Trimethylamine N-Oxide Binds and Activates PERK to Promote Metabolic Dysfunction

Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506580102 · Cited by 53,625

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease

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Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis

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One-step generation of mice carrying mutations in multiple genes by CRISPR/Cas-mediated genome engineering

Wang, H., Yang, H., Shivalila, C. S., Dawlaty, M. M., Cheng, A. W., Zhang, F., & Jaenisch, R. (2013) · Cell · doi:10.1016/j.cell.2013.04.025 · Cited by 3,495

Intestinal microbial metabolism of phosphatidylcholine and cardiovascular risk

Tang, W. H. W., Wang, Z., Levison, B. S., Koeth, R. A., Britt, E. B., Fu, X., Wu, Y., & Hazen, S. L. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1109400 · Cited by 3,400

Regulated Translation Initiation Controls Stress-Induced Gene Expression in Mammalian Cells

Harding, H. P., Novoa, I., Zhang, Y., Zeng, H., Wek, R. C., Schapira, M., & Ron, D. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00108-8 · Cited by 3,344

The Metabolic Syndrome: Time for a Critical Appraisal

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Gut Microbial Metabolite TMAO Enhances Platelet Hyperreactivity and Thrombosis Risk

Zhu, W., Gregory, J. C., Org, E., Buffa, J. A., Gupta, N., Wang, Z., Li, L., Fu, X., Wu, Y., Mehrabian, M., et al. (2016) · Cell · doi:10.1016/j.cell.2016.02.011 · Cited by 1,968

XBP1 Links ER Stress to Intestinal Inflammation and Confers Genetic Risk for Human Inflammatory Bowel Disease

Kaser, A., Lee, A., Franke, A., Glickman, J. N., Zeißig, S., Tilg, H., Nieuwenhuis, E. E. S., Higgins, D. E., Schreiber, S., Glimcher, L. H., et al. (2008) · Cell · doi:10.1016/j.cell.2008.07.021 · Cited by 1,465

FOXO transcription factors at the interface between longevity and tumor suppression

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Gut microbiota in non-alcoholic fatty liver disease: Pathophysiology, diagnosis, and therapeutics

Pandey, H., Goel, P., Srinivasan, V. M., Tang, D. W. T., Wong, S. H., & Lal, D. (2025) · World Journal of Hepatology · doi:10.4254/wjh.v17.i6.106849 · Cited by 20

Effects of choline metabolite—trimethylamine N-oxide on immunometabolism in inflammatory bowel disease

Wang, S., Ni, Y., Zhou, S., Peng, H., Cao, Y., Zhu, Y., Gong, J., Lu, Q., Han, Z., Lin, Y., et al. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1591151 · Cited by 16

Mechanism of actions of probiotics on type 2 diabetes: Development and complications

Ağagündüz, D., Çelik, E., Cemali, Ö., Yeşildemir, Ö., Demirci, K. Ş., Akkuş, G., Esatbeyoglu, T., & Özoğul, F. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.118421 · Cited by 18

The gut metabolite, trimethylamine N-oxide inhibits protein folding by affecting cis–trans isomerization and induces cell cycle arrest

Kumari, K., Warepam, M., Bansal, A. K., Dar, T. A., Uversky, V. N., & Singh, L. R. (2021) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-021-04087-z · Cited by 16

Trimethylamine N-Oxide and Related Metabolites in the Serum and Risk of Type 2 Diabetes in the Chinese Population: A Case-Control Study

Qi, S., Liu, L., He, S., Wang, L., Li, J., & Sun, X. (2023) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s398008 · Cited by 15

Activation of the PERK-CHOP signaling pathway during endoplasmic reticulum stress contributes to olanzapine-induced dyslipidemia

Liu, L., Tang, L., Luo, J., Chen, S., Yi, C.-Y., Liu, X., & Hu, C. (2023) · Acta Pharmacologica Sinica · doi:10.1038/s41401-023-01180-w · Cited by 15

Trimethylamine oxide supplementation differentially regulates fat deposition in liver, longissimus dorsi muscle and adipose tissue of growing-finishing pigs

Zha, A., Li, W., Wang, J., Bai, P., Qi, M., Liao, P., Tan, B., & Yin, Y. (2024) · Animal nutrition · doi:10.1016/j.aninu.2023.12.006 · Cited by 15

Intermittent Fasting–Improved Glucose Homeostasis Is Not Entirely Dependent on Caloric Restriction in db/db Male Mice

Zheng, D., Hong, X., He, X., Lin, J., Fan, S., Wu, J., Liang, Z., Chen, S., Yan, L., Ren, M., et al. (2024) · Diabetes · doi:10.2337/db23-0157 · Cited by 16

Vertical Transfer of Maternal Gut Microbes to Offspring of Western Diet-Fed Dams Drives Reduced Levels of Tryptophan Metabolites and Postnatal Innate Immune Response

Sugino, K. Y., Janssen, R. C., McMahan, R. H., Zimmerman, C., Friedman, J. E., & Jonscher, K. R. (2024) · Nutrients · doi:10.3390/nu16121808 · Cited by 15

Role of Trimethylamine N-Oxide in Heart Failure

Jing, L., Zhang, H., Xiang, Q., Hu, H., Zhai, C., Xu, S., & Tian, H. (2024) · Reviews in Cardiovascular Medicine · doi:10.31083/j.rcm2507240 · Cited by 16

TMAO is involved in sleep deprivation-induced cognitive dysfunction through regulating astrocytic cholesterol metabolism via SREBP2

Zhu, S., Wang, Y., Li, Y., Li, N., Zheng, Y., Li, Q., Guo, H., Sun, J., Zhai, Q., & Wang, Q. (2024) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2024.1499591 · Cited by 14

Ligand stabilization and effect on unfolding by polymorphism in human flavin-containing monooxygenase 3

Catucci, G., Aramini, D., Sadeghi, S. J., & Gilardi, G. (2020) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2020.08.032 · Cited by 15

Circulating microbiota and metabolites: Insights into cardiovascular diseases

Khan, I., Khan, I., Usman, M., Wei, Z. X., Ping, X., Khan, S., Khan, F., Jianye, Z., Zhiqiang, L., & An, L. (2022) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.24779 · Cited by 14

Emerging roles of low-molecular-weight thiols at the host–microbe interface

Dumitrescu, D. G., & Hatzios, S. K. (2023) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2023.102322 · Cited by 13

Gut microbiota in relationship to diabetes mellitus and its late complications with a focus on diabetic foot syndrome: A review

Sechovcová, H., Mahayri, T. M., Mrázek, J., Jarošíková, R., Husáková, J., Wosková, V., & Fejfarová, V. (2023) · Folia Microbiologica · doi:10.1007/s12223-023-01119-y · Cited by 14

Trimethylamine N-oxide aggravates vascular permeability and endothelial cell dysfunction under diabetic condition: in vitro and in vivo study

Jiang, J., Zhang, Q., Ren, H., Yao, Q.-Y., Liu, G., & Lu, P. (2023) · International Journal of Ophthalmology · doi:10.18240/ijo.2024.01.04 · Cited by 16

Trimethylamine N-oxide induces non-alcoholic fatty liver disease by activating the PERK

Yang, B., Tang, G., Wang, M., Ni, Y., Tong, J., Hu, C., Zhou, M., Jiao, K., & Li, Z. (2024) · Toxicology Letters · doi:10.1016/j.toxlet.2024.08.009 · Cited by 16

Association of trimethylamine N-oxide and metabolites with kidney function decline in patients with chronic kidney disease

Cheng, E., Hung, S., & Lin, T. (2024) · Clinical Nutrition · doi:10.1016/j.clnu.2024.12.001 · Cited by 14

Gut microbes with the gbu genes determine TMAO production from L-carnitine intake and serve as a biomarker for precision nutrition

Wu, W., Lo, Y.-L., Chiu, J.-Y., Hsu, C., Lo, I., Panyod, S., Liao, Y.-C., Chiu, T. H. T., Yang, Y.-T., Kuo, H., et al. (2024) · Gut Microbes · doi:10.1080/19490976.2024.2446374 · Cited by 15

Ceramides and their interactive effects with trimethylamine-N-oxide metabolites on risk of gestational diabetes: A nested case-control study

Liu, J., Li, J., Yang, K., Leng, J., Li, W., Yang, W., Huo, X., Yu, Z., Ronald, C. W., Hu, G., et al. (2020) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2020.108606 · Cited by 13

Zuogui Jiangtang Shuxin formula Ameliorates diabetic cardiomyopathy mice via modulating gut-heart axis

Huang, Y., Qin, X., Zou, J., Wu, Y., & Yu, R. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1106812 · Cited by 13

Serum metabolomics analysis reveals increased lipid catabolism in mildly hyperbilirubinemic Gilbert's syndrome individuals

Hana, C. A., Tran, L. V., Mölzer, C., Müllner, E., Hörmann-Wallner, M., Franzke, B., Tosevska, A., Zöhrer, P. A., Doberer, D., Marculescu, R., et al. (2021) · Metabolism · doi:10.1016/j.metabol.2021.154913 · Cited by 12

Gut microbiota-derived TMAO drives the kidney-bone-vascular axis in chronic kidney disease complications

Lei, Y., Xiong, G., Lei, D., Wu, H., Xu, P. H., Chen, L., Fang, Q., Wu, Y., Wu, Y., Li, X., et al. (2025) · Renal Failure · doi:10.1080/0886022x.2025.2575434 · Cited by 13

Atherosclerotic patients with diabetes mellitus may break through the threshold of healthy TMAO levels formed by long-term statins therapy

Liang, H., Yu, A., Wang, Z., Zhang, N., Wang, Q., Gao, H., Gao, J., Wang, X., & Wang, H. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e13657 · Cited by 11

Association of the trimethylamine N-oxide with cardiovascular risk and vascular alterations in middle-aged patients with risk factors for cardiovascular diseases

Spasova, N., Somleva, D., Krastev, B., Ilieva, R., Borizanova, A., Svinarov, D. A., Kinova, E., & Goudev, A. (2024) · Bioscience Reports · doi:10.1042/bsr20232090 · Cited by 13

Systems Biology of Human Microbiome for the Prediction of Personal Glycaemic Response

Kirtipal, N., Seo, Y. D., Son, J. W., & Lee, S. (2024) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2024.0382 · Cited by 12

Multi-omics reveals the mechanism of Trimethylamine N-oxide derived from gut microbiota inducing liver fatty of dairy cows

Li, C., Wang, F., Mao, Y., Ma, Y., & Guo, Y. (2025) · BMC Genomics · doi:10.1186/s12864-024-11067-7 · Cited by 11

Intermittent fasting and metabolic dysfunction-associated steatotic liver disease: the potential role of the gut-liver axis

Zhang, Z., Kong, A. P. S., Wong, V. W., & Hui, X. H. (2025) · Cell & Bioscience · doi:10.1186/s13578-025-01406-w · Cited by 14

The Non-Traditional Cardiovascular Culprits in Chronic Kidney Disease: Mineral Imbalance and Uremic Toxin Accumulation

Lu, Y., Meng, L., Wang, X., Zhang, Y., Zhang, C., & Zhang, M. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26167938 · Cited by 11

TMAO to the rescue of pathogenic protein variants

Kumari, K., Singh, K. S., Singh, K., Bakhshi, R., & Singh, L. R. (2022) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2022.130214 · Cited by 10

Impact of the gut microbiota on angiotensin Ⅱ-related disorders and its mechanisms

Liu, W., Tan, Z., Geng, M., Jiang, X. M., & Xin, Y. (2023) · Biochemical Pharmacology · doi:10.1016/j.bcp.2023.115659 · Cited by 11

Dietary Patterns, Gut Microbiota Remodeling, and Cardiometabolic Disease

Guiducci, L., Nicolini, G., & Forini, F. (2023) · Metabolites · doi:10.3390/metabo13060760 · Cited by 15

Darm-Herz-Achse

Bartolomaeus, H., McParland, V. J., & Wilck, N. (2020) · Herz · doi:10.1007/s00059-020-04897-0 · Cited by 19

Applications of traditional Chinese medicine in cancer immunotherapy via gut microbiota modulation: Current status, mechanisms, challenges and perspectives

Tao, H., Mao, K., Zhang, Z., Wei, W., Huang, X., Chen, Y., Mei, S., & Tian, X. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.108020 · Cited by 12

Association of serum trimethylamine N-oxide levels and bone mineral density in type 2 diabetes mellitus

Yuan, Y., Gan, C., Wang, M., Zou, J., Wang, Z., Li, S., & Lv, H. (2024) · Endocrine · doi:10.1007/s12020-024-03699-2 · Cited by 11

Choline Metabolites and 15-Year Risk of Incident Diabetes in a Prospective Cohort of Adults: Coronary Artery Risk Development in Young Adults (CARDIA) Study

Sprinkles, J., Lulla, A., Hullings, A. G., Trujillo‐Gonzalez, I., Klatt, K. C., Jacobs, D. R., Shah, R. V., Murthy, V. L., Howard, A. G., Gordon‐Larsen, P., et al. (2024) · Diabetes Care · doi:10.2337/dc24-1033 · Cited by 10

The role of trimethylamine N-oxide in disease pathogenesis and the therapeutic potential of traditional Chinese medicine

Qin, Z., Wu, W., Yang, X., Wang, X., Ding, A., Huang, Y., Tang, J., Jiang, S., Zhang, P., Qian, C., et al. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1592524 · Cited by 13

Understanding crosstalk between the gut and liver microbiome: pathogenesis to therapeutic approaches in liver cancer

Goyal, H., Fatima, K., & Kaur, J. (2025) · Cancer Cell International · doi:10.1186/s12935-025-03840-9 · Cited by 11

Fluorescent assay for quantitative analysis of trimethylamine N -oxide

Zhang, W., Sun, J., Wang, F., Liu, J., Han, Y., Jiang, M., & Tang, D. (2021) · Analytical Methods · doi:10.1039/d0ay02353a · Cited by 10

Enzymatically Produced Trimethylamine N-Oxide: Conserving It or Eliminating It

Catucci, G., Querio, G., Sadeghi, S. J., Gilardi, G., & Levi, R. C. (2019) · Catalysts · doi:10.3390/catal9121028 · Cited by 10

Gut microbiome metabolites as key actors in atherosclerosis co-depression disease

Liao, X.-X., Wu, X., Zhou, Y.-L., Li, J., Wen, Y.-L., & Zhou, J. (2022) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.988643 · Cited by 10

Multi-omics perspective: mechanisms of gastrointestinal injury repair

Zhao, H., Zhang, Z., Liu, H., Ma, M., Sun, P., Zhao, Y., & Liu, X. (2024) · Burns & Trauma · doi:10.1093/burnst/tkae057 · Cited by 9

Molecular mechanisms of pyroptosis in non-alcoholic steatohepatitis and feasible diagnosis and treatment strategies

Shang, D.-F., Xu, W.-Q., Zhao, Q. Y., Zhao, C., Wang, S.-Y., Han, Y., Li, H., Liu, M., & Zhao, W. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107754 · Cited by 10

Gut Microbiota‐Derived Trimethylamine N‐Oxide and the Risk of Diabetes: An Updated Systematic Review and Meta‐Analysis

Mohammadi, S., Eslami, M., Pourghazi, F., Ejtahed, H., Shahrestanaki, E., Qorbani, M., Hasani‐Ranjbar, S., & Larijani, B. A. (2025) · Obesity Reviews · doi:10.1111/obr.13963 · Cited by 12

TMAO metaorganismal pathway and chronic inflammatory diseases

Wang, Z., Man, S., & Koeth, R. (2025) · Exploration of Medicine · doi:10.37349/emed.2025.1001339 · Cited by 12

Gut microbiome in type 2 diabetes: insights from metagenomics, multi-omics, and diet–microbe interactions

Zhang, Y., & Wang, D. D. (2026) · Gut Microbes · doi:10.1080/19490976.2026.2644682 · Cited by 13

Gut microbiota in sarcopenia and heart failure

Liu, C., & Tang, W. H. W. (2022) · The Journal of Cardiovascular Aging · doi:10.20517/jca.2022.07 · Cited by 9

Dietary choline increases brown adipose tissue activation markers and improves cholesterol metabolism in female APOE*3-Leiden.CETP mice

Liu, C., Song, Z., Zhuang, L., Boon, M. R., Schönke, M., Rensen, P. C. N., & Wang, Y. (2023) · International Journal of Obesity · doi:10.1038/s41366-023-01269-6 · Cited by 10

Characteristics of elderly diabetes patients: focus on clinical manifestation, pathogenic mechanism, and the role of traditional Chinese medicine

Yang, X., Xue, C., Chen, K.-Y., Gao, D., Wang, H., & Tang, C. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1339744 · Cited by 6

Significance of the Gut Microbiome for Viral Diarrheal and Extra-Intestinal Diseases

Desselberger, U. (2021) · Viruses · doi:10.3390/v13081601 · Cited by 10

Mct11 deficiency alters hepatic glucose metabolism and energy homeostasisPreprint

Ainbinder, A., Zhao, L., Glover, P., Gelinas-Roa, K., Rusu, V., Harney, A. M., Hoch, E., Deik, A., Pierce, K. A., Bullock, K. H., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.09.08.459307 · Cited by 9

Polydatin combined with hawthorn flavonoids alleviate high fat diet induced atherosclerosis by remodeling the gut microbiota and glycolipid metabolism

Li, D., Li, Y., Yang, S., Zhang, X., Cao, Y., Zhao, R., Zhao, Y., Jin, X., Lu, J., Wang, X., et al. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1515485 · Cited by 8

Trimethylamine N-oxide induces cardiac diastolic dysfunction by down-regulating Piezo1 in mice with heart failure with preserved ejection fraction

Chen, Q., Zhang, H., Chen, Y., Peng, Y., Yao, Y., Xue, H., Guo, Q., Tian, D., Xiao, L., Teng, X., et al. (2025) · Life Sciences · doi:10.1016/j.lfs.2025.123554 · Cited by 8

Gut microbiome research: Revealing the pathological mechanisms and treatment strategies of type 2 diabetes

Fang, X., Zhang, Y., Huang, X., Miao, R., Zhang, Y., & Tian, J. (2025) · Diabetes Obesity and Metabolism · doi:10.1111/dom.16387 · Cited by 10

From Gut to Heart: Targeting Trimethylamine N-Oxide as a Novel Strategy in Heart Failure Management

Ding, Z., Yu, Y., Wei, J., Wang, Z., Lin, R., Li, Y., & Guo, Z. (2025) · Biomolecules · doi:10.3390/biom15101447 · Cited by 8

Emerging Evidence Linking the Liver to the Cardiovascular System: Liver-derived Secretory Factors

Liu, X., Shao, Y., Han, L., Zhang, R., & Chen, J. (2023) · Journal of Clinical and Translational Hepatology · doi:10.14218/jcth.2022.00122 · Cited by 8

The role of microbial metabolites in diabetic kidney disease

Zhu, T., Hu, B.-Y., Zhang, Y., Zhang, Z., Cai, K., Lei, L., Hu, B., Wang, X. H., Tang, C., Lu, Y., et al. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e17844 · Cited by 8

Breaking bugs: gut microbes metabolize dietary components and modulate vascular health

Babu, A. K. S., Srinivasan, H., & Babu, P. V. A. (2023) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2023.2251616 · Cited by 9

Danger-associated metabolites trigger metaflammation: A crowbar in cardiometabolic diseases

Wang, A., Guan, B., Zhang, H., & Xu, H. (2023) · Pharmacological Research · doi:10.1016/j.phrs.2023.106983 · Cited by 9

A new perspective in the prevention and treatment of antitumor therapy-related cardiotoxicity: Intestinal microecology

Meng, C., Wang, X., Fan, L., Fan, Y., Yan, Z., Wang, Y., Li, Y., Zhang, J., & Lv, S. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115588 · Cited by 8

Gut Microbiota Depletion Using Antibiotics to Investigate Diet‐Derived Microbial Metabolites: An Efficient Strategy

Babu, A. K. S., Petersen, C., Paz, H. A., Iglesias‐Carres, L., Li, Y., Zhong, Y., Neilson, A. P., Wankhade, U. D., & Babu, P. V. A. (2023) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202300386 · Cited by 8

Effects of Trimethylamine N-Oxide in Improving Exercise Performance in Mice: A 1H-NMR-Based Metabolomic Analysis Approach

Zou, H. B., Gong, L., Wang, Z., Huang, C., Luo, Y., Jia, X., Yu, J., Lin, D., & Zhang, Y. (2024) · Molecules · doi:10.3390/molecules29174128 · Cited by 7

Perspective: Pathological transdifferentiation—a novel therapeutic target for cardiovascular diseases and chronic inflammation

Yang, W. Y., Issa, M. B., Saaoud, F., Xu, K., Shao, Y., Lu, Y., Dornas, W. C., Cueto, R., Jiang, X., Wang, H., et al. (2024) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2024.1500775 · Cited by 7

FMO3 exacerbates hepatic endoplasmic reticulum stress in drug-induced liver injury by inhibiting CREB3/P4HB axis and activating TMAO-mediated PERK pathway

Zhang, H., Zhao, S., Fang, R., Wang, X., Chen, H., Cai, Z., Liu, Y., Tu, J., Zhang, F., Zhang, W., et al. (2025) · Life Sciences · doi:10.1016/j.lfs.2025.123699 · Cited by 7

TMAO-Activated Hepatocyte-Derived Exosomes Are Widely Distributed in Mice with Different Patterns and Promote Vascular Inflammation

Liu, X., Tu, J., Zhou, Z., Huang, B., Zhou, J., & Chen, J. (2022) · Cardiology Research and Practice · doi:10.1155/2022/5166302 · Cited by 7

Microbial metabolite as icebreaker for immunotherapy

Tang, Y., & Kang, Y. (2022) · Cell Metabolism · doi:10.1016/j.cmet.2022.03.003 · Cited by 7

Population studies of TMAO and its precursors may help elucidate mechanisms

Meyer, K. A. (2020) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/nqaa068 · Cited by 7

Gut Microbial Trimethylamine is Elevated in Alcohol-Associated Hepatitis and Contributes to Ethanol-Induced Liver Injury in MicePreprint

Helsley, R. N., Miyata, T., Kadam, A., Varadharajan, V., Sangwan, N., Huang, E., Banerjee, R., Brown, A. L., Fung, K. K., Massey, W. J., et al. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.12.31.474633 · Cited by 7

The association of trimethylamine N-oxide with diabetic retinopathy Pathology: Insights from network toxicology and molecular docking analysis

Gao, J., Zhang, J., & Tang, L. (2025) · Experimental Eye Research · doi:10.1016/j.exer.2025.110399 · Cited by 6

Alterations and mechanistic insights of gut microbiota and its metabolites in type 2 diabetes mellitus and Alzheimer's disease

Xu, G., An, Y., Du, Y., Cao, Z., Zheng, J., Wang, J., Li, T., Lei, X. G., & Lu, Y. (2025) · iMetaOmics. · doi:10.1002/imo2.70020 · Cited by 7

Dietary choline deficiency potentiates Helicobacter pylori-driven gut-liver dysfunction via microbial metabolic rewiring

Li, J., Wang, L., Meng, Z., Ma, H., Yu, Z., Zhao, J., Cui, G., Chen, Z., & Wu, D. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.115050 · Cited by 6

The association between a dietary index for the gut microbiota and frailty in older adults: emphasising the mediating role of inflammatory indicators

Yin, H., Qiu, Y., Gan, C., Zhou, Y., Chen, T., & Liang, M. (2025) · Frontiers in Nutrition · doi:10.3389/fnut.2025.1562278 · Cited by 7

Advancements in research to mitigate residual risk of atherosclerotic cardiovascular disease

Shi, F., Dou, J., & Zhang, X. (2025) · European journal of medical research · doi:10.1186/s40001-025-03006-3 · Cited by 11

Organelle stresses and energetic metabolisms promote endothelial–to–mesenchymal transition and fibrosis via upregulating FOSB and MEOX1 in Alzheimer’s disease

Saaoud, F., Issa, M., Liu, L., Xu, K., Lu, Y., Shao, Y., Han, B., Jiang, X., Liu, X., Gillespie, A., et al. (2025) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2025.1605012 · Cited by 7

Endometrial stromal cell-derived TMAO sustains decidualization to prevent recurrent spontaneous abortion

Chen, Y.-L., Tang, L.-C., Zhou, W., Sun, X., Lai, Z., Xu, S., Cai, K., Shi, Y., Zhao, R. Z., Zhou, X., et al. (2026) · Cell Metabolism · doi:10.1016/j.cmet.2025.11.014 · Cited by 6

Divergent Effects of Glycemic Control and Bariatric Surgery on Circulating Concentrations of TMAO in Newly Diagnosed T2D Patients and Morbidly Obese

Canyelles, M., Pérez, A., Junza, A., Miñambres, I., Yanes, Ó., Sardà, H., Rotllán, N., Julve, J., Benı́tez, S., Sánchez‐Quesada, J. L., et al. (2022) · Diagnostics · doi:10.3390/diagnostics12112783 · Cited by 6

Gut Microbiota and Insulin Resistance: Understanding the Mechanism of Better Treatment of Type 2 Diabetes Mellitus

Al-Busaidi, A., Alabri, O., Alomairi, J., Elsharaawy, A., Lawati, A. A., Lawati, H. A., & Das, S. (2024) · Current Diabetes Reviews · doi:10.2174/0115733998281910231231051814 · Cited by 7

1H-nuclear magnetic resonance analysis reveals dynamic changes in the metabolic profile of patients with severe burns

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