Human Brown Adipocyte Thermogenesis Is Driven by β2-AR Stimulation

Brown Adipose Tissue: Function and Physiological Significance

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Functional Brown Adipose Tissue in Healthy Adults

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UCP1 Ablation Induces Obesity and Abolishes Diet-Induced Thermogenesis in Mice Exempt from Thermal Stress by Living at Thermoneutrality

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Brown adipose tissue regulates glucose homeostasis and insulin sensitivity

Stanford, K. I., Middelbeek, R. J. W., Townsend, K. L., An, D., Nygaard, E. B., Hitchcox, K. M., Markan, K. R., Nakano, K., Hirshman, M. F., Tseng, Y.-H., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci62308 · Cited by 1,180

Activation of Human Brown Adipose Tissue by a β3-Adrenergic Receptor Agonist

Cypess, A. M., Weiner, L. S., Roberts‐Toler, C., Franquet, E., Kessler, S., Kahn, P. A., English, J., Chatman, K., Trauger, S. A., Doria, A., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2014.12.009 · Cited by 1,053

Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans

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Different Metabolic Responses of Human Brown Adipose Tissue to Activation by Cold and Insulin

Orava, J., Nuutila, P., Lidell, M. E., Oikonen, V., Noponen, T., Viljanen, T., Scheinin, M., Taittonen, M. T., Niemi, T. S., Enerbäck, S., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.06.012 · Cited by 745

Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat

Cypess, A. M., White, A. P., Vernochet, C., Schulz, T. J., Xue, R., Sass, C. A., Huang, T. L., Roberts‐Toler, C., Weiner, L. S., Sze, C., et al. (2013) · Nature Medicine · doi:10.1038/nm.3112 · Cited by 683

Fat cell adrenergic receptors and the control of white and brown fat cell function

Lafontan, M., & Berlan, M. (1993) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)37695-1 · Cited by 644

The selectivity of β‐adrenoceptor agonists at human β1‐, β2‐ and β3‐adrenoceptors

Baker, J. G. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.00754.x · Cited by 591

Protein Kinase SGK2 Is Induced by the β3 Adrenergic Receptor-cAMP-PKA-PGC-1α/NT-PGC-1α Axis but Dispensable for Brown/Beige Adipose Tissue Thermogenesis

Park, C., Moon, J., Park, M., Cheng, H., Lee, J., & Chang, J. S. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.780312 · Cited by 5

Human brown adipose tissue function: insights from current in vivo techniques

Kwok, T. C., & Stimson, R. H. (2023) · Journal of Endocrinology · doi:10.1530/joe-23-0017 · Cited by 6

Angiotensin II participates in mitochondrial thermogenic functions via the activation of glycolysis in chemically induced human brown adipocytes

Takeda, Y., Yoshikawa, T., & Dai, P. (2024) · Scientific Reports · doi:10.1038/s41598-024-61774-0 · Cited by 5

Imaging Brown Adipose Tissue Using Magnetic Resonance: A Promising Future?

Barker, P. B. (2021) · Radiology · doi:10.1148/radiol.2021210185 · Cited by 5

Salt-inducible Kinase Regulation of Adipose Tissue Metabolism

Shi, F., Agrawal, V., McKinsey, T. A., & Collins, S. (2025) · Endocrinology · doi:10.1210/endocr/bqaf092 · Cited by 4

Cross-Talk Between Signaling and Transcriptional Networks Regulating Thermogenesis—Insights into Canonical and Non-Canonical Regulatory Pathways

Simka-Lampa, K. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27020754 · Cited by 4

Sympathetic Innervation of Interscapular Brown Adipose Tissue Is Not a Predominant Mediator of Oxytocin-Induced Brown Adipose Tissue Thermogenesis in Female High Fat Diet-Fed Rats

Dodson, A. D., Herbertson, A. J., Honeycutt, M. K., Vered, R., Slattery, J. D., Goldberg, M., Tsui, E. W., Wolden‐Hanson, T., Graham, J. L., Wietecha, T., et al. (2024) · Current Issues in Molecular Biology · doi:10.3390/cimb46100679 · Cited by 4

Sympathetic innervation of interscapular brown adipose tissue is not a predominant mediator of Oxytocin (OT)-elicited reductions of body weight gain and adiposity in male diet-induced obese rats

Edwards, M. M., Nguyen, H. K., Dodson, A. D., Herbertson, A. J., Honeycutt, M. K., Slattery, J. D., Rambousek, J. R., Tsui, E. W., Wolden‐Hanson, T., Wietecha, T., et al. (2024) · Frontiers in Drug Delivery · doi:10.3389/fddev.2024.1497746 · Cited by 4

Implication of Central β2 Adrenergic Receptor for the Development of Novel Drugs Against Alzheimer's Disease

Wang, A., Since, M., Dallemagne, P., & Rochais, C. (2025) · Archiv der Pharmazie · doi:10.1002/ardp.202400750 · Cited by 4

GPR3 sets brown fat on fire

Baláž, M., & Wolfrum, C. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.06.003 · Cited by 4

Microarray analysis of hub genes, non-coding RNAs and pathways in lung after whole body irradiation in a mouse model

Aryankalayil, M. J., Bylicky, M. A., Martello, S. E., Chopra, S., Sproull, M. T., May, J. M., Shankardass, A., MacMillan, L., Vanpouille‐Box, C., Eke, I., et al. (2023) · International Journal of Radiation Biology · doi:10.1080/09553002.2023.2214205 · Cited by 4

Olodaterol promotes thermogenesis in brown adipocytes via regulation of the β2-AR/cAMP/PKA signaling pathway

Wang, L., Lei, Z., Zhang, G., Yang, C., Zhong, M., Zhang, G., & Hu, S. (2024) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2024.149689 · Cited by 4

Sleep deprivation stimulates adaptive thermogenesis by activating AMPK pathway in mice

Zheng, T.-S., Gao, X., Xu, R.-P., Zhao, Y.-F., Yang, Z.-T., & Wang, D. (2024) · Journal of Comparative Physiology B · doi:10.1007/s00360-024-01590-0 · Cited by 5

The Role of Active Brown Adipose Tissue in Patients With Pheochromocytoma or Paraganglioma

Onyema, M. C., Oštarijaš, E., Zaïr, Z. M., Roy, A., Minhas, R., Lajeunesse‐Trempe, F., Kearney, J., Drakou, E. E., Grossman, A. B., Aylwin, S. J. B., et al. (2024) · Endocrine Practice · doi:10.1016/j.eprac.2024.11.003 · Cited by 4

Exploring receptors for pro-resolving and non-pro-resolving mediators as therapeutic targets for sarcopenia

Wang, T., Chen, S., Zhou, D., & Hong, Z. (2025) · Metabolism · doi:10.1016/j.metabol.2025.156148 · Cited by 7

Contribution of perfusion to the 11C‐acetate signal in brown adipose tissue assessed by DCE‐MRI and 68Ga‐DOTA PET in a rat model

Richard, G. M., Noll, C., Archambault, M., Lebel, R., Tremblay, L., Aı̈t-Mohand, S., Guérin, B., Blondin, D. P., Carpentier, A. C., & Lepage, M. (2020) · Magnetic Resonance in Medicine · doi:10.1002/mrm.28535 · Cited by 4

Role of Endothelial Cell Lipoprotein Lipase for Brown Adipose Tissue Lipid and Glucose Handling

Thiemann, E., Schwaerzer, G. K., Evangelakos, I., Fuh, M. M., Jaeckstein, M. Y., Behrens, J. R., Nilsson, S. K., Kumari, M., Scheja, L., Pfeifer, A., et al. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.859671 · Cited by 4

Physiology of thermoregulation: central and peripheral mechanisms

Charkoudian, N., & Morrison, S. F. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-85492-4.00104-6 · Cited by 4

Circadian control of white and brown adipose tissues

Yue, K., Rensen, P. C. N., & Kooijman, S. (2023) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2023.102056 · Cited by 4

Constitutively active receptor ADGRA3 signaling induces adipose thermogenesis

Zhao, Z., Hu, L., Song, B., Jiang, T., Wu, Q., Lin, J., Li, X., Cai, Y., Li, J., Qian, B., et al. (2024) · eLife · doi:10.7554/elife.100205.4 · Cited by 21

Systematical identification of regulatory GPCRs by single-cell trajectory inference reveals the role of ADGRD1 and GPR39 in adipogenesis

Ye, C., Wang, X., Lin, J., Wu, C., Gao, Y., Guo, C., Liao, Y., Rao, Z., Huang, S., Chen, W., et al. (2025) · Science China Life Sciences · doi:10.1007/s11427-024-2732-8 · Cited by 3

Purinergic adipocyte-macrophage crosstalk promotes degeneration of thermogenic brown adipose tissue

Jaeckstein, M. Y., Fischer, A. W., Rissiek, B., Stähler, T., Heine, M., Behrens, J., Mann, O., Pfeifer, A., Magnus, T., Schlein, C., et al. (2025) · EMBO Reports · doi:10.1038/s44319-025-00642-y · Cited by 3

Thermoregulatory adaptations to cold in C3H/HeJ mice are independent of ADRB3 signaling

Beji, S., Mouchiroud, M., Gélinas, Y., Laplante, M., Michaud, A., & Caron, A. (2026) · Scientific Reports · doi:10.1038/s41598-026-38538-z · Cited by 3

Optimal HSF1 activation in response to acute cold stress in BAT requires nuclear TXNIP

Waldhart, A. N., Lau, K. H., Dykstra, H., Avequin, T., & Wu, N. (2023) · iScience · doi:10.1016/j.isci.2023.106538 · Cited by 3

Repeatability of brown adipose tissue activation measured by [18F]FDG PET after beta3-adrenergic stimuli in a mouse model

Faria, D. D. P., Vera, C. C. D. S., Marques, F. L. N., & Sapienza, M. T. (2023) · Nuclear Medicine and Biology · doi:10.1016/j.nucmedbio.2023.108390 · Cited by 3

A combination of Citrus aurantifolia fruit rind and Theobroma cacao seed extracts supplementation enhances metabolic rates in overweight subjects: a randomized, placebo-controlled, cross-over study

Ammatalli, N. K. R., Kuricheti, S. S. S. K., Veeramachaneni, S., Koo, Y. K., Ramanathan, G., & Yalamanchi, A. (2024) · Food & Nutrition Research · doi:10.29219/fnr.v68.10745 · Cited by 4

Algae-based flexible localized oxygen control around Cells: An approach leading to more Biomimetic microphysiological systems

Liu, Y., Qu, Y., Yang, Y., Deng, Q., Luo, Y., & Zhang, X. (2024) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.158040 · Cited by 3

Mirabegron and Physical Exercise Is a Potential Strategical for BAT Activation in Obesity

Antunes, G. C., Macêdo, A. P. A., da Conceição, L. R., & Pauli, J. R. (2022) · Obesities · doi:10.3390/obesities2040032 · Cited by 2

Acute effect of propranolol on resting energy expenditure in hyperthyroid patients

Senn, J. R., Loeliger, R. C., Fischer, J., Bur, F., Maushart, C. I., & Betz, M. J. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.1026998 · Cited by 3

Targeting Dlat-Trpv3 pathway by hyperforin elicits non-canonical promotion of adipose thermogenesis as an effective anti-obesity strategy

Lü, S., Jiang, Q., Zhou, P., Yin, L., Wang, N., Xu, J., Qian, Q., Tao, M., Yin, H., Han, L., et al. (2024) · Journal of Advanced Research · doi:10.1016/j.jare.2024.11.035 · Cited by 4

Fluvastatin Reduces Glucose Tolerance in Healthy Young Individuals Independently of Cold Induced BAT Activity

Felder, M., Maushart, C. I., Gashi, G., Senn, J. R., Becker, A. S., Müller, J., Baláž, M., Wolfrum, C., Burger, I. A., & Betz, M. J. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.765807 · Cited by 3

Physiology of exercise at environmental extremes: Sex as a biological variable

Greenfield, A. M., Seeley, A. D., Alba, B. K., Giersch, G. E. W., & Charkoudian, N. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-22266-5.00004-5 · Cited by 2

Glucose sensing and homeostasis by adipocyte GPCR

Hasan, N., & Chhabra, K. H. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1657747 · Cited by 3

Thermogenic Targets for Obesity Management in the Era of Incretin-Based Therapies

Soliman, S., Andrews‐Dickert, R., Ročić, P., & Mitov, M. I. (2025) · Pharmaceuticals · doi:10.3390/ph18101519 · Cited by 3

Akebia Saponin D Targeting Ubiquitin Carboxyl‐Terminal Hydrolase 4 Promotes Peroxisome Proliferator‐Activated Receptor Gamma Deubiquitination and Activation of Brown Adipose Tissue Thermogenesis in Obesity

Chen, L., Liu, D., Li, Y., Yang, S., Jia, W., Peng, L., Liu, H., Wang, X., Hu, B., Wang, Y., et al. (2025) · MedComm · doi:10.1002/mco2.70420 · Cited by 2

An ultrasound-guided biopsy technique for obtaining supraclavicular brown fat biopsies and preadipocytes

Andersen, E. S., Jespersen, N. Z., Henriksen, T. I., Lorentsen, K. M., Palani, N. P., Pedersen, B. K., Schéele, C., Nielsen, M. B., & Nielsen, S. L. (2025) · Scientific Reports · doi:10.1038/s41598-025-24183-5 · Cited by 2

The role of batokines in metabolism and their therapeutic potential

Mirmiranpour, H., & Barber, T. M. (2026) · Expert Review of Endocrinology & Metabolism · doi:10.1080/17446651.2026.2624400 · Cited by 2

Differentiation of Human Pluripotent Stem Cells (hPSCs) into Brown-Like Adipocytes

Carobbio, S., & Vidal‐Puig, A. (2023) · Methods in molecular biology · doi:10.1007/978-1-0716-3167-6_1 · Cited by 2

Effect of High-Intensity Interval Training on Fatty Infiltration After Delayed Rotator Cuff Repair in a Mouse Model

Zhou, H., Wang, Z., Chen, C., Hu, H., Jiang, B., Yin, Y., Zhang, K., Shen, M., & Wu, S. J. (2023) · Orthopaedic Journal of Sports Medicine · doi:10.1177/23259671231170192 · Cited by 2

From endoplasmic reticulum to nucleus: the fate of cellular fatty acids

Jutras-Carignan, A., Guillemette, T., & Mounier, C. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-95582-9.00018-8 · Cited by 2

Metabolically active brown adipose tissue in PPGL: an observational cohort study

Oštarijaš, E., Onyema, M. C., Zaïr, Z. M., Taylor, D. R., Lajeunesse‐Trempe, F., Reynolds, S., Mulholland, N. J. R., Corcoran, B., Halim, M., Drakou, E. E., et al. (2025) · Endocrine Related Cancer · doi:10.1530/erc-24-0200 · Cited by 2

The DMH GABA Neurons Play a Crucial Role in the Regulation of Cold‐Induced White Adipose Browning through DMH to LPO Projection

Su, Z., Hou, Y., Wang, B., Zhou, Q., Yang, W. Y., Guo, B., Zhang, C., Zhao, M., Yang, X., Liu, J., et al. (2025) · Advanced Science · doi:10.1002/advs.202508513 · Cited by 2

Live cold to grow old? Thermogenesis to fight cancer

Langer, H. T., Cantley, L. C., & Goncalves, M. D. (2022) · Cell Research · doi:10.1038/s41422-022-00723-w · Cited by 2

Les tissus adipeux thermogéniques : un rôle dans le traitement de l’obésité ?

Langin, D. (2022) · Médecine des Maladies Métaboliques · doi:10.1016/j.mmm.2022.09.010 · Cited by 2

Decoding temporal thermogenesis: coregulator selectivity and transcriptional control in brown and beige adipocytes

Jeon, Y. G., Kim, S. W., & Kim, J. B. (2024) · Adipocyte · doi:10.1080/21623945.2024.2391511 · Cited by 2

FDG Uptake in Brown Adipose Tissue Activated by a Long-Acting β2-Adrenergic Receptor Agonist Inhaler Prescribed for Bronchial Asthma

Nitta, A., Kotani, T., & Okuyama, C. (2024) · Clinical Nuclear Medicine · doi:10.1097/rlu.0000000000005529 · Cited by 1

Secretin infusion decreases food intake in healthy men—a randomized, placebo-controlled, double-blind, crossover study

Heimbürger, S. M. N., BENTZEN, M. J., Kizilkaya, H. S., Hartmann, B., Holst, J. J., ROSENKILDE, M. M., Dela, F., Hansen, S. H., Rehfeld, J. F., Christensen, M., et al. (2024) · European Journal of Endocrinology · doi:10.1093/ejendo/lvae147 · Cited by 1

Metabolic Function of the Adipose Tissue

Deevska, G. M. (2024) · Contemporary Endocrinology · doi:10.1007/978-3-031-72570-8_3 · Cited by 1

Effects of time-of-day on the noradrenaline, adrenaline, cortisol and blood lipidome response to an ice bath

Braunsperger, A., Bauer, M., Brahim, C. B., Seep, L., Tischer, D., Peitzsch, M., Hasenauer, J., Figueroa, S. H., Worthmann, A., Heeren, J., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-85304-8 · Cited by 2

Impact of β 3 ‐adrenergic receptor agonist on kidney cancer risk in patients with overactive bladder

Park, J. S., Choi, S. B., Kim, J., Jang, W. S., & Ham, W. S. (2025) · British Journal of Urology · doi:10.1111/bju.16771 · Cited by 1

Impact of β3-adrenergic receptor agonist on tumor progression and metastasis in renal cell carcinoma models

Park, J. S., Lee, M. E., Jung, M., Kim, J., Jang, W. S., & Ham, W. S. (2025) · Cancer Cell International · doi:10.1186/s12935-025-03834-7 · Cited by 1

Nutritional Influences on Brown and Beige Adipocyte: Unraveling the Molecular Mechanisms and Metabolic Implications

Wang, Y., Zhang, K. X., Kan, C., Zhang, W., Sun, X., & Li, L. (2025) · Food Science & Nutrition · doi:10.1002/fsn3.70613 · Cited by 1

Thermogenic Differentiation of Human Adipocyte Precursors in Culture: A Systematic Review

de Paula, G. L. A. D. S., Garcia, E. C., Beserra, B. T. S., & Amato, A. A. (2025) · Cells · doi:10.3390/cells14231907 · Cited by 1

Infrared thermography in the assessment of brown and white adipose tissue in children with different nutritional states

Bailich, G., Lopes, P. R. S., de Sá-Caputo, D. D. C., Sartório, A., Peixe, G., Filho, M. B. F., de Freitas, A. E., & Sonza, A. (2026) · Jornal de Pediatria · doi:10.1016/j.jped.2025.101498 · Cited by 1

Nicotiflorin Alleviates Obesity by Activating Brown Adipose Tissue Through the β3–Adrenergic Receptor Pathway

Chiu, C.-Y., Tzeng, C., Liu, S.-W., Chen, C., Yu-Hsiang, K., Hu, C., & Chen, W. (2026) · Advances in Pharmacological and Pharmaceutical Sciences · doi:10.1155/adpp/8627692 · Cited by 1

ADGRL4 induces adipose browning and weight loss via AKT activation

Hu, L., Zhao, Z., Wu, Q., Song, B., Li, J., Liu, S., & Yang, Z. (2026) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2026.112774 · Cited by 1

Brown Adipose Tissue Thermogenesis

Blondin, D. P. (2026) · Physiology · doi:10.1152/physiol.00002.2026 · Cited by 1

Brown adipose tissue and beyond: lipolysis and glycerolipid cycling in thermogenesis

Langin, D., & Carpentier, A. C. (2026) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2026.01.009 · Cited by 1

Sulforaphene‐Enriched Raphanus sativus L. Seed Extract Promotes Norepinephrine‐Induced Thermogenesis and Weight Loss by Modulating the Interplay Between Adipocytes and Immune Cells in Adipose Tissue

Hur, G., Lee, T. K., Kim, J. H., Yang, H., & Lee, K. W. (2026) · Phytotherapy Research · doi:10.1002/ptr.70282 · Cited by 1

EBF2 condensates enable adipose thermogenesis through ZFP423 sequestration and epigenetic remodeling

Wang, X., Li, C., Gui, Z., Jin, Y., Xia, S., Zhao, H., Wang, Y., Dai, M., He, S., Zhong, Y., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-72233-x · Cited by 1

Neural Innervation of Adipose Tissue: Current Understanding and Future Perspective

Wang, C.-N., & Yang, C. (2026) · Neuroendocrinology · doi:10.1159/000551952 · Cited by 1

Targeting perivascular adipose tissue in vascular aging: innovative translational strategies for disease prevention and monitoring

Wang, P.-X., He, S.-Q., Huang, B., Liu, Z., Xu, F., Yang, J., Lu, S., Chen, H.-X., Cai, Z.-Q., Yuan, L., et al. (2026) · APOPTOSIS · doi:10.1007/s10495-026-02360-9 · Cited by 1

UCP1-Dependent Thermogenic Adipose Tissue in Human Disease: Adipose-Centered Mechanisms, Biomarker Limitations, and Translational Perspectives

Yan, M., Wang, H.-Q., Sha, W., & Fu, Y. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27146416 · Cited by 1

Pulmonary cold sensing through Club cells triggers adipose thermogenesis to ameliorate obesity

Jiang, J., Liang, C., Wang, Z., Lu, Z., Yu, W., Wang, X. L., Zhang, C., Zhang, Z., & Luan, B. (2026) · Developmental Cell · doi:10.1016/j.devcel.2026.07.003 · Cited by 1

Artificial intelligence-enabled clinical phenotyping of human brown fat

Gómez-Banoy, N., Barrero, J. A., de Carvalho, L. R. P., Jiang, C. S., Lama, T. D., Karandikar, N., Koenen, M., Lam, T., Plucińska, K., Morozova, K., et al. (2026) · Nature · doi:10.1038/s41586-026-11162-7 · Cited by 1

Clinical pharmacology of β-3 adrenergic receptor agonists for cardiovascular diseases

Balligand, J., & Michel, L. Y. M. (2023) · Expert Review of Clinical Pharmacology · doi:10.1080/17512433.2023.2193681 · Cited by 1

Metabolic and structural remodeling during browning of primary human adipocytes derived from omental and subcutaneous depots

Lee, M., Puri, V., & Fried, S. K. (2023) · Obesity · doi:10.1002/oby.23912 · Cited by 1

Brief Communication: Histological Assessment of Nonhuman Primate Brown Adipose Tissue Highlights the Importance of Sympathetic Innervation

Williams, A. G., Long, M., & Kavanagh, K. (2023) · Journal of Obesity · doi:10.1155/2023/5651084 · Cited by 1

Relationship between Brown Adipose Tissue and Cardiovascular Disease

田, 源. (2024) · Advances in Clinical Medicine · doi:10.12677/acm.2024.14102761 · Cited by 1

Adipocyte-specific deletion of the oxygen-sensor PHD2 sustains elevated energy expenditure at thermoneutralityPreprint

Gomez-Salazar, M. A., Cervera, I. P., Wang, R., French, K. L., García-Martín, R., Blüher, M., Schofield, C. J., Stimson, R. H., Chavakis, T., Gudmundsson, E. F., et al. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.01.05.425401 · Cited by 1

Inhibition of the beta-1 adrenergic receptor does not potentiate mirabegron-stimulated human brown adipose tissue thermogenesis.Preprint

Dumont, L., Caron, A., Richard, G. M., Croteau, É., Fortin, M., Frisch, F., Phoenix, S., Dubreuil, S., Guérin, B., Turcotte, É. E., et al. (2023) · medRxiv · doi:10.1101/2023.03.22.23287600 · Cited by 1

New models of adipogenic differentiation highlight a cellautonomous response to temperature

Veličković, K., Leija, H. A. L., McGinlay, S., Symonds, M. E., & Sottile, V. (2020) · Biocell · doi:10.32604/biocell.2020.012942

Review of Al-Qaeda's Armies: Middle East Affiliate Groups and the Next Generation of Terror

Jorisch, A. (2005) · Middle East Quarterly

β-Arrestins as regulators of key metabolic processes

Barella, L. F., Pydi, S. P., Zhu, L., & Wess, J. (2022) · Elsevier eBooks · doi:10.1016/b978-0-323-85756-7.00006-6

White, Brown and Beige Adipocytes: From the Tissue to the Single-Cell Level

Carobbio, S., & Vidal‐Puig, A. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-821618-7.00091-2

Brown adipose tissue: Implications for human health

Boost, M., Martínez‐Téllez, B., Gil, Á., & Ruiz, J. R. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-821848-8.00134-7

Inhibition of the serotonin transporter induces dysfunction of human brown adipose tissue

(2023) · Nature Metabolism · doi:10.1038/s42255-023-00851-6

Ablation of carotid body activity reverses diabesity by improving white and brown adipose tissue sympathetic innervation and metabolismPreprint

Melo, B. F., Sacramento, J. F., Lavergne, J., Martins, F. O., Silva, D., Panzolini, C., Melo, G. M., Prego, C. S., Falvey, A., Olea, E., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.08.04.552063

Patent Highlights February–March 2023

Mucke, H. A. (2023) · Pharmaceutical Patent Analyst · doi:10.4155/ppa-2023-0023

Impacto da expressão da proteína de transferência de colesteril éster (CETP) no metabolismo energético em condição de exposição ao frio e termoneutralidade

Castelli, J. Z. (2022) · doi:10.47749/t/unicamp.2021.1239211

In Vitro Differentiation of Beige/Brown Adipocytes for the Treatment of Metabolic Diseases

Bouchekioua, A., Pourquié, O., & Mayeuf-Louchart, A. (2024) · IntechOpen eBooks · doi:10.5772/intechopen.1002886

The Role of ADGRA3 in Adipose Thermogenesis: A Potential Therapeutic Target for ObesityPreprint

Zhao, Z., Hu, L., Song, B., Jiang, T., Wu, Q., Lin, J., Li, X., Cai, Y., Li, J., Qian, B., et al. (2024) · eLife · doi:10.7554/elife.100205.1

Sympathetic innervation of interscapular brown adipose tissue is not a predominant mediator of OT-elicited reductions of body weight gain and adiposity in male diet-induced obese ratsPreprint

Edwards, M. M., Nguyen, H. K., Dodson, A. D., Herbertson, A. J., Honeycutt, M. K., Slattery, J. D., Rambousek, J. R., Tsui, E. W., Wolden‐Hanson, T., Wietecha, T., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.09.12.612710

Constitutively active receptor ADGRA3 signaling induces adipose thermogenesisPreprint

Zhao, Z., Hu, L., Song, B., Jiang, T., Wu, Q., Lin, J., Li, X., Cai, Y., Li, J., Qian, B., et al. (2024) · eLife · doi:10.7554/elife.100205.2

Constitutively active receptor ADGRA3 signaling induces adipose thermogenesisPreprint

Zhao, Z., Hu, L., Song, B., Jiang, T., Wu, Q., Lin, J., Li, X., Cai, Y., Li, J., Qian, B., et al. (2024) · eLife · doi:10.7554/elife.100205.3

Targeting Adipose Tissue: Therapeutic Strategies and Future Directions

Dai, B., Zheng, L., & Qin, L. (2024) · Contemporary Endocrinology · doi:10.1007/978-3-031-72570-8_8

Brown and Beige Adipose Tissue: From Activators to Physiological Relevance

Tischer, D., & Soriano‐Arroquia, A. (2025) · IntechOpen eBooks · doi:10.5772/intechopen.1009135

Serum secreted EMC10 (scEMC10) levels are inversely associated with metabolically active brown adipose tissue in humans

Miao, Q., Wang, Y., Zhang, Q., Wu, W., Yu, Y., Zeng, F., Yang, Y., Zuo, C., Guan, Y., Liew, C. W., et al. (2025) · International Journal of Obesity · doi:10.1038/s41366-025-01744-2

β2-Adrenergic Receptor Endocytosis and Signaling

Borah, M. K., War, A. R., Soni, N., & Baidya, M. (2025) · The Receptors · doi:10.1007/978-3-031-81991-9_6

Sarcopenic obesity: prospects of mitochondrial transplantation to combat metabolic deterioration in aging

Islam, M. A., Gu, W., Song, Y., Xu, Y., & Xu, H. (2025) · Acta Materia Medica · doi:10.15212/amm-2024-0091

miR-196a-5p and miR-342-3p mediate skeletal muscle and thermogenic adipose tissue crosstalk through extracellular vesiclesPreprint

Tischer, D., Schranner, D., Kallabis, S., Braunsperger, A., Schönfelder, M., Gnad, T., Jost, P. J., Nesic, S., Renziehausen, F., Fester, L., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.28.656129

Β 2 AR Agonists Sustain Thermogenesis and Leanness via SympathofacilitationPreprint

Cheung, S. W., Sidarta-Oliveira, D., Yao, L., Zhu, Y., Sarker, G., Lundh, S. H., Morgan, D. A., Qu, J., Wilcox, S. L., Vyazovskiy, V. V., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.06.13.659468

Reversal of Diabesity Through Modulating Sympathetic Inputs to Adipose Tissue Following Carotid Body Resection

Melo, B. F., Sacramento, J. F., Lavergne, J., Martins, F. O., Silva, D., Panzolini, C., Prego, C. S., Falvey, A., Olea, E., Matafome, P. N., et al. (2025) · Acta Physiologica · doi:10.1111/apha.70074

Thermogenesis dynamics and influenza A virus: unveiling the intriguing interplay

Park, E., Marakkalage, K. G., & Kim, K. (2025) · Critical Reviews in Microbiology · doi:10.1080/1040841x.2025.2545217

Dietary sulfur amino acid restriction elicits a cold-like transcriptional response in inguinal but not epididymal white adipose tissue of male mice

Ruppert, P. M. M., Güller, A. S., Rosendal, M., Stanić, N., & Kornfeld, J. (2026) · eLife · doi:10.1101/2025.08.06.669020

18F-Fluorocholine uptake is greater by human supraclavicular brown than white adipose tissue and inversely associated with body mass index

Suchacki, K. J., Ramage, L. E., Boyle, L. D., Kwok, T. C., Blanco, G. R., Kelman, A., Gray, C. D., von Kriegsheim, A., Gregoriades, M., Oniscu, G. C., et al. (2026) · Journal of Translational Medicine · doi:10.1101/2025.08.24.671970

Effects of Whole‐Body Cryotherapy Combined With Conventional Obesity Management Versus Obesity Management Alone: A Clinical Trial

Karppinen, J. E., Suojanen, L.-U., Heinonen, S., Kaye, S. M., van der Kolk, B. W., White, J. P., Orava, J., Lee, S. H., Dillon, E., Muniandy, M., et al. (2025) · Obesity · doi:10.1002/oby.70019

Dietary sulfur amino acid restriction elicits a cold-like transcriptional response in inguinal but not epididymal white adipose tissue of male micePreprint

Ruppert, P. M. M., Güller, A. S., Skjæveland, M., Stanić, N., & Kornfeld, J. (2025) · eLife · doi:10.7554/elife.108825 · Cited by 1

Dietary sulfur amino acid restriction elicits a cold-like transcriptional response in inguinal but not epididymal white adipose tissue of male micePreprint

Ruppert, P. M. M., Güller, A. S., Rosendal, M., Stanić, N., & Kornfeld, J. (2025) · eLife · doi:10.7554/elife.108825.1

Ancestral tributyltin exposure produces male-specific brown adipose thermogenic dysregulatoinPreprint

Huang, Y., Chang, R. C.-A., Nguyen, K. U., To, K., Gibbs, M., Honjoh, H., Shioda, T., & Blumberg, B. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.11.04.686561

Human BAT Thermogenesis is Stimulated by the β 2-Adrenergic ReceptorPreprint

Blondin, D. P., Severinsen, M. C. K., Kuipers, E. N., Hirschberg, V., Miard, S., Jespersen, N. Z., Kooijman, S., Boon, M. R., Fortin, M., Phoenix, S., et al. (2019) · SSRN Electronic Journal · doi:10.2139/ssrn.3440265 · Cited by 2

β3-Adrenergic receptors regulate human brown/beige adipocyte lipolysis and thermogenesis

Cero, C., Lea, H. J., ZHU, K. Y., Shamsi, F., Tseng, Y., & Cypess, A. M. (2021) · JCI Insight · doi:10.1172/jci.insight.139160 · Cited by 250

Stimulation of the ß3-Adrenergic Receptor via Mirabegron Induces Lipolysis and Thermogenesis in Human Adipocytes

Cero, C., O’Mara, A. E., Johnson, J. W., Baskin, A. S., Linderman, J. D., & Cypess, A. M. (2018) · Diabetes · doi:10.2337/db18-2049-p · Cited by 3

2020-P: ß3-Adrenergic Receptors Regulate Lipolysis and Thermogenesis in Human Brown/Beige Adipocytes

Cero, C., Lea, H. J., ZHU, K. Y., & Cypess, A. M. (2020) · Diabetes · doi:10.2337/db20-2020-p · Cited by 8

Activation of Human Brown Adipose Tissue by a β3-Adrenergic Receptor Agonist

Cypess, A. M., Weiner, L. S., Roberts‐Toler, C., Franquet, E., Kessler, S., Kahn, P. A., English, J., Chatman, K., Trauger, S. A., Doria, A., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2014.12.009 · Cited by 1,053