Role and Potential Mechanisms of Nicotinamide Mononucleotide in Aging

Hallmarks of aging: An expanding universe

López-Otín, C., Blasco, M. A., Partridge, L., Serrano, M., & Kroemer, G. (2023) · Cell · doi:10.1016/j.cell.2022.11.001 · Cited by 6,549 · see citing works

The DNA damage response and cancer therapy

Lord, C. J., & Ashworth, A. (2012) · Nature · doi:10.1038/nature10760 · Cited by 1,843 · see citing works

NAD+ Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus

Cantó, C., Menzies, K. J., & Auwerx, J. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.05.023 · Cited by 1,648 · see citing works

Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging

Gomes, A. P., Price, N. L., Ling, A. J. Y., Moslehi, J. J., Montgomery, M. K., Rajman, L., White, J. P., Teodoro, J. S., Wrann, C. D., Hubbard, B. P., et al. (2013) · Cell · doi:10.1016/j.cell.2013.11.037 · Cited by 1,482 · see citing works

NAD+ and sirtuins in aging and disease

Imai, S.-I., & Guarente, L. (2014) · Trends in Cell Biology · doi:10.1016/j.tcb.2014.04.002 · Cited by 1,481 · see citing works

Nicotinamide Mononucleotide, a Key NAD+ Intermediate, Treats the Pathophysiology of Diet- and Age-Induced Diabetes in Mice

Yoshino, J., Mills, K. F., Yoon, M. J., & Imai, S.-I. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.08.014 · Cited by 1,340 · see citing works

NAD ⁺ in aging, metabolism, and neurodegeneration

Verdin, E. (2015) · Science · doi:10.1126/science.aac4854 · Cited by 1,319 · see citing works

Autophagy in healthy aging and disease

Aman, Y., Schmauck-Medina, T., Hansen, M., Morimoto, R. I., Simon, A. K., Bjedov, I., Palikaras, K., Simonsen, A., Johansen, T., Tavernarakis, N., et al. (2021) · Nature Aging · doi:10.1038/s43587-021-00098-4 · Cited by 1,313 · see citing works

Age and Age-Related Diseases: Role of Inflammation Triggers and Cytokines

Rea, I. M., Gibson, D. S., McGilligan, V., McNerlan, S. E., Alexander, H. D., & Ross, O. A. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00586 · Cited by 1,267 · see citing works

The NAD+ Precursor Nicotinamide Riboside Enhances Oxidative Metabolism and Protects against High-Fat Diet-Induced Obesity

Cantó, C., Houtkooper, R. H., Pirinen, E., Youn, D. Y., Oosterveer, M. H., Cen, Y., Fernandez-Marcos, P. J., Yamamoto, H., Andreux, P. A., Cettour-Rose, P., et al. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.04.022 · Cited by 1,238 · see citing works

The NAD+/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling

Mouchiroud, L., Houtkooper, R. H., Moullan, N., Katsyuba, E., Ryu, D., Cantó, C., Mottis, A., Jo, Y.-S., Viswanathan, M., Schoonjans, K., et al. (2013) · Cell · doi:10.1016/j.cell.2013.06.016 · Cited by 1,210 · see citing works

Biological and Chemical Approaches to Diseases of Proteostasis Deficiency

Powers, E. T., Morimoto, R. I., Dillin, A., Kelly, J. W., & Balch, W. E. (2009) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.052308.114844 · Cited by 1,149 · see citing works

NAD+ Intermediates: The Biology and Therapeutic Potential of NMN and NR

Yoshino, J., Baur, J. A., & Imai, S.-I. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2017.11.002 · Cited by 1,061 · see citing works

World Population Prospects 2022: Summary of Results

Nations, U. (2022) · Statistical Papers - United Nations (Ser. A), Population and Vital Statistics Report · doi:10.18356/9789210014380 · Cited by 1,010 · see citing works

Long-Term Administration of Nicotinamide Mononucleotide Mitigates Age-Associated Physiological Decline in Mice

Mills, K. F., Yoshida, S., Stein, L. R., Grozio, A., Kubota, S., Sasaki, Y., Redpath, P., Migaud, M. E., Apte, R. S., Uchida, K., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.09.013 · Cited by 930 · see citing works

Interdependence of AMPK and SIRT1 for metabolic adaptation to fasting and exercise in skeletal muscle

Cantó, C., Jiang, L. Q., Deshmukh, A. S., Mataki, C., Coste, A., Lagouge, M., Zierath, J. R., & Auwerx, J. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2010.02.006 · Cited by 921 · see citing works

Nampt/PBEF/Visfatin Regulates Insulin Secretion in β Cells as a Systemic NAD Biosynthetic Enzyme

Revollo, J. R., Körner, A., Mills, K. F., Satoh, A., Wang, T., Garten, A., Dasgupta, B., Sasaki, Y., Wolberger, C., Townsend, R. R., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.09.003 · Cited by 911 · see citing works

CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism

Camacho-Pereira, J., Tarragó, M. G., Chini, C. C. S., Nin, V., Escande, C., Warner, G. M., Puranik, A. S., Schoon, R. A., Reid, J. M., Galina, A., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.05.006 · Cited by 901 · see citing works

Mitophagy and Alzheimer’s Disease: Cellular and Molecular Mechanisms

Kerr, J. S., Adriaanse, B. A., Greig, N. H., Mattson, M. P., Cader, M. Z., Bohr, V. A., & Fang, E. F. (2017) · Trends in Neurosciences · doi:10.1016/j.tins.2017.01.002 · Cited by 870 · see citing works

Compromised autophagy and neurodegenerative diseases

Menzies, F. M., Fleming, A., & Rubinsztein, D. C. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3961 · Cited by 851 · see citing works

Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds

Bonkowski, M. S., & Sinclair, D. A. (2016) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2016.93 · Cited by 834 · see citing works

Sirtuin 1 Modulates Cellular Responses to Hypoxia by Deacetylating Hypoxia-Inducible Factor 1α

Lim, J.-H., Lee, Y.-M., Chun, Y.-S., Chen, J., Kim, J.-E., & Park, J.-W. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.05.023 · Cited by 758 · see citing works

Discoveries of Nicotinamide Riboside as a Nutrient and Conserved NRK Genes Establish a Preiss-Handler Independent Route to NAD+ in Fungi and Humans

Bieganowski, P., & Brenner, C. (2004) · Cell · doi:10.1016/s0092-8674(04)00416-7 · Cited by 750 · see citing works

Defective Mitophagy in XPA via PARP-1 Hyperactivation and NAD+/SIRT1 Reduction

Fang, E. F., Scheibye-Knudsen, M., Brace, L. E., Kassahun, H., SenGupta, T., Nilsen, H., Mitchell, J. R., Croteau, D. L., & Bohr, V. A. (2014) · Cell · doi:10.1016/j.cell.2014.03.026 · Cited by 711 · see citing works

DNA damage response and cellular senescence in tissues of aging mice

Wang, C., Jurk, D., Maddick, M., Nelson, G., Martin‐Ruiz, C., & Von Zglinicki, T. (2009) · Aging Cell · doi:10.1111/j.1474-9726.2009.00481.x · Cited by 696 · see citing works

Circadian Clock NAD + Cycle Drives Mitochondrial Oxidative Metabolism in Mice

Peek, C. B., Affinati, A. H., Ramsey, K. M., Kuo, H.-Y., Yu, W., Sena, L. A., Ilkayeva, O., Marcheva, B., Kobayashi, Y., Omura, C., et al. (2013) · Science · doi:10.1126/science.1243417 · Cited by 658 · see citing works

Enhancing mitochondrial proteostasis reduces amyloid-β proteotoxicity

Sorrentino, V., Romani, M., Mouchiroud, L., Beck, J. S., Zhang, H., D’Amico, D., Moullan, N., Potenza, F., Schmid, A. W., Rietsch, S., et al. (2017) · Nature · doi:10.1038/nature25143 · Cited by 630 · see citing works

NAD + Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair

Fang, E. F., Kassahun, H., Croteau, D. L., Scheibye-Knudsen, M., Marosi, K., Lu, H., Shamanna, R. A., Kalyanasundaram, S., Bollineni, R. C., Wilson, M. A., et al. (2016) · Cell Metabolism · doi:10.1016/j.cmet.2016.09.004 · Cited by 575 · see citing works

Quantitative Analysis of NAD Synthesis-Breakdown Fluxes

Liu, L., Su, X., Quinn, W. J., Hui, S., Krukenberg, K., Frederick, D. W., Redpath, P., Zhan, L., Chellappa, K., White, E., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.03.018 · Cited by 564 · see citing works

Tryptophan metabolism in the central nervous system: medical implications

Ruddick, J. P., Evans, A. K., Nutt, D. J., Lightman, S. L., Rook, G. A. W., & Lowry, C. A. (2006) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399406000068 · Cited by 519 · see citing works

Impairment of an endothelial NAD(+)-H2S signaling network is a reversible cause of vascular aging

Das, A., Huang, G. X., Bonkowski, M. S., Longchamp, A., Li, C., Schultz, M. B., Kim, L.-J., Osborne, B., Joshi, S., Lu, Y., et al. (2018) · Cell · doi:10.1016/j.cell.2018.02.008 · Cited by 496 · see citing works

NAD + metabolism: Bioenergetics, signaling and manipulation for therapy

Yang, Y. J., & Sauve, A. A. (2016) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2016.06.014 · Cited by 488 · see citing works

Endogenous Nmnat2 Is an Essential Survival Factor for Maintenance of Healthy Axons

Gilley, J., & Coleman, M. P. (2010) · PLoS Biology · doi:10.1371/journal.pbio.1000300 · Cited by 472 · see citing works

Environmental Noise Pollution in the United States: Developing an Effective Public Health Response

Hammer, M. S., Swinburn, T. K., & Neitzel, R. L. (2013) · Environmental Health Perspectives · doi:10.1289/ehp.1307272 · Cited by 458 · see citing works

p21 loss compromises the relative quiescence of forebrain stem cell proliferation leading to exhaustion of their proliferation capacity

Kippin, T. E., Martens, D. J., & van der Kooy, D. (2005) · Genes & Development · doi:10.1101/gad.1272305 · Cited by 442 · see citing works

Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women

Yoshino, M., Yoshino, J., Kayser, B. D., Patti, G. J., Franczyk, M. P., Mills, K. F., Sindelar, M., Pietka, T., Patterson, B. W., Imai, S.-I., et al. (2021) · Science · doi:10.1126/science.abe9985 · Cited by 439 · see citing works

De novo NAD+ synthesis enhances mitochondrial function and improves health

Katsyuba, E., Mottis, A., Ziętak, M., Franco, F., van der Velpen, V., Gariani, K., Ryu, D., Cialabrini, L., Matilainen, O., Liscio, P., et al. (2018) · Nature · doi:10.1038/s41586-018-0645-6 · Cited by 436 · see citing works

Longevity pathways converge on autophagy genes to regulate life span inCaenorhabditis elegans

Tóth, M. L., Sigmond, T., Borsos, É., Barna, J., Erdélyi, P., Takács‐Vellai, K., Orosz, L., Kovács, A., Csikós, G., Sass, M., et al. (2008) · Autophagy · doi:10.4161/auto.5618 · Cited by 429 · see citing works

DNA deletions and clonal mutations drive premature aging in mitochondrial mutator mice

Vermulst, M., Wanagat, J., Kujoth, G. C., Bielas, J. H., Rabinovitch, P. S., Prolla, T. A., & Loeb, L. A. (2008) · Nature Genetics · doi:10.1038/ng.95 · Cited by 411 · see citing works

Nicotinamide Riboside Promotes Sir2 Silencing and Extends Lifespan via Nrk and Urh1/Pnp1/Meu1 Pathways to NAD+

Belenky, P., Racette, F. G., Bogan, K. L., McClure, J. M., Smith, J. S., & Brenner, C. (2007) · Cell · doi:10.1016/j.cell.2007.03.024 · Cited by 411 · see citing works

Extracellular vesicle-contained eNAMPT delays aging and extends lifespan in mice

Yoshida, M., Satoh, A., Lin, J. B., Mills, K. F., Sasaki, Y., Rensing, N., Wong, M., Apte, R. S., & Imai, S.-I. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.05.015 · Cited by 407 · see citing works

Nicotinamide mononucleotide supplementation reverses vascular dysfunction and oxidative stress with aging in mice

Picciotto, N. E., Gano, L. B., Johnson, L. C., Martens, C. R., Sindler, A. L., Mills, K. F., Imai, S., & Seals, D. R. (2016) · Aging Cell · doi:10.1111/acel.12461 · Cited by 396 · see citing works

Nuclear DNA damage signalling to mitochondria in ageing

Fang, E. F., Scheibye-Knudsen, M., Chua, K. F., Mattson, M. P., Croteau, D. L., & Bohr, V. A. (2016) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2016.14 · Cited by 387 · see citing works

Progeria syndromes and ageing: what is the connection?

Burtner, C. R., & Kennedy, B. K. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2944 · Cited by 386 · see citing works

NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells

Ratajczak, J., Joffraud, M., Trammell, S. A. J., Ras, R., Canela, N., Boutant, M., Kulkarni, S. S., Rodrigues, M., Redpath, P., Migaud, M. E., et al. (2016) · Nature Communications · doi:10.1038/ncomms13103 · Cited by 378 · see citing works

Nicotinamide riboside restores cognition through an upregulation of proliferator-activated receptor-γ coactivator 1α regulated β-secretase 1 degradation and mitochondrial gene expression in Alzheimer's mouse models

Gong, B., Pan, Y., Vempati, P., Zhao, W., Knable, L., Ho, L., Wang, J., Sastre, M., Ono, K., Sauve, A. A., et al. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.12.005 · Cited by 345 · see citing works

Nicotinamide Improves Aspects of Healthspan, but Not Lifespan, in Mice

Mitchell, S. J., Bernier, M., Aon, M. A., Cortassa, S., Kim, E. Y., Fang, E. F., Palacios, H. H., Ali, A., Navas-Enamorado, I., Di Francesco, A., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.02.001 · Cited by 338 · see citing works

NAD+ Repletion Rescues Female Fertility during Reproductive Aging

Bertoldo, M. J., Listijono, D. R., Ho, W.-H. J., Riepsamen, A. H., Goss, D. M., Richani, D., Jin, X. L., Mahbub, S. B., Campbell, J. M., Habibalahi, A., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.01.058 · Cited by 328 · see citing works

Age‐associated loss of Sirt1‐mediated enhancement of glucose‐stimulated insulin secretion in beta cell‐specific Sirt1‐overexpressing (BESTO) mice

Ramsey, K. M., Mills, K. F., Satoh, A., & Imai, S. (2008) · Aging Cell · doi:10.1111/j.1474-9726.2007.00355.x · Cited by 321 · see citing works

Nicotinamide Mononucleotide Supplementation Reverses the Declining Quality of Maternally Aged Oocytes

Miao, Y., Cui, Z., Gao, Q., Rui, R., & Xiong, B. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.107987 · Cited by 312 · see citing works

Nicotinamide Mononucleotide, an Intermediate of NAD+ Synthesis, Protects the Heart from Ischemia and Reperfusion

Yamamoto, T., Byun, J., Zhai, P., Ikeda, Y., Oka, S., & Sadoshima, J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0098972 · Cited by 305 · see citing works

Slc12a8 is a nicotinamide mononucleotide transporter

Grozio, A., Mills, K. F., Yoshino, J., Bruzzone, S., Sociali, G., Tokizane, K., Lei, H. C., Cunningham, R., Sasaki, Y., Migaud, M. E., et al. (2019) · Nature Metabolism · doi:10.1038/s42255-018-0009-4 · Cited by 287 · cited 1× · see citing works

Nicotinamide mononucleotide (NMN) supplementation rescues cerebromicrovascular endothelial function and neurovascular coupling responses and improves cognitive function in aged mice

Tarantini, S., Valcarcel‐Ares, M. N., Tóth, P., Yabluchanskiy, A., Tucsek, Z., Kiss, T., Hertelendy, P., Kinter, M. T., Ballabh, P., Süle, Z., et al. (2019) · Redox Biology · doi:10.1016/j.redox.2019.101192 · Cited by 285 · see citing works

NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome

Fang, E. F., Hou, Y., Lautrup, S., Jensen, M. B., Yang, B., SenGupta, T., Caponio, D., Khezri, R., Demarest, T. G., Aman, Y., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-13172-8 · Cited by 279 · see citing works

Effect of inflammation on lacrimal gland function

Zoukhri, D. (2005) · Experimental Eye Research · doi:10.1016/j.exer.2005.10.018 · Cited by 266 · see citing works

Specific ablation of Nampt in adult neural stem cells recapitulates their functional defects during aging

Stein, L. R., & Imai, S. (2014) · The EMBO Journal · doi:10.1002/embj.201386917 · Cited by 265 · see citing works

Novel roles for A‐type lamins in telomere biology and the DNA damage response pathway

González-Suárez, I., Redwood, A. B., Perkins, S. M., Vermolen, B. J., Lichtensztejin, D., Grotsky, D. A., Morgado-Palacin, L., Gapud, E. J., Sleckman, B. P., Sullivan, T. L., et al. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.196 · Cited by 259 · see citing works

PARP-2 Regulates SIRT1 Expression and Whole-Body Energy Expenditure

Bai, P., Cantó, C., Brunyánszki, A., Huber, A., Szántó, M., Cen, Y., Yamamoto, H., Houten, S. M., Kiss, B., Oudart, H., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.03.013 · Cited by 250 · see citing works

SIRT2 induces the checkpoint kinase BubR1 to increase lifespan

North, B. J., Rosenberg, M. A., Jeganathan, K. B., Hafner, A. V., Michán, S., Dai, J., Baker, D. J., Cen, Y., Wu, L. E., Sauve, A. A., et al. (2014) · The EMBO Journal · doi:10.15252/embj.201386907 · Cited by 244 · see citing works

SIRT1-Mediated eNAMPT Secretion from Adipose Tissue Regulates Hypothalamic NAD+ and Function in Mice

Yoon, M. J., Yoshida, M., Johnson, S., Takikawa, A., Usui, I., Tobe, K., Nakagawa, T., Yoshino, J., & Imai, S. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2015.04.002 · Cited by 242 · see citing works

Nicotinamide forestalls pathology and cognitive decline in Alzheimer mice: evidence for improved neuronal bioenergetics and autophagy procession

Liu, D., Pitta, M., Jiang, H., Lee, J.-H., Zhang, G., Chen, X., Kawamoto, E. M., & Mattson, M. P. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.11.020 · Cited by 238 · see citing works

Nicotinamide Mononucleotide, an NAD+ Precursor, Rescues Age-Associated Susceptibility to AKI in a Sirtuin 1–Dependent Manner

Guan, Y., Wang, S.-R., Huang, X.-Z., Xie, Q.-H., Xu, Y.-Y., Shang, D., & Hao, C.-M. (2017) · Journal of the American Society of Nephrology · doi:10.1681/asn.2016040385 · Cited by 238 · see citing works

The sirtuin family’s role in aging and age-associated pathologies

Hall, J. A., Dominy, J. E., Lee, Y., & Puigserver, P. (2013) · Journal of Clinical Investigation · doi:10.1172/jci64094 · Cited by 235 · see citing works

A Microarray-Based Genetic Screen for Yeast Chronological Aging Factors

Matecic, M., Smith, D. L., Pan, X., Maqani, N., Bekiranov, S., Boeke, J. D., & Smith, J. S. (2010) · PLoS Genetics · doi:10.1371/journal.pgen.1000921 · Cited by 224 · see citing works

The NAD-booster nicotinamide riboside potently stimulates hematopoiesis through increased mitochondrial clearance

Vannini, N., Campos, V., Girotra, M., Trachsel, V., Rojas-Sutterlin, S., Tratwal, J., Ragusa, S., Stefanidis, E., Ryu, D., Rainer, P. Y., et al. (2019) · Cell Stem Cell · doi:10.1016/j.stem.2019.02.012 · Cited by 218 · see citing works

Nicotinamide mononucleotide protects against β-amyloid oligomer-induced cognitive impairment and neuronal death

Wang, X., Hu, X., Yang, Y., Takata, T., & Sakurai, T. (2016) · Brain Research · doi:10.1016/j.brainres.2016.04.060 · Cited by 217 · see citing works

Autophagy in aging and longevity

Wong, S. Q., Kumar, A. V., Mills, J., & Lapierre, L. R. (2019) · Human Genetics · doi:10.1007/s00439-019-02031-7 · Cited by 204 · see citing works

Effect of nicotinamide mononucleotide on brain mitochondrial respiratory deficits in an Alzheimer’s disease-relevant murine model

Long, A. N., Owens, K., Schlappal, A. E., Kristián, T., Fishman, P. S., & Schuh, R. A. (2015) · BMC Neurology · doi:10.1186/s12883-015-0272-x · Cited by 198 · see citing works

Effect of oral administration of nicotinamide mononucleotide on clinical parameters and nicotinamide metabolite levels in healthy Japanese men

Irie, J., Inagaki, E., Fujita, M., Nakaya, H., Mitsuishi, M., Yamaguchi, S., Yamashita, K., Shigaki, S., Ono, T., Yukioka, H., et al. (2020) · Endocrine Journal · doi:10.1507/endocrj.ej19-0313 · Cited by 191 · see citing works

A conserved NAD + binding pocket that regulates protein-protein interactions during aging

Li, J., Bonkowski, M. S., Moniot, S., Zhang, D., Hubbard, B. P., Ling, A. J. Y., Rajman, L. A., Qin, B., Lou, Z., Gorbunova, V. A., et al. (2017) · Science · doi:10.1126/science.aad8242 · Cited by 188 · see citing works

NAMPT-Mediated NAD+ Biosynthesis Is Essential for Vision In Mice

Lin, J. B., Kubota, S., Ban, N., Yoshida, M., Santeford, A. C., Sène, A., Nakamura, R. E. I., Zapata, N., Kubota, M., Tsubota, K., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.08.073 · Cited by 185 · see citing works

Telomere Dysfunction Induces Sirtuin Repression that Drives Telomere-Dependent Disease

Amano, H., Chaudhury, A., Rodriguez-Aguayo, C., Lu, L., Akhanov, V., Catic, A., Popov, Y. V., Verdin, E., Johnson, H., Stossi, F., et al. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.03.001 · Cited by 182 · see citing works

Nicotinamide Mononucleotide: A Promising Molecule for Therapy of Diverse Diseases by Targeting NAD+ Metabolism

Hong, W., Mo, F., Zhang, Z., Huang, M., & Wei, X. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00246 · Cited by 179 · see citing works

Life Span Extension and Neuronal Cell Protection by Drosophila Nicotinamidase

Balan, V., Miller, G. S., Kaplun, L., Balan, K., Chong, Z.-Z., Li, F., Kaplun, A., VanBerkum, M. F. A., Arking, R., Freeman, D. C., et al. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m804681200 · Cited by 174 · see citing works

Dietary Restriction Extends Lifespan through Metabolic Regulation of Innate Immunity

Wu, Z., Isik, M., Moroz, N., Steinbaugh, M. J., Zhang, P., & Blackwell, T. K. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.02.013 · Cited by 158 · see citing works

Nicotinamide mononucleotide protects against pro-inflammatory cytokine-mediated impairment of mouse islet function

Caton, P. W., Kieswich, J., Yaqoob, M. M., Holness, M. J., & Sugden, M. C. (2011) · Diabetologia · doi:10.1007/s00125-011-2288-0 · Cited by 140 · see citing works

Mitophagy and NAD + inhibit Alzheimer disease

Fang, E. F. (2019) · Autophagy · doi:10.1080/15548627.2019.1596497 · Cited by 140 · see citing works

Preclinical and clinical evidence of NAD+ precursors in health, disease, and ageing

Reiten, O. K., Wilvang, M. A., Mitchell, S. J., Hu, Z., & Fang, E. F. (2021) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2021.111567 · Cited by 133 · see citing works

Nicotinamide mononucleotide requires SIRT3 to improve cardiac function and bioenergetics in a Friedreich’s ataxia cardiomyopathy model

Martin, A. S., Abraham, D. M., Hershberger, K. A., Bhatt, D. P., Mao, L., Cui, H., Liu, J., Liu, X., Muehlbauer, M. J., Grimsrud, P. A., et al. (2017) · JCI Insight · doi:10.1172/jci.insight.93885 · Cited by 128 · see citing works

Targeting NAD+ Metabolism as Interventions for Mitochondrial Disease

Lee, C. F., Caudal, A., Abell, L., Gowda, G. A. N., & Tian, R. (2019) · Scientific Reports · doi:10.1038/s41598-019-39419-4 · Cited by 120 · see citing works

Alzheimer's disease pathology is attenuated in a <scp>CD</scp>38‐deficient mouse model

Blacher, E., Dadali, T., Bespalko, A., Haupenthal, V. J., Grimm, M. O. W., Hartmann, T., Lund, F. E., Stein, R., & Levy, A. (2015) · Annals of Neurology · doi:10.1002/ana.24425 · Cited by 117 · see citing works

Oral Administration of Nicotinamide Mononucleotide Is Safe and Efficiently Increases Blood Nicotinamide Adenine Dinucleotide Levels in Healthy Subjects

Okabe, K., Yaku, K., Uchida, Y., Fukamizu, Y., Sato, T., Sakurai, T., Tobe, K., & Nakagawa, T. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.868640 · Cited by 105 · see citing works

Dissecting systemic control of metabolism and aging in the NAD World: The importance of SIRT1 and NAMPT‐mediated NAD biosynthesis

Imai, S. (2011) · FEBS Letters · doi:10.1016/j.febslet.2011.04.060 · Cited by 104 · see citing works

Metabolic design for selective production of nicotinamide mononucleotide from glucose and nicotinamide

Shoji, S., Yamaji, T., Makino, H., Ishii, J., & Kondo, A. (2020) · Metabolic Engineering · doi:10.1016/j.ymben.2020.11.008 · Cited by 104 · see citing works

Head to Head Comparison of Short-Term Treatment with the NAD+ Precursor Nicotinamide Mononucleotide (NMN) and 6 Weeks of Exercise in Obese Female Mice

Uddin, G. M., Youngson, N. A., Sinclair, D. A., & Morris, M. J. (2016) · Frontiers in Pharmacology · doi:10.3389/fphar.2016.00258 · Cited by 95 · see citing works

Nicotinamide mononucleotide synthetase is the key enzyme for an alternative route of NAD biosynthesis in Francisella tularensis

Sorci, L., Martynowski, D., Rodionov, D. A., Eyobo, Y., Zogaj, X., Klose, K. E., Nikolaev, E. V., Magni, G., Zhang, H., & Osterman, A. L. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0811718106 · Cited by 94 · see citing works

A possibility of nutriceuticals as an anti-aging intervention: Activation of sirtuins by promoting mammalian NAD biosynthesis

Imai, S. (2010) · Pharmacological Research · doi:10.1016/j.phrs.2010.01.006 · Cited by 89 · see citing works

NAMPT as a Therapeutic Target against Stroke

Wang, P., & Miao, C. (2015) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2015.08.012 · Cited by 86 · see citing works

Short-term administration of Nicotinamide Mononucleotide preserves cardiac mitochondrial homeostasis and prevents heart failure

Zhang, R., Shen, Y., Zhou, L., Sangwung, P., Fujioka, H., Zhang, L., & Liao, X. (2017) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2017.09.001 · Cited by 78 · see citing works

Effect of 12-Week Intake of Nicotinamide Mononucleotide on Sleep Quality, Fatigue, and Physical Performance in Older Japanese Adults: A Randomized, Double-Blind Placebo-Controlled Study

Kim, M., Seol, J., Sato, T., Fukamizu, Y., Sakurai, T., & Okura, T. (2022) · Nutrients · doi:10.3390/nu14040755 · Cited by 77 · see citing works

Long-term treatment of Nicotinamide mononucleotide improved age-related diminished ovary reserve through enhancing the mitophagy level of granulosa cells in mice

Huang, P., Zhou, Y., Tang, W., Ren, C., Jiang, A., Wang, X., Qian, X., Zhou, Z., & Gong, A. (2021) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2021.108911 · Cited by 74 · see citing works

Systematic Engineering of Escherichia coli for Efficient Production of Nicotinamide Mononucleotide From Nicotinamide

Huang, Z., Li, N., Yu, S., Zhang, W., Zhang, T., & Zhou, J. (2022) · ACS Synthetic Biology · doi:10.1021/acssynbio.2c00100 · Cited by 71 · see citing works

β-nicotinamide mononucleotide (NMN) production in Escherichia coli

Marinescu, G. C., Popescu, R. G., Stoian, G., & Dinischiotu, A. (2018) · Scientific Reports · doi:10.1038/s41598-018-30792-0 · Cited by 70 · see citing works

Metabolic engineering of Escherichia coli for optimized biosynthesis of nicotinamide mononucleotide, a noncanonical redox cofactor

Black, W. B., Aspacio, D., Bever, D., King, E. J., Zhang, L., & Li, H. (2020) · Microbial Cell Factories · doi:10.1186/s12934-020-01415-z · Cited by 67 · see citing works

Nicotinamide Mononucleotide and Melatonin Alleviate Aging-induced Cognitive Impairment via Modulation of Mitochondrial Function and Apoptosis in the Prefrontal Cortex and Hippocampus

Hosseini, L., Farokhi-Sisakht, F., Badalzadeh, R., Khabbaz, A., Mahmoudi, J., & Sadigh‐Eteghad, S. (2019) · Neuroscience · doi:10.1016/j.neuroscience.2019.09.037 · Cited by 66 · see citing works

Nicotinamide mononucleotide preserves mitochondrial function and increases survival in hemorrhagic shock

Sims, C. A., Guan, Y., Mukherjee, S., Singh, K., Botolin, P., Dávila, A., & Baur, J. A. (2018) · JCI Insight · doi:10.1172/jci.insight.120182 · Cited by 64 · see citing works

Absence of evidence that Slc12a8 encodes a nicotinamide mononucleotide transporter

Schmidt, M. S., & Brenner, C. (2019) · Nature Metabolism · doi:10.1038/s42255-019-0085-0 · Cited by 64 · see citing works

Re‐equilibration of imbalanced NAD metabolism ameliorates the impact of telomere dysfunction

Sun, C., Wang, K., Stock, A. J., Gong, Y., Demarest, T. G., Yang, B., Giri, N., Harrington, L. A., Alter, B. P., Savage, S. A., et al. (2020) · The EMBO Journal · doi:10.15252/embj.2019103420 · Cited by 62 · see citing works

Supplementation with NAD+ and Its Precursors to Prevent Cognitive Decline across Disease Contexts

Campbell, J. M. (2022) · Nutrients · doi:10.3390/nu14153231 · Cited by 62 · see citing works

Nicotinamide adenine dinucleotide extends the lifespan of Caenorhabditis elegans mediated by sir-2.1 and daf-16

Hashimoto, T., Horikawa, M., Nomura, T., & Sakamoto, K. (2009) · Biogerontology · doi:10.1007/s10522-009-9225-3 · Cited by 61 · see citing works

SS‐31 and NMN: Two paths to improve metabolism and function in aged hearts

Whitson, J. D., Bitto, A., Zhang, H., Sweetwyne, M. T., Coig, R., Bhayana, S., Shankland, E. G., Wang, L., Bammler, T. K., Mills, K. F., et al. (2020) · Aging Cell · doi:10.1111/acel.13213 · Cited by 61 · see citing works

TFEB-driven lysosomal biogenesis is pivotal for PGC1α-dependent renal stress resistance

Lynch, M. R., Tran, M. T., Ralto, K. M., Zsengellér, Z. K., Raman, V., Bhasin, S. S., Sun, N., Chen, X., Brown, D., Rovira, I. I., et al. (2019) · JCI Insight · doi:10.1172/jci.insight.126749 · Cited by 61 · see citing works

Nicotinamide Mononucleotide Attenuates Renal Interstitial Fibrosis After AKI by Suppressing Tubular DNA Damage and Senescence

Jia, Y., Kang, X., Tan, L., Ren, Y., Qu, L., Tang, J., Liu, G., Wang, S., Xiong, Z., & Yang, L. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.649547 · Cited by 59 · see citing works

A Multicentre, Randomised, Double Blind, Parallel Design, Placebo Controlled Study to Evaluate the Efficacy and Safety of Uthever (NMN Supplement), an Orally Administered Supplementation in Middle Aged and Older Adults

Huang, H. (2022) · Frontiers in Aging · doi:10.3389/fragi.2022.851698 · Cited by 59 · see citing works

Nicotinamide mononucleotide supplementation protects the intestinal function in aging mice and d -galactose induced senescent cells

Ru, M., Wang, W., Zhai, Z., Wang, R., Li, Y., Jiang, L., Kothari, D., Niu, K., & Wu, X. (2022) · Food & Function · doi:10.1039/d2fo00525e · Cited by 59 · see citing works

Metabolic engineering of Escherichia coli for biosynthesis of β‐nicotinamide mononucleotide from nicotinamide

Liu, Y., Yasawong, M., & Yu, B. (2021) · Microbial Biotechnology · doi:10.1111/1751-7915.13901 · Cited by 57 · see citing works

Pharmacological Targeting of IDO-Mediated Tolerance for Treating Autoimmune Disease

Penberthy, W. T. (2007) · Current Drug Metabolism · doi:10.2174/138920007780362545 · Cited by 56 · see citing works

TFEB-driven lysosomal biogenesis is pivotal for PGC1α-dependent renal stress resistance

Lynch, M. R., Tran, M. T., Ralto, K. M., Zsengellér, Z. K., Raman, V., Bhasin, S. S., Sun, N., Chen, X., Brown, D., Rovira, I. I., et al. (2020) · JCI Insight · doi:10.1172/jci.insight.142898 · Cited by 55 · see citing works

The Impacts of Short-Term NMN Supplementation on Serum Metabolism, Fecal Microbiota, and Telomere Length in Pre-Aging Phase

Niu, K., Bao, T., Gao, L., Ru, M., Li, Y., Jiang, L., Ye, C., Wang, S., & Wu, X. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.756243 · Cited by 54 · see citing works

NAMPT-Mediated Salvage Synthesis of NAD+ Controls Morphofunctional Changes of Macrophages

Venter, G., Oerlemans, F. T. J. J., Willemse, M. P., Wijers, M., Fransen, J. A. M., & Wieringa, B. (2014) · PLoS ONE · doi:10.1371/journal.pone.0097378 · Cited by 51 · see citing works

Biosynthesis of a Therapeutically Important Nicotinamide Mononucleotide through a Phosphoribosyl Pyrophosphate Synthetase 1 and 2 Engineered Strain of Escherichia coli

Maharjan, A., Singhvi, M. S., & Kim, B. S. (2021) · ACS Synthetic Biology · doi:10.1021/acssynbio.1c00333 · Cited by 50 · see citing works

Comparative genomics of mortal and immortal cnidarians unveils novel keys behind rejuvenation

Pascual-Torner, M., Carrero, D., Pérez-Silva, J. G., Álvarez-Puente, D., Roiz‐Valle, D., Bretones, G., Rodríguez, D., Maeso, D., Mateo-González, E., Español, Y., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2118763119 · Cited by 49 · see citing works

Reprogramming aging and progeria

Freije, J. M. P., & López-Otı́n, C. (2012) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2012.08.009 · Cited by 47 · see citing works

Nicotinamide mononucleotide production by fructophilic lactic acid bacteria

Sugiyama, K., Iijima, K., Yoshino, M., Dohra, H., Tokimoto, Y., Nishikawa, K., Idogaki, H., & Yoshida, N. (2021) · Scientific Reports · doi:10.1038/s41598-021-87361-1 · Cited by 46 · see citing works

NAD+ and its possible role in gut microbiota: Insights on the mechanisms by which gut microbes influence host metabolism

Ren, Z., Xu, Y., Li, T., Sun, W., Tang, Z., Wang, Y., Zhou, K., Li, J., Ding, Q., Liang, K., et al. (2022) · Animal Nutrition · doi:10.1016/j.aninu.2022.06.009 · Cited by 44 · see citing works

Meta-analysis of gene expression in the mouse liver reveals biomarkers associated with inflammation increased early during aging

Lee, J. S., Ward, W. O., Ren, H., Vallanat, B., Darlington, G., Han, E., Laguna, J. C., DeFord, J. H., Papaconstantinou, J., Selman, C., et al. (2012) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2012.05.006 · Cited by 43 · see citing works

Untitled work

(2020) · doi:10.1101/2020.09.10.289561 · Cited by 41 · see citing works

Host–microbiome interactions in nicotinamide mononucleotide (NMN) deamidation

Kim, L., Chalmers, T. J., Madawala, R. J., Smith, G. C., Li, C., Das, A., Poon, E. W. K., Wang, J., Tucker, S. P., Sinclair, D. A., et al. (2023) · FEBS Letters · doi:10.1002/1873-3468.14698 · Cited by 41 · see citing works

Enzymatic synthesis of high-titer nicotinamide mononucleotide with a new nicotinamide riboside kinase and an efficient ATP regeneration system

Qian, X., Dai, Y.-S., Li, C., Jiang, P., Xu, J., & Mu, B. (2022) · Bioresources and Bioprocessing · doi:10.1186/s40643-022-00514-6 · Cited by 39 · see citing works

Impacts of obesity, maternal obesity and nicotinamide mononucleotide supplementation on sperm quality in mice

Youngson, N. A., Uddin, G. M., Das, A., Martinez, C., Connaughton, H. S., Whiting, S., Yu, J., Sinclair, D. A., Aitken, R. J., & Morris, M. J. (2019) · Reproduction · doi:10.1530/rep-18-0574 · Cited by 38 · see citing works

Slc12a8 in the lateral hypothalamus maintains energy metabolism and skeletal muscle functions during aging

Ito, N., Takatsu, A., Ito, H., Koike, Y., Yoshioka, K., Kamei, Y., & Imai, S. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.111131 · Cited by 38 · see citing works

Biological synthesis of nicotinamide mononucleotide

Shen, Q., Zhang, S., Xue, Y.-Z., Peng, F., Cheng, D., Xue, Y., & Zheng, Y. (2021) · Biotechnology Letters · doi:10.1007/s10529-021-03191-1 · Cited by 35 · see citing works

Yeast Cell Surface Engineering of a Nicotinamide Riboside Kinase for the Production of β-Nicotinamide Mononucleotide via Whole-Cell Catalysis

He, Z., Yang, X., Tian, X., Li, L., & Liu, M. (2022) · ACS Synthetic Biology · doi:10.1021/acssynbio.2c00350 · Cited by 35 · see citing works

Administration of Nicotinamide Mononucleotide (NMN) Reduces Metabolic Impairment in Male Mouse Offspring from Obese Mothers

Uddin, G. M., Youngson, N. A., Chowdhury, S. S., Hagan, C., Sinclair, D. A., & Morris, M. J. (2020) · Cells · doi:10.3390/cells9040791 · Cited by 32 · see citing works

Design of an in vitro multienzyme cascade system for the biosynthesis of nicotinamide mononucleotide

Zhou, C.-L., Feng, J., Wang, J., Hao, N., Wang, X., & Chen, K. (2022) · Catalysis Science & Technology · doi:10.1039/d1cy01798e · Cited by 30 · see citing works

NAD+-boosting molecules suppress mast cell degranulation and anaphylactic responses in mice

Kim, H.-W., Ryoo, G.-H., Jang, H., Rah, S., Lee, D. H., Kim, D., Bae, E. J., & Park, B. (2022) · Theranostics · doi:10.7150/thno.69684 · Cited by 29 · see citing works

An artificial multi-enzyme cascade biocatalysis for biomanufacturing of nicotinamide mononucleotide from starch and nicotinamide in one-pot

Li, Q., Meng, D., & You, C. (2022) · Enzyme and Microbial Technology · doi:10.1016/j.enzmictec.2022.110122 · Cited by 27 · see citing works

Size Exclusion Chromatography Method for Purification of Nicotinamide Mononucleotide (NMN) from Bacterial Cells

Marinescu, G. C., Popescu, R. G., & Dinischiotu, A. (2018) · Scientific Reports · doi:10.1038/s41598-018-22806-8 · Cited by 26 · see citing works

The Science Behind NMN-A Stable, Reliable NAD+Activator and Anti-Aging Molecule.

Shade, C. W. (2020) · Europe PMC (PubMed Central) · Cited by 26 · see citing works

Enhancing the biosynthesis of nicotinamide mononucleotide in Lactococcus lactis by heterologous expression of FtnadE *

Kong, L., Liu, T., Yao, Q., Zhang, X., Xu, W., & Qin, J. (2022) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.12253 · Cited by 26 · see citing works

Synthesis of Nicotinamide Mononucleotide from Xylose via Coupling Engineered Escherichia coli and a Biocatalytic Cascade

Ngivprom, U., Lasin, P., Khunnonkwao, P., et al. (2022) · ChemBioChem · doi:10.1002/cbic.202200071 · Cited by 24 · see citing works

Quantification of localized NAD+ changes reveals unique specificity of NAD+ regulation in the hypothalamus

Johnson, S., Yoshioka, K., Brace, C. S., & Imai, S. (2023) · npj Aging · doi:10.1038/s41514-023-00098-1 · Cited by 18 · see citing works

Effect of β-nicotinamide mononucleotide on tumor formation and growth in a lung cancer mouse model

Pan, F., Kang, S., Zhao, Y., Dai, L., Shao, Q., Yang, Y., Chen, Q., Zhu, J., & Cui, L. (2020) · Materials Chemistry Frontiers · doi:10.1039/d0qm00897d · Cited by 5 · see citing works

Nicotinamide riboside and nicotinamide mononucleotide facilitate NAD ⁺ synthesis via enterohepatic circulation

Yaku, K., Palikhe, S., Iqbal, T., Hayat, F., Watanabe, Y., Fujisaka, S., Izumi, H., Yoshida, T., Karim, M., Uchida, H., et al. (2025) · Science Advances · doi:10.1126/sciadv.adr1538 · Cited by 40 · see citing works

Pyridine nucleotide synthesis in 3T3 cells

Jacobson, E. L., Lange, R. A., & Jacobson, M. K. (1979) · Journal of Cellular Physiology · doi:10.1002/jcp.1040990316 · Cited by 84 · see citing works

Oral Administration of Nicotinamide Mononucleotide Increases Nicotinamide Adenine Dinucleotide Level in an Animal Brain

Ramanathan, C., Lackie, T., Williams, D. H., Simone, P. S., Zhang, Y., & Bloomer, R. J. (2022) · Nutrients · doi:10.3390/nu14020300 · Cited by 33 · see citing works

Identification of the nicotinamide salvage pathway as a new toxification route for antimetabolites

Buonvicino, D., Mazzola, F., Zamporlini, F., Resta, F., Ranieri, G., Camaioni, E., Muzzi, M., Zecchi, R., Pieraccini, G., Dölle, C., et al. (2018) · Cell Chemical Biology · doi:10.1016/j.chembiol.2018.01.012 · Cited by 73 · see citing works

Reduced nicotinamide mononucleotide is a new and potent NAD + precursor in mammalian cells and mice

Perez, R. Z., Tammaro, A., Schomakers, B. V., Scantlebery, A. M. L., Denis, S. W., Elfrink, H. L., Giroud‐Gerbetant, J., Cantó, C., López‐Leonardo, C., McIntyre, R. L., et al. (2021) · The FASEB Journal · doi:10.1096/fj.202001826r · Cited by 75 · see citing works

&amp;beta;-Nicotinamide Mononucleotide, an Anti-Aging Candidate Compound, Is Retained in the Body for Longer than Nicotinamide in Rats

KAWAMURA, T., MORI, N., & SHIBATA, K. (2016) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.62.272 · Cited by 23 · see citing works