Glutamine Links Obesity to Inflammation in Human White Adipose Tissue

Fast and accurate short read alignment with Burrows-Wheeler transform

Li, H., & Durbin, R. (2009) · Bioinformatics · doi:10.1093/bioinformatics/btp324 · Cited by 58,607

Obesity is associated with macrophage accumulation in adipose tissue

Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041

Inflammation and metabolic disorders

Hotamisligil, G. S. (2006) · Nature · doi:10.1038/nature05485 · Cited by 9,199

Metabolic regulation of gene expression by histone lactylation

Zhang, D., Tang, Z., Huang, H., Zhou, G., Cui, C., Weng, Y., Liu, W., Kim, S., Lee, S., Perez-Neut, M., et al. (2019) · Nature · doi:10.1038/s41586-019-1678-1 · Cited by 4,371

Type 2 diabetes as an inflammatory disease

Donath, M. Y., & Shoelson, S. E. (2011) · Nature Reviews Immunology · doi:10.1038/nri2925 · Cited by 3,737

What we talk about when we talk about fat

Rosen, E. D., & Spiegelman, B. M. (2014) · Cell · doi:10.1016/j.cell.2013.12.012 · Cited by 2,373

Obesity and the Environment: Where Do We Go from Here?

Hill, J. O., Wyatt, H. R., Reed, G. W., & Peters, J. C. (2003) · Science · doi:10.1126/science.1079857 · Cited by 2,180

Integrated, Nontargeted Ultrahigh Performance Liquid Chromatography/Electrospray Ionization Tandem Mass Spectrometry Platform for the Identification and Relative Quantification of the Small-Molecule Complement of Biological Systems

Evans, A. M., DeHaven, C. D., Barrett, T., Mitchell, M. W., & Milgram, K. E. (2009) · Analytical Chemistry · doi:10.1021/ac901536h · Cited by 1,317

α-ketoglutarate orchestrates macrophage activation through metabolic and epigenetic reprogramming

Liu, P.-S., Wang, H., Li, X., Chao, T., Teav, T., Christen, S., Di Conza, G., Cheng, W.-C., Chou, C.-H., Vavakova, M., et al. (2017) · Nature Immunology · doi:10.1038/ni.3796 · Cited by 1,264

Glutamine: Metabolism and Immune Function, Supplementation and Clinical Translation

Cruzat, V., Macedo Rogero, M., Noel Keane, K., Curi, R., & Newsholme, P. (2018) · Nutrients · doi:10.3390/nu10111564 · Cited by 1,261

Glutamine reliance in cell metabolism

Yoo, H. C., Yu, Y. C., Sung, Y., & Han, J. M. (2020) · Experimental & Molecular Medicine · doi:10.1038/s12276-020-00504-8 · Cited by 1,021

Small molecule metabolites: discovery of biomarkers and therapeutic targets

Qiu, S., Cai, Y., Yao, H., Lin, C., Xie, Y., Tang, S., & Zhang, A. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01399-3 · Cited by 993

Amino acid metabolism in health and disease

Ling, Z., Jiang, Y.-F., Ru, J.-N., Lu, J.-H., Ding, B., & Wu, J. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01569-3 · Cited by 590

Signaling pathways in obesity: mechanisms and therapeutic interventions

Wen, X., Zhang, B., Wu, B., Xiao, H., Li, Z., Li, R., Xu, X., & Li, T. (2022) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-022-01149-x · Cited by 490

Mendelian randomization analyses support causal relationships between blood metabolites and the gut microbiome

Liu, X., Tong, X., Zou, Y., Lin, X., Zhao, H., Tian, L., Jie, Z., Wang, Q., Zhang, Z., Lu, H., et al. (2022) · Nature Genetics · doi:10.1038/s41588-021-00968-y · Cited by 383

Inflammation: the incubator of the tumor microenvironment

Denk, D., & Greten, F. R. (2022) · Trends in cancer · doi:10.1016/j.trecan.2022.07.002 · Cited by 287

Adipose tissue retains an epigenetic memory of obesity after weight loss

Hinte, L. C., Castellano‐Castillo, D., Ghosh, A., Melrose, K., Gasser, E., Noé, F., Massier, L., Dong, H., Sun, W., Hoffmann, A., et al. (2024) · Nature · doi:10.1038/s41586-024-08165-7 · Cited by 320

The Hexosamine Biosynthesis Pathway: Regulation and Function

Paneque, A., Fortus, H., Zheng, J., Werlen, G., & Jacinto, E. (2023) · Genes · doi:10.3390/genes14040933 · Cited by 257

White adipocyte dysfunction and obesity-associated pathologies in humans

Hagberg, C. E., & Spalding, K. L. (2023) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-023-00680-1 · Cited by 236

Adipocyte-derived lactate is a signalling metabolite that potentiates adipose macrophage inflammation via targeting PHD2

Feng, T., Zhao, X., Gu, P., Yang, W., Wang, C., Guo, Q., Long, Q., Liu, Q., Cheng, Y., Li, J., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-32871-3 · Cited by 201

Emerging role of targeting macrophages in rheumatoid arthritis: Focus on polarization, metabolism and apoptosis

Yang, X., Chang, Y., & Wei, W. (2020) · Cell Proliferation · doi:10.1111/cpr.12854 · Cited by 176

PPAR-γ integrates obesity and adipocyte clock through epigenetic regulation of Bmal1

Wang, S., Lin, Y., Gao, L., Yang, Z., Lin, J., Ren, S., Li, F., Chen, J., Wang, Z., Dong, Z., et al. (2022) · Theranostics · doi:10.7150/thno.69054 · Cited by 119

Metabolic Architecture of Acute Exercise Response in Middle-Aged Adults in the Community

Nayor, M. G., Shah, R. V., Miller, P. E., Blodgett, J. B., Tanguay, M., Pico, A. R., Murthy, V. L., Malhotra, R. K., Houstis, N. E., Deik, A., et al. (2020) · Circulation · doi:10.1161/circulationaha.120.050281 · Cited by 110

3D Adipose Tissue Culture Links the Organotypic Microenvironment to Improved Adipogenesis

Shen, J. X., Couchet, M., Dufau, J., Barbosa, T. D. C., Ulbrich, M. H., Helmstädter, M., Kemas, A. M., Shafagh, R. Z., Marqués, M.-A., Hansen, J. B., et al. (2021) · Advanced Science · doi:10.1002/advs.202100106 · Cited by 94

Obesity and Cancer Metastasis: Molecular and Translational Perspectives

Annett, S., Moore, G., & Robson, T. (2020) · Cancers · doi:10.3390/cancers12123798 · Cited by 93

Circulating Pro- and Anti-Inflammatory Metabolites and Its Potential Role in Rheumatoid Arthritis Pathogenesis

Coras, R., Murillo‐Saich, J., & Gumá, M. (2020) · Cells · doi:10.3390/cells9040827 · Cited by 90

Glutamine suppresses senescence and promotes autophagy through glycolysis inhibition-mediated AMPKα lactylation in intervertebral disc degeneration

Zhang, Y., Huang, Z., Han, W., Wu, J., Li, S., Qin, T., Zhang, C., Shi, M., Han, S., Gao, B., et al. (2024) · Communications Biology · doi:10.1038/s42003-024-06000-3 · Cited by 86

OGT suppresses S6K1-mediated macrophage inflammation and metabolic disturbance

Yang, Y., Li, X., Luan, H. H., Zhang, B., Zhang, K., Nam, J. H., Li, Z., Fu, M., Munk, A., Zhang, D., et al. (2020) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1916121117 · Cited by 78

Macrophages and T cells in metabolic disorder-associated cancers

Taranto, D., Kloosterman, D. J., & Akkari, L. (2024) · Nature reviews. Cancer · doi:10.1038/s41568-024-00743-1 · Cited by 81

San-Huang-Yi-Shen Capsule Ameliorates Diabetic Nephropathy in Rats Through Modulating the Gut Microbiota and Overall Metabolism

Su, X., Yu, W., Liu, A., Wang, C., Li, X., Gao, J., Liu, X.-F., Jiang, W., Yang, Y., & Lv, S. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.808867 · Cited by 64

Dietary metabolic signatures and cardiometabolic risk

Shah, R. V., Steffen, L. M., Nayor, M. G., Reis, J. P., Jacobs, D. R., Allen, N. B., Lloyd‐Jones, D. M., Meyer, K. A., Cole, J. B., Piaggi, P., et al. (2022) · European Heart Journal · doi:10.1093/eurheartj/ehac446 · Cited by 70

Causal Association Between Obesity, Circulating Glutamine Levels, and Depression: A Mendelian Randomization Study

He, R., Zheng, R., Zheng, J., Li, M., Wang, T., Zhao, Z., Wang, S., Lin, H., Lu, J., Chen, Y., et al. (2022) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgac707 · Cited by 62

Fermented Rosa Roxburghii Tratt Juice Alleviates High-Fat Diet-Induced Hyperlipidemia in Rats by Modulating Gut Microbiota and Metabolites

Ji, J., Zhang, S., Yuan, M., Zhang, M., Tang, L., Wang, P., Liu, Y., Xu, C., Luo, P., & Gao, X. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.883629 · Cited by 60

Phenotyping obesity: A focus on metabolically healthy obesity and metabolically unhealthy normal weight

Agius, R., Pace, N. P., & Fava, S. (2023) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.3725 · Cited by 64

Asparagine reinforces mTORC1 signaling to boost thermogenesis and glycolysis in adipose tissues

Xu, Y., Shi, T., Cui, X., Yan, L., Wang, Q., Xu, X., Zhao, Q., Xu, X., Tang, Q., Tang, H., et al. (2021) · The EMBO Journal · doi:10.15252/embj.2021108069 · Cited by 58

Age-Induced Reduction in Human Lipolysis: A Potential Role for Adipocyte Noradrenaline Degradation

Gao, H., Arner, P., Beauchef, G., Guéré, C., Vié, K., Dahlman, I. A., Mejhert, N., & Rydén, M. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2020.06.007 · Cited by 57

Glutamine metabolism in Th17/Treg cell fate: applications in Th17 cell-associated diseases

Yang, G., Xia, Y., & Ren, W. (2020) · Science China Life Sciences · doi:10.1007/s11427-020-1703-2 · Cited by 55

Impaired phosphocreatine metabolism in white adipocytes promotes inflammation

Maqdasy, S., Lecoutre, S., Renzi, G., Frendo‐Cumbo, S., Rizo‐Roca, D., Möritz, T., Juvany, M., Hodek, O., Gao, H., Couchet, M., et al. (2022) · Nature Metabolism · doi:10.1038/s42255-022-00525-9 · Cited by 54

Traditional Chinese medicine in regulating macrophage polarization in immune response of inflammatory diseases

Chen, S., Zeng, J., Li, R., Zhang, Y., Tao, Y., Hou, Y., Lu, Y., Zhang, Y., Wu, J., & Meng, X. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.117838 · Cited by 56

Comorbidity-associated glutamine deficiency is a predisposition to severe COVID-19

Matsuyama, T., Yoshinaga, S. K., Shibue, K., & Mak, T. W. (2021) · Cell Death and Differentiation · doi:10.1038/s41418-021-00892-y · Cited by 54

Acetyl-CoA and Metabolite Fluxes Regulate White Adipose Tissue Expansion

Felix, J. B., Cox, A. R., & Hartig, S. M. (2021) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2021.02.008 · Cited by 52

Mitochondrial heterogeneity and adaptations to cellular needs

Granath-Panelo, M., & Kajimura, S. (2024) · Nature Cell Biology · doi:10.1038/s41556-024-01410-1 · Cited by 50

Importance of the Microenvironment and Mechanosensing in Adipose Tissue Biology

Lecoutre, S., Lambert, M., Drygalski, K., Dugail, I., Maqdasy, S., Hautefeuille, M., & Clément, K. (2022) · Cells · doi:10.3390/cells11152310 · Cited by 56

A spatiotemporal proteomic map of human adipogenesis

Klingelhuber, F., Frendo‐Cumbo, S., Omar‐Hmeadi, M., Massier, L., Kakimoto, P. A., Taylor, A. J., Couchet, M., Ribičić, S., Wabitsch, M., Messias, A. C., et al. (2024) · Nature Metabolism · doi:10.1038/s42255-024-01025-8 · Cited by 51

Obesity and renal cell carcinoma: Biological mechanisms and perspectives

Venkatesh, N., Martini, A., McQuade, J. L., Msaouel, P., & Hahn, A. W. (2023) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2023.06.001 · Cited by 46

Glutamine Regulates Skeletal Muscle Immunometabolism in Type 2 Diabetes

Dollet, L., Kuefner, M., Caria, E., Rizo‐Roca, D., Pendergrast, L. A., Abdelmoez, A. M., Karlsson, H., Bjrnholm, M., Dalbram, E., Treebak, J. T., et al. (2022) · Diabetes · doi:10.2337/db20-0814 · Cited by 50

Mechanisms of metabolism-coupled protein modifications

Zhang, B., & Schroeder, F. C. (2025) · Nature Chemical Biology · doi:10.1038/s41589-024-01805-z · Cited by 46

Metabolomics in cardiometabolic diseases: Key biomarkers and therapeutic implications for insulin resistance and diabetes

Rizo‐Roca, D., Henderson, J. D., & Zierath, J. R. (2025) · Journal of Internal Medicine · doi:10.1111/joim.20090 · Cited by 51

Lactobacillus-fermentation enhances nutritional value and improves the inhibition on pancreatic lipase and oral pathogens of edible red seaweed Bangia fusco-purpurea

Li, Z., Dong, Y., Zhang, Y., Zheng, M., Jiang, Z., Zhu, Y., Deng, S., Li, Q., & Ni, H. (2023) · LWT · doi:10.1016/j.lwt.2023.114643 · Cited by 42

Targeting fuel pocket of cancer cell metabolism: A focus on glutaminolysis

Sharma, S., Agnihotri, N., & Kumar, S. (2022) · Biochemical Pharmacology · doi:10.1016/j.bcp.2022.114943 · Cited by 42

Enhancing adipose tissue plasticity: progenitor cell roles in metabolic health

Lecoutre, S., Rebière, C., Maqdasy, S., Lambert, M., Dussaud, S., Abatan, J. B., Dugail, I., Gautier, E. L., Clément, K., & Marcelin, G. (2025) · Nature Reviews Endocrinology · doi:10.1038/s41574-024-01071-y · Cited by 52

STAT1 Dissociates Adipose Tissue Inflammation From Insulin Sensitivity in Obesity

Admin, A., Cox, A. R., Chernis, N., Bader, D., Saha, P. K., Masschelin, P. M., Felix, J. B., Sharp, R., 连泽勤, Putluri, V., et al. (2020) · Diabetes · doi:10.2337/db20-0384 · Cited by 42

A Comprehensive Summary of the Current Understanding of the Relationship between Severe Obesity, Metabolic Syndrome, and Inflammatory Status

Ion, R.-M., Sibianu, M., Huţanu, A., Beresescu, G. F., Sala, D. T., Mocian, F., Rosca, A., Constantin, C., Scurtu, A., Moriczi, R., et al. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12113818 · Cited by 40

Altered metabolomic profiling of overweight and obese adolescents after combined training is associated with reduced insulin resistance

Duft, R. G., Castro, A., Bonfante, I. L. P., Lopes, W. A., da Silva, L. R., Chacon‐Mikahil, M. P. T., Leite, N., & Cavaglieri, C. R. (2020) · Scientific Reports · doi:10.1038/s41598-020-73943-y · Cited by 36

Diabetes and Metabolic Drivers of Trained Immunity

Choudhury, R. P., Edgar, L., Rydén, M., & Fisher, E. A. A. (2021) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.120.314211 · Cited by 37

Adipose Tissue in Cardiovascular Disease: From Basic Science to Clinical Translation

Polkinghorne, M., West, H. W., & Antoniades, C. A. (2023) · Annual Review of Physiology · doi:10.1146/annurev-physiol-042222-021346 · Cited by 35

Obesity Is Associated with Sustained Symptomatology and Unique Inflammatory Features in Children with Asthma

Fitzpatrick, A. M., Mutic, A. D., Mohammad, A. F., Stephenson, S. T., & Grunwell, J. R. (2021) · The Journal of Allergy and Clinical Immunology In Practice · doi:10.1016/j.jaip.2021.10.020 · Cited by 34

Probiotic, Postbiotic, and Paraprobiotic Effects of Lactobacillus rhamnosus as a Modulator of Obesity-Associated Factors

López-Almada, G., Mejía-León, M. E., & Salazar‐López, N. J. (2024) · Foods · doi:10.3390/foods13223529 · Cited by 36

The Role of Physical Exercise as a Therapeutic Tool to Improve Lipedema: A Consensus Statement from the Italian Society of Motor and Sports Sciences (Società Italiana di Scienze Motorie e Sportive, SISMeS) and the Italian Society of Phlebology (Società Italiana di Flebologia, SIF)

Annunziata, G., Paoli, A., Manzi, V., Camajani, E., Laterza, F., Verde, L., Capó, X., Padua, E., Bianco, A., Carraro, A., et al. (2024) · Current Obesity Reports · doi:10.1007/s13679-024-00579-8 · Cited by 33

O-GlcNAc modification of leucyl-tRNA synthetase 1 integrates leucine and glucose availability to regulate mTORC1 and the metabolic fate of leucine

Kim, K., Yoo, H. C., Kim, B., Kim, S., Sung, Y., Yoon, I., Yu, Y. C., Park, S. J., Kim, J. H., Myung, K., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-30696-8 · Cited by 31

Sodium Butyrate Attenuates AGEs-Induced Oxidative Stress and Inflammation by Inhibiting Autophagy and Affecting Cellular Metabolism in THP-1 Cells

Yan, M., Li, X., Sun, C. L., Tan, J., Liu, Y., Li, M., Qi, Z., He, J., Wang, D., & Wu, L. (2022) · Molecules · doi:10.3390/molecules27248715 · Cited by 35

Reduced adipocyte glutaminase activity promotes energy expenditure and metabolic health

Lecoutre, S., Maqdasy, S., Rizo‐Roca, D., Renzi, G., Vlassakev, I., Alaeddine, L. M., Higos, R., Jalkanen, J., Zhong, J., Zareifi, D., et al. (2024) · Nature Metabolism · doi:10.1038/s42255-024-01083-y · Cited by 33

Molecular Signature of Multisystem Cardiometabolic Stress and Its Association With Prognosis

Murthy, V. L., Yu, B., Wang, W., Zhang, X., Alkis, T., Pico, A. R., Yeri, A., Bhupathiraju, S. N., Bressler, J., Ballantyne, C. M., et al. (2020) · JAMA Cardiology · doi:10.1001/jamacardio.2020.2686 · Cited by 27

The impact of obesity on immune function in pediatric asthma

Hay, C., & Henrickson, S. E. (2021) · Current Opinion in Allergy and Clinical Immunology · doi:10.1097/aci.0000000000000725 · Cited by 31

Theabrownin from Fu Brick tea ameliorates high-fat induced insulin resistance, hepatic steatosis, and inflammation in mice by altering the composition and metabolites of gut microbiota

Lu, Z., Zheng, Y., Zheng, J., Liang, Q., Zhen, Q., Cui, M., Yang, H., Wu, H., Tian, C., Zhu, K., et al. (2024) · Food & Function · doi:10.1039/d3fo05459d · Cited by 28

Exercise-induced crosstalk between immune cells and adipocytes in humans: Role of oncostatin-M

Dollet, L., Lundell, L. S., Chibalin, A., Pendergrast, L. A., Pillon, N. J., Lansbury, E., Elmastas, M., Frendo‐Cumbo, S., Jalkanen, J., Barbosa, T. D. C., et al. (2023) · Cell Reports Medicine · doi:10.1016/j.xcrm.2023.101348 · Cited by 28

Preventive Effects of l -Glutamine on High-Fat Diet-Induced Metabolic Disorders Linking with Regulation of Intestinal Barrier Integrity, Hepatic Lipid Metabolism, and Gut Microbiota in Rats

He, Y., Song, Z., Ji, Y. S., Tso, P., & Wu, Z. (2022) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.2c01975 · Cited by 26

An Eclectic Cast of Cellular Actors Orchestrates Innate Immune Responses in the Mechanisms Driving Obesity and Metabolic Perturbation

Arivazhagan, L., Ruiz, H. H., Wilson, R. A., Manigrasso, M. B., Gugger, P. F., Fisher, E. A. A., Moore, K. J., Ramasamy, R., & Schmidt, A. M. (2020) · Circulation Research · doi:10.1161/circresaha.120.315900 · Cited by 25

The Role of Glutamine and Glutaminase in Pulmonary Hypertension

Wang, S., Yan, Y., Xu, W., Gong, S., Zhong, X.-J., An, Q.-Y., Zhao, Y., Liu, J., Wang, L., Yuan, P., et al. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.838657 · Cited by 25

Socioeconomic disparities and household crowding in association with the fecal microbiome of school-age children

Lapidot, Y., Reshef, L., Maya, M., Cohen, D., Gophna, U., & Muhsen, K. (2022) · npj Biofilms and Microbiomes · doi:10.1038/s41522-022-00271-6 · Cited by 26

Metabolism in atherosclerotic plaques: immunoregulatory mechanisms in the arterial wall

Forteza, M. J., & Ketelhuth, D. F. J. (2022) · Clinical Science · doi:10.1042/cs20201293 · Cited by 25

Tangshen Formula alleviates inflammatory injury against aged diabetic kidney disease through modulating gut microbiota composition and related amino acid metabolism

Chen, D., Zhang, H., Zhang, W., Feng, K., Liu, H., Zhao, H., & Li, P. (2024) · Experimental Gerontology · doi:10.1016/j.exger.2024.112393 · Cited by 26

Macrophage SUCLA2 coupled glutaminolysis manipulates obesity through AMPK

Peng, C., Jiang, H., Jing, L., Yang, W., Guan, X., Wang, H., Yu, S., Cao, Y., Wang, M., Ma, H., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-57044-w · Cited by 26

Adipocytes orchestrate obesity-related chronic inflammation through β2-microglobulin

Li, J., Li, Y., Zhou, X., Yang, S., Liu, D., Wen, H., Chen, X., Duan, C., Yu, M., Zhang, M., et al. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02486-3 · Cited by 24

Hydrogen Sulfide, Adipose Tissue and Diabetes Mellitus

Zhu, L., Yang, B., Ma, D., Wang, L., & Wu, D. (2020) · Diabetes Metabolic Syndrome and Obesity · doi:10.2147/dmso.s249605 · Cited by 24

Fucoidan antagonizes diet-induced obesity and inflammation in mice

Wang, L., Zhang, K., Ding, X., Wang, Y., Bai, H., Yang, Q., Ben, J., Zhang, H., Li, X., Chen, Q., et al. (2020) · Journal of Biomedical Research · doi:10.7555/jbr.34.20200153 · Cited by 24

Impaired mRNA splicing and proteostasis in preadipocytes in obesity-related metabolic disease

Sánchez-Ceinos, J., Guzmán‐Ruiz, R., Rangel-Zúñiga, O. A., López‐Alcalá, J., Moreno-Caño, E., del Río-Moreno, M., Romero‐Cabrera, J. L., Pérez‐Martínez, P., Maymó‐Masip, E., Vendrell, J. J., et al. (2021) · eLife · doi:10.7554/elife.65996 · Cited by 23

Adipocyte FMO3-derived TMAO induces WAT dysfunction and metabolic disorders by promoting inflammasome activation in ageing

Ganapathy, T. P., Yuan, J.-T., Ho, M. Y.-M., Wu, K. K.-L., Hoque, M. M., Wang, B., Li, X., Wang, K., Wabitsch, M., Feng, X., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-63905-1 · Cited by 22

Glutamine Production by Glul Promotes Thermogenic Adipocyte Differentiation Through Prdm9-Mediated H3K4me3 and Transcriptional Reprogramming

Pan, X., Ye, L., Guo, X., Wang, W., Zhang, Z., Wang, Q., Huang, J., Xu, J., Cai, Y., Shou, X., et al. (2023) · Diabetes · doi:10.2337/db23-0162 · Cited by 23

Diabetes mellitus-driven pulmonary injury: multidimensional mechanisms linking metabolic dysregulation to gut-lung axis and promising therapies

Sun, J., Chen, J., Shen, Y., Yao, X., Sun, H., Chen, B., & Feng, J. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1689522 · Cited by 25

Metabolomic phenotyping of obesity for profiling cardiovascular and ocular diseases

Zhong, P., Tan, S., Zhu, Z., Bulloch, G., Long, E., Huang, W., He, M., & Wang, W. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04244-x · Cited by 25

Discrimination exposure impacts unhealthy processing of food cues: Crosstalk between the brain and gut

Zhang, X., Wang, H., Kilpatrick, L. A., Dong, T. S., Gee, G. C., Labus, J. S., Osadchiy, V., Beltran-Sanchez, H., Wang, M. C., Vaughan, A., et al. (2023) · Nature Mental Health · doi:10.1038/s44220-023-00134-9 · Cited by 20

Cancer-associated adipocytes in the ovarian cancer microenvironment

Cai, Q. (2024) · American Journal of Cancer Research · doi:10.62347/xzri9189 · Cited by 21

Normalizing glucose levels reconfigures the mammary tumor immune and metabolic microenvironment and decreases metastatic seeding

Alsheikh, H. A., Metge, B. J., Ha, C., Hinshaw, D. C., Mota, M., Kammerud, S. C., Lama-Sherpa, T. D., Sharafeldin, N., Wende, A. R., Samant, R. S., et al. (2021) · Cancer Letters · doi:10.1016/j.canlet.2021.05.022 · Cited by 21

Glutamine metabolism in tumor metastasis: Genes, mechanisms and the therapeutic targets

Zhong, X., He, Z., Li, Y., Fan, Y., Yu, T., Kang, Y., & Bi, Q. (2023) · Heliyon · doi:10.1016/j.heliyon.2023.e20656 · Cited by 20

Gut Microbiota and Adipose Tissue Microenvironment Interactions in Obesity

Wang, C., Yi, Z., Ye, J., Shen, Z., Yang, F., & Zhu, S. (2023) · Metabolites · doi:10.3390/metabo13070821 · Cited by 23

Metabotissugenic citrate biomaterials orchestrate bone regeneration via citrate-mediated signaling pathways

Xu, H., Tan, X., Gerhard, E. M., Zhang, H., Ray, R., Wang, Y., Kothapalli, S., Rizk, E., Armstrong, A. D., Yan, S., et al. (2025) · Science Advances · doi:10.1126/sciadv.ady2862 · Cited by 19

Improving the Microbial Production of Amino Acids: From Conventional Approaches to Recent Trends

Zhang, G., Ren, X., Liang, X., Wang, Y., Feng, D., Zhang, Y., Xian, M., & Zou, H. (2021) · Biotechnology and Bioprocess Engineering · doi:10.1007/s12257-020-0390-1 · Cited by 20

Transcriptome of visceral adipose tissue identifies an inflammation-related ceRNA network that regulates obesity

Li, G., Zhang, H., Cao, K., Zhai, Z., Wang, Z., Yang, L., & Han, J. (2022) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-022-04362-y · Cited by 20

Ten metabolites-based algorithm predicts the future development of type 2 diabetes in Chinese

Su, X., Cheung, C. Y. Y., Zhong, J., Ru, Y., Fong, C. H.-Y., Lee, C., Liu, Y., Cheung, C., Lam, K. S. L., Xu, A., et al. (2023) · Journal of Advanced Research · doi:10.1016/j.jare.2023.11.026 · Cited by 19

Moderate altitude exposure impacts host fasting blood glucose and serum metabolome by regulation of the intestinal flora

Liu, D., Gao, X., Huang, X., Fan, Y., Wang, Y.-E., Zhang, Y., Chen, X., Wen, J., He, H., Hong, Y., et al. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.167016 · Cited by 20

Glutamine Ameliorates Liver Steatosis via Regulation of Glycolipid Metabolism and Gut Microbiota in High-Fat Diet-Induced Obese Mice

Zhou, X., Zhang, J., Sun, Y., Shen, J., Sun, B., & Ma, Q. (2023) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.3c05566 · Cited by 18

Adrenomedullin Attenuates Inflammation in White Adipose Tissue of Obese Rats Through Receptor‐Mediated PKA Pathway

Dai, H., Wang, F., Kang, Y., Sun, J. Y., Zhou, Y., Gao, Q., Li, Z., Qian, P., Zhu, G., & Zhou, Y. (2020) · Obesity · doi:10.1002/oby.23012 · Cited by 19

Circulating metabolite profile in young adulthood identifies long-term diabetes susceptibility: the Coronary Artery Risk Development in Young Adults (CARDIA) study

Murthy, V. L., Nayor, M. G., Carnethon, M. R., Reis, J. P., Lloyd‐Jones, D. M., Allen, N. B., Kitchen, R. R., Piaggi, P., Steffen, L. M., Vasan, R. S., et al. (2022) · Diabetologia · doi:10.1007/s00125-021-05641-x · Cited by 17

LRH ‐1 activation alleviates diabetes‐induced podocyte injury by promoting GLS2 ‐mediated glutaminolysis

Hu, J., Zhang, Z., Hu, H., Yang, K., Zhu, Z., Yang, Q., & Liang, W. (2023) · Cell Proliferation · doi:10.1111/cpr.13479 · Cited by 17

β-Carotene suppresses cancer cachexia by regulating the adipose tissue metabolism and gut microbiota dysregulation

Kim, Y., Jung, S., Park, G., Shin, H., Heo, S. C., & Kim, Y. (2022) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2022.109248 · Cited by 16

Protein O‐GlcNAcylation: The sweet hub in liver metabolic flexibility from a (patho)physiological perspective

Hu, Y., Zhang, X., Lv, H., Liu, Y., & Li, S. (2023) · Liver International · doi:10.1111/liv.15812 · Cited by 16

Glutamine metabolism in adipocytes: a bona fide epigenetic modulator of inflammation

Lecoutre, S., Maqdasy, S., Petrus, P., Ludzki, A. C., Couchet, M., Mejhert, N., & Rydén, M. (2020) · Adipocyte · doi:10.1080/21623945.2020.1831825 · Cited by 16

Identification of core gene in obese type 2 diabetes patients using bioinformatics analysis

Dong, Z., Lei, X., Kujawa, S. A., Bolu, N. E., Zhao, H., & Wang, C. (2021) · Adipocyte · doi:10.1080/21623945.2021.1933297 · Cited by 16

Traumatic acid inhibits ACSL4 associated lipid accumulation in adipocytes to attenuate high‐fat diet‐induced obesity

Gao, J., Zhang, Z., Dong, X., Jing, Z., Peng, Z., Zhang, L., Xu, Z., Xu, L., Wang, X., & Guo, X. (2023) · The FASEB Journal · doi:10.1096/fj.202301166r · Cited by 15

Serum Metabolomic Profiling of Patients with Lipedema

Kempa, S., Buechler, C., Föh, B., Felthaus, O., Prantl, L., Günther, U. L., Müller, M., Derer, S., Sina, C., Schmelter, F., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242417437 · Cited by 17

Glutamine prevents high-fat diet-induced hepatic lipid accumulation in mice by modulating lipolysis and oxidative stress

Zhang, Y., Wang, Y., Liao, X., Liu, Y., Yang, F., Yang, K., Zhou, Z., Fu, Y., Fu, T., Sysa, A. G., et al. (2024) · Nutrition & Metabolism · doi:10.1186/s12986-024-00784-1 · Cited by 16

Synergistic Anti-Ageing through Senescent Cells Specific Reprogramming

Chen, R., & Skutella, T. (2022) · Cells · doi:10.3390/cells11050830 · Cited by 15

Glutamine deficiency induces lipolysis in adipocytes

Okuro, K., Fukuhara, A., Minemura, T., Hayakawa, T., Nishitani, S., Okuno, Y., Otsuki, M., & Shimomura, I. (2021) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2021.11.043 · Cited by 15

HIF3A Inhibition Triggers Browning of White Adipocytes via Metabolic Rewiring

Cuomo, F., Dell’Aversana, C., Chioccarelli, T., Porreca, V., Manfrevola, F., Papulino, C., Carafa, V., Benedetti, R., Altucci, L., Cobellis, G., et al. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.740203 · Cited by 14

Regulatory of miRNAs in tri-lineage differentiation of C3H10T1/2

Huang, W., Wu, X., Xiang, S., Qiao, M., Li, H., Zhu, Y., Zhu, Z., & Zhao, Z. (2022) · Stem Cell Research & Therapy · doi:10.1186/s13287-022-03205-3 · Cited by 16

xCT-mediated glutamate excretion in white adipocytes stimulates interferon-γ production by natural killer cells in obesity

Kim, H., Shim, Y., Kim, H., Yang, K., Ryu, T., Kim, K., Choi, S. E., Kim, M., Woo, C., Chung, K. P. S., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112636 · Cited by 14

Plasma metabolite predictors of metabolic syndrome incidence and reversion

Semnani‐Azad, Z., Toledo, E., Babió, N., Ruiz‐Canela, M., Wittenbecher, C., Razquín, C., Wang, F., Dennis, C., Deik, A., Clish, C. B., et al. (2023) · Metabolism · doi:10.1016/j.metabol.2023.155742 · Cited by 15

Glutamine supplementation alleviated aortic atherosclerosis in mice model and in vitro

Zhang, H., Wang, C., Sun, H., Zhou, T. J., Ma, C., Han, X., Zhang, T., & Xia, J. (2023) · PROTEOMICS · doi:10.1002/pmic.202300179 · Cited by 13

Circulating glutamine/glutamate ratio is closely associated with type 2 diabetes and its associated complications

Han, F., Xu, C., Hangfu, X., Liu, Y., Zhang, Y., Sun, B., & Chen, L. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1422674 · Cited by 15

Obesity-linked inflammation tied to glutamine levels

Starling, S. (2020) · Nature Reviews Endocrinology · doi:10.1038/s41574-020-0321-4 · Cited by 2

Glutamine metabolism in adipocytes: a bona fide epigenetic modulator of inflammation

Lecoutre, S., Maqdasy, S., Petrus, P., Ludzki, A. C., Couchet, M., Mejhert, N., & Rydén, M. (2020) · Adipocyte · doi:10.1080/21623945.2020.1831825 · Cited by 16

Adipose glutaminolysis resurfaces in metabolic disease

Haley, J. D., & Guertin, D. A. (2024) · Nature Metabolism · doi:10.1038/s42255-024-01084-x · Cited by 1

Sex-dependent effects of a high-fat diet and glutamine supplementation on adipose tissue in obese mice

Lefebvre, C., Tiffay, A., Breemeersch, C.-E., Dreux, V., Bôle‐Feysot, C., Guerin, C., Breton, J., Monnoye, M., Douard, V., Déchelotte, P., et al. (2023) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2023.09.386

Reduced adipocyte glutaminase activity promotes energy expenditure and metabolic health

Lecoutre, S., Maqdasy, S., Rizo‐Roca, D., Renzi, G., Vlassakev, I., Alaeddine, L. M., Higos, R., Jalkanen, J., Zhong, J., Zareifi, D., et al. (2024) · Nature Metabolism · doi:10.1038/s42255-024-01083-y · Cited by 33