Hyperpolarized MRI of Human Prostate Cancer Reveals Increased Lactate with Tumor Grade Driven by Monocarboxylate Transporter 1

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Bray, F., Ferlay, J., Soerjomataram, I., Siegel, R. L., Torre, L. A., & Jemal, A. (2018) · CA: A Cancer Journal for Clinicians · doi:10.3322/caac.21492 · Cited by 84,109 · see citing works

Cancer statistics, 2018

Siegel, R. L., Miller, K. D., & Jemal, A. (2018) · CA A Cancer Journal for Clinicians · doi:10.3322/caac.21442 · Cited by 16,632 · see citing works

voom: precision weights unlock linear model analysis tools for RNA-seq read counts

Law, C. W., Chen, Y., Shi, W., & Smyth, G. K. (2014) · Genome Biology · doi:10.1186/gb-2014-15-2-r29 · Cited by 6,155 · see citing works

Regulation of cancer cell metabolism

Cairns, R. A., Harris, I. S., & Mak, T. W. (2011) · Nature Reviews Cancer · doi:10.1038/nrc2981 · Cited by 4,744 · see citing works

The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation

DeBerardinis, R. J., Lum, J. J., Hatzivassiliou, G., & Thompson, C. B. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2007.10.002 · Cited by 4,088 · see citing works

Integrative Genomic Profiling of Human Prostate Cancer

Taylor, B. S., Schultz, N. D., Hieronymus, H., Gopalan, A., Xiao, Y., Carver, B. S., Arora, V. K., Kaushik, P., Cerami, E. G., Reva, B. A., et al. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.05.026 · Cited by 3,653 · see citing works

The Molecular Taxonomy of Primary Prostate Cancer

Abeshouse, A. A., Ahn, J., Akbani, R., Ally, A., Amin, S. B., Andry, C., Annala, M., Aprikian, A. G., Armenia, J., Arora, A., et al. (2015) · Cell · doi:10.1016/j.cell.2015.10.025 · Cited by 3,081 · see citing works

Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets (MSK-IMPACT)

Cheng, D. T., Mitchell, T. N., Zehir, A., Shah, R. H., Benayed, R., Syed, A., Chandramohan, R., Liu, Z. Y., Won, H. H., Scott, S. N., et al. (2015) · The Journal of Molecular Diagnostics · doi:10.1016/j.jmoldx.2014.12.006 · Cited by 2,119 · see citing works

Radical Prostatectomy versus Watchful Waiting in Early Prostate Cancer

Bill‐Axelson, A., Holmberg, L., Ruutu, M. L., Garmo, H., Rider, J. R., Busch, C., Nordling, S., Häggman, M., Andersson, S., BRATELL, S., et al. (2011) · New England Journal of Medicine · doi:10.1056/nejmoa1011967 · Cited by 1,899 · see citing works

Glucose feeds the TCA cycle via circulating lactate

Hui, S., Ghergurovich, J. M., Morscher, R. J., Jang, C., Teng, X., Lu, W., Esparza, L. A., Reya, T., Zhan, L., Yanxiang Guo, J., et al. (2017) · Nature · doi:10.1038/nature24057 · Cited by 1,721 · see citing works

The proton-linked monocarboxylate transporter (MCT) family: structure, function and regulation

Halestrap, A. P., & Price, N. T. (1999) · Biochemical Journal · doi:10.1042/bj3430281 · Cited by 1,346 · see citing works

Lactate Metabolism in Human Lung Tumors

Faubert, B., Li, K. Y., Cai, L., Hensley, C. T., Kim, J., Zacharias, L. G., Yang, C., Do, Q. N., Doucette, S., Burguete, D., et al. (2017) · Cell · doi:10.1016/j.cell.2017.09.019 · Cited by 1,343 · see citing works

Metabolic Imaging of Patients with Prostate Cancer Using Hyperpolarized [1- 13 C]Pyruvate

Nelson, S. J., Kurhanewicz, J. V., Vigneron, D. B., Larson, P. E. Z., Harzstark, A. L., Ferrone, M., Criekinge, M. V., Chang, J. W., Bok, R., Park, I., et al. (2013) · Science Translational Medicine · doi:10.1126/scitranslmed.3006070 · Cited by 1,289 · see citing works

The genomic complexity of primary human prostate cancer

Berger, M. F., Lawrence, M. S., Demichelis, F., Drier, Y., Cibulskis, K., Sivachenko, A., Sboner, A., Esgueva, R., Pflueger, D., Sougnez, C. L., et al. (2011) · Nature · doi:10.1038/nature09744 · Cited by 1,213 · see citing works

The Multiple Roles of PTEN in Tumor Suppression

Di Cristofano, A., & Pandolfi, P. P. (2000) · Cell · doi:10.1016/s0092-8674(00)80674-1 · Cited by 1,182 · see citing works

Radical Prostatectomy versus Watchful Waiting in Early Prostate Cancer

Bill-Axelson, A., Holmberg, L., Ruutu, M., Häggman, M., Andersson, S.-O., Bratell, S., Spångberg, A., Busch, C., Nordling, S., Garmo, H., et al. (2005) · New England Journal of Medicine · doi:10.1056/nejmoa043739 · Cited by 1,111 · see citing works

Detecting tumor response to treatment using hyperpolarized 13C magnetic resonance imaging and spectroscopy

Day, S. E., Kettunen, M. I., Gallagher, F. A., Hu, D., Lerche, M. H., Wolber, J., Golman, K., Ardenkjær‐Larsen, J. H., & Brindle, K. M. (2007) · Nature Medicine · doi:10.1038/nm1650 · Cited by 882 · see citing works

Natural History of Early, Localized Prostate Cancer

Johansson, J. (2004) · JAMA · doi:10.1001/jama.291.22.2713 · Cited by 698 · see citing works

The androgen receptor fuels prostate cancer by regulating central metabolism and biosynthesis

Massie, C. E., Lynch, A., Ramos‐Montoya, A., Boren, J., Stark, R., Fazli, L., Warren, A., Scott, H., Madhu, B., Sharma, N., et al. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.158 · Cited by 624 · see citing works

Reexamining cancer metabolism: lactate production for carcinogenesis could be the purpose and explanation of the Warburg Effect

San-Millán, I., & Brooks, G. A. (2016) · Carcinogenesis · doi:10.1093/carcin/bgw127 · Cited by 613 · see citing works

PATTERNS OF PROGRESSION IN PROSTATE CANCER

McNeal, J. E., Kindrachuk, R. W., Freiha, F. S., Bostwick, D. G., Redwine, E. A., & Stamey, T. A. (1986) · The Lancet · doi:10.1016/s0140-6736(86)90715-4 · Cited by 582 · see citing works

Akt-dependent metabolic reprogramming regulates tumor cell histone acetylation

Lee, J. V., Carrer, A., Shah, S., Snyder, N. W., Wei, S., Venneti, S., Worth, A. J., Yuan, Z.-F., Lim, H.-W., Liu, S., et al. (2014) · Cell Metabolism · doi:10.1016/j.cmet.2014.06.004 · Cited by 563 · see citing works

Hyperpolarized 13C Lactate, Pyruvate, and Alanine: Noninvasive Biomarkers for Prostate Cancer Detection and Grading

Albers, M. J., Bok, R., Chen, A. P., Cunningham, C. H., Zierhut, M. L., Zhang, V. Y., Kohler, S. J., Tropp, J. S., Hurd, R. E., Yen, Y., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-0749 · Cited by 521 · see citing works

Hyperpolarized 13C MRI: Path to Clinical Translation in Oncology

Kurhanewicz, J. V., Vigneron, D. B., Ardenkjær‐Larsen, J. H., Bankson, J. A., Brindle, K. M., Cunningham, C. H., Gallagher, F. A., Keshari, K. R., Kjær, A., Laustsen, C., et al. (2018) · Neoplasia · doi:10.1016/j.neo.2018.09.006 · Cited by 441 · see citing works

Hyperpolarized 13 C Metabolic MRI of the Human Heart

Cunningham, C. H., Lau, J. Y. C., Chen, A. P., Geraghty, B. J., Perks, W. J., Roifman, I., Wright, G. A., & Connelly, K. A. (2016) · Circulation Research · doi:10.1161/circresaha.116.309769 · Cited by 359 · see citing works

Chemistry and biochemistry of 13 C hyperpolarized magnetic resonance using dynamic nuclear polarization

Keshari, K. R., & Wilson, D. M. (2013) · Chemical Society Reviews · doi:10.1039/c3cs60124b · Cited by 357 · see citing works

Pathway Thermodynamics Highlights Kinetic Obstacles in Central Metabolism

Noor, Ε., Bar‐Even, A., Flamholz, A. I., Reznik, E., Liebermeister, W., & Milo, R. (2014) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1003483 · Cited by 342 · see citing works

Metabolic Reprogramming of Stromal Fibroblasts through p62-mTORC1 Signaling Promotes Inflammation and Tumorigenesis

Valencia, T., Kim, J. Y., Abu-Baker, S., Moscat-Pardos, J., Ahn, C. S., Reina-Campos, M., Duran, A., Castilla, E. A., Metallo, C. M., Diaz-Meco, M. T., et al. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.05.004 · Cited by 304 · see citing works

ERA SPECIFIC BIOCHEMICAL RECURRENCE-FREE SURVIVAL FOLLOWING RADICAL PROSTATECTOMY FOR CLINICALLY LOCALIZED PROSTATE CANCER

Han, M., Partin, A. W., Piantadosi, S., Epstein, J. I., & Walsh, P. C. (2001) · The Journal of Urology · doi:10.1016/s0022-5347(05)65955-1 · Cited by 286 · see citing works

A Comparison of the Incidence and Location of Positive Surgical Margins in Robotic Assisted Laparoscopic Radical Prostatectomy and Open Retropubic Radical Prostatectomy

Smith, J. A. J., Chan, R. C., Chang, S. S., Herrell, S. D., Clark, P. E., Baumgartner, R., & Cookson, M. S. (2007) · The Journal of Urology · doi:10.1016/j.juro.2007.08.008 · Cited by 279 · see citing works

Metabolic Imaging of the Human Brain with Hyperpolarized 13C Pyruvate Demonstrates 13C Lactate Production in Brain Tumor Patients

Miloushev, V. Z., Granlund, K. L., Boltyanskiy, R., Lyashchenko, S. K., DeAngelis, L. M., Mellinghoff, I. K., Brennan, C. W., Tabar, V., Yang, J. T., Holodny, A. I., et al. (2018) · Cancer Research · doi:10.1158/0008-5472.can-18-0221 · Cited by 218 · see citing works

Evaluation of lactate and alanine as metabolic biomarkers of prostate cancer using 1H HR‐MAS spectroscopy of biopsy tissues

Tessem, M., Swanson, M. G., Keshari, K. R., Albers, M. J., Joun, D., Tabatabai, Z. L., Simko, J., Shinohara, K., Nelson, S. J., Vigneron, D. B., et al. (2008) · Magnetic Resonance in Medicine · doi:10.1002/mrm.21694 · Cited by 200 · see citing works

Prostate Cancer: Correlation of MR Imaging and MR Spectroscopy with Pathologic Findings after Radiation Therapy–Initial Experience

Pucar, D., Shukla‐Dave, A., Hricak, H., Moskowitz, C. S., Kuroiwa, K., Olgac, S., Ebora, L. E., Scardino, P. T., Koutcher, J. A., & Zakian, K. L. (2005) · Radiology · doi:10.1148/radiol.2362040739 · Cited by 197 · see citing works

Molecular imaging using hyperpolarized 13C

Golman, K., Olsson, L. E., Axelsson, O., Månsson, S., Karlsson, M. G., & Petersson, J. (2003) · British Journal of Radiology · doi:10.1259/bjr/26631666 · Cited by 182 · see citing works

Hyperpolarized 1-[ 13 C]-Pyruvate Magnetic Resonance Imaging Detects an Early Metabolic Response to Androgen Ablation Therapy in Prostate Cancer

Aggarwal, R. R., Vigneron, D. B., & Kurhanewicz, J. V. (2017) · European Urology · doi:10.1016/j.eururo.2017.07.022 · Cited by 153 · see citing works

AKT1 and MYC Induce Distinctive Metabolic Fingerprints in Human Prostate Cancer

Priolo, C., Pyne, S., Rose, J. A., Regan, E. R., Zadra, G., Photopoulos, C., Cacciatore, S., Schultz, D., Scaglia, N., McDunn, J. E., et al. (2014) · Cancer Research · doi:10.1158/0008-5472.can-14-1490 · Cited by 135 · see citing works

Investigation of analysis methods for hyperpolarized 13C‐pyruvate metabolic MRI in prostate cancer patients

Larson, P. E. Z., Chen, H., Gordon, J. W., Korn, N. J., Maidens, J., Arcak, M., Tang, S., Criekinge, M. V., Carvajal, L. E., Mammoli, D., et al. (2018) · NMR in Biomedicine · doi:10.1002/nbm.3997 · Cited by 111 · see citing works

Metabolic Reprogramming and Validation of Hyperpolarized13C Lactate as a Prostate Cancer Biomarker Using a Human Prostate Tissue Slice Culture Bioreactor

Keshari, K. R., Sriram, R., Criekinge, M. V., Wilson, D. M., Wang, Z. J., Vigneron, D. B., Peehl, D. M., & Kurhanewicz, J. V. (2013) · The Prostate · doi:10.1002/pros.22665 · Cited by 105 · see citing works

Importance of Additional “Extreme” Anterior Apical Needle Biopsies in the Initial Detection of Prostate Cancer

Moussa, A. S., Meshref, A. W., Schoenfield, L. R., Masoud, A., Abdelrahman, S. F., Li, J., Flazoura, S., Magi‐Galluzzi, C., Fergany, A. F., Fareed, K., et al. (2010) · Urology · doi:10.1016/j.urology.2009.11.008 · Cited by 99 · see citing works

Improved prostate cancer detection with anterior apical prostate biopsies

Wright, J. L., & Ellis, W. J. (2006) · Urologic Oncology Seminars and Original Investigations · doi:10.1016/j.urolonc.2006.03.003 · Cited by 76 · see citing works

Transmembrane Protease TMPRSS11B Promotes Lung Cancer Growth by Enhancing Lactate Export and Glycolytic Metabolism

Updegraff, B. L., Zhou, X., Guo, Y., Padanad, M. S., Chen, P.-H., Yang, C., Sudderth, J., Tirado, C. R., Girard, L., Minna, J. D., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.10.100 · Cited by 57 · see citing works

Very distal apical prostate tumours: identification on multiparametric MRI at 3 Tesla

Nix, J. W., Türkbey, B., Hoang, A., Volkin, D., Yerram, N. K., Chua, C., Linehan, W. M., Wood, B. J., Choyke, P. L., & Pinto, P. A. (2012) · British Journal of Urology · doi:10.1111/j.1464-410x.2012.11503.x · Cited by 56 · see citing works

Multi-channel metabolic imaging, with SENSE reconstruction, of hyperpolarized [1-13C] pyruvate in a live rat at 3.0tesla on a clinical MR scanner

Tropp, J. S., Lupo, J., Chen, A., Calderon, P. D., McCune, D., Grafendorfer, T., Öztürk-Işık, E., Larson, P. E. Z., Hu, S., Yen, Y., et al. (2010) · Journal of Magnetic Resonance · doi:10.1016/j.jmr.2010.10.007 · Cited by 54 · see citing works

High‐speed 3T MR spectroscopic imaging of prostate with flyback echo‐planar encoding

Chen, A. P., Cunningham, C. H., Öztürk-Işık, E., Xu, D., Hurd, R. E., Kelley, D. A. C., Pauly, J. M., Kurhanewicz, J. V., Nelson, S. J., & Vigneron, D. B. (2007) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.20916 · Cited by 50 · see citing works

Prostate Cancer: Top Places Where Tumors Hide on Multiparametric MRI

Rosenkrantz, A. B., Verma, S., & Türkbey, B. (2015) · American Journal of Roentgenology · doi:10.2214/ajr.14.13280 · Cited by 40 · see citing works

Location of residual cancer after transrectal high‐intensity focused ultrasound ablation for clinically localized prostate cancer

Boutier, R., Girouin, N., Cheikh, A. B., Belot, A., Rabilloud, M., Gelet, A., Chapelon, J., & Rouvière, O. (2011) · British Journal of Urology · doi:10.1111/j.1464-410x.2011.10251.x · Cited by 38 · see citing works

Hyperpolarized MRI Visualizes Warburg Effects and Predicts Treatment Response to mTOR Inhibitors in Patient-Derived ccRCC Xenograft Models

Dong, Y., Eskandari, R., Ray, C., Granlund, K. L., Cunha, L. S., Miloushev, V. Z., Tee, S. S., Jeong, S., Aras, Ö., Chen, Y., et al. (2018) · Cancer Research · doi:10.1158/0008-5472.can-18-2231 · Cited by 36 · see citing works

Metabolic response of prostate cancer to nicotinamide phophoribosyltransferase inhibition in a hyperpolarized MR/PET compatible bioreactor

Keshari, K. R., Wilson, D. M., Criekinge, M. V., Sriram, R., Koelsch, B. L., Wang, Z. J., VanBrocklin, H. F., Peehl, D. M., O'Brien, T., Sampath, D., et al. (2015) · The Prostate · doi:10.1002/pros.23036 · Cited by 33 · see citing works

MRI of the Pelvis: A Text Atlas

Carrington, B. M., & Hricak, H. (1992) · Medical Entomology and Zoology · Cited by 31 · see citing works

ERA SPECIFIC BIOCHEMICAL RECURRENCE-FREE SURVIVAL FOLLOWING RADICAL PROSTATECTOMY FOR CLINICALLY LOCALIZED PROSTATE CANCER

Han, M., Partin, A. W., Piantadosi, S., et al. (2001) · The Journal of Urology · doi:10.1097/00005392-200108000-00005 · Cited by 26 · see citing works

Methods for metabolic evaluation of prostate cancer cells using proton and 13C HR‐MAS spectroscopy and [3‐13C] pyruvate as a metabolic substrate

Levin, Y. S., Albers, M. J., Butler, T. N., Spielman, D. M., Peehl, D. M., & Kurhanewicz, J. V. (2009) · Magnetic Resonance in Medicine · doi:10.1002/mrm.22120 · Cited by 24 · see citing works

Measurement Repeatability of18F-FDG PET/CT Versus18F-FDG PET/MRI in Solid Tumors of the Pelvis

Fraum, T. J., Fowler, K. J., Crandall, J. P., Laforest, R. A., Salter, A. R., An, H., Jacobs, M. A., Grigsby, P. W., Dehdashti, F., & Wahl, R. L. (2019) · Journal of Nuclear Medicine · doi:10.2967/jnumed.118.218735 · Cited by 24 · see citing works

Targeted AKT Inhibition in Prostate Cancer Cells and Spheroids Reduces Aerobic Glycolysis and Generation of Hyperpolarized [1-13C] Lactate

Tee, S. S., Suster, I., Truong, S., Jeong, S., Eskandari, R., DiGialleonardo, V., Alvarez, J. A., Aldeborgh, H. N., & Keshari, K. R. (2018) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-17-0458 · Cited by 23 · see citing works

Noninvasive Interrogation of Cancer Metabolism with Hyperpolarized 13C MRI

Cho, A., Lau, J. Y. C., Geraghty, B. J., Cunningham, C. H., & Keshari, K. R. (2017) · Journal of Nuclear Medicine · doi:10.2967/jnumed.116.182170 · Cited by 22 · see citing works

Characterization and stratification of prostate lesions based on comprehensive multiparametric MRI using detailed whole‐mount histopathology as a reference standard

Starobinets, O., Simko, J., Kuchinsky, K., Kornak, J., Carroll, P. R., Greene, K. L., Kurhanewicz, J. V., & Noworolski, S. M. (2017) · NMR in Biomedicine · doi:10.1002/nbm.3796 · Cited by 22 · see citing works

Multinuclear NMR and MRI Reveal an Early Metabolic Response to mTOR Inhibition in Sarcoma

Gialleonardo, V. D., Aldeborgh, H. N., Miloushev, V. Z., Folkers, K. M., Granlund, K. L., Tap, W. D., Lewis, J. S., Weber, W., & Keshari, K. R. (2017) · Cancer Research · doi:10.1158/0008-5472.can-16-3310 · Cited by 19 · see citing works

Bolus tracking for improved metabolic imaging of hyperpolarised compounds

Durst, M., Koellisch, U., Gringeri, C. V., Janich, M., Rancan, G., Frank, A., Wiesinger, F., Menzel, M. I., Haase, A., & Schulte, R. F. (2014) · Journal of Magnetic Resonance · doi:10.1016/j.jmr.2014.02.011 · Cited by 18 · see citing works

SIFT, a Postprocessing Method That Increases the Signal-to-Noise Ratio of Spectra Which Vary in Time

Doyle, M., Chapman, B. L. W., Balschi, J. A., & Pohost, G. M. (1994) · Journal of Magnetic Resonance Series B · doi:10.1006/jmrb.1994.1020 · Cited by 9 · see citing works

Metabolic reprogramming and cancer progression

Faubert, B., Solmonson, A., & DeBerardinis, R. J. (2020) · Science · doi:10.1126/science.aaw5473 · Cited by 2,740 · see citing works

Limited Environmental Serine and Glycine Confer Brain Metastasis Sensitivity to PHGDH Inhibition

Ngo, B., Kim, E., Osorio-Vasquez, V., Doll, S., Bustraan, S., Liang, R. J., Luengo, A., Davidson, S. M., Ali, A., Ferraro, G. B., et al. (2020) · Cancer Discovery · doi:10.1158/2159-8290.cd-19-1228 · Cited by 268 · see citing works

HIF1α lactylation enhances KIAA1199 transcription to promote angiogenesis and vasculogenic mimicry in prostate cancer

Luo, Y., Yang, Z., Yu, Y., & Zhang, P. (2022) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2022.10.014 · Cited by 252 · see citing works

The oncogenic and clinical implications of lactate induced immunosuppression in the tumour microenvironment

Hayes, C., Donohoe, C. L., Davern, M., & Donlon, N. E. (2020) · Cancer Letters · doi:10.1016/j.canlet.2020.12.021 · Cited by 215 · see citing works

The pleiotropic functions of reactive oxygen species in cancer

Wu, K., Zowalaty, A. E. E., Sayin, V. I., & Papagiannakopoulos, T. Y. (2024) · Nature Cancer · doi:10.1038/s43018-024-00738-9 · Cited by 203 · see citing works

The emerging role of lactate in tumor microenvironment and its clinical relevance

Chen, S., Xu, Y., Zhuo, W., & Zhang, L. (2024) · Cancer Letters · doi:10.1016/j.canlet.2024.216837 · Cited by 200 · see citing works

Imaging breast cancer using hyperpolarized carbon-13 MRI

Gallagher, F. A., Woitek, R., McLean, M. A., Gill, A. B., García, R. M., Provenzano, E., Riemer, F., Kaggie, J. D., Chhabra, A., Ursprung, S., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1913841117 · Cited by 199 · see citing works

Lactate Rewires Lipid Metabolism and Sustains a Metabolic–Epigenetic Axis in Prostate Cancer

Ippolito, L., Comito, G., Parri, M., Iozzo, M., Duatti, A., Virgilio, F., Lorito, N., Bacci, M., Pardella, E., Sandrini, G., et al. (2022) · Cancer Research · doi:10.1158/0008-5472.can-21-0914 · Cited by 181 · see citing works

Metabolic analysis as a driver for discovery, diagnosis, and therapy

DeBerardinis, R. J., & Keshari, K. R. (2022) · Cell · doi:10.1016/j.cell.2022.06.029 · Cited by 172 · see citing works

MRI-guided Radiation Therapy: An Emerging Paradigm in Adaptive Radiation Oncology

Otazo, R., Lambin, P., Pignol, J., Ladd, M. E., Schlemmer, H., Baumann, M. A., & Hricak, H. (2020) · Radiology · doi:10.1148/radiol.2020202747 · Cited by 170 · see citing works

Tumour metabolism and its unique properties in prostate adenocarcinoma

Bader, D. A., & McGuire, S. E. (2020) · Nature Reviews Urology · doi:10.1038/s41585-020-0288-x · Cited by 154 · see citing works

Metabolic pathway analysis using stable isotopes in patients with cancer

Bartman, C., Faubert, B., Rabinowitz, J. D., & DeBerardinis, R. J. (2023) · Nature reviews. Cancer · doi:10.1038/s41568-023-00632-z · Cited by 87 · see citing works

Hyperpolarized [1- 13 C]pyruvate-to-[1- 13 C]lactate conversion is rate-limited by monocarboxylate transporter-1 in the plasma membrane

Rao, Y., Gammon, S. T., Zacharias, N. M., Liu, T. W. B., Salzillo, T. C., Xi, Y., Wang, J., Bhattacharya, P. K., & Piwnica-Worms, D. R. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2003537117 · Cited by 79 · see citing works

Metabolic adaptations in prostate cancer

Pujana-Vaquerizo, M., Bozal‐Basterra, L., & Carracedo, A. (2024) · British Journal of Cancer · doi:10.1038/s41416-024-02762-z · Cited by 72 · see citing works

Current methods for hyperpolarized [ 1‐ 13 C ]pyruvate MRI human studies

Larson, P. E. Z., Bernard, J. M. L., Bankson, J. A., Bøgh, N., Bok, R., Chen, A. P., Cunningham, C. H., Gordon, J. W., Hövener, J., Laustsen, C., et al. (2024) · Magnetic Resonance in Medicine · doi:10.1002/mrm.29875 · Cited by 69 · see citing works

Lactate induces tumor-associated macrophage polarization independent of mitochondrial pyruvate carrier-mediated metabolism

Xia, F., Zhao, P., Gao, S., Liu, D., Zhang, S., Shan, M., Wang, Y., Herrmann, J., Li, Q., & Wang, F. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.123810 · Cited by 69 · see citing works

Hyperpolarised 13C-MRI identifies the emergence of a glycolytic cell population within intermediate-risk human prostate cancer

Sushentsev, N., McLean, M. A., Warren, A. Y., Benjamin, A. J. V., Brodie, C. R., Frary, A. J., Gill, A. B., Jones, J. L., Kaggie, J. D., Lamb, B. W., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-28069-2 · Cited by 67 · see citing works

Targeting Mitochondrial OXPHOS and Their Regulatory Signals in Prostate Cancers

Chen, C., Lin, C., & Kung, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222413435 · Cited by 62 · see citing works

Metabolic imaging with hyperpolarized 13 C pyruvate magnetic resonance imaging in patients with renal tumors—Initial experience

Tang, S., Meng, M. V., Slater, J. B., Gordon, J. W., Vigneron, D. B., Stohr, B. A., Larson, P. E. Z., & Wang, Z. J. (2021) · Cancer · doi:10.1002/cncr.33554 · Cited by 57 · see citing works

Obesogenic High-Fat Diet and MYC Cooperate to Promote Lactate Accumulation and Tumor Microenvironment Remodeling in Prostate Cancer

Boufaied, N., Chetta, P., Hallal, T., Cacciatore, S., Lalli, D., Luthold, C., Homsy, K., Imada, E. L., Syamala, S., Photopoulos, C., et al. (2024) · Cancer Research · doi:10.1158/0008-5472.can-23-0519 · Cited by 54 · see citing works

Hyperpolarized Carbon-13 MRI for Early Response Assessment of Neoadjuvant Chemotherapy in Breast Cancer Patients

Woitek, R., McLean, M. A., Ursprung, S., Rueda, O. M., García, R. M., Locke, M. J., Beer, L., Baxter, G. C., Rundo, L., Provenzano, E., et al. (2021) · Cancer Research · doi:10.1158/0008-5472.can-21-1499 · Cited by 53 · see citing works

Clinical and genomic features of SPOP‐mutant prostate cancer

Nakazawa, M., Fang, M., Marshall, C. H., Lotan, T. L., Velho, P. I., & Antonarakis, E. S. (2021) · The Prostate · doi:10.1002/pros.24269 · Cited by 53 · see citing works

Hyperpolarized 13C-Pyruvate Metabolism as a Surrogate for Tumor Grade and Poor Outcome in Renal Cell Carcinoma—A Proof of Principle Study

Ursprung, S., Woitek, R., McLean, M. A., Priest, A. N., Crispin‐Ortuzar, M., Brodie, C. R., Gill, A. B., Gehrung, M., Beer, L., Riddick, A. C. P., et al. (2022) · Cancers · doi:10.3390/cancers14020335 · Cited by 52 · see citing works

pH-Channeling in Cancer: How pH-Dependence of Cation Channels Shapes Cancer Pathophysiology

Pethő, Z., Najder, K., Carvalho, T. M. A., McMorrow, R., Todesca, L. M., Rugi, M., Bulk, E., Chan, A. B., Löwik, C. W. G. M., Reshkin, S. J., et al. (2020) · Cancers · doi:10.3390/cancers12092484 · Cited by 51 · see citing works

Nutrient transporters: connecting cancer metabolism to therapeutic opportunities

Nwosu, Z. C., Song, M. G., di Magliano, M. P., Lyssiotis, C. A., & Kim, S. E. (2023) · Oncogene · doi:10.1038/s41388-023-02593-x · Cited by 47 · see citing works

The use of hyperpolarised 13C-MRI in clinical body imaging to probe cancer metabolism

Woitek, R., & Gallagher, F. A. (2021) · British Journal of Cancer · doi:10.1038/s41416-020-01224-6 · Cited by 46 · see citing works

Hyperpolarized Carbon 13 MRI: Clinical Applications and Future Directions in Oncology

Deen, S. S., Rooney, C. H. E., Shinozaki, A., McGing, J., Grist, J. T., Tyler, D. J., Serrão, E. M., & Gallagher, F. A. (2023) · Radiology Imaging Cancer · doi:10.1148/rycan.230005 · Cited by 46 · see citing works

A variable resolution approach for improved acquisition of hyperpolarized 13 C metabolic MRI

Gordon, J. W., Autry, A. W., Tang, S., Graham, J. Y., Bok, R., Zhu, X., Villanueva-Meyer, J. E., Li, Y., Ohliger, M. A., Abraham, M. R., et al. (2020) · Magnetic Resonance in Medicine · doi:10.1002/mrm.28421 · Cited by 46 · see citing works

Comprehensive Literature Review of Hyperpolarized Carbon-13 MRI: The Road to Clinical Application

Væggemose, M., Schulte, R. F., & Laustsen, C. (2021) · Metabolites · doi:10.3390/metabo11040219 · Cited by 45 · see citing works

Preclinical models of prostate cancer — modelling androgen dependency and castration resistance in vitro, ex vivo and in vivo

Germain, L., Lafront, C., Paquette, V., Neveu, B., Paquette, J., Pouliot, F., & Audet‐Walsh, É. (2023) · Nature Reviews Urology · doi:10.1038/s41585-023-00726-1 · Cited by 43 · see citing works

Lactate as Key Metabolite in Prostate Cancer Progression: What Are the Clinical Implications?

Chetta, P., Sriram, R., & Zadra, G. (2023) · Cancers · doi:10.3390/cancers15133473 · Cited by 43 · see citing works

Hyperpolarized 13C MRI data acquisition and analysis in prostate and brain at University of California, San Francisco

Crane, J. C., Gordon, J. W., Chen, H., Autry, A. W., Li, Y., Olson, M. P., Kurhanewicz, J. V., Vigneron, D. B., Larson, P. E. Z., & Xu, D. (2020) · NMR in Biomedicine · doi:10.1002/nbm.4280 · Cited by 42 · see citing works

Targeting metabolic reprogramming in hepatocellular carcinoma to overcome therapeutic resistance: A comprehensive review

Wang, Q., Liu, J., Chen, Z., Zheng, J., Wang, Y., & Dong, J. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.116021 · Cited by 40 · see citing works

Hyperpolarized MRI, functional MRI, MR spectroscopy and CEST to provide metabolic information in vivo

van Zijl, P. C. M., Brindle, K. M., Lu, H., Barker, P. B., Edden, R. A. E., Yadav, N. N., & Knutsson, L. (2021) · Current Opinion in Chemical Biology · doi:10.1016/j.cbpa.2021.06.003 · Cited by 38 · see citing works

Prostate lineage-specific metabolism governs luminal differentiation and response to antiandrogen treatment

Giafaglione, J. M., Crowell, P. D., Delcourt, A. M. L., Hashimoto, T., Ha, S. M., Atmakuri, A., Nunley, N. M., Dang, R. M. A., Tian, M., Diaz, J. A., et al. (2023) · Nature Cell Biology · doi:10.1038/s41556-023-01274-x · Cited by 37 · see citing works

Fast Imaging for Hyperpolarized MR Metabolic Imaging

Gordon, J. W., Chen, H., Dwork, N., Tang, S., & Larson, P. E. Z. (2020) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.27070 · Cited by 36 · see citing works

Dual inhibition of oxidative phosphorylation and glycolysis exerts a synergistic antitumor effect on colorectal and gastric cancer by creating energy depletion and preventing metabolic switch

Aisu, Y., Oshima, N., Hyodo, F., Elhelaly, A. E., Masuo, A., Okada, T., Hisamori, S., Tsunoda, S., Hida, K., Morimoto, T., et al. (2024) · PLoS ONE · doi:10.1371/journal.pone.0309700 · Cited by 35 · see citing works

Metabolomics in hepatocellular carcinoma: From biomarker discovery to precision medicine

Wu, X., Wang, Z., Luo, L., Shu, D., & Wang, K. (2023) · Frontiers in Medical Technology · doi:10.3389/fmedt.2022.1065506 · Cited by 35 · see citing works

New Horizons in Hyperpolarized 13C MRI

Chaumeil, M. M., Bankson, J. A., Brindle, K. M., Epstein, S., Gallagher, F. A., Grashei, M., Guglielmetti, C., Kaggie, J. D., Keshari, K. R., Knecht, S., et al. (2023) · Molecular Imaging and Biology · doi:10.1007/s11307-023-01888-5 · Cited by 33 · see citing works

Multi-nuclear magnetic resonance spectroscopy: state of the art and future directions

Wei, Y., Yang, C., Jiang, H., Li, Q., Che, F., Wan, S., Yao, S., Gao, F., Zhang, T., Wang, J., et al. (2022) · Insights into Imaging · doi:10.1186/s13244-022-01262-z · Cited by 33 · see citing works

Clinical Cardiovascular Applications of Hyperpolarized Magnetic Resonance

Lewis, A., Tyler, D. J., & Rider, O. J. (2020) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-020-06942-w · Cited by 29 · see citing works

PFKFB3-mediated Pro-glycolytic Shift in Hepatocellular Carcinoma Proliferation

Dou, Q., Grant, A. K., Callahan, C. J., de Souza, P. C., Mwin, D., Booth, A. L., Nasser, I. A., Moussa, M., Ahmed, M., & Tsai, L. L. (2022) · Cellular and Molecular Gastroenterology and Hepatology · doi:10.1016/j.jcmgh.2022.09.009 · Cited by 28 · see citing works

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Fidelito, G., Watt, M. J., & Taylor, R. A. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2021.778761 · Cited by 27 · see citing works

A Hybrid End-to-End Approach Integrating Conditional Random Fields into CNNs for Prostate Cancer Detection on MRI

Lapa, P., Castelli, M., Gonçalves, I., Sala, E., & Rundo, L. (2020) · Applied Sciences · doi:10.3390/app10010338 · Cited by 26 · see citing works

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Pichler, V., Martinho, R. P., Temming, L., Segers, T., Wurm, F. R., & Koshkina, O. (2025) · Advanced Science · doi:10.1002/advs.202404411 · Cited by 25 · see citing works

Hyperpolarized Metabolic MRI—Acquisition, Reconstruction, and Analysis Methods

Larson, P. E. Z., & Gordon, J. W. (2021) · Metabolites · doi:10.3390/metabo11060386 · Cited by 25 · see citing works

Hyperpolarized [5- 13 C,4,4- 2 H 2 ,5- 15 N]-L-glutamine provides a means of annotating in vivo metabolic utilization of glutamine

Eskandari, R., Kim, N., Mamakhanyan, A., Saoi, M., Zhang, G., Berishaj, M., Granlund, K. L., Poot, A. J., Cross, J. R., Thompson, C. B., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2120595119 · Cited by 25 · see citing works

Federated Learning from Small DatasetsPreprint

Kamp, M., Fischer, J., & Vreeken, J. (2021) · arXiv (Cornell University) · doi:10.48550/arxiv.2110.03469 · Cited by 25 · see citing works

Consensus recommendations for hyperpolarized [1‐ 13 C ]pyruvate MRI multi‐center human studies

Punwani, S., Larson, P. E. Z., Laustsen, C., van der Meulen, J., Ardenkjær‐Larsen, J. H., Autry, A. W., Bankson, J. A., Bernard, J. M. L., Bok, R., Bertelsen, L. B., et al. (2025) · Magnetic Resonance in Medicine · doi:10.1002/mrm.30570 · Cited by 24 · see citing works

Predicting response to radiotherapy of intracranial metastases with hyperpolarized $$^{13}$$C MRI

Lee, C. Y., Soliman, H., Bragagnolo, N. D., Sahgal, A., Geraghty, B. J., Chen, A. P., Endre, R., Perks, W. J., Detsky, J. S., Leung, E., et al. (2021) · Journal of Neuro-Oncology · doi:10.1007/s11060-021-03725-7 · Cited by 24 · see citing works

Emerging MR methods for improved diagnosis of prostate cancer by multiparametric MRI

Dwivedi, D. K., & Jagannathan, N. R. (2022) · Magnetic Resonance Materials in Physics Biology and Medicine · doi:10.1007/s10334-022-01031-5 · Cited by 24 · see citing works

Initial Experience on Hyperpolarized [1-13C]Pyruvate MRI Multicenter Reproducibility—Are Multicenter Trials Feasible?

Bøgh, N., Gordon, J. W., Hansen, E. S. S., Bok, R., Blicher, J. U., Hu, J. Y., Larson, P. E. Z., Vigneron, D. B., & Laustsen, C. (2022) · Tomography · doi:10.3390/tomography8020048 · Cited by 21 · see citing works

First in‐human evaluation of [ 1‐ 13 C ]pyruvate in D 2 O for hyperpolarized MRI of the brain: A safety and feasibility study

Deh, K., Zhang, G., Park, A. H., Cunningham, C. H., Bragagnolo, N. D., Lyashchenko, S. K., Ahmmed, S., Leftin, A., Coffee, E., Hricak, H., et al. (2024) · Magnetic Resonance in Medicine · doi:10.1002/mrm.30002 · Cited by 21 · see citing works

Comparison of 13C MRI of hyperpolarized [1‐13C]pyruvate and lactate with the corresponding mass spectrometry images in a murine lymphoma model

Fala, M., Somai, V., Dannhorn, A., Hamm, G. R., Gibson, K., Couturier, D., Hesketh, R. L., Wright, A. J., Takáts, Z., Bunch, J., et al. (2021) · Magnetic Resonance in Medicine · doi:10.1002/mrm.28652 · Cited by 19 · see citing works

Hyperpolarized 13C-glucose magnetic resonance highlights reduced aerobic glycolysis in vivo in infiltrative glioblastoma

Mishkovsky, M., Gusyatiner, O., Lanz, B., Cudalbu, C., Vassallo, I., Hamou, M., Bloch, J., Comment, A., Rolf Gruetter, A., & Hegi, M. E. (2021) · Scientific Reports · doi:10.1038/s41598-021-85339-7 · Cited by 18 · see citing works

Quo Vadis Hyperpolarized 13C MRI?

Wodtke, P., Grashei, M., & Schilling, F. (2023) · Zeitschrift für Medizinische Physik · doi:10.1016/j.zemedi.2023.10.004 · Cited by 17 · see citing works

Lactate signaling and immune suppression in tumors: mechanisms and therapeutic implications

Wang, X., Xiong, D., Cui, S., Duan, B., Ding, G., Huang, Y., & Wang, Q. (2026) · Cellular Oncology · doi:10.1007/s13402-026-01186-6 · Cited by 16 · see citing works

PDGF-BB accelerates TSCC via fibroblast lactates limiting miR-26a-5p and boosting mitophagy

Xu, J., Bian, L., You, D., Li, Z., Wang, T., Li, Y., Ren, X., & He, Y. (2024) · Cancer Cell International · doi:10.1186/s12935-023-03172-6 · Cited by 16 · see citing works

Metabolic imaging across scales reveals distinct prostate cancer phenotypes

Sushentsev, N., Hamm, G. R., Flint, L., Birtles, D., Zakirov, A., Richings, J., Ling, S., Tan, J. Y., McLean, M. A., Ayyappan, V., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-50362-5 · Cited by 16 · see citing works

Integrative metabolic flux analysis reveals an indispensable dimension of phenotypes

Law, R. C., Lakhani, A., O’Keeffe, S., Erşan, S., & Park, J. O. (2022) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2022.102701 · Cited by 16 · see citing works

Prostate cancer stem cell dynamics in the evolution of drug resistance

Zhang, X., Zhang, X., Deng, X., Cao, J., Bao, Q., Wang, H., Chen, D., & Tang, H. (2025) · International Journal of Surgery · doi:10.1097/js9.0000000000002611 · Cited by 15 · see citing works

Measuring the Metabolic Evolution of Glioblastoma throughout Tumor Development, Regression, and Recurrence with Hyperpolarized Magnetic Resonance

Salzillo, T. C., Mawoneke, V., Weygand, J., Shetty, A., Gumin, J., Zacharias, N. M., Gammon, S. T., Piwnica-Worms, D. R., Fuller, G. N., Logothetis, C. J., et al. (2021) · Cells · doi:10.3390/cells10102621 · Cited by 15 · see citing works

Hyperpolarized Carbon-13 MRI in Breast Cancer

Woitek, R., & Brindle, K. M. (2023) · Diagnostics · doi:10.3390/diagnostics13132311 · Cited by 14 · see citing works

Biopolymer and Biomaterial Conjugated Iron Oxide Nanomaterials as Prostate Cancer Theranostic Agents: A Comprehensive Review

Rayhan, M. A., Hossen, M. S., Niloy, M. S., Bhuiyan, M. H., Paul, S., & Shakil, M. S. (2021) · Symmetry · doi:10.3390/sym13060974 · Cited by 14 · see citing works

Imaging immunomodulatory treatment responses in a multiple sclerosis mouse model using hyperpolarized 13C metabolic MRI

Guglielmetti, C., Cordano, C., Najac, C., Green, A., & Chaumeil, M. M. (2023) · Communications Medicine · doi:10.1038/s43856-023-00300-1 · Cited by 13 · see citing works

Imaging tumor lactate is feasible for identifying intermediate-risk prostate cancer patients with postsurgical biochemical recurrence

Sushentsev, N., Hamm, G. R., Richings, J., McLean, M. A., Menih, I. H., Ayyappan, V., Mills, I. G., Warren, A. Y., Gnanapragasam, V. J., Barry, S. T., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2312261120 · Cited by 13 · see citing works

Specialized computational methods for denoising, B 1 correction, and kinetic modeling in hyperpolarized 13 C MR EPSI studies of liver tumors

Lee, P. M., Chen, H., Gordon, J. W., Zhu, Z., Larson, P. E. Z., Dwork, N., Criekinge, M. V., Carvajal, L. E., Ohliger, M. A., Wang, Z. J., et al. (2021) · Magnetic Resonance in Medicine · doi:10.1002/mrm.28901 · Cited by 13 · see citing works

Emerging methods for prostate cancer imaging: evaluating cancer structure and metabolic alterations more clearly

Retter, A., Gong, F., Syer, T., Singh, S., Adeleke, S. M., & Punwani, S. (2021) · Molecular Oncology · doi:10.1002/1878-0261.13071 · Cited by 13 · see citing works

Kinetic analysis of multi‐resolution hyperpolarized 13C human brain MRI to study cerebral metabolism

Hu, J. Y., Kim, Y., Autry, A. W., Frost, M., Bok, R., Villanueva-Meyer, J. E., Xu, D., Li, Y., Larson, P. E. Z., Vigneron, D. B., et al. (2022) · Magnetic Resonance in Medicine · doi:10.1002/mrm.29354 · Cited by 12 · see citing works

Characterizing Metabolic Heterogeneity of Hepatocellular Carcinoma with Hyperpolarized 13 C Pyruvate MRI and Mass Spectrometry

Dou, Q., Grant, A. K., de Souza, P. C., Moussa, M., Nasser, I. A., Ahmed, M., & Tsai, L. L. (2024) · Radiology Imaging Cancer · doi:10.1148/rycan.230056 · Cited by 11 · see citing works

Hyperpolarized Carbon-13 Magnetic Resonance Imaging: Technical Considerations and Clinical Applications

Lai, Y., Hsieh, C., Juan, Y., Lu, K., Lee, H.-J., Ng, S., Wan, Y., & Lin, G. (2024) · Korean Journal of Radiology · doi:10.3348/kjr.2024.0069 · Cited by 11 · see citing works

Hyperpolarized Dihydroxyacetone Is a Sensitive Probe of Hepatic Gluconeogenic State

Ragavan, M., McLeod, M., Giacalone, A., & Merritt, M. E. (2021) · Metabolites · doi:10.3390/metabo11070441 · Cited by 11 · see citing works

Advances in application of novel magnetic resonance imaging technologies in liver disease diagnosis

Qi, Y., & Xiao, E. (2023) · World Journal of Gastroenterology · doi:10.3748/wjg.v29.i28.4384 · Cited by 11 · see citing works

Hyperpolarised 13C-MRI using 13C-pyruvate in breast cancer: A review

Arponen, O., Wodtke, P., Gallagher, F. A., & Woitek, R. (2023) · European Journal of Radiology · doi:10.1016/j.ejrad.2023.111058 · Cited by 11 · see citing works

Hyperpolarized [2–13C]pyruvate MR molecular imaging with whole brain coverage

Chung, B. T., Kim, Y., Gordon, J. W., Chen, H., Autry, A. W., Lee, P. M., Hu, J. Y., Tan, C. T., Suszczynski, C., Chang, S. M., et al. (2023) · NeuroImage · doi:10.1016/j.neuroimage.2023.120350 · Cited by 11 · see citing works

Non-Invasive Differentiation of M1 and M2 Activation in Macrophages Using Hyperpolarized 13C MRS of Pyruvate and DHA at 1.47 Tesla

Qiao, K., Page, L. M. L., & Chaumeil, M. M. (2021) · Metabolites · doi:10.3390/metabo11070410 · Cited by 11 · see citing works

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Lin, G., Elkashif, A., Saha, C., Coulter, J. A., Dunne, N., & McCarthy, H. O. (2025) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2025.104643 · Cited by 10 · see citing works

Prospective clinical sequencing of 1016 Chinese prostate cancer patients: uncovering genomic characterization and race disparity

Yu, W., Zhang, T., Wang, B., Pan, J. G., Jin, S., Fang, B., Gu, W., Qin, X., Dai, B., Lin, G., et al. (2023) · Molecular Oncology · doi:10.1002/1878-0261.13511 · Cited by 9 · see citing works

Improving multiparametric MR ‐ transrectal ultrasound guided fusion prostate biopsies with hyperpolarized 13 C pyruvate metabolic imaging: A technical development study

Chen, H., Bok, R., Cooperberg, M. R., Nguyen, H. G., Shinohara, K., Westphalen, A. C., Wang, Z. J., Ohliger, M. A., Gebrezgiabhier, D., Carvajal, L. E., et al. (2022) · Magnetic Resonance in Medicine · doi:10.1002/mrm.29399 · Cited by 9 · see citing works

Combined 23Na and 13C imaging at 3.0 Tesla using a single‐tuned large FOV birdcage coil

Kaggie, J. D., Lanz, T. E., McLean, M. A., Riemer, F., Schulte, R. F., Benjamin, A. J. V., Kessler, D. A., Sun, C. J., Gilbert, F. J., Graves, M. J., et al. (2021) · Magnetic Resonance in Medicine · doi:10.1002/mrm.28772 · Cited by 9 · see citing works

Prostate cancer research in the 21st century; report from the 2021 Coffey‐Holden prostate cancer academy meeting

Miyahira, A. K., Zarif, J. C., Coombs, C. C., Flavell, R. R., Russo, J. W., Zaidi, S., Zhao, D., Zhao, S. G., Pienta, K. J., & Soule, H. R. (2021) · The Prostate · doi:10.1002/pros.24262 · Cited by 8 · see citing works

Metabolomic profiles of intact tissues reflect clinically relevant prostate cancer subtypes

Dudka, I., Lundquist, K., Wikström, P., Bergh, A. R. J., & Gröbner, G. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04747-7 · Cited by 8 · see citing works

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Farah, C., Mignion, L., & Jordan, B. F. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25031725 · Cited by 8 · see citing works

Dual hyperpolarized [1-13C]pyruvate and [13C]urea magnetic resonance imaging of prostate cancer

de Kouchkovsky, I., Nguyen, H. G., Chen, H., Liu, X., Qin, H., Stohr, B. A., Santos, R. D., Ohliger, M. A., Wang, Z. J., Bok, R., et al. (2024) · Journal of Magnetic Resonance Open · doi:10.1016/j.jmro.2024.100165 · Cited by 8 · see citing works

The potential of hyperpolarised 13C-MRI to target glycolytic tumour core in prostate cancer

Sushentsev, N., McLean, M. A., Warren, A. Y., Brodie, C. R., Jones, J. L., Gallagher, F. A., & Barrett, T. (2022) · European Radiology · doi:10.1007/s00330-022-08929-7 · Cited by 7 · see citing works

Functional Genetic Screening Enables Theranostic Molecular Imaging in Cancer

Perkons, N. R., Johnson, O., Pilla, G., Profka, E., Mercadante, M., Ackerman, D., & Gade, T. P. F. (2020) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-20-0826 · Cited by 7 · see citing works

Cardiac pH-Imaging With Hyperpolarized MRI

Bøgh, N., Hansen, E. S. S., Mariager, C. Ø., Bertelsen, L. B., Ringgaard, S., & Laustsen, C. (2020) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2020.603674 · Cited by 7 · see citing works

Metabolic traits ruling the specificity of the immune response in different cancer types

Flerin, N. C., Cappellesso, F., Pretto, S., & Mazzone, M. (2020) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2020.10.011 · Cited by 7 · see citing works

Emerging role of multiparametric magnetic resonance imaging in identifying clinically relevant localized prostate cancer

Williams, C., Daneshvar, M., & Pinto, P. A. (2021) · Current Opinion in Oncology · doi:10.1097/cco.0000000000000717 · Cited by 7 · see citing works

Characterization of Distinctive In Vivo Metabolism between Enhancing and Non-Enhancing Gliomas Using Hyperpolarized Carbon-13 MRI

Park, S., Hashizume, R., Kim, S. K., & Park, I. (2021) · Metabolites · doi:10.3390/metabo11080504 · Cited by 7 · see citing works

Hyperpolarized 13C tracers: Technical advancements and perspectives for clinical applications

Fiedorowicz, M., Wieteska, M., Rylewicz, K., Kossowski, B., Piątkowska-Janko, E., Czarnecka, A. M., Toczyłowska, B., & Bogorodzki, P. (2021) · Journal of Applied Biomedicine · doi:10.1016/j.bbe.2021.03.010 · Cited by 7 · see citing works

Targeting carbonic anhydrase IX / XII prevents the anti‐ferroptotic effect of stromal lactic acid in prostate carcinoma

Pardella, E., Comito, G., Ippolito, L., Pranzini, E., Iozzo, M., Gangarossa, G., Virgilio, F. D., Bua, S., Nocentini, A., Sandrini, G., et al. (2025) · Molecular Oncology · doi:10.1002/1878-0261.70083 · Cited by 6 · see citing works

Icariin-curcumol inhibits histone H3K18 lactylation and FOXM1 expression to enhance the sensitivity of prostate cancer cells to docetaxel

Sheng, W., Li, Y., Tan, T., Yu, X., Huang, X., Li, L., Zhang, C., Chen, Y., Liu, L., Feng, M., et al. (2025) · Cancer Cell International · doi:10.1186/s12935-025-03927-3 · Cited by 6 · see citing works

Mutual-information based optimal experimental design for hyperpolarized $$^{13}$$C-pyruvate MRI

Jha, P. K., Walker, C. J., Mitchell, D., Oden, J. T., Schellingerhout, D., Bankson, J. A., & Fuentes, D. (2023) · Scientific Reports · doi:10.1038/s41598-023-44958-y · Cited by 5 · see citing works

A reproducible dynamic phantom for sequence testing in hyperpolarised 13C-magnetic resonance

Chowdhury, R., Papoutsaki, M., Müller, C. A., Smith, L. A., Gong, F., Bullock, M., Rogers, H. J., Mathew, M., Syer, T., Singh, S., et al. (2022) · British Journal of Radiology · doi:10.1259/bjr.20210770 · Cited by 5 · see citing works

Micro-Slab Coil Design for Hyperpolarized Metabolic Flux Analysis in Multiple Samples

Lee, G., Ruan, T., Wong, C., Deh, K., Abolarin, A., Correa, A., Keshari, K. R., & Jeong, S. (2022) · Bioengineering · doi:10.3390/bioengineering10010014 · Cited by 5 · see citing works

Dynamic volumetric hyperpolarized 13C imaging with multi‐echo EPI

Deh, K., Granlund, K. L., Eskandari, R., Kim, N., Mamakhanyan, A., & Keshari, K. R. (2020) · Magnetic Resonance in Medicine · doi:10.1002/mrm.28466 · Cited by 5 · see citing works

Moving from conventional to adaptive risk stratification for oropharyngeal cancer

Sandulache, V. C., Kirby, R. P., & Lai, S. Y. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1287010 · Cited by 4 · see citing works

Multivariate Framework of Metabolism in Advanced Prostate Cancer Using Whole Abdominal and Pelvic Hyperpolarized 13C MRI—A Correlative Study with Clinical Outcomes

Chen, H., de Kouchkovsky, I., Bok, R., Ohliger, M. A., Wang, Z. J., Gebrezgiabhier, D., Nickles, T. M., Carvajal, L. E., Gordon, J. W., Larson, P. E. Z., et al. (2025) · Cancers · doi:10.3390/cancers17132211 · Cited by 4 · see citing works

Initial Experience of Metabolic Imaging With Hyperpolarized [1‐ 13C ]pyruvate MRI in Kidney Transplant Patients

Liu, X., Lai, Y., Cui, D., Kung, S., Park, M., Laszik, Z. G., Larson, P. E. Z., & Wang, Z. J. (2024) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.29580 · Cited by 4 · see citing works

In vivo hyperpolarized carbon-13 diffusion weighted MRI measures lactate metabolism and transport in prostate cancer

Qin, H. (2015) · eScholarship (California Digital Library)

Elevated Tumor Lactate and Efflux in High-grade Prostate Cancer demonstrated by Hyperpolarized 13C Magnetic Resonance Spectroscopy of Prostate Tissue Slice Cultures

Sriram, R., Criekinge, M. V., Santos, J. D., Ahamed, F., Qin, H., Nolley, R., Santos, R. D., Tabatabai, Z. L., Bok, R., Keshari, K. R., et al. (2020) · Cancers · doi:10.3390/cancers12030537 · Cited by 26 · see citing works

Hyperpolarized 13C-pyruvate MRI detects real-time metabolic flux in prostate cancer metastases to bone and liver: a clinical feasibility study

Chen, H., Aggarwal, R. R., Bok, R., Ohliger, M. A., Zhu, Z., Lee, P., Gordon, J. W., Criekinge, M. V., Carvajal, L. E., Slater, J. B., et al. (2019) · Prostate Cancer and Prostatic Diseases · doi:10.1038/s41391-019-0180-z · Cited by 105 · see citing works

Hyperpolarized 13C Lactate, Pyruvate, and Alanine: Noninvasive Biomarkers for Prostate Cancer Detection and Grading

Albers, M. J., Bok, R., Chen, A. P., Cunningham, C. H., Zierhut, M. L., Zhang, V. Y., Kohler, S. J., Tropp, J. S., Hurd, R. E., Yen, Y., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-0749 · Cited by 521 · see citing works

Abstract 4106: Hyperpolarized [1-13C]-pyruvate/lactate magnetic resonance spectroscopic imaging of prostate cancer in vivo predicts response to lactate dehydrogenase inhibition

Scroggins, B. T., Matsuo, M., White, A. O., Saito, K., Munasinghe, J., Sourbier, C., Yamamoto, K., Diaz, V., Mitchell, J. B., Krishna, M. C., et al. (2018) · Cancer Research · doi:10.1158/1538-7445.am2018-4106