta-analysis of the SIRT1 response to exercise

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Nicotinamide phosphoribosyltransferase in NAD+ metabolism: physiological and pathophysiological implications

Zhang, W., Ren, H., Chen, W., Hu, B., Feng, C., Li, P., Shi, Y., & Fang, J. (2025) · Cell Death Discovery · doi:10.1038/s41420-025-02672-w · Cited by 52

Implications of NAD+ Metabolism in the Aging Retina and Retinal Degeneration

Jadeja, R. N., Thounaojam, M. C., Bartoli, M., & Martin, P. M. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/2692794 · Cited by 45

NAD+ Precursors: A Questionable Redundancy

Cantó, C. (2022) · Metabolites · doi:10.3390/metabo12070630 · Cited by 41

DMHPpp1r17 neurons regulate aging and lifespan in mice through hypothalamic-adipose inter-tissue communication

Tokizane, K., Brace, C. S., & Imai, S. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2023.12.011 · Cited by 41

Exosomes from young plasma alleviate osteoporosis through miR-217-5p-regulated osteogenesis of bone marrow mesenchymal stem cell

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Inter-organ communication is a critical machinery to regulate metabolism and aging

Tokizane, K., & Imai, S. (2024) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2024.11.013 · Cited by 43

Rapamycin maintains NAD+/NADH redox homeostasis in muscle cells

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Circulating plasma factors involved in rejuvenation

Kang, J. S., & Yang, Y. R. (2020) · Aging · doi:10.18632/aging.103933 · Cited by 39

Interplay between the brain and adipose tissue: a metabolic conversation

Díaz‐Castro, F., Morselli, E., & Claret, M. (2024) · EMBO Reports · doi:10.1038/s44319-024-00321-4 · Cited by 44

Visfatin regulates Pg LPS-induced proinflammatory/prodegradative effects in healthy and inflammatory periodontal cells partially via NF-κB pathway

Yao, S., Jiang, C., Zhang, H., Gao, X., Guo, Y., & Cao, Z. (2021) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2021.119042 · Cited by 37

NAMPT mitigates colitis severity by supporting redox-sensitive activation of phagocytosis in inflammatory macrophages

Hong, S. M., Lee, A., Hwang, S., Ha, Y., Kim, M.-J., Min, S., Hwang, W., Yoon, G., Kwon, S. M., Woo, H. G., et al. (2022) · Redox Biology · doi:10.1016/j.redox.2022.102237 · Cited by 38

Ancient Evolutionary Origin and Properties of Universally Produced Natural Exosomes Contribute to Their Therapeutic Superiority Compared to Artificial Nanoparticles

Askenase, P. W. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22031429 · Cited by 41

Role and Potential Mechanisms of Nicotinamide Mononucleotide in Aging

Rahman, S. U., Qadeer, A., & Wu, Z. (2024) · Aging and disease · doi:10.14336/ad.2023.0519-1 · Cited by 34

The Aged Intestine: Performance and Rejuvenation

Wang, Q., Qi, Y., Shen, W., Xu, J., Wang, L., Chen, S., Hou, T., & Si, J. (2021) · Aging and Disease · doi:10.14336/ad.2021.0202 · Cited by 36

NAMPT encapsulated by extracellular vesicles from young adipose-derived mesenchymal stem cells treated tendinopathy in a “One-Stone-Two-Birds” manner

Wu, G., Su, Q., Li, J., Xue, C. H., Zhu, J., Cai, Q., Huang, J., Ji, S., Cheng, B., & Ge, H. (2023) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01763-5 · Cited by 35

Obesity and Adipose-Derived Extracellular Vesicles: Implications for Metabolic Regulation and Disease

Malaguarnera, M., Cauli, O., & Cabrera‐Pastor, A. (2025) · Biomolecules · doi:10.3390/biom15020231 · Cited by 39

The Extracellular NADome Modulates Immune Responses

Audrito, V., Messana, V. G., Brandimarte, L., & Deaglio, S. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.704779 · Cited by 35

Therapeutic Potential of Extracellular Vesicles in Aging and Age-Related Diseases

Sanz‐Ros, J., Mas‐Bargues, C., Romero-García, N., Huete-Acevedo, J., Dromant, M., & Borrás, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232314632 · Cited by 35

The Cytokine Nicotinamide Phosphoribosyltransferase (eNAMPT; PBEF; Visfatin) Acts as a Natural Antagonist of C-C Chemokine Receptor Type 5 (CCR5)

Torretta, S., Colombo, G., Travelli, C., Boumya, S., Lim, D., Genazzani, A. A., & Grolla, A. A. (2020) · Cells · doi:10.3390/cells9020496 · Cited by 33

Circadian mechanisms in adipose tissue bioenergetics and plasticityPreprint

Hepler, C., & Bass, J. T. (2023) · Genes & Development · doi:10.1101/gad.350759.123 · Cited by 35

The function of nicotinamide phosphoribosyl transferase (NAMPT) and its role in diseases

Peng, A., Li, J., Xing, J., Yao, Y., Niu, X., & Zhang, K. (2024) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2024.1480617 · Cited by 39

NAD+ Metabolism as an Emerging Therapeutic Target for Cardiovascular Diseases Associated With Sudden Cardiac Death

Xu, W., Li, L., & Zhang, L. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00901 · Cited by 35

Non-canonical roles of NAMPT and PARP in inflammation

Martínez-Morcillo, F. J., Cantón-Sandoval, J., Martínez‐Menchón, T., Corbalán-Vélez, R., Mesa-del-Castillo, P., Pérez‐Oliva, A. B., García‐Moreno, D., & Mulero, V. (2020) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2020.103881 · Cited by 33

Friends and foes: Extracellular vesicles in aging and rejuvenation

Lananna, B. V., & Imai, S. (2021) · FASEB BioAdvances · doi:10.1096/fba.2021-00077 · Cited by 30

The effect of lactoferrin in aging: role and potential

Li, B., Zhang, B., Liu, X., Zheng, Y., Han, K., Liu, H., Wu, C., Li, J., Fan, S., Peng, W., et al. (2021) · Food & Function · doi:10.1039/d1fo02750f · Cited by 32

The Role of Extracellular Vesicles in Aging and Age-Related Disorders

Ganesh, B. H., Padinjarathil, H., Rajendran, R. L., Ramani, P., Gangadaran, P., & Ahn, B. (2025) · Antioxidants · doi:10.3390/antiox14020177 · Cited by 33

NAD+ precursor supplementation in human ageing: clinical evidence and challenges

Vinten, K. T., Trętowicz, M. M., Coskun, E., van Weeghel, M., Cantó, C., Perez, R. Z., Janssens, G. E., & Houtkooper, R. H. (2025) · Nature Metabolism · doi:10.1038/s42255-025-01387-7 · Cited by 40

Nampt affects mitochondrial function in aged oocytes by mediating the downstream effector FoxO3a

Zhuan, Q., Li, J., Du, X., Zhang, L., Meng, L., Cheng, K., Zhu, S., Hou, Y., & Fu, X. (2021) · Journal of Cellular Physiology · doi:10.1002/jcp.30532 · Cited by 29

Molecular insights into the interaction between human nicotinamide phosphoribosyltransferase and Toll-like receptor 4

Gasparrini, M., Mazzola, F., Cuccioloni, M., Sorci, L., Audrito, V., Zamporlini, F., Fortunato, C., Amici, A., Cianci, M., Deaglio, S., et al. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.101669 · Cited by 29

NAD World 3.0: the importance of the NMN transporter and eNAMPT in mammalian aging and longevity control

Imai, S. (2025) · npj Aging · doi:10.1038/s41514-025-00192-6 · Cited by 30

NAD+ Metabolism and Diseases with Motor Dysfunction

Lundt, S., & Ding, S. (2021) · Genes · doi:10.3390/genes12111776 · Cited by 27

Impacts of systemic milieu on cerebrovascular and brain aging: insights from heterochronic parabiosis, blood exchange, and plasma transfer experiments

Gulej, R., Patai, R., Ungvari, A., Kállai, A., Tarantini, S., Yabluchanskiy, A., Huffman, D. M., Conboy, M. J., Conboy, I. M., Mika Kivimaki, B., et al. (2025) · GeroScience · doi:10.1007/s11357-025-01657-y · Cited by 29

Neural Stem Cell-Derived Extracellular Vesicles Counteract Insulin Resistance-Induced Senescence of Neurogenic Niche

Natale, F., Leone, L., Rinaudo, M., Sollazzo, R., Barbati, S. A., Greca, F. L., Spinelli, M., Fusco, S., & Grassi, C. (2022) · Stem Cells · doi:10.1093/stmcls/sxab026 · Cited by 28

Extracellular nicotinamide phosphoribosyltransferase boosts IFNγ-induced macrophage polarization independently of TLR4

Colombo, G., Travelli, C., Porta, C., & Genazzani, A. A. (2022) · iScience · doi:10.1016/j.isci.2022.104147 · Cited by 28

Exploiting the telomere machinery to put the brakes on inflamm-aging

Bonafè, M., Sabbatinelli, J., & Olivieri, F. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101027 · Cited by 27

Circulating extracellular vesicles delivering beneficial cargo as key players in exercise effects

Siqueira, I. R., Palazzo, R. P., & Cechinel, L. R. (2021) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2021.06.007 · Cited by 29

Small Extracellular Vesicles Derived from Adipocytes Attenuate Intervertebral Disc Degeneration in Rats by Rejuvenating Senescent Nucleus Pulposus Cells and Endplate Cells by Delivering Exogenous NAMPT

Sun, Y., Li, X., Yang, X., Chen, B., & Zhang, W. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/9955448 · Cited by 29

Exercise, healthy ageing, and the potential role of small extracellular vesicles

McIlvenna, L. C., & Whitham, M. (2022) · The Journal of Physiology · doi:10.1113/jp282468 · Cited by 27

The Science Behind NMN-A Stable, Reliable NAD+Activator and Anti-Aging Molecule.

Shade, C. W. (2020) · Europe PMC (PubMed Central) · Cited by 24

Mesenchymal stromal cells attenuate alveolar type 2 cells senescence through regulating NAMPT-mediated NAD metabolism

Lai, X., Huang, S., Lin, S., Pu, L., Wang, Y., Lin, Y., Huang, W., & Wang, Z. (2022) · Stem Cell Research & Therapy · doi:10.1186/s13287-021-02688-w · Cited by 26

Extracellular Vesicle-Based Therapeutics in Neurological Disorders

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NAD+ Metabolism and Interventions in Premature Renal Aging and Chronic Kidney Disease

Chanvillard, L., Tammaro, A., & Sorrentino, V. (2022) · Cells · doi:10.3390/cells12010021 · Cited by 28

Single vesicle analysis reveals the release of tetraspanin positive extracellular vesicles into circulation with high intensity intermittent exercise

McIlvenna, L. C., Parker, H., Seabright, A. P., Sale, B., Anghileri, G., Weaver, S. R., Lucas, S. J. E., & Whitham, M. (2023) · The Journal of Physiology · doi:10.1113/jp284047 · Cited by 29

Recent clinical trials with stem cells to slow or reverse normal aging processes

Garay, R. P. (2023) · Frontiers in Aging · doi:10.3389/fragi.2023.1148926 · Cited by 27

Circulating blood eNAMPT drives the circadian rhythms in locomotor activity and energy expenditure

Park, J.-W., Roh, E., Kang, G. M., Gil, S. Y., Kim, H. K., Lee, C. H., Jang, W. H., Park, S. E., Moon, S. Y., Kim, S. J., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-37517-6 · Cited by 26

An Integrated LC-MS/MS Strategy for Quantifying the Oxidative-Redox Metabolome in Multiple Biological Samples

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Aging clocks & mortality timers, methylation, glycomic, telomeric and more. A window to measuring biological age

Palmer, R. D. (2022) · Aging Medicine · doi:10.1002/agm2.12197 · Cited by 25

Peripheral and central macrophages in obesity

Mukherjee, S., Skrede, S., Haugstøyl, M. E., López, M., & Fernø, J. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1232171 · Cited by 27

NAD+ metabolism and therapeutic strategies in cardiovascular diseases

Shi, C., Wen, Z., Yang, Y., Shi, L., & Liu, D. (2024) · Atherosclerosis Plus · doi:10.1016/j.athplu.2024.06.001 · Cited by 23

Nicotinamide Mononucleotide Supplementation: Understanding Metabolic Variability and Clinical Implications

Benjamin, C., & Crews, R. (2024) · Metabolites · doi:10.3390/metabo14060341 · Cited by 25

Embryonic vitamin D deficiency programs hematopoietic stem cells to induce type 2 diabetes

Oh, J., Riek, A. E., Bauerle, K. T., Dusso, A., McNerney, K. P., Barve, R. A., Darwech, I., Sprague, J., Moynihan, C., Zhang, R. M., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-38849-z · Cited by 28

Importance of Adipose Tissue NAD+ Biology in Regulating Metabolic Flexibility

Franczyk, M. P., Qi, N., Stromsdorfer, K. L., Li, C., Yamaguchi, S., Itoh, H., Yoshino, M., Sasaki, Y., Brookheart, R. T., Finck, B. N., et al. (2021) · Endocrinology · doi:10.1210/endocr/bqab006 · Cited by 23

Extracellular Vesicles: Recent Developments in Aging and Reproductive Diseases

Liu, Y., Shen, Q., Zhang, L., & Xiang, W. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.577084 · Cited by 23

New Insights into the Genetics and Epigenetics of Aging Plasticity

Zhang, J., Wang, S., & Liu, B. (2023) · Genes · doi:10.3390/genes14020329 · Cited by 25

Metabolomics in Parkinson’s Disease and Correlation with Disease State

Ostrakhovitch, E. A., Ono, K., & Yamasaki, T. R. (2025) · Metabolites · doi:10.3390/metabo15030208 · Cited by 24

Plasma level and expression of visfatin in the porcine hypothalamus during the estrous cycle and early pregnancy

Kamiński, T., Kieżun, M., Zaobidna, E., Dobrzyń, K., Wasilewska, B., Mlyczyńska, E., Rytelewska, E., Kisielewska, K., Gudelska, M., Bors, K., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-88103-z · Cited by 24

The Double-Edged Role of Extracellular Vesicles in the Hallmarks of Aging

Romero-García, N., Huete-Acevedo, J., Mas‐Bargues, C., Sanz‐Ros, J., Dromant, M., & Borrás, C. (2023) · Biomolecules · doi:10.3390/biom13010165 · Cited by 25

Extracellular nicotinamide phosphoribosyltransferase (eNAMPT) neutralization counteracts T cell immune evasion in breast cancer

Travelli, C., Colombo, G., Aliotta, M., Fagiani, F., Fava, N., Sanctis, R. D., Grolla, A. A., Garcia, J. G. N., Clemente, N., Portararo, P., et al. (2023) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2023-007010 · Cited by 22

Telomeres: Dysfunction, Maintenance, Aging and Cancer

Liao, P., Yan, B., Wang, C., & Lei, P. (2023) · Aging and Disease · doi:10.14336/ad.2023.1128 · Cited by 22

Targeting NAMPT‐OPA1 for treatment of senile osteoporosis

Bai, C., Tian, B., Zhang, M., Qin, Q., Shi, X., Yang, X., Gao, X., Zhou, X., Shan, H., & Bai, J. (2024) · Aging Cell · doi:10.1111/acel.14400 · Cited by 24

Dynamic Aging: Channeled Through Microenvironment

Tan, Q., Liang, N., Zhang, X., & Li, J. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.702276 · Cited by 25

Proteomic analysis reveals microvesicles containing NAMPT as mediators of radioresistance in glioma

Panizza, E., Regalado, B. D., Wang, F., Nakano, I., Vacanti, N. M., Cerione, R. A., & Antonyak, M. A. (2023) · Life Science Alliance · doi:10.26508/lsa.202201680 · Cited by 21

The significance of precisely regulating heme oxygenase-1 expression: Another avenue for treating age-related ocular disease?

Wei, D., Qu, C., Zhao, N., Li, S., Pu, N., Song, Z., & Tao, Y. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102308 · Cited by 22

Pharmacotherapy to gene editing: potential therapeutic approaches for Hutchinson–Gilford progeria syndrome

Saxena, S., & Kumar, S. (2020) · GeroScience · doi:10.1007/s11357-020-00167-3 · Cited by 23

Energetic Stress‐Induced Metabolic Regulation by Extracellular Vesicles

Crewe, C. (2023) · Comprehensive physiology · doi:10.1002/cphy.c230001 · Cited by 48

Extracellular vesicle encapsulated nicotinamide delivered via a trans-scleral route provides retinal ganglion cell neuroprotection

Kim, M.-J., Kim, J. Y., Rhim, W.-K., Cimaglia, G., Want, A., Morgan, J. E., Williams, P. A., Park, C. G., Han, D. K., & Rho, S. (2024) · Acta Neuropathologica Communications · doi:10.1186/s40478-024-01777-0 · Cited by 21

Extracellular Vesicles and Hematopoietic Stem Cell Aging

Goldberg, L. R. (2021) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.120.314643 · Cited by 20

Nucleophosmin3 carried by small extracellular vesicles contribute to white adipose tissue browning

Zhang, Y., Yu, M., Dong, J., Wu, Y., & Tian, W. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01381-1 · Cited by 20

From Rate-Limiting Enzyme to Therapeutic Target: The Promise of NAMPT in Neurodegenerative Diseases

Zhu, Y., Xu, P., Huang, X., Wen, S., Liu, L., Zhang, S., Zhao, R., Hu, X., & Wang, G. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.920113 · Cited by 21

Age-related mechanisms in the context of rheumatic disease

Alsaleh, G., Richter, F. C., & Simon, A. K. (2022) · Nature Reviews Rheumatology · doi:10.1038/s41584-022-00863-8 · Cited by 20

Identification of Novel Senescent Markers in Small Extracellular Vesicles

Misawa, T., Hitomi, K., Miyata, K., Tanaka, Y., Fujii, R., Chiba, M., Loo, T. M., Hanyu, A., Kawasaki, H., Kato, H., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032421 · Cited by 21

Source of nicotinamide governs its metabolic fate in cultured cells, mice, and humans

Dutta, T., Kapoor, N., Mathew, M., Chakraborty, S. S., Ward, N. P., Prieto-Farigua, N., Falzone, A., DeLany, J. P., Smith, S. R., Coen, P. M., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112218 · Cited by 19

Transcriptome analysis reveals therapeutic potential of NAMPT in protecting against abdominal aortic aneurysm in human and mouse

Ouyang, Y., Hong, Y., Mai, C., Yang, H., Wu, Z., Gao, X., Zeng, W., Deng, X., Liu, B., Zhang, Y., et al. (2023) · Bioactive Materials · doi:10.1016/j.bioactmat.2023.11.020 · Cited by 20

Intercellular communication is crucial in the regulation of healthy aging via exosomes

Sun, H., Xia, T., Ma, S., Lv, T., & Li, Y. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107591 · Cited by 25

Therapeutic Efficacy and Promise of Human Umbilical Cord Mesenchymal Stem Cell-Derived Extracellular Vesicles in Aging and Age-Related Disorders

Zhang, A., Li, Q., & Chen, Z. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms26010225 · Cited by 21

NAD+: An old but promising therapeutic agent for skeletal muscle ageing

Xu, Y., & Xiao, W. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.102106 · Cited by 20

Engineered extracellular vesicles with sequential cell recruitment and osteogenic functions to effectively promote senescent bone repair

Qi, L., Wang, J., Yan, J., Jiang, W., Ge, W., Fang, X., Wang, X., Shen, S. G., Liu, L., & Zhang, L. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03168-6 · Cited by 20

Quantification of localized NAD+ changes reveals unique specificity of NAD+ regulation in the hypothalamus

Johnson, S., Yoshioka, K., Brace, C. S., & Imai, S. (2023) · npj Aging · doi:10.1038/s41514-023-00098-1 · Cited by 18

iPSC-derived exosomes promote angiogenesis in naturally aged mice

Li, X., Zhang, H., Wang, X., Lu, M., Ding, Q., Chen, A. F., Xiang, M., & Chen, S. (2023) · Aging · doi:10.18632/aging.204845 · Cited by 18

Triple-Isotope Tracing for Pathway Discernment of NMN-Induced NAD+ Biosynthesis in Whole Mice

Sauve, A. A., Wang, Q., Zhang, N., Kang, S., Rathmann, A., & Yang, Y. J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241311114 · Cited by 19

Emerging role of extracellular vesicles in veterinary practice: novel opportunities and potential challenges

Xiong, Y., Lou, P., Xu, C., Han, B., Liu, J., & Gao, J. (2024) · Frontiers in Veterinary Science · doi:10.3389/fvets.2024.1335107 · Cited by 18

Low magnitude vibration alleviates age-related bone loss by inhibiting cell senescence of osteogenic cells in naturally senescent rats

Wen, J., Bao, M., Tang, M., He, X., Yao, X., & Li, L. (2021) · Aging · doi:10.18632/aging.202907 · Cited by 17

Nurturing longevity through natural compounds: Where do we stand, and where do we go?

Todorova, M. N., Savova, M. S., Mihaylova, L. V., & Georgiev, M. I. (2024) · Food Frontiers · doi:10.1002/fft2.350 · Cited by 17

Influence of Adipokines on Metabolic Dysfunction and Aging

Park, S., & Shimokawa, I. (2024) · Biomedicines · doi:10.3390/biomedicines12040873 · Cited by 20

Extracellular Vesicle‐Contained Thrombospondin 1 Retards Age‐Related Degenerative Tendinopathy by Rejuvenating Tendon Stem/Progenitor Cell Senescence

Cai, Z., Xin, Z., Wang, H., Wang, C., & Liu, X. (2024) · Small · doi:10.1002/smll.202400598 · Cited by 18

Exosome-based targeted delivery of NF-κB ameliorates age-related neuroinflammation in the aged mouse brain

Lee, C.-J., Jang, S.-H., Lim, J., Park, H., Ahn, S., Park, S. Y., Seo, H., Song, S., Shin, J., Choi, C., et al. (2025) · Experimental & Molecular Medicine · doi:10.1038/s12276-024-01388-8 · Cited by 18

Expression of Exosome Biogenesis Genes Is Differentially Altered by Aging in the Mouse and in the Human Brain During Alzheimer’s Disease

Lark, D. S., & LaRocca, T. J. (2021) · The Journals of Gerontology Series A · doi:10.1093/gerona/glab322 · Cited by 17

Adipose tissue senescence: Biological changes, hallmarks and therapeutic approaches

Zhang, Y., Jiang, Y., Yang, X., Huang, Y., Pan, A., & Liao, Y. (2024) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2024.111988 · Cited by 17

Cardioprotective Effects of 1-(3,6-Dibromo-carbazol-9-yl)-3-Phenylamino-Propan-2-Ol in Diabetic Hearts via Nicotinamide Phosphoribosyltransferase Activation

Tur, J., Badole, S. L., Manickam, R., Chapalamadugu, K. C., Xuan, W., Guida, W. C., Crews, J. J., Bisht, K. S., & Tipparaju, S. M. (2022) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.122.001122 · Cited by 16

Nicotinamide reprograms adipose cellular metabolism and increases mitochondrial biogenesis to ameliorate obesity

Luo, C., Yang, C., Wang, X., Chen, Y., Liu, X., & Deng, H. (2022) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2022.109056 · Cited by 16

Long-term NMN treatment increases lifespan and healthspan in mice in a sex dependent mannerPreprint

Kane, A. E., Chellappa, K., Schultz, M. B., Arnold, M. W., Li, J., Amorim, J., Diener, C., Zhu, D., Mitchell, S. J., Griffin, P. T., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.06.21.599604 · Cited by 16

Adipocytes and Stromal Cells Regulate Brown Adipogenesis Through Secretory Factors During the Postnatal White-to-Brown Conversion of Adipose Tissue in Syrian Hamsters

Mae, J., Nagaya, K., Okamatsu‐Ogura, Y., Tsubota, A., Matsuoka, S., Nio‐Kobayashi, J., & Kimura, K. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.698692 · Cited by 16

Human plasma-derived eNAMPT-containing extracellular vesicles promote NAD+ biosynthesis and thermogenesis in mice

Yoshioka, K., Sugimoto, T., Oyabu, M., Ito, N., Kodama, A., Kamei, Y., & Imai, S. (2025) · npj Aging · doi:10.1038/s41514-025-00297-y · Cited by 6

The Role of eNAMPT-mediated Systemic NAD+ Biosynthesis in Aging and Lifespan

Yoshida, M. (2021) · Open Scholarship Institutional Repository (Washington University in St. Louis) · doi:10.7936/zswy-dd49

Exercise increases the release of NAMPT in extracellular vesicles and alters NAD + activity in recipient cells

Chong, M. C., Silva, A., James, P. F., Wu, S. S. X., & Howitt, J. A. (2022) · Aging Cell · doi:10.1111/acel.13647 · Cited by 62

Adipose Tissue Overexpression of Nicotinamide Phosphoribosyltransferase Prevents Metabolic Dysfunction in Obese Mice via Extracellular Vesicles

Ferguson, D., Gadson, E. I., Markan, K. R., Yoshino, J., Palacios, H. H., Lin, M., Habibi, M., Tiash, S., Cui, X., Kouranova, E. V., et al. (2026) · Diabetes · doi:10.2337/db25-0914

NAD World 3.0: the importance of the NMN transporter and eNAMPT in mammalian aging and longevity control

Imai, S. (2025) · npj Aging · doi:10.1038/s41514-025-00192-6 · Cited by 30