What we talk about when we talk about fat
Open accessAbstract
There has been an upsurge of interest in the adipocyte coincident with the onset of the obesity epidemic and the realization that adipose tissue plays a major role in the regulation of metabolic function. The past few years, in particular, have seen significant changes in the way that we classify adipocytes and how we view adipose development and differentiation. We have new perspective on the roles played by adipocytes in a variety of homeostatic processes and on the mechanisms used by adipocytes to communicate with other tissues. Finally, there has been significant progress in understanding how these relationships are altered during metabolic disease and how they might be manipulated to restore metabolic health.
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They observed a marked decrease in the proportion of capillary endothelial cells in eWAT specifically during HFD feeding, consistent with the previously documented capillary rarefaction and elevated hypoxia associated with adipose tissue expansion.
“We observed a marked decrease in the proportion of capillary endothelial cells in eWAT specifically during HFD feeding, consistent with the previously documented capillary rarefaction and elevated hypoxia associated with adipose tissue expansion (Rosen and Spiegelman, 2014; Pasarica et al., 2009).”
From Robust single-nucleus RNA sequencing reveals depot-specific cell population dynamics in adipose tissue remodeling during obesity (2025) · cites this paper as Rosen and Spiegelman, 2014
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Cites
Obesity is associated with macrophage accumulation in adipose tissue
Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041 · see citing works
Xu, H., Barnes, G. T., Yang, Q., Tan, G., Yang, D., Chou, C. J., Sole, J., Nichols, A., Ross, J. S., Tartaglia, L. A., et al. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319451 · Cited by 6,760 · see citing works
Brown Adipose Tissue: Function and Physiological Significance
CANNON, B., & NEDERGAARD, J. (2004) · Physiological Reviews · doi:10.1152/physrev.00015.2003 · Cited by 6,433 · see citing works
Obesity induces a phenotypic switch in adipose tissue macrophage polarization
Lumeng, C. N., Bodzin, J. L., & Saltiel, A. R. (2007) · Journal of Clinical Investigation · doi:10.1172/jci29881 · Cited by 4,664 · see citing works
TLR4 links innate immunity and fatty acid-induced insulin resistance
Shi, H., Kokoeva, M. V., Inouye, K., Tzameli, I., Yin, H., & Flier, J. S. (2006) · Journal of Clinical Investigation · doi:10.1172/jci28898 · Cited by 3,690 · see citing works
Functional Brown Adipose Tissue in Healthy Adults
Virtanen, K. A., Lidell, M. E., Orava, J., Heglind, M., Westergren, R., Niemi, T., Taittonen, M., Laine, J., Savisto, N.-J., Enerbäck, S., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0808949 · Cited by 3,058 · see citing works
Adipocyte differentiation from the inside out
Rosen, E. D., & MacDougald, O. A. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2066 · Cited by 2,607 · see citing works
Self-citationReactive oxygen species have a causal role in multiple forms of insulin resistance
Houstis, N., Rosen, E. D., & Lander, E. S. (2006) · Nature · doi:10.1038/nature04634 · Cited by 2,525 · see citing works
Self-citationDynamics of fat cell turnover in humans
Spalding, K. L., Arner, E., Westermark, P. O., Bernard, S., Buchholz, B. A., Bergmann, O., Blomqvist, L., Hoffstedt, J., Näslund, E., Britton, T., et al. (2008) · Nature · doi:10.1038/nature06902 · Cited by 2,357 · see citing works
PRDM16 controls a brown fat/skeletal muscle switch
Seale, P., Bjork, B., Yang, W., Kajimura, S., Chin, S., Kuang, S., Scimè, A., Devarakonda, S., Conroe, H. M., Erdjument-Bromage, H., et al. (2008) · Nature · doi:10.1038/nature07182 · Cited by 2,347 · see citing works
Self-citationFeuerer, M., Herrero, L., Cipolletta, D., Naaz, A., Wong, J., Nayer, A., Lee, J., Goldfine, A. B., Benoist, C., Shoelson, S., et al. (2009) · Nature Medicine · doi:10.1038/nm.2002 · Cited by 2,145 · see citing works
Macrophage-specific PPARγ controls alternative activation and improves insulin resistance
Odegaard, J. I., Ricardo-Gonzalez, R. R., Goforth, M. H., Morel, C. R., Subramanian, V., Mukundan, L., Eagle, A. R., Vats, D., Brombacher, F., Ferrante, A. W., et al. (2007) · Nature · doi:10.1038/nature05894 · Cited by 2,107 · cited 1× · see citing works
“Interestingly, M2 macrophages also express PPARg (Odegaard et al., 2007), aligning nicely with long-time reports that PPARg can promote insulin sensi-”
Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes
Yang, Q., Graham, T. E., Mody, N., Preitner, F., Peroni, O. D., Zabolotny, J. M., Kotani, K., Quadro, L., & Kahn, B. B. (2005) · Nature · doi:10.1038/nature03711 · Cited by 2,086 · see citing works
Fat and Beyond: The Diverse Biology of PPARγ
Tontonoz, P., & Spiegelman, B. M. (2008) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.77.061307.091829 · Cited by 2,085 · see citing works
Self-citationMuscle injury activates resident fibro/adipogenic progenitors that facilitate myogenesis
Joe, A. W. B., Yi, L., Natarajan, A., Le Grand, F., So, L., Wang, J., Rudnicki, M. A., & Rossi, F. M. V. (2010) · Nature Cell Biology · doi:10.1038/ncb2015 · Cited by 1,690 · see citing works
Brown adipose tissue activity controls triglyceride clearance
Bartelt, A., Bruns, O. T., Reimer, R., Hohenberg, H., Ittrich, H., Peldschus, K., Kaul, M. G., Tromsdorf, U. I., Weller, H., Waurisch, C., et al. (2011) · Nature Medicine · doi:10.1038/nm.2297 · Cited by 1,608 · see citing works
A role for brown adipose tissue in diet-induced thermogenesis
Rothwell, N. J., & Stock, M. J. (1979) · Nature · doi:10.1038/281031a0 · Cited by 1,606 · see citing works
Obesity-associated improvements in metabolic profile through expansion of adipose tissue
Kim, J.-Y., van de Wall, E., Laplante, M., Azzara, A., Trujillo, M. E., Hofmann, S. M., Schraw, T., Durand, J. L., Li, H., Li, G., et al. (2007) · Journal of Clinical Investigation · doi:10.1172/jci31021 · Cited by 1,310 · see citing works
Bone-marrow adipocytes as negative regulators of the haematopoietic microenvironment
Naveiras, O., Nardi, V., Wenzel, P. L., Hauschka, P. V., Fahey, F., & Daley, G. Q. (2009) · Nature · doi:10.1038/nature08099 · Cited by 1,129 · cited 1× · see citing works
“There is an inverse relationship between the number of fat cells and the number of hematopoietic precursors, and elimination of marrow fat by genetic or pharmacologic means enhances the rate of engraftment following radioablation (Naveiras et al., 2009).”
Development of obesity in transgenic mice after genetic ablation of brown adipose tissue
Lowell, B. B., S-Susulic, V., Hamann, A., Lawitts, J. A., Himms-Hagen, J., Boyer, B. B., Kozak, L. P., & Flier, J. S. (1993) · Nature · doi:10.1038/366740a0 · Cited by 1,075 · see citing works
Absence of an Effect of Liposuction on Insulin Action and Risk Factors for Coronary Heart Disease
Klein, S., Fontana, L., Young, V. L., Coggan, A. R., Kilo, C., Patterson, B. W., & Mohammed, B. S. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa033179 · Cited by 909 · see citing works
Hypoxia-Inducible Factor 1α Induces Fibrosis and Insulin Resistance in White Adipose Tissue
Halberg, N., Khan, T., Trujillo, M. E., Wernstedt-Asterholm, I., Attie, A. D., Sherwani, S., Wang, Z. V., Landskroner-Eiger, S., Dineen, S., Magalang, U. J., et al. (2009) · Molecular and Cellular Biology · doi:10.1128/mcb.00192-09 · Cited by 896 · see citing works
Klöting, N., Fasshauer, M., Dietrich, A., Kovacs, P., Schön, M. R., Kern, M., Stumvoll, M., & Blüher, M. (2010) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00586.2009 · Cited by 856 · see citing works
Adiponectin Stimulates AMP-Activated Protein Kinase in the Hypothalamus and Increases Food Intake
Kubota, N., Yano, W., Kubota, T., Yamauchi, T., Itoh, S., Kumagai, H., Kozono, H., Takamoto, I., Okamoto, S., Shiuchi, T., et al. (2007) · Cell Metabolism · doi:10.1016/j.cmet.2007.06.003 · Cited by 844 · see citing works
Weight loss and lipolysis promote a dynamic immune response in murine adipose tissue
Kosteli, A., Sugaru, E., Haemmerle, G., Martin, J. F., Lei, J., Zechner, R., & Ferrante, A. W. (2010) · Journal of Clinical Investigation · doi:10.1172/jci42845 · Cited by 726 · cited 1× · see citing works
“During fasting and weight loss, macrophages become recruited to the fat pad by the products of lipolysis, where they are responsible for taking up the newly available lipids (Granneman et al., 2005; Kosteli et al., 2010).”
Multilocular fat cells in WAT of CL-316243-treated rats derive directly from white adipocytes
Himms-Hagen, J., Melnyk, A., Zingaretti, M. C., Ceresi, E., Barbatelli, G., & Cinti, S. (2000) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.2000.279.3.c670 · Cited by 593 · see citing works
Regulation of the brown and white fat gene programs through a PRDM16/CtBP transcriptional complex
Kajimura, S., Seale, P., Tomaru, T., Erdjument-Bromage, H., Cooper, M. P., Ruas, J. L., Chin, S., Tempst, P., Lazar, M. A., & Spiegelman, B. M. (2008) · Genes & Development · doi:10.1101/gad.1666108 · Cited by 468 · see citing works
Self-citationSympathetic and sensory innervation of brown adipose tissue
Bartness, T. J., Vaughan, C. H., & Song, C. K. (2010) · International Journal of Obesity · doi:10.1038/ijo.2010.182 · Cited by 459 · cited 1× · see citing works
“Classic brown adipocytes cluster as specific depots located in the interscapular and perirenal regions of rodents and are richly innervated and vascularized (Bartness et al., 2010b).”
Endocrine fibroblast growth factors 15/19 and 21: from feast to famine
Potthoff, M. J., Kliewer, S. A., & Mangelsdorf, D. J. (2012) · Genes & Development · doi:10.1101/gad.184788.111 · Cited by 442 · see citing works
Leinninger, G. M., Jo, Y.-H., Leshan, R. L., Louis, G. W., Yang, H., Barrera, J. G., Wilson, H., Opland, D. M., Faouzi, M. A., Gong, Y., et al. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2009.06.011 · Cited by 412 · see citing works
Angiogenesis Inhibitor, TNP-470, Prevents Diet-Induced and Genetic Obesity in Mice
Bråkenhielm, E., Cao, R., Gao, B., Angelin, B., Cannon, B., Parini, P., & Cao, Y. (2004) · Circulation Research · doi:10.1161/01.res.0000132745.76882.70 · Cited by 326 · see citing works
Michalakis, K., Mintziori, G., Kaprara, A., Tarlatzis, B. C., & Goulis, D. G. (2013) · Metabolism · doi:10.1016/j.metabol.2012.08.012 · Cited by 321 · see citing works
Granneman, J. G., Li, P., Zhu, Z., & Lu, Y. (2005) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00009.2005 · Cited by 298 · see citing works
Sensory and sympathetic nervous system control of white adipose tissue lipolysis
Bartness, T. J., Shrestha, Y. B., Vaughan, C. H., Schwartz, G. J., & Song, C. K. (2010) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2009.08.031 · Cited by 289 · cited 1× · see citing works
“Adipose tissue is richly innervated by both sympathetic and parasympathetic fibers, with the former driving lipolysis during fasting and cold exposure and the latter promoting lipid accumulation after feeding (Bartness et al., 2010a; Kreier et al., 2002).”
Xue, B., Rim, J.-S., Hogan, J. C., Coulter, A. A., Koza, R. A., & Kozak, L. P. (2007) · Journal of Lipid Research · doi:10.1194/jlr.m600287-jlr200 · Cited by 288 · see citing works
Maquoi, E., Munaut, C., Colige, A., Collen, D., & Lijnen, H. R. (2002) · Diabetes · doi:10.2337/diabetes.51.4.1093 · Cited by 271 · see citing works
Mitochondrial uncoupling as a target for drug development for the treatment of obesity.
Harper, J. A., Dickinson, K., & Brand, M. D. (2001) · Obesity Reviews · doi:10.1046/j.1467-789x.2001.00043.x · Cited by 250 · see citing works
Wellen, K. E., Fucho, R., Gregor, M. F., Furuhashi, M., Morgan, C., Lindstad, T., Vaillancourt, E., Gorgun, C. Z., Saatcioglu, F., & Hotamisligil, G. S. (2007) · Cell · doi:10.1016/j.cell.2007.02.049 · Cited by 222 · see citing works
Morris, D. L., Cho, K. W., DelProposto, J. L., Oatmen, K. E., Geletka, L. M., Martinez-Santibanez, G., Singer, K., & Lumeng, C. N. (2013) · Diabetes · doi:10.2337/db12-1404 · Cited by 217 · see citing works
Site and mechanism of leptin action in a rodent form of congenital lipodystrophy
Asilmaz, E., Cohen, P., Miyazaki, M., Dobrzyn, P., Ueki, K., Fayzikhodjaeva, G., Soukas, A. A., Kahn, C. R., Ntambi, J. M., Socci, N. D., et al. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200419511 · Cited by 210 · see citing works
Müller, T. D., Sullivan, L. M., Habegger, K., Yi, C., Kabra, D., Grant, E., Ottaway, N., Krishna, R., Holland, J., Hembree, J., et al. (2012) · Journal of Peptide Science · doi:10.1002/psc.2408 · Cited by 156 · see citing works
Flagged first, then by citations
Research works printed but not linked: 259
- Ahmadian M Abbott MJ Tang T Hudak CS Kim Y Bruss M Hellerstein MK Lee HY Samuel VT Shulman GI 2011 Desnutrin/ATGL is regulated by AMPK and is required for a brown adipose phenotype Cell metabolism 13 739 748 21641555 PMC3148136
- Ahmadian M Suh JM Hah N Liddle C Atkins AR Downes M Evans RM 2013 PPARgamma signaling and metabolism: the good, the bad and the future Nature medicine 19 557 566 PMC3870016 23652116
- Alvarez R de Andres J Yubero P Vinas O Mampel T Iglesias R Giralt M Villarroya F 1995 A novel regulatory pathway of brown fat thermogenesis. Retinoic acid is a transcriptional activator of the mitochondrial uncoupling protein gene The Journal of biological chemistry 270 5666 5673 7890689
- Arch JR 2002 beta(3)-Adrenoceptor agonists: potential, pitfalls and progress European journal of pharmacology 440 99 107 12007528
- Barnhart KF Christianson DR Hanley PW Driessen WH Bernacky BJ Baze WB Wen S Tian M Ma J Kolonin MG 2011 A peptidomimetic targeting white fat causes weight loss and improved insulin resistance in obese monkeys Science translational medicine 3 108ra112 PMC3666164 22072637
- Bathija A Davis S Trubowitz S 1979 Bone marrow adipose tissue: response to acute starvation American journal of hematology 6 191 198 484542
- Becker M Siems WE Kluge R Gembardt F Schultheiss HP Schirner M Walther T 2010 New function for an old enzyme: NEP deficient mice develop late-onset obesity PloS one 5 PMC2940827 20862277
- Benezech C Mader E Desanti G Khan M Nakamura K White A Ware CF Anderson G Caamano JH 2012 Lymphotoxin-beta receptor signaling through NF-kappaB2-RelB pathway reprograms adipocyte precursors as lymph node stromal cells Immunity 37 721 734 22940098 PMC3809035
- Berry DC Jacobs H Marwarha G Gely-Pernot A O'Byrne SM Desantis D Klopfenstein M Feret B Dennefeld C Blaner WS 2013 The STRA6 Receptor Is Essential for Retinol-binding Protein-induced Insulin Resistance but Not for Maintaining Vitamin A Homeostasis in Tissues Other Than the Eye The Journal of biological chemistry 288 24528 24539 23839944 PMC3750151
- Berry R Rodeheffer MS 2013 Characterization of the adipocyte cellular lineage in vivo Nature cell biology 15 302 308 PMC3721064 23434825
- Billon N Iannarelli P Monteiro MC Glavieux-Pardanaud C Richardson WD Kessaris N Dani C Dupin E 2007 The generation of adipocytes by the neural crest Development 134 2283 2292 17507398 PMC6334830
- Birsoy K Berry R Wang T Ceyhan O Tavazoie S Friedman JM Rodeheffer MS 2011 Analysis of gene networks in white adipose tissue development reveals a role for ETS2 in adipogenesis Development 138 4709 4719 21989915 PMC3190384
- Bjorntorp P Carlgren G Isaksson B Krotkiewski M Larsson B Sjostrom L 1975 Effect of an energy-reduced dietary regimen in relation to adipose tissue cellularity in obese women The American journal of clinical nutrition 28 445 452 1130302
- Bostrom P Wu J Jedrychowski MP Korde A Ye L Lo JC Rasbach KA Bostrom EA Choi JH Long JZ 2012 A PGC1-alpha-dependent myokine that drives brown-fat-like development of white fat and thermogenesis Nature 481 463 468 22237023 PMC3522098
- Boustany-Kari CM Jackson VM Gibbons CP Swick AG 2011 Leptin potentiates the anti-obesity effects of rimonabant European journal of pharmacology 658 270 276 21371466
- Bowers RR Festuccia WT Song CK Shi H Migliorini RH Bartness TJ 2004 Sympathetic innervation of white adipose tissue and its regulation of fat cell number American journal of physiology Regulatory, integrative and comparative physiology 286 R1167 1175 15142857
- Bremer AA Jialal I 2013 Adipose tissue dysfunction in nascent metabolic syndrome Journal of obesity 2013 393192 23653857 PMC3638696
- Brito NA Brito MN Bartness TJ 2008 Differential sympathetic drive to adipose tissues after food deprivation, cold exposure or glucoprivation American journal of physiology Regulatory, integrative and comparative physiology 294 R1445 1452 18321949
- Bruss MD Khambatta CF Ruby MA Aggarwal I Hellerstein MK 2010 Calorie restriction increases fatty acid synthesis and whole body fat oxidation rates American journal of physiology Endocrinology and metabolism 298 E108 116 19887594 PMC4056782
- Campos-Sandoval JA Redondo C Kinsella GK Pal A Jones G Eyre GS Hirst SC Findlay JB 2011 Fenretinide derivatives act as disrupters of interactions of serum retinol binding protein (sRBP) with transthyretin and the sRBP receptor Journal of medicinal chemistry 54 4378 4387 21591606
- Cani PD Amar J Iglesias MA Poggi M Knauf C Bastelica D Neyrinck AM Fava F Tuohy KM Chabo C 2007 Metabolic endotoxemia initiates obesity and insulin resistance Diabetes 56 1761 1772 17456850
- Cao H Gerhold K Mayers JR Wiest MM Watkins SM Hotamisligil GS 2008 Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism Cell 134 933 944 18805087 PMC2728618
- Cao H Sekiya M Ertunc ME Burak MF Mayers JR White A Inouye K Rickey LM Ercal BC Furuhashi M 2013 Adipocyte lipid chaperone AP2 is a secreted adipokine regulating hepatic glucose production Cell metabolism 17 768 778 23663740 PMC3755450
- Cao Y 2013 Angiogenesis and Vascular Functions in Modulation of Obesity, Adipose Metabolism, and Insulin Sensitivity Cell metabolism 24035587
- Carbone F La Rocca C Matarese G 2012 Immunological functions of leptin and adiponectin Biochimie 94 2082 2088 22750129
- Cawthorn WP Scheller EL MacDougald OA 2012 Adipose tissue stem cells meet preadipocyte commitment: going back to the future Journal of lipid research 53 227 246 22140268 PMC3269153
- Chakrabarti P Kandror KV 2009 FoxO1 controls insulin-dependent adipose triglyceride lipase (ATGL) expression and lipolysis in adipocytes The Journal of biological chemistry 284 13296 13300 19297333 PMC2679428
- Chechi K Carpentier AC Richard D 2013 Understanding the brown adipocyte as a contributor to energy homeostasis Trends in endocrinology and metabolism: TEM 24 408 420 23711353
- Chen KY Brychta RJ Linderman JD Smith S Courville A Dieckmann W Herscovitch P Millo CM Remaley A Lee P 2013a Brown fat activation mediates cold-induced thermogenesis in adult humans in response to a mild decrease in ambient temperature The Journal of clinical endocrinology and metabolism 98 E1218 1223 23780370 PMC3701264
- Chen L Song J Cui J Hou J Zheng X Li C Liu L 2013b microRNAs regulate adipocyte differentiation Cell biology international 37 533 546 23504919
- Cherian S Lopaschuk GD Carvalho E 2012 Cellular cross-talk between epicardial adipose tissue and myocardium in relation to the pathogenesis of cardiovascular disease American journal of physiology Endocrinology and metabolism 303 E937 949 22895783
- Choi JH Banks AS Estall JL Kajimura S Bostrom P Laznik D Ruas JL Chalmers MJ Kamenecka TM Bluher M 2010a Anti-diabetic drugs inhibit obesity-linked phosphorylation of PPARgamma by Cdk5 Nature 466 451 456 20651683 PMC2987584
- Choi JH Banks AS Kamenecka TM Busby SA Chalmers MJ Kumar N Kuruvilla DS Shin Y He Y Bruning JB 2011 Antidiabetic actions of a non-agonist PPARgamma ligand blocking Cdk5-mediated phosphorylation Nature 477 477 481 21892191 PMC3179551
- Choi SM Tucker DF Gross DN Easton RM DiPilato LM Dean AS Monks BR Birnbaum MJ 2010b Insulin regulates adipocyte lipolysis via an Akt-independent signaling pathway Molecular and cellular biology 30 5009 5020 20733001 PMC2953052
- Chou SH Chamberland JP Liu X Matarese G Gao C Stefanakis R Brinkoetter MT Gong H Arampatzi K Mantzoros CS 2011 Leptin is an effective treatment for hypothalamic amenorrhea Proceedings of the National Academy of Sciences of the United States of America 108 6585 6590 21464293 PMC3080974
- Choy L Skillington J Derynck R 2000 Roles of autocrine TGF-beta receptor and Smad signaling in adipocyte differentiation The Journal of cell biology 149 667 682 10791980 PMC2174852
- Cinti S Cigolini M Bosello O Bjorntorp P 1984 A morphological study of the adipocyte precursor Journal of submicroscopic cytology 16 243 251 6325721
- Cinti S Mitchell G Barbatelli G Murano I Ceresi E Faloia E Wang S Fortier M Greenberg AS Obin MS 2005 Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans Journal of lipid research 46 2347 2355 16150820
- Cipolletta D Feuerer M Li A Kamei N Lee J Shoelson SE Benoist C Mathis D 2012 PPAR-gamma is a major driver of the accumulation and phenotype of adipose tissue Treg cells Nature 486 549 553 22722857 PMC3387339
- Colman E 2007 Dinitrophenol and obesity: an early twentieth-century regulatory dilemma Regulatory toxicology and pharmacology: RTP 48 115 117 17475379
- Considine RV 2001 Regulation of leptin production Reviews in endocrine & metabolic disorders 2 357 363 11725722
- Cristancho AG Lazar MA 2011 Forming functional fat: a growing understanding of adipocyte differentiation Nature reviews Molecular cell biology 12 722 734 PMC7171550 21952300
- Cristancho AG Schupp M Lefterova MI Cao S Cohen DM Chen CS Steger DJ Lazar MA 2011 Repressor transcription factor 7-like 1 promotes adipogenic competency in precursor cells Proceedings of the National Academy of Sciences of the United States of America 108 16271 16276 21914845 PMC3182685
- Cypess AM Lehman S Williams G Tal I Rodman D Goldfine AB Kuo FC Palmer EL Tseng YH Doria A 2009 Identification and importance of brown adipose tissue in adult humans The New England journal of medicine 360 1509 1517 19357406 PMC2859951
- Cypess AM White AP Vernochet C Schulz TJ Xue R Sass CA Huang TL Roberts-Toler C Weiner LS Sze C 2013 Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat Nature medicine 19 635 639 PMC3650129 23603815
- Dani C 2013 Activins in adipogenesis and obesity Int J Obes (Lond) 37 163 166 22370854
- Degerman E Landstrom TR Wijkander J Holst LS Ahmad F Belfrage P Manganiello V 1998 Phosphorylation and activation of hormone-sensitive adipocyte phosphodiesterase type 3B Methods 14 43 53 9500857
- Deng T Lyon CJ Minze LJ Lin J Zou J Liu JZ Ren Y Yin Z Hamilton DJ Reardon PR 2013 Class II major histocompatibility complex plays an essential role in obesity-induced adipose inflammation Cell metabolism 17 411 422 23473035 PMC3619392
- Denis GV Obin MS 2013 'Metabolically healthy obesity': origins and implications Molecular aspects of medicine 34 59 70 23068072 PMC3583231
- Denzel MS Scimia MC Zumstein PM Walsh K Ruiz-Lozano P Ranscht B 2010 T-cadherin is critical for adiponectin-mediated cardioprotection in mice The Journal of clinical investigation 120 4342 4352 21041950 PMC2993592
- Devlin MJ Cloutier AM Thomas NA Panus DA Lotinun S Pinz I Baron R Rosen CJ Bouxsein ML 2010 Caloric restriction leads to high marrow adiposity and low bone mass in growing mice Journal of bone and mineral research: the official journal of the American Society for Bone and Mineral Research 25 2078 2088 20229598 PMC3127399
- Dobson DE Kambe A Block E Dion T Lu H Castellot JJ Jr Spiegelman BM 1990 1-Butyryl-glycerol: a novel angiogenesis factor secreted by differentiating adipocytes Cell 61 223 230 1691958
- Eguchi J Kong X Tenta M Wang X Kang S Rosen ED 2013 Interferon regulatory factor 4 regulates obesity-induced inflammation through regulation of adipose tissue macrophage polarization Diabetes PMC3781469 23835343
- Eguchi J Wang X Yu S Kershaw EE Chiu PC Dushay J Estall JL Klein U Maratos-Flier E Rosen ED 2011 Transcriptional control of adipose lipid handling by IRF4 Cell metabolism 13 249 259 21356515 PMC3063358
- Elias I Franckhauser S Bosch F 2013 New insights into adipose tissue VEGF-A actions in the control of obesity and insulin resistance Adipocyte 2 109 112 23805408 PMC3661112
- Eller K Kirsch A Wolf AM Sopper S Tagwerker A Stanzl U Wolf D Patsch W Rosenkranz AR Eller P 2011 Potential role of regulatory T cells in reversing obesity-linked insulin resistance and diabetic nephropathy Diabetes 60 2954 2962 21911743 PMC3198056
- Enerback S Jacobsson A Simpson EM Guerra C Yamashita H Harper ME Kozak LP 1997 Mice lacking mitochondrial uncoupling protein are cold-sensitive but not obese Nature 387 90 94 9139827
- English JT Patel SK Flanagan MJ 1973 Association of pheochromocytomas with brown fat tumors Radiology 107 279 281 4695890
- Fain JN Ballou LR Bahouth SW 2001 Obesity is induced in mice heterozygous for cyclooxygenase-2 Prostaglandins & other lipid mediators 65 199 209 11444591
- Fazeli PK Horowitz MC Macdougald OA Scheller EL Rodeheffer MS Rosen CJ Klibanski A 2013 Marrow Fat and Bone--New Perspectives The Journal of clinical endocrinology and metabolism PMC3590487 23393168
- Fedorenko A Lishko PV Kirichok Y 2012 Mechanism of fatty-acid-dependent UCP1 uncoupling in brown fat mitochondria Cell 151 400 413 23063128 PMC3782081
- Festa E Fretz J Berry R Schmidt B Rodeheffer M Horowitz M Horsley V 2011 Adipocyte lineage cells contribute to the skin stem cell niche to drive hair cycling Cell 146 761 771 21884937 PMC3298746
- Flynn EJ 3rd Trent CM Rawls JF 2009 Ontogeny and nutritional control of adipogenesis in zebrafish (Danio rerio) Journal of lipid research 50 1641 1652 19366995 PMC2724053
- Foster MT Bartness TJ 2006 Sympathetic but not sensory denervation stimulates white adipocyte proliferation American journal of physiology Regulatory, integrative and comparative physiology 291 R1630 1637 16887921
- Fukumura D Ushiyama A Duda DG Xu L Tam J Krishna V Chatterjee K Garkavtsev I Jain RK 2003 Paracrine regulation of angiogenesis and adipocyte differentiation during in vivo adipogenesis Circulation research 93 e88 97 14525808 PMC2755542
- Furuhashi M Hotamisligil GS 2008 Fatty acid-binding proteins: role in metabolic diseases and potential as drug targets Nature reviews Drug discovery 7 489 503 PMC2821027 18511927
- Gabrielsen JS Gao Y Simcox JA Huang J Thorup D Jones D Cooksey RC Gabrielsen D Adams TD Hunt SC 2012 Adipocyte iron regulates adiponectin and insulin sensitivity The Journal of clinical investigation 122 3529 3540 22996660 PMC3461897
- Gabriely I Ma XH Yang XM Atzmon G Rajala MW Berg AH Scherer P Rossetti L Barzilai N 2002 Removal of visceral fat prevents insulin resistance and glucose intolerance of aging: an adipokine-mediated process? Diabetes 51 2951 2958 12351432
- Garg A 2011 Clinical review#: Lipodystrophies: genetic and acquired body fat disorders The Journal of clinical endocrinology and metabolism 96 3313 3325 21865368 PMC7673254
- Garten A Schuster S Kiess W 2012 The insulin-like growth factors in adipogenesis and obesity Endocrinology and metabolism clinics of North America 41 283 295 v vi 22682631
- Giguere V 2008 Transcriptional control of energy homeostasis by the estrogen-related receptors Endocrine reviews 29 677 696 18664618
- Goldstein BJ Scalia RG Ma XL 2009 Protective vascular and myocardial effects of adiponectin Nature clinical practice Cardiovascular medicine 6 27 35 PMC2658652 19029992
- Graham TE Kahn BB 2007 Tissue-specific alterations of glucose transport and molecular mechanisms of intertissue communication in obesity and type 2 diabetes Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 39 717 721 17952832
- Granneman JG Moore HP Krishnamoorthy R Rathod M 2009 Perilipin controls lipolysis by regulating the interactions of AB-hydrolase containing 5 (Abhd5) and adipose triglyceride lipase (Atgl) The Journal of biological chemistry 284 34538 34544 19850935 PMC2787315
- Greenwood MR Hirsch J 1974 Postnatal development of adipocyte cellularity in the normal rat Journal of lipid research 15 474 483 4415153
- Griffith JF Yeung DK Ahuja AT Choy CW Mei WY Lam SS Lam TP Chen ZY Leung PC 2009 A study of bone marrow and subcutaneous fatty acid composition in subjects of varying bone mineral density Bone 44 1092 1096 19268721
- Guo H Jin D Zhang Y Wright W Bazuine M Brockman DA Bernlohr DA Chen X 2010 Lipocalin-2 deficiency impairs thermogenesis and potentiates diet-induced insulin resistance in mice Diabetes 59 1376 1385 20332347 PMC2874698
- Gupta RK Arany Z Seale P Mepani RJ Ye L Conroe HM Roby YA Kulaga H Reed RR Spiegelman BM 2010 Transcriptional control of preadipocyte determination by Zfp423 Nature 464 619 623 20200519 PMC2845731
- Gupta RK Mepani RJ Kleiner S Lo JC Khandekar MJ Cohen P Frontini A Bhowmick DC Ye L Cinti S 2012 Zfp423 expression identifies committed preadipocytes and localizes to adipose endothelial and perivascular cells Cell metabolism 15 230 239 22326224 PMC3366493
- Gustafson B Hammarstedt A Hedjazifar S Smith U 2013 Restricted Adipogenesis in Hypertrophic Obesity: The Role of WISP2, WNT, and BMP4 Diabetes 62 2997 3004 23970518 PMC3749334
- Haemmerle G Moustafa T Woelkart G Buttner S Schmidt A van de Weijer T Hesselink M Jaeger D Kienesberger PC Zierler K 2011 ATGL-mediated fat catabolism regulates cardiac mitochondrial function via PPAR-alpha and PGC-1 Nature medicine 17 1076 1085 PMC3244833 21857651
- Hamann A Flier JS Lowell BB 1996 Decreased brown fat markedly enhances susceptibility to diet-induced obesity, diabetes, and hyperlipidemia Endocrinology 137 21 29 8536614
- Han J Lee JE Jin J Lim JS Oh N Kim K Chang SI Shibuya M Kim H Koh GY 2011 The spatiotemporal development of adipose tissue Development 138 5027 5037 22028034
- Haslam DW James WP 2005 Obesity Lancet 366 1197 1209 16198769
- Hayward JS Lisson PA 1992 Evolution of brown fat: its absence in marsupials and monotremes Canadian Journal of Zoology 70 171 179
- Hellman B Larsson S Westman S 1963 Mast cell content and fatty acid metabolism in the epididymal fat pad of obese mice Acta physiologica Scandinavica 58 255 262 13953609
- Henry RR Scheaffer L Olefsky JM 1985 Glycemic effects of intensive caloric restriction and isocaloric refeeding in noninsulin-dependent diabetes mellitus The Journal of clinical endocrinology and metabolism 61 917 925 4044780
- Heredia JE Mukundan L Chen FM Mueller AA Deo RC Locksley RM Rando TA Chawla A 2013 Type 2 innate signals stimulate fibro/adipogenic progenitors to facilitate muscle regeneration Cell 153 376 388 23582327 PMC3663598
- Herman MA Peroni OD Villoria J Schon MR Abumrad NA Bluher M Klein S Kahn BB 2012 A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism Nature 484 333 338 22466288 PMC3341994
- Hernandez TL Kittelson JM Law CK Ketch LL Stob NR Lindstrom RC Scherzinger A Stamm ER Eckel RH 2011 Fat redistribution following suction lipectomy: defense of body fat and patterns of restoration Obesity (Silver Spring) 19 1388 1395 21475140
- Hesslein DG Fretz JA Xi Y Nelson T Zhou S Lorenzo JA Schatz DG Horowitz MC 2009 Ebf1-dependent control of the osteoblast and adipocyte lineages Bone 44 537 546 19130908 PMC2657874
- Heymsfield SB Greenberg AS Fujioka K Dixon RM Kushner R Hunt T Lubina JA Patane J Self B Hunt P 1999 Recombinant leptin for weight loss in obese and lean adults: a randomized, controlled, dose-escalation trial JAMA: the journal of the American Medical Association 282 1568 1575 10546697
- Holland WL Adams AC Brozinick JT Bui HH Miyauchi Y Kusminski CM Bauer SM Wade M Singhal E Cheng CC 2013 An FGF21-Adiponectin-Ceramide Axis Controls Energy Expenditure and Insulin Action in Mice Cell metabolism 17 790 797 23663742 PMC3667496
- Hollenberg AN Susulic VS Madura JP Zhang B Moller DE Tontonoz P Sarraf P Spiegelman BM Lowell BB 1997 Functional antagonism between CCAAT/Enhancer binding protein-alpha and peroxisome proliferator-activated receptor-gamma on the leptin promoter The Journal of biological chemistry 272 5283 5290 9030601
- Hotamisligil GS 2010 Endoplasmic reticulum stress and the inflammatory basis of metabolic disease Cell 140 900 917 20303879 PMC2887297
- Hotamisligil GS Shargill NS Spiegelman BM 1993 Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance Science 259 87 91 7678183
- Hu E Tontonoz P Spiegelman BM 1995 Transdifferentiation of myoblasts by the adipogenic transcription factors PPAR gamma and C/EBP alpha Proceedings of the National Academy of Sciences of the United States of America 92 9856 9860 7568232 PMC40901
- Huh JY Kim JI Park YJ Hwang IJ Lee YS Sohn JH Lee SK Alfadda AA Kim SS Choi SH 2013 A Novel Function of Adipocytes in Lipid Antigen Presentation to iNKT Cells Molecular and cellular biology 33 328 339 23149942 PMC3554106
- Huttunen P Hirvonen J Kinnula V 1981 The occurrence of brown adipose tissue in outdoor workers European journal of applied physiology and occupational physiology 46 339 345 6266825
- Iglesias P Selgas R Romero S Diez JJ 2012 Biological role, clinical significance, and therapeutic possibilities of the recently discovered metabolic hormone fibroblastic growth factor 21 European journal of endocrinology / European Federation of Endocrine Societies 167 301 309 22740503
- Iizuka K Bruick RK Liang G Horton JD Uyeda K 2004 Deficiency of carbohydrate response element-binding protein (ChREBP) reduces lipogenesis as well as glycolysis Proceedings of the National Academy of Sciences of the United States of America 101 7281 7286 15118080 PMC409910
- Ilan Y Maron R Tukpah AM Maioli TU Murugaiyan G Yang K Wu HY Weiner HL 2010 Induction of regulatory T cells decreases adipose inflammation and alleviates insulin resistance in ob/ob mice Proceedings of the National Academy of Sciences of the United States of America 107 9765 9770 20445103 PMC2906892
- Jespersen NZ Larsen TJ Peijs L Daugaard S Homoe P Loft A de Jong J Mathur N Cannon B Nedergaard J 2013 A classical brown adipose tissue mRNA signature partly overlaps with brite in the supraclavicular region of adult humans Cell metabolism 17 798 805 23663743
- Jiang C Kim JH Li F Qu A Gavrilova O Shah YM Gonzalez FJ 2013 Hypoxia-inducible factor 1alpha regulates a SOCS3-STAT3-adiponectin signal transduction pathway in adipocytes The Journal of biological chemistry 288 3844 3857 23255598 PMC3567639
- Jonker JW Suh JM Atkins AR Ahmadian M Li P Whyte J He M Juguilon H Yin YQ Phillips CT 2012 A PPARgamma-FGF1 axis is required for adaptive adipose remodelling and metabolic homeostasis Nature 485 391 394 22522926 PMC3358516
- Jun LS Siddall CP Rosen ED 2011 A minor role for lipocalin 2 in high-fat diet-induced glucose intolerance American journal of physiology Endocrinology and metabolism 301 E825 835 21771968 PMC4073944
- Kajimura S Seale P Kubota K Lunsford E Frangioni JV Gygi SP Spiegelman BM 2009 Initiation of myoblast to brown fat switch by a PRDM16-C/EBP-beta transcriptional complex Nature 460 1154 1158 19641492 PMC2754867
- Kallen CB Lazar MA 1996 Antidiabetic thiazolidinediones inhibit leptin (ob) gene expression in 3T3-L1 adipocytes Proceedings of the National Academy of Sciences of the United States of America 93 5793 5796 8650171 PMC39140
- Kanazawa A Tsukada S Kamiyama M Yanagimoto T Nakajima M Maeda S 2005 Wnt5b partially inhibits canonical Wnt/beta-catenin signaling pathway and promotes adipogenesis in 3T3-L1 preadipocytes Biochemical and biophysical research communications 330 505 510 15796911
- Kanda T Brown JD Orasanu G Vogel S Gonzalez FJ Sartoretto J Michel T Plutzky J 2009 PPARgamma in the endothelium regulates metabolic responses to high-fat diet in mice The Journal of clinical investigation 119 110 124 19065047 PMC2613459
- Kang S Akerblad P Kiviranta R Gupta RK Kajimura S Griffin MJ Min J Baron R Rosen ED 2012 Regulation of early adipose commitment by Zfp521 PLoS biology 10 e1001433 23209378 PMC3507953
- Kanneganti TD Dixit VD 2012 Immunological complications of obesity Nature immunology 13 707 712 22814340
- Karsenty G 2006 Convergence between bone and energy homeostases: leptin regulation of bone mass Cell metabolism 4 341 348 17084709
- Khan T Muise ES Iyengar P Wang ZV Chandalia M Abate N Zhang BB Bonaldo P Chua S Scherer PE 2009 Metabolic dysregulation and adipose tissue fibrosis: role of collagen VI Molecular and cellular biology 29 1575 1591 19114551 PMC2648231
- Khandekar MJ Cohen P Spiegelman BM 2011 Molecular mechanisms of cancer development in obesity Nature reviews Cancer 11 886 895 22113164
- Kiefer FW Vernochet C O'Brien P Spoerl S Brown JD Nallamshetty S Zeyda M Stulnig TM Cohen DE Kahn CR 2012 Retinaldehyde dehydrogenase 1 regulates a thermogenic program in white adipose tissue Nature medicine 18 918 925 PMC3792792 22561685
- Kim DH Sartor MA Bain JR Sandoval D Stevens RD Medvedovic M Newgard CB Woods SC Seeley RJ 2012 Rapid and weight-independent improvement of glucose tolerance induced by a peptide designed to elicit apoptosis in adipose tissue endothelium Diabetes 61 2299 2310 22733798 PMC3425411
- Kim DH Woods SC Seeley RJ 2010 Peptide designed to elicit apoptosis in adipose tissue endothelium reduces food intake and body weight Diabetes 59 907 915 20103704 PMC2844838
- Kim YW Kim JY Park YH Park SY Won KC Choi KH Huh JY Moon KH 2006 Metformin restores leptin sensitivity in high-fat-fed obese rats with leptin resistance Diabetes 55 716 724 16505235
- Kitamura T Kitamura Y Kuroda S Hino Y Ando M Kotani K Konishi H Matsuzaki H Kikkawa U Ogawa W 1999 Insulin-induced phosphorylation and activation of cyclic nucleotide phosphodiesterase 3B by the serine-threonine kinase Akt Molecular and cellular biology 19 6286 6296 10454575 PMC84592
- Knittle JL Timmers K Ginsberg-Fellner F Brown RE Katz DP 1979 The growth of adipose tissue in children and adolescents. Cross-sectional and longitudinal studies of adipose cell number and size The Journal of clinical investigation 63 239 246 429551 PMC371945
- Koh YJ Kang S Lee HJ Choi TS Lee HS Cho CH Koh GY 2007 Bone marrow-derived circulating progenitor cells fail to transdifferentiate into adipocytes in adult adipose tissues in mice The Journal of clinical investigation 117 3684 3695 18060029 PMC2096460
- Kolonin MG Saha PK Chan L Pasqualini R Arap W 2004 Reversal of obesity by targeted ablation of adipose tissue Nature medicine 10 625 632 15133506
- Konige M Wang H Sztalryd C 2013 Role of adipose specific lipid droplet proteins in maintaining whole body energy homeostasis Biochimica et biophysica acta PMC4507416 23688782
- Kral JG Bjorntorp P Schersten T Sjostrom L 1977 Body composition and adipose tissue cellularity before and after jejuno-ileostomy in severely obese subjects European journal of clinical investigation 7 413 419 411671
- Kreier F Fliers E Voshol PJ Van Eden CG Havekes LM Kalsbeek A Van Heijningen CL Sluiter AA Mettenleiter TC Romijn JA 2002 Selective parasympathetic innervation of subcutaneous and intra-abdominal fat--functional implications The Journal of clinical investigation 110 1243 1250 12417562 PMC151610
- Krishnan J Danzer C Simka T Ukropec J Walter KM Kumpf S Mirtschink P Ukropcova B Gasperikova D Pedrazzini T 2012 Dietary obesity-associated Hif1alpha activation in adipocytes restricts fatty acid oxidation and energy expenditure via suppression of the Sirt2-NAD+ system Genes & development 26 259 270 22302938 PMC3278893
- Krotkiewski M Bjorntorp P Sjostrom L Smith U 1983 Impact of obesity on metabolism in men and women. Importance of regional adipose tissue distribution The Journal of clinical investigation 72 1150 1162 6350364 PMC1129283
- Law IK Xu A Lam KS Berger T Mak TW Vanhoutte PM Liu JT Sweeney G Zhou M Yang B 2010 Lipocalin-2 deficiency attenuates insulin resistance associated with aging and obesity Diabetes 59 872 882 20068130 PMC2844835
- Lee MJ Wu Y Fried SK 2013 Adipose tissue heterogeneity: mplication of depot differences in adipose tissue for obesity complications Molecular aspects of medicine 34 1 11 23068073 PMC3549425
- Lee YH Petkova AP Mottillo EP Granneman JG 2012 In vivo identification of bipotential adipocyte progenitors recruited by beta3-adrenoceptor activation and high-fat feeding Cell metabolism 15 480 491 22482730 PMC3322390
- Lepper C Fan CM 2010 Inducible lineage tracing of Pax7-descendant cells reveals embryonic origin of adult satellite cells Genesis 48 424 436 20641127 PMC3113517
- Li P Fan W Xu J Lu M Yamamoto H Auwerx J Sears DD Talukdar S Oh D Chen A 2011 Adipocyte NCoR knockout decreases PPARgamma phosphorylation and enhances PPARgamma activity and insulin sensitivity Cell 147 815 826 22078880 PMC3783197
- Lidell ME Betz MJ Dahlqvist Leinhard O Heglind M Elander L Slawik M Mussack T Nilsson D Romu T Nuutila P 2013 Evidence for two types of brown adipose tissue in humans Nature medicine 19 631 634 23603813
- Liew CW Boucher J Cheong JK Vernochet C Koh HJ Mallol C Townsend K Langin D Kawamori D Hu J 2013 Ablation of TRIP-Br2, a regulator of fat lipolysis, thermogenesis and oxidative metabolism, prevents diet-induced obesity and insulin resistance Nature medicine 19 217 226 PMC3567215 23291629
- Lin Z Tian H Lam KS Lin S Hoo RC Konishi M Itoh N Wang Y Bornstein SR Xu A 2013 Adiponectin Mediates the Metabolic Effects of FGF21 on Glucose Homeostasis and Insulin Sensitivity in Mice Cell metabolism 17 779 789 23663741
- Linhart HG Ishimura-Oka K DeMayo F Kibe T Repka D Poindexter B Bick RJ Darlington GJ 2001 C/EBPalpha is required for differentiation of white, but not brown, adipose tissue Proceedings of the National Academy of Sciences of the United States of America 98 12532 12537 11606718 PMC60088
- Lu YP Lou YR Bernard JJ Peng QY Li T Lin Y Shih WJ Nghiem P Shapses S Wagner GC 2012 Surgical removal of the parametrial fat pads stimulates apoptosis and inhibits UVB-induced carcinogenesis in mice fed a high-fat diet Proceedings of the National Academy of Sciences of the United States of America 109 9065 9070 22615388 PMC3384184
- Lumeng CN Deyoung SM Bodzin JL Saltiel AR 2007b Increased inflammatory properties of adipose tissue macrophages recruited during diet-induced obesity Diabetes 56 16 23 17192460
- MacKellar J Cushman SW Periwal V 2010 Waves of adipose tissue growth in the genetically obese Zucker fatty rat PloS one 5 e8197 20107501 PMC2809739
- Macotela Y Emanuelli B Mori MA Gesta S Schulz TJ Tseng YH Kahn CR 2012 Intrinsic differences in adipocyte precursor cells from different white fat depots Diabetes 61 1691 1699 22596050 PMC3379665
- Majka SM Fox KE Psilas JC Helm KM Childs CR Acosta AS Janssen RC Friedman JE Woessner BT Shade TR 2010 De novo generation of white adipocytes from the myeloid lineage via mesenchymal intermediates is age, adipose depot, and gender specific Proceedings of the National Academy of Sciences of the United States of America 107 14781 14786 20679227 PMC2930432
- Mathis D 2013 Immunological goings-on in visceral adipose tissue Cell metabolism 17 851 859 23747244 PMC4264591
- Mauer MM Harris RB Bartness TJ 2001 The regulation of total body fat: lessons learned from lipectomy studies Neuroscience and biobehavioral reviews 25 15 28 11166075
- Maymo JL Perez AP Gambino Y Calvo JC Sanchez-Margalet V Varone CL 2011 Review: Leptin gene expression in the placenta--regulation of a key hormone in trophoblast proliferation and survival Placenta 32 Suppl 2 S146 153 21303721
- McCullough AW 1944 Evidence of the macrophagal origin of adipose cells in the white rat as shown by studies on straved animals Journal of Morphology 75 193 201
- Mikkelsen TS Xu Z Zhang X Wang L Gimble JM Lander ES Rosen ED 2010 Comparative epigenomic analysis of murine and human adipogenesis Cell 143 156 169 20887899 PMC2950833
- Mittendorfer B Horowitz JF DePaoli AM McCamish MA Patterson BW Klein S 2011 Recombinant human leptin treatment does not improve insulin action in obese subjects with type 2 diabetes Diabetes 60 1474 1477 21411512 PMC3292320
- Molofsky AB Nussbaum JC Liang HE Van Dyken SJ Cheng LE Mohapatra A Chawla A Locksley RM 2013 Innate lymphoid type 2 cells sustain visceral adipose tissue eosinophils and alternatively activated macrophages The Journal of experimental medicine 210 535 549 23420878 PMC3600903
- Montague CT Farooqi IS Whitehead JP Soos MA Rau H Wareham NJ Sewter CP Digby JE Mohammed SN Hurst JA 1997 Congenital leptin deficiency is associated with severe early-onset obesity in humans Nature 387 903 908 9202122
- Moon HS Dalamaga M Kim SY Polyzos SA Hamnvik OP Magkos F Paruthi J Mantzoros CS 2013 Leptin's role in lipodystrophic and nonlipodystrophic insulin-resistant and diabetic individuals Endocrine reviews 34 377 412 23475416 PMC3660716
- Morroni M Giordano A Zingaretti MC Boiani R De Matteis R Kahn BB Nisoli E Tonello C Pisoschi C Luchetti MM 2004 Reversible transdifferentiation of secretory epithelial cells into adipocytes in the mammary gland Proceedings of the National Academy of Sciences of the United States of America 101 16801 16806 15556998 PMC534744
- Murphy KT Schwartz GJ Nguyen NL Mendez JM Ryu V Bartness TJ 2013 Leptin Sensitive Sensory Nerves Innervate White Fat American journal of physiology Endocrinology and metabolism PMC3680695 23612999
- Myers MG Jr Heymsfield SB Haft C Kahn BB Laughlin M Leibel RL Tschop MH Yanovski JA 2012 Challenges and opportunities of defining clinical leptin resistance Cell metabolism 15 150 156 22326217 PMC3281561
- Myers MG Jr Munzberg H Leinninger GM Leshan RL 2009 The geometry of leptin action in the brain: more complicated than a simple ARC Cell metabolism 9 117 123 19187770 PMC2648854
- Natarajan A Lemos DR Rossi FM 2010 Fibro/adipogenic progenitors: a double-edged sword in skeletal muscle regeneration Cell Cycle 9 2045 2046 20505371
- Nawarskas J Rajan V Frishman WH 2001 Vasopeptidase inhibitors, neutral endopeptidase inhibitors, and dual inhibitors of angiotensin-converting enzyme and neutral endopeptidase Heart Dis 3 378 385 11975822
- Nawrocki AR Rajala MW Tomas E Pajvani UB Saha AK Trumbauer ME Pang Z Chen AS Ruderman NB Chen H 2006 Mice lacking adiponectin show decreased hepatic insulin sensitivity and reduced responsiveness to peroxisome proliferator-activated receptor gamma agonists The Journal of biological chemistry 281 2654 2660 16326714
- Nguyen KD Qiu Y Cui X Goh YP Mwangi J David T Mukundan L Brombacher F Locksley RM Chawla A 2011 Alternatively activated macrophages produce catecholamines to sustain adaptive thermogenesis Nature 480 104 108 22101429 PMC3371761
- Nieman KM Kenny HA Penicka CV Ladanyi A Buell-Gutbrod R Zillhardt MR Romero IL Carey MS Mills GB Hotamisligil GS 2011 Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth Nature medicine 17 1498 1503 PMC4157349 22037646
- Norseen J Hosooka T Hammarstedt A Yore MM Kant S Aryal P Kiernan UA Phillips DA Maruyama H Kraus BJ 2012 Retinol-binding protein 4 inhibits insulin signaling in adipocytes by inducing proinflammatory cytokines in macrophages through a c-Jun N-terminal kinase- and toll-like receptor 4-dependent and retinol-independent mechanism Molecular and cellular biology 32 2010 2019 22431523 PMC3347417
- Oelkrug R Goetze N Exner C Lee Y Ganjam GK Kutschke M Muller S Stohr S Tschop MH Crichton PG 2013 Brown fat in a protoendothermic mammal fuels eutherian evolution Nature communications 4 2140 PMC3717499 23860571
- Oh DY Morinaga H Talukdar S Bae EJ Olefsky JM 2012 Increased macrophage migration into adipose tissue in obese mice Diabetes 61 346 354 22190646 PMC3266418
- Okada-Iwabu M Yamauchi T Iwabu M Honma T Hamagami KI Matsuda K Yamaguchi M Tanabe H Kimura-Someya T Shirouzu M 2013 A small-molecule AdipoR agonist for type 2 diabetes and short life in obesity Nature 24172895
- Okamura M Kudo H Wakabayashi K Tanaka T Nonaka A Uchida A Tsutsumi S Sakakibara I Naito M Osborne TF 2009 COUP-TFII acts downstream of Wnt/beta-catenin signal to silence PPARgamma gene expression and repress adipogenesis Proceedings of the National Academy of Sciences of the United States of America 106 5819 5824 19307559 PMC2667001
- Oskowitz AZ Lu J Penfornis P Ylostalo J McBride J Flemington EK Prockop DJ Pochampally R 2008 Human multipotent stromal cells from bone marrow and microRNA: regulation of differentiation and leukemia inhibitory factor expression Proceedings of the National Academy of Sciences of the United States of America 105 18372 18377 19011087 PMC2587615
- Ota T 2013 Chemokine systems link obesity to insulin resistance Diabetes & metabolism journal 37 165 172 23807918 PMC3689012
- Ottaviani E Malagoli D Franceschi C 2011 The evolution of the adipose tissue: a neglected enigma General and comparative endocrinology 174 1 4 21781968
- Ouellet V Labbe SM Blondin DP Phoenix S Guerin B Haman F Turcotte EE Richard D Carpentier AC 2012 Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans The Journal of clinical investigation 122 545 552 22269323 PMC3266793
- Park BO Ahrends R Teruel MN 2012 Consecutive positive feedback loops create a bistable switch that controls preadipocyte-to-adipocyte conversion Cell reports 2 976 990 23063366 PMC4959269
- Park J Euhus DM Scherer PE 2011 Paracrine and endocrine effects of adipose tissue on cancer development and progression Endocrine reviews 32 550 570 21642230 PMC3369575
- Park J Scherer PE 2012 Adipocyte-derived endotrophin promotes malignant tumor progression The Journal of clinical investigation 122 4243 4256 23041627 PMC3484450
- Petrovic N Walden TB Shabalina IG Timmons JA Cannon B Nedergaard J 2010 Chronic peroxisome proliferator-activated receptor gamma (PPARgamma) activation of epididymally derived white adipocyte cultures reveals a population of thermogenically competent, UCP1-containing adipocytes molecularly distinct from classic brown adipocytes The Journal of biological chemistry 285 7153 7164 20028987 PMC2844165
- Pittenger MF Mackay AM Beck SC Jaiswal RK Douglas R Mosca JD Moorman MA Simonetti DW Craig S Marshak DR 1999 Multilineage potential of adult human mesenchymal stem cells Science 284 143 147 10102814
- Poissonnet CM Burdi AR Bookstein FL 1983 Growth and development of human adipose tissue during early gestation Early human development 8 1 11 6851910
- Poissonnet CM Burdi AR Garn SM 1984 The chronology of adipose tissue appearance and distribution in the human fetus Early human development 10 1 11 6499712
- Pond CM 1992 An evolutionary and functional view of mammalian adipose tissue The Proceedings of the Nutrition Society 51 367 377 1480631
- Pond CM Mattacks CA 2002 The activation of the adipose tissue associated with lymph nodes during the early stages of an immune response Cytokine 17 131 139 11895331
- Preitner F Mody N Graham TE Peroni OD Kahn BB 2009 Long-term Fenretinide treatment prevents high-fat diet-induced obesity, insulin resistance, and hepatic steatosis American journal of physiology Endocrinology and metabolism 297 E1420 1429 19826103 PMC2793052
- Puigserver P Spiegelman BM 2003 Peroxisome proliferator-activated receptor-gamma coactivator 1 alpha (PGC-1 alpha): transcriptional coactivator and metabolic regulator Endocrine reviews 24 78 90 12588810
- Qiang L Wang L Kon N Zhao W Lee S Zhang Y Rosenbaum M Zhao Y Gu W Farmer SR 2012 Brown remodeling of white adipose tissue by SirT1-dependent deacetylation of Ppargamma Cell 150 620 632 22863012 PMC3413172
- Rajakumari S Wu J Ishibashi J Lim HW Giang AH Won KJ Reed RR Seale P 2013 EBF2 determines and maintains brown adipocyte identity Cell metabolism 17 562 574 23499423 PMC3622114
- Ravussin E Smith SR Mitchell JA Shringarpure R Shan K Maier H Koda JE Weyer C 2009 Enhanced weight loss with pramlintide/metreleptin: an integrated neurohormonal approach to obesity pharmacotherapy Obesity (Silver Spring) 17 1736 1743 19521351 PMC2754219
- Rigamonti A Brennand K Lau F Cowan CA 2011 Rapid cellular turnover in adipose tissue PloS one 6 e17637 21407813 PMC3047582
- Rockson SG 2010 Causes and consequences of lymphatic disease Annals of the New York Academy of Sciences 1207 Suppl 1 E2 6 20961302
- Rodeheffer MS Birsoy K Friedman JM 2008 Identification of white adipocyte progenitor cells in vivo Cell 135 240 249 18835024
- Rosen ED 2002 The molecular control of adipogenesis, with special reference to lymphatic pathology Annals of the New York Academy of Sciences 979 143 158 discussion 188–196 12543724
- Rosen ED Hsu CH Wang X Sakai S Freeman MW Gonzalez FJ Spiegelman BM 2002 C/EBPalpha induces adipogenesis through PPARgamma: a unified pathway Genes & development 16 22 26 11782441 PMC155311
- Rosenwald M Perdikari A Rulicke T Wolfrum C 2013 Bi-directional interconversion of brite and white adipocytes Nature cell biology 15 659 667 23624403
- Roth JD Roland BL Cole RL Trevaskis JL Weyer C Koda JE Anderson CM Parkes DG Baron AD 2008 Leptin responsiveness restored by amylin agonism in diet-induced obesity: evidence from nonclinical and clinical studies Proceedings of the National Academy of Sciences of the United States of America 105 7257 7262 18458326 PMC2438237
- Rupnick MA Panigrahy D Zhang CY Dallabrida SM Lowell BB Langer R Folkman MJ 2002 Adipose tissue mass can be regulated through the vasculature Proceedings of the National Academy of Sciences of the United States of America 99 10730 10735 12149466 PMC125027
- Ryden M Arner P 2007 Tumour necrosis factor-alpha in human adipose tissue -- from signalling mechanisms to clinical implications Journal of internal medicine 262 431 438 17875179
- Salans LB Horton ES Sims EA 1971 Experimental obesity in man: cellular character of the adipose tissue The Journal of clinical investigation 50 1005 1011 5552403 PMC292021
- Sanchez-Gurmaches J Hung CM Sparks CA Tang Y Li H Guertin DA 2012 PTEN loss in the Myf5 lineage redistributes body fat and reveals subsets of white adipocytes that arise from Myf5 precursors Cell metabolism 16 348 362 22940198 PMC3488151
- Savage DB Sewter CP Klenk ES Segal DG Vidal-Puig A Considine RV O'Rahilly S 2001 Resistin / Fizz3 expression in relation to obesity and peroxisome proliferator-activated receptor-gamma action in humans Diabetes 50 2199 2202 11574398
- Schmidt BA Horsley V 2013 Intradermal adipocytes mediate fibroblast recruitment during skin wound healing Development 140 1517 1527 23482487 PMC3596993
- Schmidt SF Jorgensen M Chen Y Nielsen R Sandelin A Mandrup S 2011 Cross species comparison of C/EBPalpha and PPARgamma profiles in mouse and human adipocytes reveals interdependent retention of binding sites BMC genomics 12 152 21410980 PMC3068983
- Schulz TJ Huang P Huang TL Xue R McDougall LE Townsend KL Cypess AM Mishina Y Gussoni E Tseng YH 2013 Brown-fat paucity due to impaired BMP signalling induces compensatory browning of white fat Nature 495 379 383 23485971 PMC3623555
- Schulz TJ Huang TL Tran TT Zhang H Townsend KL Shadrach JL Cerletti M McDougall LE Giorgadze N Tchkonia T 2011 Identification of inducible brown adipocyte progenitors residing in skeletal muscle and white fat Proceedings of the National Academy of Sciences of the United States of America 108 143 148 21173238 PMC3017184
- Seale P Kajimura S Spiegelman BM 2009 Transcriptional control of brown adipocyte development and physiological function--of mice and men Genes & development 23 788 797 19339685 PMC2763499
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Adipogenesis and metabolic health
Ghaben, A. L., & Scherer, P. E. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0093-z · Cited by 1,395 · see citing works
Lipid-associated macrophages control metabolic homeostasis in a Trem2-dependent manner
Jaitin, D. A., Adlung, L., Thaiss, C. A., Weiner, A., Li, B., Descamps, H., Lundgren, P., Bleriot, C., Liu, Z., Deczkowska, A., et al. (2019) · Cell · doi:10.1016/j.cell.2019.05.054 · Cited by 1,377 · see citing works
Metabolism disrupting chemicals and metabolic disorders
Heindel, J. J., Blumberg, B., Cave, M., Machtinger, R., Mantovani, A., Mendez, M. A., Nadal, A., Palanza, P., Panzica, G., Sargis, R., et al. (2017) · Reproductive Toxicology · doi:10.1016/j.reprotox.2016.10.001 · Cited by 1,101 · see citing works
Epigenome-wide association study of body mass index, and the adverse outcomes of adiposity
Wahl, S., Drong, A., Lehne, B., Loh, M., Scott, W. R., Kunze, S., Tsai, P.-C., Ried, J. S., Zhang, W., Yang, Y., et al. (2017) · Nature · doi:10.1038/nature20784 · Cited by 945 · see citing works
Group 2 innate lymphoid cells promote beiging of white adipose tissue and limit obesity
Brestoff, J. R., Kim, B. S., Saenz, S. A., Stine, R. R., Monticelli, L. A., Sonnenberg, G. F., Thome, J. J., Farber, D. L., Lutfy, K., Seale, P., et al. (2015) · Nature · doi:10.1038/nature14115 · Cited by 968 · see citing works
FGF/FGFR signaling in health and disease
Xie, Y., Su, N., Yang, J., Tan, Q., Huang, S., Jin, M., Ni, Z., Zhang, B., Zhang, D., Luo, F., et al. (2020) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00222-7 · Cited by 904 · see citing works
The spectrum of inflammatory responses
Medzhitov, R. (2021) · Science · doi:10.1126/science.abi5200 · Cited by 718 · see citing works
Targeting adipose tissue in the treatment of obesity-associated diabetes
Kusminski, C. M., Bickel, P. E., & Scherer, P. E. (2016) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.75 · Cited by 678 · see citing works
Panduro, M., Benoist, C., & Mathis, D. (2016) · Annual Review of Immunology · doi:10.1146/annurev-immunol-032712-095948 · Cited by 536 · see citing works
Contribution of adipogenesis to healthy adipose tissue expansion in obesity
Vishvanath, L., & Gupta, R. K. (2019) · Journal of Clinical Investigation · doi:10.1172/jci129191 · Cited by 558 · see citing works
The obese adipose tissue microenvironment in cancer development and progression
Quail, D. F., & Dannenberg, A. J. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-018-0126-x · Cited by 542 · see citing works
Insulin resistance causes inflammation in adipose tissue
Shimobayashi, M., Albert, V., Woelnerhanssen, B., Frei, I. C., Weissenberger, D., Meyer-Gerspach, A. C., Clement, N., Moes, S., Colombi, M., Meier, J. A., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci96139 · Cited by 480 · see citing works
Obesity and related consequences to ageing
Jura, M., & Kozak, L. P. (2016) · AGE · doi:10.1007/s11357-016-9884-3 · Cited by 473 · see citing works
Branched-chain amino acid catabolism fuels adipocyte differentiation and lipogenesis
Green, C. R., Wallace, M., Divakaruni, A. S., Phillips, S. A., Murphy, A. N., Ciaraldi, T. P., & Metallo, C. M. (2016) · Nature Chemical Biology · doi:10.1038/nchembio.1961 · Cited by 471 · see citing works
The role of adipokines in health and disease
Clemente-Suárez, V. J., Redondo-Flórez, L., Beltrán-Velasco, A. I., Martín-Rodríguez, A., Martínez-Guardado, I., Navarro-Jiménez, E., Laborde-Cárdenas, C. C., & Tornero-Aguilera, J. F. (2023) · Biomedicines · doi:10.3390/biomedicines11051290 · Cited by 463 · see citing works
Impaired adipogenesis and dysfunctional adipose tissue in human hypertrophic obesity
Hammarstedt, A., Gogg, S., Hedjazifar, S., Nerstedt, A., & Smith, U. (2018) · Physiological Reviews · doi:10.1152/physrev.00034.2017 · Cited by 462 · see citing works
Characteristics of obesity in polycystic ovary syndrome: Etiology, treatment, and genetics
Glueck, C. J., & Goldenberg, N. (2019) · Metabolism · doi:10.1016/j.metabol.2018.11.002 · Cited by 442 · see citing works
Leeners, B., Geary, N., Tobler, P. N., & Asarian, L. (2017) · Human Reproduction Update · doi:10.1093/humupd/dmw045 · Cited by 407 · see citing works
Reassessing human adipose tissue
Cypess, A. M. (2022) · New England Journal of Medicine · doi:10.1056/nejmra2032804 · Cited by 404 · see citing works
Rapid depot-specific activation of adipocyte precursor cells at the onset of obesity
Jeffery, E., Church, C. D., Holtrup, B., Colman, L., & Rodeheffer, M. S. (2015) · Nature Cell Biology · doi:10.1038/ncb3122 · Cited by 404 · see citing works
Leptin and Insulin Act on POMC Neurons to Promote the Browning of White Fat
Dodd, G. T., Decherf, S., Loh, K., Simonds, S. E., Wiede, F., Balland, E., Merry, T. L., Münzberg, H., Zhang, Z.-Y., Kahn, B. B., et al. (2015) · Cell · doi:10.1016/j.cell.2014.12.022 · Cited by 398 · see citing works
Inflammation and the Metabolic Syndrome: The Tissue-Specific Functions of NF-κB
Catrysse, L., & van Loo, G. (2017) · Trends in Cell Biology · doi:10.1016/j.tcb.2017.01.006 · Cited by 329 · see citing works
Marangoni, R. G., Korman, B. D., Wei, J., Wood, T. A., Graham, L. V., Whitfield, M. L., Scherer, P. E., Tourtellotte, W. G., & Varga, J. (2015) · Arthritis & Rheumatology · doi:10.1002/art.38990 · Cited by 337 · see citing works
FGF21 Regulates Metabolism Through Adipose-Dependent and -Independent Mechanisms
BonDurant, L. D., Ameka, M., Naber, M. C., Markan, K. R., Idiga, S. O., Acevedo, M. R., Walsh, S. A., Ornitz, D. M., & Potthoff, M. J. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.03.005 · Cited by 330 · see citing works
mTOR signaling in cellular and organismal energetics
Albert, V., & Hall, M. N. (2015) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2014.12.001 · Cited by 304 · see citing works
Molecular Mechanisms of Glucocorticoid-Induced Insulin Resistance
Beaupere, C., Liboz, A., Fève, B., Blondeau, B., & Guillemain, G. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22020623 · Cited by 271 · see citing works
Glutamine Links Obesity to Inflammation in Human White Adipose Tissue
Petrus, P., Lecoutre, S., Dollet, L., Wiel, C., Sulen, A., Gao, H., Tavira, B., Laurencikiene, J., Rooyackers, O., Checa, A., et al. (2020) · Cell Metabolism · doi:10.1016/j.cmet.2019.11.019 · Cited by 254 · see citing works
Inter-organ crosstalk during development and progression of type 2 diabetes mellitus
Xourafa, G., Korbmacher, M., & Roden, M. (2024) · Nature Reviews Endocrinology · doi:10.1038/s41574-023-00898-1 · Cited by 274 · see citing works
Wu, L., Zhang, L., Li, B., Jiang, H., Duan, Y., Xie, Z., Shuai, L., Li, J., & Li, J. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00122 · Cited by 255 · see citing works
Bertholet, A. M., Kazak, L., Chouchani, E. T., Bogaczyńska, M. G., Paranjpe, I., Wainwright, G. L., Bétourné, A., Kajimura, S., Spiegelman, B. M., & Kirichok, Y. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.03.002 · Cited by 225 · see citing works
Self-citationFibroblast Growth Factor 21: A Versatile Regulator of Metabolic Homeostasis
BonDurant, L. D., & Potthoff, M. J. (2018) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-071816-064800 · Cited by 222 · see citing works
Mechanisms of weight regain after weight loss — the role of adipose tissue
van Baak, M. A., & Mariman, E. C. M. (2019) · Nature Reviews Endocrinology · doi:10.1038/s41574-018-0148-4 · Cited by 203 · see citing works
Phenotypes of prediabetes and stratification of cardiometabolic risk
Stefan, N., Fritsche, A., Schick, F., & Häring, H.-U. (2016) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(16)00082-6 · Cited by 208 · see citing works
Jiang, H., Ding, X., Cao, Y., Wang, H., & Zeng, W. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.08.016 · Cited by 204 · see citing works
Immunologic and endocrine functions of adipose tissue: implications for kidney disease
Zhu, Q., & Scherer, P. E. (2018) · Nature Reviews Nephrology · doi:10.1038/nrneph.2017.157 · Cited by 200 · see citing works
Targeting fatty acid metabolism to improve glucose metabolism
Stinkens, R., Goossens, G. H., Jocken, J. W. E., & Blaak, E. E. (2015) · Obesity Reviews · doi:10.1111/obr.12298 · Cited by 183 · see citing works
The regulation of adipose tissue health by estrogens
Steiner, B. M., & Berry, D. C. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.889923 · Cited by 171 · see citing works
Polycystic ovary syndrome, adipose tissue and metabolic syndrome
Delitala, A. P., Capobianco, G., Delitala, G., Cherchi, P. L., & Dessole, S. (2017) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-017-4429-2 · Cited by 159 · see citing works
Adipose tissue hyperplasia and hypertrophy in common and syndromic obesity-the case of BBS obesity
Horwitz, A., & Birk, R. (2023) · Nutrients · doi:10.3390/nu15153445 · Cited by 143 · see citing works
Obesity, estrogens and adipose tissue dysfunction - implications for pulmonary arterial hypertension
Mair, K. M., Gaw, R., & MacLean, M. R. (2020) · Pulmonary Circulation · doi:10.1177/2045894020952023 · Cited by 129 · see citing works
Xu, Y., Yu, T., Ma, G., Zheng, L., Jiang, X., Yang, F., Wang, Z., Li, N., He, Z., Song, X., et al. (2021) · International Journal of Biological Sciences · doi:10.7150/ijbs.62556 · Cited by 110 · see citing works
Kolnes, K. J., Petersen, M. H., Lien-Iversen, T., Højlund, K., & Jensen, J. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.737709 · Cited by 112 · see citing works
Barazzoni, R., Deutz, N. E. P., Biolo, G., Bischoff, S., Boirie, Y., Cederholm, T., Cuerda, C., Delzenne, N., Leon Sanz, M., Ljungqvist, O., et al. (2017) · Clinical Nutrition · doi:10.1016/j.clnu.2016.09.010 · Cited by 112 · see citing works
Menopause is a determinant of breast adipose inflammation
Iyengar, N. M., Morris, P. G., Zhou, X. K., Gucalp, A., Giri, D., Harbus, M. D., Falcone, D. J., Krasne, M. D., Vahdat, L. T., Subbaramaiah, K., et al. (2015) · Cancer Prevention Research · doi:10.1158/1940-6207.capr-14-0243 · Cited by 106 · see citing works
HDAC11 suppresses the thermogenic program of adipose tissue via BRD2
Bagchi, R. A., Ferguson, B. S., Stratton, M. S., Hu, T., Cavasin, M. A., Sun, L., Lin, Y.-H., Liu, D., Londono, P., Song, K., et al. (2018) · JCI Insight · doi:10.1172/jci.insight.120159 · Cited by 110 · see citing works
Cimini, F. A., Barchetta, I., Carotti, S., Bertoccini, L., Baroni, M. G., Vespasiani-Gentilucci, U., Cavallo, M.-G., & Morini, S. (2017) · World Journal of Gastroenterology · doi:10.3748/wjg.v23.i19.3407 · Cited by 101 · see citing works
Prolactin Promotes Adipose Tissue Fitness and Insulin Sensitivity in Obese Males
Ruiz-Herrera, X., de los Ríos, E. A., Díaz, J. M., Lerma-Alvarado, R. M., de la Escalera, L. M., López-Barrera, F., Lemini, M., Arnold, E., de la Escalera, G. M., Clapp, C., et al. (2016) · Endocrinology · doi:10.1210/en.2016-1444 · Cited by 93 · see citing works
Liver Derived FGF21 Maintains Core Body Temperature During Acute Cold Exposure
Ameka, M., Markan, K. R., Morgan, D. A., BonDurant, L. D., Idiga, S. O., Naber, M. C., Zhu, Z., Zingman, L. V., Grobe, J. L., Rahmouni, K., et al. (2019) · Scientific Reports · doi:10.1038/s41598-018-37198-y · Cited by 93 · see citing works
Age-associated telomere attrition in adipocyte progenitors predisposes to metabolic disease
Gao, Z., Daquinag, A. C., Fussell, C., Zhao, Z., Dai, Y., Rivera, A., Snyder, B. E., Eckel-Mahan, K. L., & Kolonin, M. G. (2020) · Nature Metabolism · doi:10.1038/s42255-020-00320-4 · Cited by 92 · see citing works
PCOS and nutritional approaches: Differences between lean and obese phenotype
Barrea, L., Frias-Toral, E., Verde, L., Ceriani, F., Cucalón, G., Garcia-Velasquez, E., Moretti, D., Savastano, S., Colao, A., & Muscogiuri, G. (2021) · Metabolism Open · doi:10.1016/j.metop.2021.100123 · Cited by 86 · see citing works
Obesity: pathophysiology and therapeutic interventions
Kong, Y., Yang, H., Nie, R., Zhang, X., Zuo, F., Zhang, H., & Nian, X. (2025) · Molecular Biomedicine · doi:10.1186/s43556-025-00264-9 · Cited by 89 · see citing works
Immunological contributions to adipose tissue homeostasis
DiSpirito, J. R., & Mathis, D. (2015) · Seminars in Immunology · doi:10.1016/j.smim.2015.10.005 · Cited by 88 · see citing works
“Rather, we possess BAT-like thermogenic cells in the neck and supraclavicular regions [9].”
Adipose stem cell niche reprograms the colorectal cancer stem cell metastatic machinery
Di Franco, S., Bianca, P., Sardina, D. S., Turdo, A., Gaggianesi, M., Veschi, V., Nicotra, A., Mangiapane, L. R., Lo Iacono, M., Pillitteri, I., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-25333-9 · Cited by 80 · see citing works
The hepatokine Tsukushi gates energy expenditure via brown fat sympathetic innervation
Wang, Q., Sharma, V. P., Shen, H., Xiao, Y., Zhu, Q., Xiong, X., Guo, L., Jiang, L., Ohta, K., Li, S., et al. (2019) · Nature Metabolism · doi:10.1038/s42255-018-0020-9 · Cited by 71 · see citing works
No evidence of white adipocyte browning after endurance exercise training in obese men
Tsiloulis, T., Carey, A. L., Bayliss, J., Canny, B., Meex, R. C. R., & Watt, M. J. (2018) · International Journal of Obesity · doi:10.1038/ijo.2017.295 · Cited by 70 · see citing works
A Hypothalamic Phosphatase Switch Coordinates Energy Expenditure with Feeding
Dodd, G. T., Andrews, Z. B., Simonds, S. E., Michael, N. J., DeVeer, M., Brüning, J. C., Spanswick, D., Cowley, M. A., & Tiganis, T. (2017) · Cell Metabolism · doi:10.1016/j.cmet.2017.07.013 · Cited by 66 · see citing works
You, Y., Han, X., Guo, J., Guo, Y., Yin, M., Liu, G., Huang, W., & Zhan, J. (2018) · Journal of Functional Foods · doi:10.1016/j.jff.2017.12.025 · Cited by 65 · see citing works
Bahrami-Nejad, Z., Zhao, M. L., Tholen, S., Hunerdosse, D., Tkach, K. E., van Schie, S., Chung, M., & Teruel, M. N. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.03.012 · Cited by 65 · see citing works
Estradiol signaling mediates gender difference in visceral adiposity via autophagy
Tao, Z., Zheng, L. D., Smith, C., Luo, J., Robinson, A., Almeida, F. A., Wang, Z., Olumi, A. F., Liu, D., & Cheng, Z. (2018) · Cell Death & Disease · doi:10.1038/s41419-018-0372-9 · Cited by 63 · see citing works
Zheng, X., Huang, W., Li, Q., Chen, Y., Wu, L., Dong, Y., Huang, X., He, X., Ou, Z., & Peng, Y. (2023) · Microbiology Spectrum · doi:10.1128/spectrum.04323-22 · Cited by 62 · see citing works
Cai, H., Wang, X., Zhang, Z., Chen, J., Wang, F., Wang, L., & Liu, J. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.101768 · Cited by 60 · see citing works
Hyperinsulinaemic androgen excess in adolescent girls
Ibáñez, L., Ong, K. K., López-Bermejo, A., Dunger, D. B., & de Zegher, F. (2014) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2014.58 · Cited by 56 · see citing works
SIRT1 limits adipocyte hyperplasia through c-Myc inhibition
Abdesselem, H., Madani, A., Hani, A., Al-Noubi, M., Goswami, N., Ben Hamidane, H., Billing, A. M., Pasquier, J., Bonkowski, M. S., Halabi, N., et al. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.675645 · Cited by 56 · see citing works
Chen, Q., Lai, S. M., Xu, S., Tan, Y., Leong, K., Liu, D., Tan, J. C., Naik, R. R., Barron, A. M., Adav, S. S., et al. (2021) · The EMBO Reports · doi:10.15252/embr.202152835 · Cited by 56 · see citing works
Is Glucagon Receptor Activation the Thermogenic Solution for Treating Obesity?
Conceição-Furber, E., Coskun, T., Sloop, K. W., & Samms, R. J. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.868037 · Cited by 48 · see citing works
Looking on the “brite” side exercise-induced browning of white adipose tissue
Townsend, L. K., & Wright, D. C. (2019) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-018-2177-1 · Cited by 44 · see citing works
Loss of transcriptional repression by BCL6 confers insulin sensitivity in the setting of obesity
Senagolage, M. D., Sommars, M. A., Ramachandran, K., Futtner, C. R., Omura, Y., Allred, A. L., Wang, J., Yang, C., Procissi, D., Evans, R. M., et al. (2018) · Cell Reports · doi:10.1016/j.celrep.2018.11.074 · Cited by 44 · see citing works
Tu, W.-Z., Fu, Y.-B., & Xie, X. (2019) · Acta Pharmacologica Sinica · doi:10.1038/s41401-019-0264-2 · Cited by 33 · see citing works
The circadian clock control of adipose tissue physiology and metabolism
Lekkas, D., & Paschos, G. K. (2019) · Autonomic Neuroscience · doi:10.1016/j.autneu.2019.05.001 · Cited by 26 · see citing works
Exercise remodels subcutaneous fat tissue and improves metabolism
Wallberg-Henriksson, H., & Zierath, J. R. (2015) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2015.24 · Cited by 22 · see citing works
Michael, N. J., Simonds, S. E., van den Top, M., Cowley, M. A., & Spanswick, D. (2017) · Molecular Metabolism · doi:10.1016/j.molmet.2017.07.002 · Cited by 21 · see citing works
So, J., Strobel, O., Wann, J., Kim, K., Paul, A., Acri, D. J., Dabin, L. C., Kim, J., Peng, G., & Roh, H. C. (2025) · eLife · doi:10.7554/elife.97981 · Cited by 18 · see citing works
Guru, B., Tamrakar, A. K., Manjula, S. N., & Prashantha Kumar, B. R. (2022) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2022.175322 · Cited by 18 · see citing works
- Authors
- Rosen, E. D., & Spiegelman, B. M.
- Affiliations
- Broad Institute (US)
- Harvard University (US)
- Corresponding author
- Rosen, Evan D.
- Spiegelman, Bruce M.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2014-01
- Volume
- 156
- Issue
- 1-2
- Pages
- 20-44
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC3934003
- OpenAlex
- W2008150005
- Cited by
- 2,373
- References
- 41
- Citations by year
- 2026: 180 · 2025: 181 · 2024: 177 · 2023: 220 · 2022: 234 · 2021: 222 · 2020: 212 · 2019: 201 · 2018: 197 · 2017: 186 · 2016: 164 · 2015: 136 · 2014: 62
- FWCI
- 20.99
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (R01DK087092, R01DK085171)
- Topics
- Health Sciences › Medicine › Physiology › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Keywords
- adipocytes, adipose tissue, obesity, adipogenesis, adipose tissue development, metabolic regulation, metabolic disorders, metabolic health
- MeSH terms
- Animals, Humans, Obesity, Adipocytes, Adipogenesis, Lipid Metabolism
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