Human Brown Adipocyte Thermogenesis Is Driven by β2-AR Stimulation

Brown Adipose Tissue: Function and Physiological Significance

CANNON, B., & NEDERGAARD, J. (2004) · Physiological Reviews · doi:10.1152/physrev.00015.2003 · Cited by 6,433

Functional Brown Adipose Tissue in Healthy Adults

Virtanen, K. A., Lidell, M. E., Orava, J., Heglind, M., Westergren, R., Niemi, T., Taittonen, M., Laine, J., Savisto, N.-J., Enerbäck, S., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0808949 · Cited by 3,058

UCP1 Ablation Induces Obesity and Abolishes Diet-Induced Thermogenesis in Mice Exempt from Thermal Stress by Living at Thermoneutrality

Feldmann, H. M., Golozoubova, V., Cannon, B., & Nedergaard, J. (2009) · Cell Metabolism · doi:10.1016/j.cmet.2008.12.014 · Cited by 1,318

Brown adipose tissue regulates glucose homeostasis and insulin sensitivity

Stanford, K. I., Middelbeek, R. J. W., Townsend, K. L., An, D., Nygaard, E. B., Hitchcox, K. M., Markan, K. R., Nakano, K., Hirshman, M. F., Tseng, Y.-H., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci62308 · Cited by 1,180

Activation of Human Brown Adipose Tissue by a β3-Adrenergic Receptor Agonist

Cypess, A. M., Weiner, L. S., Roberts‐Toler, C., Franquet, E., Kessler, S., Kahn, P. A., English, J., Chatman, K., Trauger, S. A., Doria, A., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2014.12.009 · Cited by 1,053

Brown adipose tissue oxidative metabolism contributes to energy expenditure during acute cold exposure in humans

Ouellet, V., Labbé, S. M., Blondin, D. P., Phoenix, S., Guérin, B., Haman, F., Turcotte, É. E., Richard, D., & Carpentier, A. C. (2012) · Journal of Clinical Investigation · doi:10.1172/jci60433 · Cited by 985

Different Metabolic Responses of Human Brown Adipose Tissue to Activation by Cold and Insulin

Orava, J., Nuutila, P., Lidell, M. E., Oikonen, V., Noponen, T., Viljanen, T., Scheinin, M., Taittonen, M. T., Niemi, T. S., Enerbäck, S., et al. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.06.012 · Cited by 745

Anatomical localization, gene expression profiling and functional characterization of adult human neck brown fat

Cypess, A. M., White, A. P., Vernochet, C., Schulz, T. J., Xue, R., Sass, C. A., Huang, T. L., Roberts‐Toler, C., Weiner, L. S., Sze, C., et al. (2013) · Nature Medicine · doi:10.1038/nm.3112 · Cited by 683

Fat cell adrenergic receptors and the control of white and brown fat cell function

Lafontan, M., & Berlan, M. (1993) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)37695-1 · Cited by 644

The selectivity of β‐adrenoceptor agonists at human β1‐, β2‐ and β3‐adrenoceptors

Baker, J. G. (2010) · British Journal of Pharmacology · doi:10.1111/j.1476-5381.2010.00754.x · Cited by 591

The cellular and functional complexity of thermogenic fat

Cohen, P., & Kajimura, S. (2021) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-021-00350-0 · Cited by 572

Reassessing human adipose tissue

Cypess, A. M. (2022) · New England Journal of Medicine · doi:10.1056/nejmra2032804 · Cited by 404

β3-Adrenergic receptors regulate human brown/beige adipocyte lipolysis and thermogenesis

Cero, C., Lea, H. J., ZHU, K. Y., Shamsi, F., Tseng, Y., & Cypess, A. M. (2021) · JCI Insight · doi:10.1172/jci.insight.139160 · Cited by 250

Brown Adipose Tissue—A Translational Perspective

Carpentier, A. C., Blondin, D. P., Haman, F., & Richard, D. (2022) · Endocrine Reviews · doi:10.1210/endrev/bnac015 · Cited by 218

Adipose Tissue and Metabolic Health

An, S.-M., Cho, S.-H., & Yoon, J. C. (2023) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2023.0011 · Cited by 184

Obesity and Thyroid Axis

Walczak, K., & Siemińśka, L. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18189434 · Cited by 182

The evolving view of thermogenic adipocytes — ontogeny, niche and function

Shamsi, F., Wang, C., & Tseng, Y. (2021) · Nature Reviews Endocrinology · doi:10.1038/s41574-021-00562-6 · Cited by 184

Beyond appetite regulation: Targeting energy expenditure, fat oxidation, and lean mass preservation for sustainable weight loss

Christoffersen, B. Ø., Sanchez‐Delgado, G., John, L. M., Ryan, D. H., Raun, K., & Ravussin, E. (2022) · Obesity · doi:10.1002/oby.23374 · Cited by 142

An Update on the Secretory Functions of Brown, White, and Beige Adipose Tissue: Towards Therapeutic Applications

Ghesmati, Z., Rashid, M., Fayezi, S., Gieseler, F., Alizadeh, E., & Darabi, M. (2024) · Reviews in Endocrine and Metabolic Disorders · doi:10.1007/s11154-023-09850-0 · Cited by 139

Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis

Johansen, O. S., Ma, T., Hansen, J. B., Markussen, L. K., Schreiber, R., Reverte-Salisa, L., Dong, H., Christensen, D. P., Sun, W., Gnad, T., et al. (2021) · Cell · doi:10.1016/j.cell.2021.04.037 · Cited by 134

β3-Adrenergic receptor downregulation leads to adipocyte catecholamine resistance in obesity

Valentine, J. M., Ahmadian, M., Keinan, O., Abu-Odeh, M., Zhao, P., Zhou, X., Keller, M. P., Gao, H., Yu, R. T., Liddle, C., et al. (2021) · Journal of Clinical Investigation · doi:10.1172/jci153357 · Cited by 152

The sympathetic nervous system in the 21st century: Neuroimmune interactions in metabolic homeostasis and obesity

Martínez‐Sánchez, N., Sweeney, O., Sidarta-Oliveira, D., Caron, A., Stanley, S. A., & Domingos, A. I. (2022) · Neuron · doi:10.1016/j.neuron.2022.10.017 · Cited by 127

Of mice and men: Pinpointing species differences in adipose tissue biology

Börgeson, E., Boucher, J., & Hagberg, C. E. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.1003118 · Cited by 125

Human Brown Adipose Tissue and Metabolic Health: Potential for Therapeutic Avenues

Singh, R., Barrios, A., Dirakvand, G., & Pervin, S. (2021) · Cells · doi:10.3390/cells10113030 · Cited by 114

Sex Differences in Brown Adipose Tissue Function: Sex Hormones, Glucocorticoids, and Their Crosstalk

Kaikaew, K., Grefhorst, A., & Visser, J. A. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.652444 · Cited by 103

β-Adrenergic Receptors and Adipose Tissue Metabolism: Evolution of an Old Story

Collins, S. (2022) · Annual Review of Physiology · doi:10.1146/annurev-physiol-060721-092939 · Cited by 105

Loss of UCP1 function augments recruitment of futile lipid cycling for thermogenesis in murine brown fat

Oeckl, J., Janovská, P., Adamcová, K., Bardová, K., Brunner, S. P., Dieckmann, S., Ecker, J., Fromme, T., Funda, J., Gantert, T., et al. (2022) · Molecular Metabolism · doi:10.1016/j.molmet.2022.101499 · Cited by 101

Modelling metabolic diseases and drug response using stem cells and organoids

Hu, W., & Lazar, M. A. (2022) · Nature Reviews Endocrinology · doi:10.1038/s41574-022-00733-z · Cited by 99

Batokines: Mediators of Inter-Tissue Communication (a Mini-Review)

Yang, F. T., & Stanford, K. I. (2022) · Current Obesity Reports · doi:10.1007/s13679-021-00465-7 · Cited by 100

An update on brown adipose tissue biology: a discussion of recent findings

Gaspar, R. C., Pauli, J. R., Shulman, G. I., & Muñoz, V. R. (2021) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00310.2020 · Cited by 91

100 th anniversary of the discovery of insulin perspective: insulin and adipose tissue fatty acid metabolism

Carpentier, A. C. (2021) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00620.2020 · Cited by 93

Futile cycles: Emerging utility from apparent futility

Sharma, A. K., Khandelwal, R., & Wolfrum, C. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.03.008 · Cited by 91

β3-Adrenergic receptor downregulation leads to adipocyte catecholamine resistance in obesity

Valentine, J. M., Ahmadian, M., Keinan, O., Abu-Odeh, M., Zhao, P., Zhou, X., Keller, M. P., Gao, H., Yu, R. T., Liddle, C., et al. (2022) · DOAJ (DOAJ: Directory of Open Access Journals) · Cited by 89

Emerging debates and resolutions in brown adipose tissue research

Cypess, A. M., Cannon, B., Nedergaard, J., Kazak, L., Chang, D. C., Krakoff, J. A., Tseng, Y., Schéele, C., Boucher, J., Petrovič, N., et al. (2024) · Cell Metabolism · doi:10.1016/j.cmet.2024.11.002 · Cited by 93

The Beta3 Adrenergic Receptor in Healthy and Pathological Cardiovascular Tissues

Michel, L. Y. M., Farah, C., & Balligand, J. (2020) · Cells · doi:10.3390/cells9122584 · Cited by 83

The Role of AMPK Signaling in Brown Adipose Tissue Activation

van der Vaart, J. I., Boon, M. R., & Houtkooper, R. H. (2021) · Cells · doi:10.3390/cells10051122 · Cited by 90

Altered brown fat thermoregulation and enhanced cold-induced thermogenesis in young, healthy, winter-swimming men

Søberg, S., Löfgren, J., Philipsen, F. E., Jensen, M., Hansen, A. E., Ahrens, E., Nystrup, K. B., Nielsen, R. D., Sølling, C., Wedell‐Neergaard, A., et al. (2020) · Cell Reports Medicine · doi:10.1016/j.xcrm.2021.100408 · Cited by 78

Proteomics analysis of adipose depots after intermittent fasting reveals visceral fat preservation mechanisms

Harney, D., Cielesh, M., Chu, R., Cooke, K. C., James, D. E., Stöckli, J., & Larance, M. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.108804 · Cited by 68

Substrate Utilization by Brown Adipose Tissue: What’s Hot and What’s Not?

McNeill, B. T., Morton, N. M., & Stimson, R. H. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.571659 · Cited by 65

Many Ways to Rome: Exercise, Cold Exposure and Diet—Do They All Affect BAT Activation and WAT Browning in the Same Manner?

Scheel, A. K., Espelage, L., & Chadt, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094759 · Cited by 68

ADRA1A–Gαq signalling potentiates adipocyte thermogenesis through CKB and TNAP

Rahbani, J. F., Scholtes, C., Lagarde, D., Hussain, M. F., Roesler, A. A., Dykstra, C. B., Bunk, J., Samborska, B., O’Brien, S. L., Tripp, E., et al. (2022) · Nature Metabolism · doi:10.1038/s42255-022-00667-w · Cited by 60

The metabolic and functional roles of sensory nerves in adipose tissues

Mishra, G., & Townsend, K. L. (2023) · Nature Metabolism · doi:10.1038/s42255-023-00868-x · Cited by 59

Thyroid hormones in the regulation of brown adipose tissue thermogenesis

Sentis, S. C., Oelkrug, R., & Mittag, J. (2021) · Endocrine Connections · doi:10.1530/ec-20-0562 · Cited by 60

Lipolysis-Derived Linoleic Acid Drives Beige Fat Progenitor Cell Proliferation via CD36

Abe, I., Oguri, Y., Verkerke, A. R. P., Monteiro, L. D. B., Knuth, C. M., Auger, C., Qiu, Y., Westcott, G. P., Cinti, S., Shinoda, K., et al. (2022) · Developmental Cell · doi:10.1016/j.devcel.2022.11.007 · Cited by 58

Brown adipose tissue involution associated with progressive restriction in progenitor competence

Huang, Z., Zhang, Z., Moazzami, Z., Heck, R., Hu, P., Nanda, H. A., Ren, K., Sun, Z., Bartolomucci, A., Gao, Y., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110575 · Cited by 50

Brown adipose tissue and regulation of human body weight

Harb, E., Kheder, O., Poopalasingam, G., Rashid, R., Srinivasan, A., & Izzi‐Engbeaya, C. N. (2022) · Diabetes/Metabolism Research and Reviews · doi:10.1002/dmrr.3594 · Cited by 53

MECHANISMS IN ENDOCRINOLOGY: Human brown adipose tissue as a therapeutic target: warming up or cooling down?

McNeill, B. T., Suchacki, K. J., & Stimson, R. H. (2021) · European Journal of Endocrinology · doi:10.1530/eje-20-1439 · Cited by 55

Effects of Caffeine on Brown Adipose Tissue Thermogenesis and Metabolic Homeostasis: A Review

Schaik, L. V., Kettle, C., Green, R., Irving, H. R., & Rathner, J. A. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2021.621356 · Cited by 50

Sarcopenia and cachexia: molecular mechanisms and therapeutic interventions

Wang, T., Zhou, D., & Hong, Z. (2025) · MedComm · doi:10.1002/mco2.70030 · Cited by 46

Examining the benefits of cold exposure as a therapeutic strategy for obesity and type 2 diabetes

Ivanova, Y. M., & Blondin, D. P. (2021) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00934.2020 · Cited by 44

Role of thermogenic adipose tissue in lipid metabolism and atherosclerotic cardiovascular disease: lessons from studies in mice and humans

Ying, Z., Tramper, N., Zhou, E., Boon, M. R., Rensen, P. C. N., & Kooijman, S. (2022) · Cardiovascular Research · doi:10.1093/cvr/cvac131 · Cited by 47

Capsaicin directly promotes adipocyte browning in the chemical compound-induced brown adipocytes converted from human dermal fibroblasts

Takeda, Y., & Dai, P. (2022) · Scientific Reports · doi:10.1038/s41598-022-10644-8 · Cited by 43

UCP1 activation: Hottest target in the thermogenesis pathway to treat obesity using molecules of synthetic and natural origin

Jagtap, U. A., & Paul, A. T. (2023) · Drug Discovery Today · doi:10.1016/j.drudis.2023.103717 · Cited by 44

G-Protein-Coupled Receptor (GPCR) Signaling and Pharmacology in Metabolism: Physiology, Mechanisms, and Therapeutic Potential

Cho, Y., Kim, S., Kim, P.-K., Jo, M. J., Park, S.-E., Choi, Y., Jung, S. M., & Kang, H. J. (2025) · Biomolecules · doi:10.3390/biom15020291 · Cited by 49

Pathophysiology of obesity.

Kessler, C. (2021) · Nursing Clinics of North America · doi:10.1016/j.cnur.2021.08.001 · Cited by 43

Metabolic determinants of Alzheimer’s disease: A focus on thermoregulation

Tournissac, M., Leclerc, M., Valentin‐Escalera, J., Vandal, M., Bosoi, C. R., Planel, E., & Calon, F. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101462 · Cited by 41

Stimulation of the beta-2-adrenergic receptor with salbutamol activates human brown adipose tissue

Straat, M. E., Hoekx, C. A., van Velden, F. H. P., Arias‐Bouda, L. M. P., Dumont, L., Blondin, D. P., Boon, M. R., Martínez‐Téllez, B., & Rensen, P. C. N. (2023) · Cell Reports Medicine · doi:10.1016/j.xcrm.2023.100942 · Cited by 49

Roles of estrogens, estrogen-like compounds, and endocrine disruptors in adipocytes

Lizcano, F. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.921504 · Cited by 47

Nutritional Regulation of Human Brown Adipose Tissue

Suchacki, K. J., & Stimson, R. H. (2021) · Nutrients · doi:10.3390/nu13061748 · Cited by 45

The beta2‐adrenergic receptor – a re‐emerging target to combat obesity and induce leanness?

Hostrup, M., & Onslev, J. (2021) · The Journal of Physiology · doi:10.1113/jp281819 · Cited by 42

Reversible lysine fatty acylation of an anchoring protein mediates adipocyte adrenergic signaling

Bagchi, R. A., Robinson, E. L., Hu, T., Cao, J., Hong, J. Y., Tharp, C. A., Qasim, H., Gavin, K. M., Silva, J. P. D., Major, J. L., et al. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2119678119 · Cited by 40

The serotonin transporter sustains human brown adipose tissue thermogenesis

Suchacki, K. J., Ramage, L. E., Kwok, T. C., Kelman, A., McNeill, B. T., Rodney, S., Keegan, M., Gray, C. D., Macnaught, G., Patel, D. K., et al. (2023) · Nature Metabolism · doi:10.1038/s42255-023-00839-2 · Cited by 39

Muscle-Derived Beige Adipose Precursors Secrete Promyogenic Exosomes That Treat Rotator Cuff Muscle Degeneration in Mice and Are Identified in Humans by Single-Cell RNA Sequencing

Davies, M., Garcia, S. M., Liu, M., Chi, H. M., Kim, H. T., Raffaı̈, R. L., Liu, X., & Feeley, B. T. (2022) · The American Journal of Sports Medicine · doi:10.1177/03635465221095568 · Cited by 38

Effects of multi-organ crosstalk on the physiology and pathology of adipose tissue

Wang, S., Liu, Y., Chen, J., He, Y., Ma, W., Liu, X., & Sun, X. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1198984 · Cited by 42

Reduced hepatic bradykinin degradation accounts for cold-induced BAT thermogenesis and WAT browning in male mice

Xiao, F., Jiang, H., Li, Z., Jiang, X., Chen, S., Niu, Y., Yin, H., Shu, Y., Peng, B., Lu, W., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-38141-0 · Cited by 36

Keys to the switch of fat burning: stimuli that trigger the uncoupling protein 1 (UCP1) activation in adipose tissue

Gong, D., Lei, J., He, X., Hao, J., Zhang, F., Huang, X., Gu, W., Yang, X., & Yu, J. (2024) · Lipids in Health and Disease · doi:10.1186/s12944-024-02300-z · Cited by 43

High-fructose feeding suppresses cold-stimulated brown adipose tissue glucose uptake independently of changes in thermogenesis and the gut microbiome

Richard, G. M., Blondin, D. P., Syed, S. A., Rossi, L., Fontes, M. E., Fortin, M., Phoenix, S., Frisch, F., Dubreuil, S., Guérin, B., et al. (2022) · Cell Reports Medicine · doi:10.1016/j.xcrm.2022.100742 · Cited by 37

Adipose tissue ageing: implications for metabolic health and lifespan

Wang, G., Song, A., & Wang, Q. A. (2025) · Nature Reviews Endocrinology · doi:10.1038/s41574-025-01142-8 · Cited by 40

The good and the BAT of metabolic sex differences in thermogenic human adipose tissue

Keuper, M., & Jastroch, M. (2021) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2021.111337 · Cited by 39

Extracellular Vesicles in Adipose Tissue Communication with the Healthy and Pathological Heart

Michel, L. Y. M. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24097745 · Cited by 36

The Heartwarming Effect of Brown Adipose Tissue

Pinckard, K. M., & Stanford, K. I. (2021) · Molecular Pharmacology · doi:10.1124/molpharm.121.000328 · Cited by 33

ZFP423 controls EBF2 coactivator recruitment and PPARγ occupancy to determine the thermogenic plasticity of adipocytesPreprint

Shao, M., Zhang, Q., Truong, A., Shan, B., Vishvanath, L., Li, L., Seale, P., & Gupta, R. K. (2021) · Genes & Development · doi:10.1101/gad.348780.121 · Cited by 37

Crosstalk between fat tissue and muscle, brain, liver, and heart in obesity: cellular and molecular perspectives

Jia, Z., Wang, Z., Pan, H., Zhang, J., Wang, Q., Zhou, C., & Liu, J. (2024) · European journal of medical research · doi:10.1186/s40001-024-02176-w · Cited by 35

Diet Change Improves Obesity and Lipid Deposition in High-Fat Diet-Induced Mice

Ji, T., Fang, B., Wu, F., Liu, Y., Cheng, L., Li, Y., Wang, R., & Zhu, L. (2023) · Nutrients · doi:10.3390/nu15234978 · Cited by 38

Thermogenic adipose tissue in energy regulation and metabolic health

Xue, S., Lee, D. P. H., & Berry, D. C. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1150059 · Cited by 31

p21-activated kinase 4 counteracts PKA-dependent lipolysis by phosphorylating FABP4 and HSL

Yu, H. C., Jeon, Y. G., Na, A., Han, C. Y., Lee, M. R., Yang, J. D., Yu, H. C., Son, J. B., Kim, N. D., Kim, J. B., et al. (2024) · Nature Metabolism · doi:10.1038/s42255-023-00957-x · Cited by 30

Topical application of the pharmacological cold mimetic menthol stimulates brown adipose tissue thermogenesis through a TRPM8, UCP1, and norepinephrine dependent mechanism in mice housed at thermoneutrality

McKie, G. L., Medak, K. D., Shamshoum, H., & Wright, D. C. (2022) · The FASEB Journal · doi:10.1096/fj.202101905rr · Cited by 30

Paracrine Role of the Endothelium in Metabolic Homeostasis in Health and Nutrient Excess

Luk, C., Haywood, N. J., Bridge, K., & Kearney, M. T. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.882923 · Cited by 30

Glycerolipid Cycling in Thermogenesis, Energy Homeostasis, Signaling, and Diseases

Poursharifi, P., Madiraju, S. R. M., Oppong, A. K., Kajimura, S., Nolan, C. J., Blondin, D. P., & Prentki, M. (2025) · Physiological Reviews · doi:10.1152/physrev.00024.2024 · Cited by 29

Uncoupling Protein 1 Does Not Produce Heat without Activation

Li, Y., & Fromme, T. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23052406 · Cited by 34

Berberine as a multi-target therapeutic agent for obesity: from pharmacological mechanisms to clinical evidence

Kong, Y., Yang, H., Nie, R., Zhang, X., Zhang, H., & Nian, X. (2025) · European journal of medical research · doi:10.1186/s40001-025-02738-6 · Cited by 40

The evolutionary significance of human brown adipose tissue: Integrating the timescales of adaptation

Lévy, S., & Leonard, W. R. (2021) · Evolutionary Anthropology Issues News and Reviews · doi:10.1002/evan.21930 · Cited by 28

Increased postprandial nonesterified fatty acid efflux from adipose tissue in prediabetes is offset by enhanced dietary fatty acid adipose trapping

Montastier, É., Ye, R. Z., Noll, C., Bouffard, L., Fortin, M., Frisch, F., Phoenix, S., Guérin, B., Turcotte, É. E., Lewis, G. F., et al. (2021) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00619.2020 · Cited by 27

Intercellular and inter-organ crosstalk in browning of white adipose tissue: molecular mechanism and therapeutic complications

Cheong, L. Y., & Xu, A. (2021) · Journal of Molecular Cell Biology · doi:10.1093/jmcb/mjab038 · Cited by 28

The novel importance of miR-143 in obesity regulation

Liu, J., Wang, H., Zeng, D., Xiong, J., Luo, J., Chen, X., Chen, T., Xi, Q., Sun, J., Ren, X., et al. (2022) · International Journal of Obesity · doi:10.1038/s41366-022-01245-6 · Cited by 32

Human brown adipose tissue is not enough to combat cardiometabolic diseases

Carpentier, A. C., & Blondin, D. P. (2023) · Journal of Clinical Investigation · doi:10.1172/jci175288 · Cited by 28

β-Arrestins as Important Regulators of Glucose and Energy Homeostasis

Pydi, S. P., Barella, L. F., Zhu, L., Meister, J., Rossi, M., & Wess, J. (2021) · Annual Review of Physiology · doi:10.1146/annurev-physiol-060721-092948 · Cited by 25

The Adipose Tissue Macrophages Central to Adaptive Thermoregulation

Rahman, M. S., & Jun, H. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.884126 · Cited by 32

The Sympathetic Innervation of Adipose Tissues: Regulation, Functions, and Plasticity

Willows, J. W., Blaszkiewicz, M., & Townsend, K. L. (2023) · Comprehensive physiology · doi:10.1002/cphy.c220030 · Cited by 46

Beyond the Cold: Activating Brown Adipose Tissue as an Approach to Combat Obesity

Negroiu, C. E., Tudorașcu, I., Bezna, C. M., Godeanu, S., Diaconu, M., Dănoiu, R., & Dănoiu, S. (2024) · Journal of Clinical Medicine · doi:10.3390/jcm13071973 · Cited by 28

Therapeutic Perspectives of Thermogenic Adipocytes in Obesity and Related Complications

Wang, C., & Wei, Y. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22137177 · Cited by 28

Sympathetic Innervation of White Adipose Tissue: to Beige or Not to Beige?

Münzberg, H., Floyd, Z. E., & Chang, J. S. (2021) · Physiology · doi:10.1152/physiol.00038.2020 · Cited by 23

Influences of ovarian hormones on physiological responses to cold in women

Greenfield, A. M., Charkoudian, N., & Alba, B. K. (2021) · Temperature · doi:10.1080/23328940.2021.1953688 · Cited by 25

Brown Adipose Tissue: A Metabolic Regulator in a Hypothalamic Cross Talk?

Henningsen, J. B., & Schéele, C. (2020) · Annual Review of Physiology · doi:10.1146/annurev-physiol-032420-042950 · Cited by 24

Cold-induced expression of a truncated adenylyl cyclase 3 acts as rheostat to brown fat function

Khani, S., Topel, H., Kardinal, R., Tavanez, A. R., Josephrajan, A., Larsen, B. D., Gaudry, M. J., Leyendecker, P., Egedal, N. M., Güller, A. S., et al. (2024) · Nature Metabolism · doi:10.1038/s42255-024-01033-8 · Cited by 24

The (dys)regulation of energy storage in obesity

Levin, B. E., Geary, N., & Lutz, T. A. (2025) · Physiological Reviews · doi:10.1152/physrev.00002.2024 · Cited by 27

Thermogenic Fat: Development, Physiological Function, and Therapeutic Potential

Brandão, B. B., Poojari, A., & Rabiee, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22115906 · Cited by 25

Exercise-Induced Adipose Tissue Thermogenesis and Browning: How to Explain the Conflicting Findings?

Zhu, Y., Qi, Z., & Ding, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113142 · Cited by 27

Revisiting adipose thermogenesis for delaying aging and age-related diseases: Opportunities and challenges

Tarantini, S., Subramanian, M., Butcher, J. T., Yabluchanskiy, A., Li, X., Miller, R. A., & Balasubramanian, P. (2023) · Ageing Research Reviews · doi:10.1016/j.arr.2023.101912 · Cited by 24

Mapping the transcriptional landscape of human white and brown adipogenesis using single-nuclei RNA-seq

Gupta, A., Efthymiou, V., Kodani, S. D., Shamsi, F., Patti, M., Tseng, Y., & Streets, A. (2023) · Molecular Metabolism · doi:10.1016/j.molmet.2023.101746 · Cited by 23

Exploring the Frontiers of Cell Temperature Measurement and Thermogenesis

Zhu, H., Xu, H., Zhang, Y., Brodský, J., Gablech, I., Korabečná, M., & Neužil, P. (2024) · Advanced Science · doi:10.1002/advs.202402135 · Cited by 22

Stimulatory, but not anxiogenic, doses of caffeine act centrally to activate interscapular brown adipose tissue thermogenesis in anesthetized male rats

Schaik, L. V., Kettle, C., Green, R. A., Sievers, W., Hale, M. W., Irving, H. R., Whelan, D. R., & Rathner, J. A. (2021) · Scientific Reports · doi:10.1038/s41598-020-80505-9 · Cited by 23

Risks of Dementia After Treatment with an Anticholinergic, Beta-3 Agonist, or Combination of Both for an Overactive Bladder: A Korean National Cohort Study

Park, J. S., Choi, S. B., Jang, W. S., Kim, J., & Ham, W. S. (2024) · European Urology Focus · doi:10.1016/j.euf.2024.02.002 · Cited by 27

Pre-fertilization-origin preservation of brown fat-mediated energy expenditure in humans

Yoneshiro, T., Matsushita, M., Fuse-Hamaoka, S., Kuroiwa, M., Kurosawa, Y., Yamada, Y., Arai, M., Wei, Y., Iida, M., Kuma, K., et al. (2025) · Nature Metabolism · doi:10.1038/s42255-025-01249-2 · Cited by 24

Strength training alters the tissue fatty acids profile and slightly improves the thermogenic pathway in the adipose tissue of obese mice

de Melo, D. G., Anaruma, C. P., Rodrigues, K. C. D. C., Pereira, R. M., de Campos, T. D. P., Canciglieri, R. D. S., Ramos, C. O., Cintra, D. E., Ropelle, E. R., da Silva, A. S. R., et al. (2022) · Scientific Reports · doi:10.1038/s41598-022-10688-w · Cited by 26

Targeting skeletal muscle mitochondrial health in obesity

Pileggi, C. A., Hooks, B. G., McPherson, R., Dent, R. R. M., & Harper, M.-E. (2022) · Clinical Science · doi:10.1042/cs20210506 · Cited by 21

Genetic evidence for involvement of β2-adrenergic receptor in brown adipose tissue thermogenesis in humans

Ishida, Y., Matsushita, M., Yoneshiro, T., Saito, M., Fuse, S., Hamaoka, T., Kuroiwa, M., Tanaka, R., Kurosawa, Y., Nishimura, T., et al. (2024) · International Journal of Obesity · doi:10.1038/s41366-024-01522-6 · Cited by 21

GPCR in Adipose Tissue Function—Focus on Lipolysis

Malfacini, D., & Pfeifer, A. (2023) · Biomedicines · doi:10.3390/biomedicines11020588 · Cited by 21

Adipose tissue browning and thermogenesis under physiologically energetic challenges: a remodelled thermogenic system

Zhu, Y., Liu, W., & Qi, Z. (2023) · The Journal of Physiology · doi:10.1113/jp285269 · Cited by 22

Pioglitazone does not synergize with mirabegron to increase beige fat or further improve glucose metabolism

Finlin, B. S., Memetimin, H., Zhu, B., Confides, A. L., Vekaria, H. J., Khouli, R. H. E., Johnson, Z., Westgate, P. M., Chen, J., Morris, A. J., et al. (2021) · JCI Insight · doi:10.1172/jci.insight.143650 · Cited by 19

Human BAT Thermogenesis is Stimulated by the β 2-Adrenergic ReceptorPreprint

Blondin, D. P., Severinsen, M. C. K., Kuipers, E. N., Hirschberg, V., Miard, S., Jespersen, N. Z., Kooijman, S., Boon, M. R., Fortin, M., Phoenix, S., et al. (2019) · SSRN Electronic Journal · doi:10.2139/ssrn.3440265 · Cited by 2

β3-Adrenergic receptors regulate human brown/beige adipocyte lipolysis and thermogenesis

Cero, C., Lea, H. J., ZHU, K. Y., Shamsi, F., Tseng, Y., & Cypess, A. M. (2021) · JCI Insight · doi:10.1172/jci.insight.139160 · Cited by 250

Stimulation of the ß3-Adrenergic Receptor via Mirabegron Induces Lipolysis and Thermogenesis in Human Adipocytes

Cero, C., O’Mara, A. E., Johnson, J. W., Baskin, A. S., Linderman, J. D., & Cypess, A. M. (2018) · Diabetes · doi:10.2337/db18-2049-p · Cited by 3

2020-P: ß3-Adrenergic Receptors Regulate Lipolysis and Thermogenesis in Human Brown/Beige Adipocytes

Cero, C., Lea, H. J., ZHU, K. Y., & Cypess, A. M. (2020) · Diabetes · doi:10.2337/db20-2020-p · Cited by 8

Activation of Human Brown Adipose Tissue by a β3-Adrenergic Receptor Agonist

Cypess, A. M., Weiner, L. S., Roberts‐Toler, C., Franquet, E., Kessler, S., Kahn, P. A., English, J., Chatman, K., Trauger, S. A., Doria, A., et al. (2015) · Cell Metabolism · doi:10.1016/j.cmet.2014.12.009 · Cited by 1,053