Efferocytosis induces macrophage proliferation to help resolve tissue injury

Macrophage biology in development, homeostasis and disease

Wynn, T. A., Chawla, A., & Pollard, J. W. (2013) · Nature · doi:10.1038/nature12034 · Cited by 4,684

Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF.

Fadok, V. A., Bratton, D. L., Konowal, A., Freed, P. W., Westcott, J. Y., & Henson, P. M. (1998) · Journal of Clinical Investigation · doi:10.1172/jci1112 · Cited by 3,166

Identification of a Novel Inhibitor of Mitogen-activated Protein Kinase Kinase

Favata, M. F., Horiuchi, K. Y., Manos, E. J., Daulerio, A. J., Stradley, D. A., Feeser, W. S., Dyk, D. E. V., Pitts, W. J., Earl, R. A., Hobbs, F. W., et al. (1998) · Journal of Biological Chemistry · doi:10.1074/jbc.273.29.18623 · Cited by 3,016

Tissue-Resident Macrophages Self-Maintain Locally throughout Adult Life with Minimal Contribution from Circulating Monocytes

Hashimoto, D., Chow, A., Noizat, C., Teo, P., Beasley, M. B., Leboeuf, M., Becker, C. D., See, P., Price, J., Lucas, D., et al. (2013) · Immunity · doi:10.1016/j.immuni.2013.04.004 · Cited by 2,311

Immunosuppressive effects of apoptotic cells

Voll, R. E., Herrmann, M., Roth, E. A., Stach, C., Kalden, J. R., & Girkontaite, I. (1997) · Nature · doi:10.1038/37022 · Cited by 1,787

Immunometabolism governs dendritic cell and macrophage function

O'Neill, L. A. J., & Pearce, E. J. (2015) · The Journal of Experimental Medicine · doi:10.1084/jem.20151570 · Cited by 1,779

Local Macrophage Proliferation, Rather than Recruitment from the Blood, Is a Signature of T H 2 Inflammation

Jenkins, S. J., Rückerl, D., Cook, P. C., Jackson-Jones, L. H., Finkelman, F. D., van Rooijen, N., MacDonald, A. S., & Allen, J. E. (2011) · Science · doi:10.1126/science.1204351 · Cited by 1,404

Efferocytosis in health and disease

Doran, A. C., Yurdagul, A., & Tabas, I. (2020) · Nature Reviews Immunology · doi:10.1038/s41577-019-0240-6 · Cited by 1,066

Local proliferation dominates lesional macrophage accumulation in atherosclerosis

Robbins, C. S., Hilgendorf, I., Weber, G. F., Theurl, I., Iwamoto, Y., Figueiredo, J.-L., Gorbatov, R., Sukhova, G. K., Gerhardt, L. M. S., Smyth, D., et al. (2013) · Nature Medicine · doi:10.1038/nm.3258 · Cited by 1,041

Macrophage mediators and mechanisms in cardiovascular disease

Schelemei, P., Wagner, E., Picard, F. S. R., & Winkels, H. (2024) · The FASEB Journal · doi:10.1096/fj.202302001r · Cited by 23

The Role of Macrophage Efferocytosis in the Pathogenesis of Apical Periodontitis

Guan, X., Wang, Y., Li, W.-L., Mu, W., Tang, Y., Wang, M., Seyam, A., Yang, Y., Pan, L.-F., & Hou, T.-Z. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25073854 · Cited by 23

Efferocytosis and Its Role in Rheumatic Diseases

Tang, X., Peng, Y., Jiang, Z., Yu, B., Peng, D., Xie, X., Li, F., & Ge, Y. L. (2025) · Arthritis & Rheumatology · doi:10.1002/art.43268 · Cited by 21

MCTR3 reprograms arthritic monocytes to upregulate Arginase-1 and exert pro-resolving and tissue-protective functions in experimental arthritis

Pistorius, K., Ly, L., Souza, P. R., Gómez, E. A., Koenis, D. S., Rodrı́guez, A. R., Foster, J., Sosabowski, J. K., Hopkinson, M., Rajeeve, V., et al. (2022) · EBioMedicine · doi:10.1016/j.ebiom.2022.103974 · Cited by 20

The resolution of phagosomes

Mylvaganam, S., & Freeman, S. A. (2023) · Immunological Reviews · doi:10.1111/imr.13260 · Cited by 23

SHH induces macrophage oxidative phosphorylation and efferocytosis to promote scar formation

Zhang, J., He, Z., Xiong, C., Yao, Y., Zhang, C., Yao, W., Yang, S., Li, X., & Han, Y. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01692-w · Cited by 23

Efferocytosis: The Janus‐Faced Gatekeeper of Aging and Tumor Fate

Liu, Z., Li, Y., Ren, Y., Chen, J., Weng, S., Zhou, Z., Luo, P., Cheng, Q., Xu, H., Ba, Y., et al. (2025) · Aging Cell · doi:10.1111/acel.14467 · Cited by 21

Smtnl2 regulates apoptotic germ cell clearance and lactate metabolism in mouse Sertoli cells

Wu, D., Zhang, K., Khan, F. A., Pandupuspitasari, N. S., Liang, W., Huang, C., & Sun, F. (2022) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2022.111664 · Cited by 19

Ischemic Conditioning Promotes Transneuronal Survival and Stroke Recovery via CD36-Mediated Efferocytosis

Ju, H., Kim, I., Pavlova, I., Mu, S., Park, K. W., Minkler, J., Madkoor, A., Wang, W., Wang, X., Wu, Z., et al. (2025) · Circulation Research · doi:10.1161/circresaha.124.325428 · Cited by 21

Metabolic reprogramming in efferocytosis

Yan, Q., Li, K., Chen, L., Wang, A., Xi, Y., Xiao, H., & Yuan, L. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1677028 · Cited by 19

Deletion of myeloid HDAC3 promotes efferocytosis to ameliorate retinal ischemic injury

Shahror, R. A., Shosha, E., Morris, C., Wild, M., Mu, S., Csányi, G., Boerma, M., Rusch, N. J., & Fouda, A. Y. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03159-8 · Cited by 18

Ghost messages: cell death signals spread

Zhang, M., Lin, Y., Chen, R., Yu, H., Li, Y., Chen, M., Dou, C., Yin, P., Zhang, L., & Tang, P. (2023) · Cell Communication and Signaling · doi:10.1186/s12964-022-01004-0 · Cited by 18

Identification and validation of efferocytosis-related biomarkers for the diagnosis of metabolic dysfunction-associated steatohepatitis based on bioinformatics analysis and machine learning

Cao, C., Liu, W., Guo, X., Weng, S., Chen, Y., Luo, Y., Wang, S., Zhu, B., Liu, Y., & Peng, D. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1460431 · Cited by 16

A Critical Assessment of Fasting to Promote Metabolic Health and Longevity

Fazeli, P. K., & Steinhauser, M. L. (2025) · Endocrine Reviews · doi:10.1210/endrev/bnaf021 · Cited by 19

Manganese-Based Polyoxometalate Nanozyme-Metformin Co-functionalized Hydrogel Promotes Diabetic Wound Regeneration by Enhancing Phagocyte Efferocytosis

Li, L., Zhang, J., Yan, C., Wen, Y., Jia, L., Tang, X., Yong, Y., Jiang, K., Yang, H., Chen, L., et al. (2025) · Research · doi:10.34133/research.0964 · Cited by 18

Cross-comparison of systemic and tissue-specific metabolomes in a mouse model of Leigh syndrome

Terburgh, K., Lindeque, J. Z., van der Westhuizen, F. H., & Louw, R. (2021) · Metabolomics · doi:10.1007/s11306-021-01854-8 · Cited by 18

Myeloid Trem2 Dynamically Regulates the Induction and Resolution of Hepatic Ischemia-Reperfusion Injury Inflammation

Han, S., Li, X., Xia, N. L., Zhang, Y., Yu, W., Li, J., Jiao, C., Wang, Z., & Pu, L. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24076348 · Cited by 16

Efferocytosis: Current status and future prospects in the treatment of autoimmune diseases

Li, Q., Liu, H., Yin, G., & Xie, Q. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e28399 · Cited by 17

Lipid metabolism of apoptotic vesicles accelerates cutaneous wound healing by modulating macrophage function

Qin, Y., Chen, X., Bao, L., Ren, L., Dou, G., Lian, J., Xing, S., Li, Z., Ding, F., Qin, W., et al. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03194-4 · Cited by 15

Intercellular communication after myocardial infarction: Macrophage as the centerpiece

Li, A., Guo, K.-Z., Yu, L.-R., Ge, J., Zhou, W., & Zhang, J.-P. (2025) · Ageing Research Reviews · doi:10.1016/j.arr.2025.102757 · Cited by 17

Macrophage Efferocytosis as a Therapeutic Strategy in Intervertebral Disc Degeneration

Chen, S., Zhang, H., Wang, Z., Zhu, D., Li, Y., Zhang, Y., Wang, D., Chen, S.-W., Liu, H., & Kang, X. (2025) · Cell Proliferation · doi:10.1111/cpr.70068 · Cited by 15

Extracellular Vesicles from Compression‐Loaded Cementoblasts Promote the Tissue Repair Function of Macrophages

Yang, Y., Liu, H., Guo, K., Yu, Q., Zhao, Y., Wang, J., Huang, Y., & Li, W. (2024) · Advanced Science · doi:10.1002/advs.202402529 · Cited by 15

Challenges in Gaucher disease: Perspectives from an expert panel

Grabowski, G. A., Kishnani, P. S., Alcalay, R. N., Prakalapakorn, S. G., Rosenbloom, B. E., Tuason, D. A., & Weinreb, N. J. (2025) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2025.109074 · Cited by 17

Chemical substrate-enabled piezoelectric metabolic reprogramming therapy unlocks the vicious triad of diabetic wounds

Ge, M., Guo, Z., Ruan, Z., Ma, Y., Zhang, Z., Dong, H., Shi, T., Hu, T., Lu, L., Chen, Y., et al. (2025) · Cell Biomaterials · doi:10.1016/j.celbio.2025.100276 · Cited by 15

LPS exposure alleviates multiple tissues damage by facilitating macrophage efferocytosis

Han, Y., Hu, J., Pan, J., Song, X., Zhou, Y., Zhang, J., Yang, Y., Shi, X., Yang, J., & Sun, M. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112283 · Cited by 14

Atheroimmunology: keeping the immune system in atherosclerosis in check

Monaco, C. G., & Dib, L. H. (2024) · Nature Reviews Cardiology · doi:10.1038/s41569-024-01075-1 · Cited by 14

Extracellular vesicles as nanomaterial carriers: Endowing superior targeting capability and biosafety

Gui, H., Wang, W., Xue, Y., Zhao, W., Wang, M., Shi, L., & Wang, X. (2025) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2025.216784 · Cited by 15

Developmental endothelial locus 1: the present and future of an endogenous factor in vessels

Jiang, D., Yue, H., Liang, W., & Wu, Z. (2024) · Frontiers in Physiology · doi:10.3389/fphys.2024.1347888 · Cited by 13

Efferocytosis in tissue engineering: A comprehensive review of emerging therapeutic strategies for enhanced tissue repair and regeneration

Zhang, Y., Nie, R., Feng, Z.-Y., Fan, M., Shen, Z., Zhang, X., Zhang, Q., Zou, C., Zhang, J., Huang, K., et al. (2025) · Bioactive Materials · doi:10.1016/j.bioactmat.2025.05.026 · Cited by 13

Piezo1 Upregulation in Monocyte‐Derived Macrophages Impairs Post‐Myocardial Infarction Cardiac Repair via Defective Efferocytosis and Enhanced Ferroptosis

Lu, P., Xia, Y., Zhao, H., Guo, Y., Xu, X., Han, X., Wang, S., Ding, F., Liu, Q., Li, C., et al. (2025) · Advanced Science · doi:10.1002/advs.202510991 · Cited by 13

Inhibition of Cyclin-Dependent Kinase 9 Downregulates Cytokine Production Without Detrimentally Affecting Human Monocyte-Derived Macrophage Viability

McHugh, B. J., Stephen, J., Robb, C. T., Fox, S., Kipari, T. M. J., Cartwright, J. A., Haslett, C., Duffin, R., Lucas, C. D., & Rossi, A. G. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.905315 · Cited by 13

Cystathionine gamma-lyase (Cth) induces efferocytosis in macrophages via ERK1/2 to modulate intestinal barrier repair

Zhao, X., Yang, T., Zheng, M., Zhao, P., An, L., Qi, Y., Yi, K.-Q., Zhang, P.-C., & Sun, D. (2023) · Cell Communication and Signaling · doi:10.1186/s12964-022-01030-y · Cited by 13

Hydroxygenkwanin suppresses peritoneal metastasis in colorectal cancer by modulating tumor-associated macrophages polarization

Xun, J., Hu, Z., Wang, M., Jiang, X., Liu, B., Han, Y., Gao, R., Wu, X., Zhang, A., Yang, S., et al. (2024) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2024.111038 · Cited by 13

The TRIM28/miR133a/CD47 axis acts as a potential therapeutic target in pancreatic necrosis by impairing efferocytosis

Zhu, Q., Yuan, C., Wang, D., Tu, B., Chen, W., Dong, X., Wu, K., Tao, L., Ding, Y., Xiao, W., et al. (2024) · Molecular Therapy · doi:10.1016/j.ymthe.2024.06.005 · Cited by 14

Cytoskeletal orchestration of glucose uptake in Sertoli cell to support efferocytosis of apoptotic germ cells

Wu, D., Pandupuspitasari, N. S., Zhang, K., Tang, Y., Khan, F. A., Li, H., Huang, C., & Sun, F. (2023) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2023.119434 · Cited by 13

Macrophage efferocytosis mediated by the TP63-RAC2 pathway promotes immunosuppressive remodeling in esophageal cancer

Xi, Y., Zhao, Z., Zhou, Y., Yin, C., Li, Y., Xu, X., Jin, W., Lin, C., Zhao, K., Kuang, J., et al. (2026) · Cell Reports Medicine · doi:10.1016/j.xcrm.2025.102529 · Cited by 12

Efferocytosis in Health and Disease

Li, C., Yang, Y., Zhou, F., Jiang, Q., Jiang, Y., Huang, X., Zhang, Y., Ye, Z., Xu, G. X., Kao, G., et al. (2025) · MedComm · doi:10.1002/mco2.70546 · Cited by 15

Interaction of Macrophages with Bone Healing Microenvironment: Mechanism and Biomaterials

Lu, X., Gao, J., Bao, W., Xu, J., Sun, X., Wang, Y., & Li, B. (2023) · Tissue Engineering Part B Reviews · doi:10.1089/ten.teb.2023.0157 · Cited by 13

The efferocytosis process in aging: Supporting evidence, mechanisms, and therapeutic prospects for age-related diseases

Zhang, M., Wei, J., Sun, Y., He, C., Ma, S., Pan, X., & Zhu, X. (2024) · Journal of Advanced Research · doi:10.1016/j.jare.2024.03.008 · Cited by 15

The multifaceted functions of DNA‐PKcs: implications for the therapy of human diseases

Wu, J., Song, L., Lu, M., Gao, Q., Xu, S., Zhou, P., & Ma, T. (2024) · MedComm · doi:10.1002/mco2.613 · Cited by 11

Isoliquiritigenin alleviates SLC7A11-mediated efferocytosis inhibition to promote wounds healing in diabetes

Gong, X., Cai, J., Zheng, W., Huang, J., Chen, T., Chen, W., & Zheng, X. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117578 · Cited by 12

ApoEVs Transfer Mitochondrial Component to Modulate Macrophages in Periodontal Regeneration

Liu, X., Lyu, Y., Yu, Y., Wang, Z., Sun, Y., Li, M., Liang, C., Tian, W., & Liao, L. (2024) · Oral Diseases · doi:10.1111/odi.15181 · Cited by 12

A genome-wide CRISPR functional survey of the human phagocytosis molecular machinery

Essletzbichler, P., Sedlyarov, V., Frommelt, F., Soulat, D., Heinz, L. X., Stefanovic, A., Neumayer, B., & Superti‐Furga, G. (2023) · Life Science Alliance · doi:10.26508/lsa.202201715 · Cited by 13

Synergistic effect of CD47 blockade in combination with cordycepin treatment against cancer

Chen, F., Chen, R., Fang, W., Gao, X., Ying, H., Zheng, X., Chen, L., & Jiang, J. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1144330 · Cited by 12

MerTK-dependent efferocytosis by monocytic-MDSCs mediates resolution of ischemia/reperfusion injury after lung transplant

Leroy, V., Kollareth, D. J. M., Tu, Z., Valisno, J. A. C., Woolet-Stockton, M., Saha, B. K., Emtiazjoo, A. M., Rackauskas, M., Moldawer, L. L., Efron, P. A., et al. (2024) · JCI Insight · doi:10.1172/jci.insight.179876 · Cited by 15

Targeting Unc5b in macrophages drives atherosclerosis regression and pro-resolving immune cell function

Schlegel, M., Cyr, Y., Newman, A. A. C., Schreyer, K. F., Durán, J. G. B., Sharma, M., Bozal, F. K., Gourvest, M., Forest, M. L., Afonso, M. S., et al. (2024) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2412690121 · Cited by 12

Potentiating microglial efferocytosis by MFG ‐ E8 improves survival and neurological outcome after successful cardiopulmonary resuscitation in mice

Zhang, K., Zhang, Y., Li, Z., Chen, J., Chang, Y., Li, Y., Zeng, S., Pan, S., Pan, S., & Huang, K. (2024) · Brain Pathology · doi:10.1111/bpa.13327 · Cited by 11

Spontaneous Inflammation Resolution Inspired Nanoparticles Promote Neutrophil Apoptosis and Macrophage Efferocytosis for Acute Respiratory Distress Syndrome Treatment

Wang, Y., Zhang, L., Zhang, J., Yu, S., Li, W., Zhou, T., Xing, L., Jeong, J., & Jiang, H. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202402421 · Cited by 11

Macrophage‐Targeted Efferocytosis Therapy Promotes Diabetic Wound Healing via Cellular Level Debridement

Chen, Y., Chen, W., Ren, Y., Zhang, Y., Tan, Z., Huang, W., Bai, X., Yang, L., Liu, S., Guo, Q., et al. (2025) · Advanced Functional Materials · doi:10.1002/adfm.202503035 · Cited by 13

The trapping of live neutrophils by macrophages during infection

Cooper, K. N., Terekhova, M., Potempa, B. A., D’Aubeterre, A., Timbol, J., Chen, S. A., Dufour, A., Jin, S., Artyomov, M. N., Potempa, J., et al. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-07808-5 · Cited by 11

Ketogenic diet alleviates septic lung injury via microbial gut-lung axis

Wei, M., Yi, X., Lin, Z., Cai, J., Chen, S., Zhou, F., Cai, H., Lu, X., Tang, J., Shi, Y., et al. (2026) · Cell Metabolism · doi:10.1016/j.cmet.2026.01.005 · Cited by 11

Macrophage efferocytosis promotes inflammation resolution and accelerates wound healing

Gao, J., Zhu, D., Wang, J., Khan, M. I. U., Zhang, A., Wen, X., Li, Q., Jin, P., & Shen, C. (2026) · Communications Biology · doi:10.1038/s42003-026-10107-0 · Cited by 13

Corydalis decumbens Alleviates the Migration, Phagocytosis, and Inflammatory Response of Macrophages

Huang, S., Zheng, X., Dong, W., Lin, Y., Jiang, S., Zheng, H., & Qian, C. (2023) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2023/7000477 · Cited by 10

Osteopontin regulation of MerTK+ macrophages promotes Crohn’s disease intestinal fibrosis

Liu, J., Gong, W., Liu, P., Li, Y., Jiang, H., Wu, C., Wu, X., Zhao, Y., & Ren, J. (2024) · iScience · doi:10.1016/j.isci.2024.110226 · Cited by 11

c-Myc alone is enough to reprogram fibroblasts into functional macrophages

Li, S., Chen, G., Huang, X., Zhang, Y., Shen, S., Feng, H., & Li, Y. (2024) · Journal of Hematology & Oncology · doi:10.1186/s13045-024-01605-x · Cited by 10

TIMD4hiMHCⅡhi Macrophages Preserve Heart Function Through Retnla

Zhang, D., Wang, X., Zhu, L., Chen, Y., Yang, C., Zhong, Z., Kong, X., Nan, J., Wang, C., Hu, H., et al. (2024) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2024.08.009 · Cited by 10

Mechanistic insights into the regression of atherosclerotic plaques

Song, J., Cao, C., Wang, Z., Li, H., Yang, L., Kang, J., Meng, H., Li, L., & Liu, J. (2024) · Frontiers in Physiology · doi:10.3389/fphys.2024.1473709 · Cited by 12

USP7 Inhibition Promotes Early Osseointegration in Senile Osteoporotic Mice

Zhou, F., Wang, Z., Li, H., Wang, D., Wu, C.-T., Bai, F., Wang, Q., Luo, W., Zhang, G., Xiong, Y., et al. (2024) · Journal of Dental Research · doi:10.1177/00220345241288570 · Cited by 11

Friend or foe: the role of platelets in acute lung injury

Yang, J., Zhou, X., Qiao, X., & Shi, M. Q. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1556923 · Cited by 11

Transglutaminase 2 function in glioblastoma tumor efferocytosis

Lui, M., Sevinc, F., Elgafarawi, M., Muñoz, D. G., Keillor, J. W., Sinclair, J., Catana, D., Alhuthayl, M., Woulfe, J., & Lorimer, I. A. J. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-07819-2 · Cited by 11

Smart responsive biomaterials for spatiotemporal modulation of functional tissue repair

He, X., Han, Z., Ruan, Y., Wang, Z., Liao, B., Li, X., Tan, J., Han, X., Shen, J., & Bai, D. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.102063 · Cited by 14

Macrophage malfunction in Triptolide-induced indirect hepatotoxicity

Qin, T., Hasnat, M., Zhou, Y., Yuan, Z., & Zhang, W. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.981996 · Cited by 10

Ultrasound‐Driven Electric Conversion Hydrogel Coating Enhances Macrophage Efferocytosis for Non‐Invasive Skin Expansion

Zhao, Y., Wang, F., Li, M., Chen, M., Wang, J., Xiang, H., Mao, J., Wei, X., Xia, W., Zan, T., et al. (2025) · Advanced Functional Materials · doi:10.1002/adfm.202424713 · Cited by 9

CXCL12/CXCR4 modulates macrophage efferocytosis to induce glomerular crescent formation and fibrosis via ELMO1/DOCK180/RAC1 signaling in ANCA-associated glomerulonephritis

Li, H., Deng, Y., Song, X., Cai, X., Xiong, H.-Y., Tan, L., Wei, S., Li, Q., Wang, X., Jiang, W., et al. (2025) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-025-05750-5 · Cited by 10

Antibiotic‐mediated immune modulation in periodontitis

Suárez, L. J., Arce, R. M., Furquim, C. P., Gonçalves, C., Kantarcı, A., Feres, M., & dos Santos, N. C. C. (2025) · Periodontology 2000 · doi:10.1111/prd.70011 · Cited by 9

Macrophage WDFY3 mitigates autoimmunity by enhancing efferocytosis and suppressing T cell activation in mice

Wu, X., Wang, Z., Croce, K. R., Li, F., Cui, J. G., D’Agati, V. D., Soni, R. K., Khalid, S., Saleheen, D., Tabas, I., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-63741-3 · Cited by 10

The Dual Role of Macrophages in MIRI and MI by Immunity and Inflammation: Damage, Repair, Crosstalk, and Therapy

Miao, Z., Leung, Y., Fu, Y., Luo, L., Liu, Q., Liao, J., Xu, J., Song, Q., Huang, S., & Wu, Z. (2025) · Mediators of Inflammation · doi:10.1155/mi/9912957 · Cited by 9

Phagocytosis by macrophages promotes pancreatic β cell mass reduction after parturition in mice

Endo, A., Imai, J., Izumi, T., Kawana, Y., Sugawara, H., Kohata, M., Seike, J., Kubo, H., Komamura, H., Sato, T., et al. (2023) · Developmental Cell · doi:10.1016/j.devcel.2023.08.002 · Cited by 9

Development of synthetic lipoxin-A4 mimetics (sLXms): New avenues in the treatment of cardio-metabolic diseases

de Gaetano, M. (2022) · Seminars in Immunology · doi:10.1016/j.smim.2022.101699 · Cited by 9

Different bacterial cargo in apoptotic cells drive distinct macrophage phenotypes

Salina, A. C. G., Penteado, L. D. A., Dejani, N. N., Silva-Pereira, L., Raimundo, B. V. B., Corrêa, G. F., Oliveira, K. C., Ramalho, L. N. Z., Boko, M. M. M., Bonato, V. L. D., et al. (2023) · APOPTOSIS · doi:10.1007/s10495-023-01899-1 · Cited by 8

Longitudinal single-cell data informs deterministic modelling of inflammatory bowel disease

Kilian, C., Ulrich, H., Zouboulis, V. A., Sprezyna, P., Schreiber, J., Landsberger, T., Büttner, M., Biton, M., Villablanca, E. J., Huber, S., et al. (2024) · npj Systems Biology and Applications · doi:10.1038/s41540-024-00395-9 · Cited by 8

CXCR2 mediated trafficking of neutrophils and neutrophil extracellular traps are required for myelin clearance after a peripheral nerve injury

Balog, B. M., Niemi, J. P., Disabato, T., Hashim, F., & Zigmond, R. E. (2024) · Experimental Neurology · doi:10.1016/j.expneurol.2024.114985 · Cited by 8

The interplay between host immunity and Clostridioides difficile infection

Li, D., & Saavedra, P. H. V. (2025) · mBio · doi:10.1128/mbio.03562-24 · Cited by 9

The multifaceted role of macrophages in kidney physiology and diseases

Ma, Y., Yang, F., Yang, J., Wang, K., Hu, J., & Wu, Q. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1642525 · Cited by 12

More Than a Cleanup Crew: The Expanding Biology of Efferocytosis

Pandit, R., Hillman, H., Williams, J. W., & Yurdagul, A. (2025) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.125.323211 · Cited by 8

Modulation of oxidized low-density lipoprotein-affected macrophage efferocytosis by mitochondrial calcium uniporter in a murine model

Lu, N., Zhu, J.-F., Lv, H., Zhang, H., Wang, P.-L., Yang, J., & Wang, X. (2023) · Immunology Letters · doi:10.1016/j.imlet.2023.09.003 · Cited by 9

Enucleated bone marrow-derived mesenchymal stromal cells regulate immune microenvironment and promote testosterone production through efferocytosis

Sun, L., Huang, J., Wang, X., Huang, P., Dong, B., Liang, Z., Wu, J., & Wang, J. (2025) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-025-01352-9 · Cited by 8

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Saadh, M. J., Ahmed, H. M., Alani, Z. K., Zuhairi, R. A. H. A., Almarhoon, Z. M., Ahmad, H., Ubaid, M., & Alwan, N. H. (2024) · NeuroMolecular Medicine · doi:10.1007/s12017-024-08783-4 · Cited by 8

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Zhu, G., Wan, X., Wu, W., Jia, L., Yu, X., Mo, H., Wang, X., Zhou, Q., Tang, Q., & Wang, S. (2025) · Small Science · doi:10.1002/smsc.202400479 · Cited by 7

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Zhang, S., Li, L., Li, J., Ruan, S., Zuo, A., Lei, S., & Guo, Y. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.115056 · Cited by 7

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Zhao, X. R., Li, M., Li, J., Han, Y., Gong, Y., Zhang, Z., Shi, J., Jin, C., Liu, J., & Si, P. (2025) · Advanced Science · doi:10.1002/advs.202502876 · Cited by 7

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Huang, M., Lan, M., Liu, X., Lin, C., Zeng, L., Li, Y., Li, F., Dou, X., Zhao, Y., Shi, Y., et al. (2025) · Chinese Medicine · doi:10.1186/s13020-025-01216-9 · Cited by 7

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Wang, Z., Xie, G., Xie, Y., Hu, M., Hu, Q., Yang, M., Zhang, L., Zhu, J., & Zhang, C. (2024) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.154207 · Cited by 7

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Wang, J., Li, M., Zhao, B.-C., Chang, R., Wu, W., Zhang, H., Usman, M., Loor, J. J., & Xu, C. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c09164 · Cited by 6

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David, C., Verney, C., Si‐Tahar, M., & Guillon, A. (2025) · Cytokine · doi:10.1016/j.cyto.2025.156902 · Cited by 7

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Zhou, Y., Yang, Z., Wang, Y., Dong, Y., Wang, T., Li, Y., Liang, C., Liu, Y., Li, Z., Liu, S., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-60920-0 · Cited by 6

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Sauer, J., Schloesser, D., Koeppen, K., Fundel‐Clemens, K., Simone-Roach, C., Hall, K., Ivovic, A., Makings, J., Reiss, D., Traub, M., et al. (2025) · The Journal of Immunology · doi:10.1093/jimmun/vkaf184 · Cited by 6

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Tu, M., Zou, X., Tan, X., Liu, Y., Ge, X., Hu, Y., Peng, Q., Huang, L., Zeng, Y., Jia, C., et al. (2025) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2024.0579 · Cited by 6

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Li, W., Ying, F., Pang, X., Wu, Q., Li, G., Huang, L., Xin, J., Liu, X., Liu, P., Xu, X., et al. (2025) · Advanced Science · doi:10.1002/advs.202512508 · Cited by 6

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Hardaway, B. D., Fidler, T. P., Tavallaie, M. S., Hsu, C.-C., Schiavone, S., Xiao, T., Wang, R., Wang, N., & Tall, A. R. (2026) · Journal of Lipid Research · doi:10.1016/j.jlr.2026.101003 · Cited by 6

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Steinhauser, M. L., & Maron, B. A. (2024) · JACC Basic to Translational Science · doi:10.1016/j.jacbts.2024.04.009 · Cited by 6

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Ao, Y., Guo, Y., Zhang, Y., Xie, L., Xia, R., Xu, J., Shi, M., Gao, X., Yu, X., & Chen, Z. (2024) · Advanced Science · doi:10.1002/advs.202403921 · Cited by 6

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Shen, X., Chen, Y., Yu, L., Zheng, J., Shang, S., & Wang, J. (2025) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.2025.j036 · Cited by 5

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Liu, J.-Y., Luo, J.-F., Wu, X., Liu, T., Wang, R., Zhang, Q., Liu, Y.-M., & Wu, H. (2025) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2025.167916 · Cited by 5

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Zheng, T., Sun, C., Yun, C., Wang, H., & Liu, X. (2025) · Cancers · doi:10.3390/cancers17172787 · Cited by 7

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Baxter, A. A., Poon, I. K. H., & Karunakaran, D. (2025) · Current Opinion in Lipidology · doi:10.1097/mol.0000000000001010 · Cited by 5

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Sun, Y.-L., Guo, H.-Y., Bai, Y., Chen, J., & Li, Y.-H. (2025) · Genes and Diseases · doi:10.1016/j.gendis.2025.101937 · Cited by 8

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Lorimer, I. A. J. (2024) · Neuro-Oncology Advances · doi:10.1093/noajnl/vdae012 · Cited by 6

Transient efferocytosis-induced activation of IKKβ reprograms macrophages to promote tissue resolution in mice

Ngai, D., Chowdhury, S., Sukka, S. R., Kuriakose, G., Havens, B. T., Yalçınkaya, M., Frey, J. M., Doviak, H., Bradford, J. W., Dorweiler, B., et al. (2026) · Nature Communications · doi:10.64898/2026.04.27.720940

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Ampomah, P. B., Cai, B., Sukka, S. R., Gerlach, B. D., Yurdagul, A., Wang, X., Kuriakose, G., Darville, L. N. F., Sun, Y., Sidoli, S., et al. (2022) · Nature Metabolism · doi:10.1038/s42255-022-00551-7 · Cited by 180

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Schilperoort, M., Ngai, D., Sukka, S. R., Avrampou, K., Shi, H., & Tabas, I. A. (2023) · Immunological Reviews · doi:10.1111/imr.13214 · Cited by 184

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Ngai, D., Schilperoort, M., & Tabas, I. A. (2023) · Nature Metabolism · doi:10.1038/s42255-023-00921-9 · Cited by 103

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Kourtzelis, I., Hajishengallis, G., & Chavakis, T. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.00553 · Cited by 321