The DOI matches its Crossref record; 69 of the 69 references it cites were found in a registry or an index.
Extracellular vesicle-based interorgan transport of mitochondria from energetically stressed adipocytes
Open accessAbstract
Summary: Adipocytes undergo intense energetic stress in obesity resulting in loss of mitochondrial mass and function. We have found that adipocytes respond to mitochondrial stress by rapidly and robustly releasing small extracellular vesicles (sEVs). These sEVs contain respiration-competent, but oxidatively-damaged mitochondrial particles, which enter circulation and are taken up by cardiomyocytes where they trigger a burst of ROS. The result is compensatory antioxidant signaling in the heart that protects cardiomyocytes from acute oxidative stress, consistent with a preconditioning paradigm. As such, a single injection of sEVs from energetically stressed adipocytes limits cardiac ischemia/reperfusion injury in mice. This study provides the first description of functional mitochondrial transfer between tissues and the first vertebrate example of “inter-organ mitohormesis”. Thus, these seemingly toxic adipocyte sEVs may provide a physiological avenue of potent cardio-protection against the inevitable lipotoxic or ischemic stresses elicited by obesity.
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Immune evasion through mitochondrial transfer in the tumour microenvironment
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Inter-organ crosstalk during development and progression of type 2 diabetes mellitus
Xourafa, G., Korbmacher, M., & Roden, M. (2024) · Nature Reviews Endocrinology · doi:10.1038/s41574-023-00898-1 · Cited by 274
Mitochondria are secreted in extracellular vesicles when lysosomal function is impaired
Liang, W., Sagar, S., Ravindran, R., Najor, R. H., Quiles, J. M., Chi, L., Diao, R. Y., Woodall, B. P., Leon, L. J., Zumaya, E., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-40680-5 · Cited by 273
Metadata
- Authors
- Crewe, C., Funcke, J.-B., Li, S., Joffin, N., Gliniak, C. M., Ghaben, A. L., An, Y. A., Sadek, H. A., Gordillo, R., Akgul, Y., Chen, S., Samovski, D., Fischer-Posovszky, P., Kusminski, C. M., Klein, S., & Scherer, P. E.
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2021-09
- Volume
- 33
- Issue
- 9
- Pages
- 1853-1868.e11
- ISSN
- 1550-4131 (ISSN-L)
- OpenAlex
- W3194808340
- Cited by
- 458
- References
- 69
- FWCI
- 17.44
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Crewe, C., Funcke, J.-B., Li, S., Joffin, N., Gliniak, C. M., Ghaben, A. L., An, Y. A., Sadek, H. A., Gordillo, R., Akgul, Y., Chen, S., Samovski, D., Fischer-Posovszky, P., Kusminski, C. M., Klein, S., & Scherer, P. E. (2021). Extracellular vesicle-based interorgan transport of mitochondria from energetically stressed adipocytes. Cell Metabolism. https://doi.org/10.1016/j.cmet.2021.08.002
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