The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Oncogene Amplification in Growth Factor Signaling Pathways Renders Cancers Dependent on Membrane Lipid Remodeling
Open accessAbstract
Summary Advances in DNA sequencing technologies have reshaped our understanding of the molecular basis of cancer, providing a precise genomic view of tumors. Complementary biochemical and biophysical perspectives of cancer point towards profound shifts in nutrient uptake and utilization that propel tumor growth and major changes in the structure of the plasma membrane of tumor cells. The molecular mechanisms that bridge these fundamental aspects of tumor biology remain poorly understood. Here, we show that the lysophosphatidylcholine acyltransferase LPCAT1 functionally links specific genetic alterations in cancer with aberrant metabolism and plasma membrane remodeling to drive tumor growth. Growth factor receptor-driven cancers are found to depend on LPCAT1 to shape plasma membrane composition through enhanced saturated phosphatidylcholine content that is, in turn, required for the transduction of oncogenic signals. These results point to a genotype-informed strategy that prioritizes lipid remodeling pathways as therapeutic targets for diverse cancers.
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Cites
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BackgroundOncogenic Signaling Pathways in The Cancer Genome Atlas
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Lipid metabolism in cancer: New perspectives and emerging mechanisms
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Lipids and cancer: Emerging roles in pathogenesis, diagnosis and therapeutic intervention
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THEM6‐mediated reprogramming of lipid metabolism supports treatment resistance in prostate cancer
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Phosphatidylserine synthesis controls oncogenic B cell receptor signaling in B cell lymphoma
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Metadata
- Authors
- Bi, J., Ichu, T.-A., Zanca, C., Yang, H., Zhang, W., Gu, Y., Chowdhry, S., Reed, A., Ikegami, S., Turner, K. M., Zhang, W., Villa, G. R., Wu, S., Quehenberger, O., Yong, W. H., Kornblum, H. I., Rich, J. N., Cloughesy, T. F., Cavenee, W. K., Furnari, F. B., Cravatt, B. F., & Mischel, P. S.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2019-09
- Volume
- 30
- Issue
- 3
- Pages
- 525-538.e8
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W2956607536
- Cited by
- 225
- References
- 10
- FWCI
- 6.29
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Bi, J., Ichu, T.-A., Zanca, C., Yang, H., Zhang, W., Gu, Y., Chowdhry, S., Reed, A., Ikegami, S., Turner, K. M., Zhang, W., Villa, G. R., Wu, S., Quehenberger, O., Yong, W. H., Kornblum, H. I., Rich, J. N., Cloughesy, T. F., Cavenee, W. K., . . . Mischel, P. S. (2019). Oncogene Amplification in Growth Factor Signaling Pathways Renders Cancers Dependent on Membrane Lipid Remodeling. Cell Metabolism. https://doi.org/10.1016/j.cmet.2019.06.014
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
