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Hallmarks of Endothelial Cell Metabolism in Health and Disease
Open accessAbstract
In 2009, it was postulated that endothelial cells (ECs) would only be able to execute the orders of growth factors if these cells would accordingly adapt their metabolism. Ten years later, it has become clear that ECs, often differently from other cell types, rely on distinct metabolic pathways to survive and form new blood vessels; that manipulation of EC metabolic pathways alone (even without changing angiogenic signaling) suffices to alter vessel sprouting; and that perturbations of these metabolic pathways can underlie excess formation of new blood vessels (angiogenesis) in cancer and ocular diseases. Initial proof of evidence has been provided that targeting (normalizing) these metabolic perturbations in diseased ECs and delivery of metabolites deserve increasing attention as novel therapeutic approaches for inhibiting or stimulating vessel growth in multiple disorders.
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mTOR Signaling in Growth, Metabolism, and Disease
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Self-citationFunctional genomics reveal that the serine synthesis pathway is essential in breast cancer
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Single-Cell Transcriptome Atlas of Murine Endothelial Cells
Kalucka, J., de Rooij, L. P. M. H., Goveia, J., Rohlenova, K., Dumas, S. J., Meta, E., Conchinha, N. V., Taverna, F., Teuwen, L.-A., Veys, K., et al. (2020) · Cell · doi:10.1016/j.cell.2020.01.015 · Cited by 1,351
Self-citationTargeting cancer metabolism in the era of precision oncology
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Self-citationMetabolic programming and immune suppression in the tumor microenvironment
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Metadata
- Authors
- Li, X., Sun, X., & Carmeliet, P.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2019-09
- Volume
- 30
- Issue
- 3
- Pages
- 414-433
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W2972146978
- Cited by
- 453
- References
- 16
- FWCI
- 12.75
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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