Cited by 272COVID-19 Clinical Research StudiesSARS-CoV-2 and COVID-19 ResearchDiabetes, Cardiovascular Risks, and Lipoproteins

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Diabetes, obesity, metabolism, and SARS-CoV-2 infection: the end of the beginning

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Drucker, Daniel J.·2021·Cell Metabolism

DOI 10.1016/j.cmet.2021.01.016PMC PMC7825982

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Abstract

The increased prevalence of obesity, diabetes, and cardiovascular risk factors in people hospitalized with severe COVID-19 illness has engendered considerable interest in the metabolic aspects of SARS-CoV-2-induced pathophysiology. Here, I update concepts informing how metabolic disorders and their co-morbidities modify the susceptibility to, natural history, and potential treatment of SARS-CoV-2 infection, with a focus on human biology. New data informing genetic predisposition, epidemiology, immune responses, disease severity, and therapy of COVID-19 in people with obesity and diabetes are highlighted. The emerging relationships of metabolic disorders to viral-induced immune responses and viral persistence, and the putative importance of adipose and islet ACE2 expression, glycemic control, cholesterol metabolism, and glucose- and lipid-lowering drugs is reviewed, with attention to controversies and unresolved questions. Rapid progress in these areas informs our growing understanding of SARS-CoV-2 infection in people with diabetes and obesity, while refining the therapeutic strategies and research priorities in this vulnerable population.

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Additional file 1 of Obesity as a clinical predictor for severe manifestation of dengue: a systematic review and meta-analysis
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Additional file 4 of Obesity as a clinical predictor for severe manifestation of dengue: a systematic review and meta-analysis
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Additional file 2 of Modelling the potential acute and post-acute burden of COVID-19 under the Australian border re-opening plan
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Additional file 4 of Modelling the potential acute and post-acute burden of COVID-19 under the Australian border re-opening plan
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Additional file 5 of Obesity as a clinical predictor for severe manifestation of dengue: a systematic review and meta-analysis
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Additional file 2 of Obesity as a clinical predictor for severe manifestation of dengue: a systematic review and meta-analysis
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Authors: Drucker, D. J.
Affiliations: University of Toronto (CA)
Corresponding author: Drucker, Daniel J.
ORCID: Drucker, Daniel J.
Venue: Cell Metabolism
Publisher: Elsevier BV
Published: 2021-03
Volume: 33
Issue: 3
Pages: 479-498
ISSN: 1550-4131 (ISSN-L)
DOI: 10.1016/j.cmet.2021.01.016
PMC: PMC7825982
OpenAlex: W3124063857
Cited by: 272
References: 190
Citations by year: 2026: 16 · 2025: 25 · 2024: 38 · 2023: 49 · 2022: 86 · 2021: 58
FWCI: 6.76
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 366 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Cell Metabolism (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Canadian Institutes of Health Research (154321)
University of Toronto
Novo Nordisk
Novo Nordisk Fonden
Pfizer (GLP-2)
Topics: Health Sciences › Medicine › Infectious Diseases › COVID-19 Clinical Research Studies
Health Sciences › Medicine › Infectious Diseases › SARS-CoV-2 and COVID-19 Research
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
Keywords: SARS-CoV-2, COVID-19 pandemic, obesity, diabetes mellitus, metabolic disorders, ACE2 expression, adipose tissue, pancreatic islets, glycemic control, cholesterol metabolism, antidiabetic drugs, lipid-lowering drugs, immune response, viral persistence, disease severity, genetic susceptibility, comorbidities
MeSH terms: Heart Disease Risk Factors, Angiotensin-Converting Enzyme 2, COVID-19, SARS-CoV-2, COVID-19 Drug Treatment, Blood Glucose, Cholesterol, Diabetes Mellitus, Glucose, Humans, Hyperglycemia, Metabolic Diseases, Obesity, Comorbidity, Genetic Predisposition to Disease

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Diabetes, obesity, metabolism, and SARS-CoV-2 infection: the end of the beginning

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