Immunosuppressive effects of apoptotic cells

Interleukin-10 and the Interleukin-10 Receptor

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Immunogenic cell death and DAMPs in cancer therapy

Krysko, D. V., Garg, A. D., Kaczmarek, A., Krysko, O., Agostinis, P., & Vandenabeele, P. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3380 · Cited by 3,223 · see citing works

Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy

Hotchkiss, R. S., Monneret, G., & Payen, D. (2013) · Nature Reviews Immunology · doi:10.1038/nri3552 · Cited by 2,772 · see citing works

Resolution of inflammation: the beginning programs the end

Serhan, C. N., & Savill, J. (2005) · Nature Immunology · doi:10.1038/ni1276 · Cited by 2,552 · see citing works

The metabolic signature of macrophage responses

Viola, A., Munari, F., Sánchez-Rodríguez, R., Scolaro, T., & Castegna, A. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01462 · Cited by 2,021 · see citing works

Low-density lipoproteins cause atherosclerotic cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus statement from the European Atherosclerosis Society Consensus Panel

Borén, J., Chapman, M. J., Krauss, R. M., Packard, C. J., Bentzon, J. F., Binder, C. J., Daemen, M. J., Demer, L. L., Hegele, R. A., Nicholls, S. J., et al. (2020) · European Heart Journal · doi:10.1093/eurheartj/ehz962 · Cited by 1,601 · see citing works

Inflammation in Neurodegenerative Disease—A Double-Edged Sword

Wyss-Coray, T., & Mucke, L. (2002) · Neuron · doi:10.1016/s0896-6273(02)00794-8 · Cited by 1,235 · see citing works

Immature Dendritic Cells Phagocytose Apoptotic Cells via αvβ5 and CD36, and Cross-present Antigens to Cytotoxic T Lymphocytes

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Immunogenic and tolerogenic cell death

Green, D. R., Ferguson, T., Zitvogel, L., & Kroemer, G. (2009) · Nature Reviews Immunology · doi:10.1038/nri2545 · Cited by 1,176 · see citing works

Clearance of apoptotic neurons without inflammation by microglial triggering receptor expressed on myeloid cells-2

Takahashi, K., Rochford, C. D. P., & Neumann, H. (2005) · The Journal of Experimental Medicine · doi:10.1084/jem.20041611 · Cited by 1,124 · see citing works

Efferocytosis in health and disease

Doran, A. C., Yurdagul, A., & Tabas, I. (2020) · Nature Reviews Immunology · doi:10.1038/s41577-019-0240-6 · Cited by 1,066 · see citing works

Phagocyte partnership during the onset and resolution of inflammation

Soehnlein, O., & Lindbom, L. (2010) · Nature Reviews Immunology · doi:10.1038/nri2779 · Cited by 1,054 · see citing works

Macrophage Polarization in Physiological and Pathological Pregnancy

Yao, Y., Xu, X.-H., & Jin, L. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00792 · Cited by 825 · see citing works

A Null Mutation in Murine CD36 Reveals an Important Role in Fatty Acid and Lipoprotein Metabolism

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Phagocytosis and the actin cytoskeleton

May, R. C., & Machesky, L. M. (2001) · Journal of Cell Science · doi:10.1242/jcs.114.6.1061 · Cited by 715 · see citing works

Macrophage Dysfunction Impairs Resolution of Inflammation in the Wounds of Diabetic Mice

Khanna, S., Biswas, S., Shang, Y., Collard, E., Azad, A., Kauh, C., Bhasker, V., Gordillo, G. M., Sen, C. K., & Roy, S. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009539 · Cited by 694 · see citing works

HMGB1: A multifunctional alarmin driving autoimmune and inflammatory disease

Harris, H. E., Andersson, U., & Pisetsky, D. S. (2012) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2011.222 · Cited by 689 · see citing works

Suppression of Interleukin-33 Bioactivity through Proteolysis by Apoptotic Caspases

Lüthi, A. U., Cullen, S. P., McNeela, E. A., Duriez, P. J., Afonina, I. S., Sheridan, C., Brumatti, G., Taylor, R. C., Kersse, K., Vandenabeele, P., et al. (2009) · Immunity · doi:10.1016/j.immuni.2009.05.007 · Cited by 677 · see citing works

Para-Inflammation in the Aging Retina

Xu, H., Chen, M., & Forrester, J. V. (2009) · Progress in Retinal and Eye Research · doi:10.1016/j.preteyeres.2009.06.001 · Cited by 659 · see citing works

Phagocytosis

Stuart, L. M., & Ezekowitz, R. A. B. (2005) · Immunity · doi:10.1016/j.immuni.2005.05.002 · Cited by 667 · see citing works

TNF and increased intracellular iron alter macrophage polarization to a detrimental M1 phenotype in the injured spinal cord

Kroner, A., Greenhalgh, A. D., Zarruk, J. G., Passos dos Santos, R., Gaestel, M., & David, S. (2014) · Neuron · doi:10.1016/j.neuron.2014.07.027 · Cited by 655 · see citing works

Adiponectin Promotes Macrophage Polarization toward an Anti-inflammatory Phenotype

Ohashi, K., Parker, J. L., Ouchi, N., Higuchi, A., Vita, J. A., Gokce, N., Pedersen, A. A., Kalthoff, C., Tullin, S., Sams, A., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.088708 · Cited by 646 · see citing works

Janus-faced microglia: beneficial and detrimental consequences of microglial phagocytosis

Sierra, A., Abiega, O., Shahraz, A., & Neumann, H. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00006 · Cited by 574 · see citing works

Beginnings of a Good Apoptotic Meal: The Find-Me and Eat-Me Signaling Pathways

Ravichandran, K. S. (2011) · Immunity · doi:10.1016/j.immuni.2011.09.004 · Cited by 559 · see citing works

The Role of Complement in the Development of Systemic Lupus Erythematosus

Manderson, A. P., Botto, M., & Walport, M. J. (2004) · Annual Review of Immunology · doi:10.1146/annurev.immunol.22.012703.104549 · Cited by 538 · see citing works

Clearance of apoptotic neutrophils and resolution of inflammation

Greenlee‐Wacker, M. C. (2016) · Immunological Reviews · doi:10.1111/imr.12453 · Cited by 478 · see citing works

TREM2-Transduced Myeloid Precursors Mediate Nervous Tissue Debris Clearance and Facilitate Recovery in an Animal Model of Multiple Sclerosis

Takahashi, K., Prinz, M., Stagi, M., Chechneva, O., & Neumann, H. (2007) · PLoS Medicine · doi:10.1371/journal.pmed.0040124 · Cited by 414 · see citing works

Neutrophils in innate host defense against Staphylococcus aureus infections

Rigby, K. M., & DeLeo, F. R. (2012) · Seminars in Immunopathology · doi:10.1007/s00281-011-0295-3 · Cited by 400 · see citing works

Molecular Mechanisms of Radiation-Induced Cancer Cell Death: A Primer

Sia, J., Szmyd, R., Hau, E., & Gee, H. E. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00041 · Cited by 378 · see citing works

PPAR-δ senses and orchestrates clearance of apoptotic cells to promote tolerance

Mukundan, L., Odegaard, J. I., Morel, C. R., Heredia, J. E., Mwangi, J. W., Ricardo-Gonzalez, R. R., Goh, Y. P. S., Eagle, A. R., Dunn, S. E., Awakuni, J. U. H., et al. (2009) · Nature Medicine · doi:10.1038/nm.2048 · Cited by 368 · see citing works

Innate immune recognition of infected apoptotic cells directs TH17 cell differentiation

Torchinsky, M. B., Garaude, J., Martin, A. P., & Blander, J. M. (2009) · Nature · doi:10.1038/nature07781 · Cited by 364 · see citing works

Efferocytosis induces macrophage proliferation to help resolve tissue injury

Gerlach, B. D., Ampomah, P. B., Yurdagul, A., Liu, C., Lauring, M. C., Wang, X., Kasikara, C., Kong, N., Shi, J., Tao, W., et al. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2021.10.015 · Cited by 360 · see citing works

Chemokines in cancer

Vicari, A. P., & Caux, C. (2002) · Cytokine & Growth Factor Reviews · doi:10.1016/s1359-6101(01)00033-8 · Cited by 351 · see citing works

Engulfment of Apoptotic Cells by Macrophages: A Role of MicroRNA-21 in the Resolution of Wound Inflammation

Das, A., Ganesh, K., Khanna, S., Sen, C. K., & Roy, S. (2014) · The Journal of Immunology · doi:10.4049/jimmunol.1300613 · Cited by 320 · see citing works

Mechanisms and Consequences of Defective Efferocytosis in Atherosclerosis

Yurdagul, A., Doran, A. C., Cai, B., Fredman, G., & Tabas, I. A. (2018) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2017.00086 · Cited by 300 · see citing works

The regulatory role of nitric oxide in proinflammatory cytokine expression during the induction and resolution of inflammation

Kobayashi, Y. (2010) · Journal of Leukocyte Biology · doi:10.1189/jlb.0310149 · Cited by 306 · see citing works

Mesenchymal stromal cell apoptosis is required for their therapeutic function

Pang, S. H. M., D’Rozario, J., Mendonca, S., Bhuvan, T., Payne, N. L., Zheng, D., Hisana, A., Wallis, G., Barugahare, A., Powell, D., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-26834-3 · Cited by 245 · see citing works

Molecular Mechanisms of UV-Induced Apoptosis and Its Effects on Skin Residential Cells: The Implication in UV-Based Phototherapy

Lee, C.-H., Wu, S.-B., Hong, C.-H., Yu, H.-S., & Wei, Y.-H. (2013) · International Journal of Molecular Sciences · doi:10.3390/ijms14036414 · Cited by 271 · see citing works

Macrophages Acquire Neutrophil Granules for Antimicrobial Activity against Intracellular Pathogens

Tan, B. H., Meinken, C., Bastian, M., Bruns, H., Legaspi, A., Ochoa, M. T., Krutzik, S. R., Bloom, B. R., Ganz, T., Modlin, R. L., et al. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.3.1864 · Cited by 267 · see citing works

Vascular Smooth Muscle Cell Apoptosis Induces Interleukin-1–Directed Inflammation: Effects of Hyperlipidemia-Mediated Inhibition of Phagocytosis

Clarke, M. C. H., Talib, S., Figg, N. L., & Bennett, M. R. (2010) · Circulation Research · doi:10.1161/circresaha.109.208389 · Cited by 216 · see citing works

Autophagy within the antigen donor cell facilitates efficient antigen cross-priming of virus-specific CD8+ T cells

Uhl, M., Kepp, O., Jusforgues-Saklani, H., Vicencio, J.-M., Kroemer, G., & Albert, M. L. (2009) · Cell Death & Differentiation · doi:10.1038/cdd.2009.8 · Cited by 196 · see citing works

Apoptotic interactions of cytochrome c: Redox flirting with anionic phospholipids within and outside of mitochondria

Bayir, H., Fadeel, B., Palladino, M. J., Witasp, E., Kurnikov, I. V., Tyurina, Y. Y., Tyurin, V. A., Amoscato, A. A., Jiang, J., Kochanek, P. M., et al. (2006) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2006.03.002 · Cited by 175 · see citing works

Innate Immunity in the Persistent Inflammation, Immunosuppression, and Catabolism Syndrome and Its Implications for Therapy

Horiguchi, H., Loftus, T. J., Hawkins, R. B., Raymond, S. L., Stortz, J. A., Hollen, M. K., Weiss, B. P., Miller, E. S., Bihorac, A., Larson, S. D., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00595 · Cited by 164 · see citing works

Differential Regulation and Function of the Fas/Fas Ligand System in Human Trophoblast Cells1

Aschkenazi, S., Straszewski, S., Verwer, K. M. A., Foellmer, H., Rutherford, T., & Mor, G. (2002) · Biology of Reproduction · doi:10.1095/biolreprod66.6.1853 · Cited by 161 · see citing works

Regulation of Microglial Phagocytosis and Inflammatory Gene Expression by Gas6 Acting on the Axl/Mer Family of Tyrosine Kinases

Grommes, C., Lee, C. Y. D., Wilkinson, B. L., Jiang, Q., Koenigsknecht-Talboo, J. L., Varnum, B., & Landreth, G. E. (2008) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-007-9090-2 · Cited by 162 · see citing works

Enhanced Apoptotic Cell Clearance Capacity and B Cell Survival Factor Production by IL-10-Activated Macrophages: Implications for Burkitt’s Lymphoma

Ogden, C. A., Pound, J. D., Batth, B. K., Owens, S., Johannessen, I., Wood, K., & Gregory, C. D. (2005) · The Journal of Immunology · doi:10.4049/jimmunol.174.5.3015 · Cited by 147 · see citing works

Extracellular Matrix Cues Regulate Mechanosensing and Mechanotransduction of Cancer Cells

Mierke, C. T. (2024) · Cells · doi:10.3390/cells13010096 · Cited by 146 · see citing works

How neutrophils meet their end

Lawrence, S. M., Corriden, R., & Nizet, V. (2020) · Trends in Immunology · doi:10.1016/j.it.2020.03.008 · Cited by 144 · see citing works

Regulation of efferocytosis as a novel cancer therapy

Zhou, Y., Yao, Y., Deng, Y., & Shao, A. (2020) · Cell Communication and Signaling · doi:10.1186/s12964-020-00542-9 · Cited by 100 · see citing works

Apoptotic cell identity induces distinct functional responses to IL-4 in efferocytic macrophages

Liebold, I., Al Jawazneh, A., Casar, C., Lanzloth, C., Leyk, S., Hamley, M., Wong, M. N., Kylies, D., Gräfe, S. K., Edenhofer, I., et al. (2024) · Science · doi:10.1126/science.abo7027 · Cited by 96 · see citing works

The many ways tissue phagocytes respond to dying cells

Blander, J. M. (2017) · Immunological Reviews · doi:10.1111/imr.12537 · Cited by 84 · see citing works

A paradox of immunodeficiency and inflammation in human aging: lessons learned from apoptosis

Gupta, S., Agrawal, A., Agrawal, S., Su, H., & Gollapudi, S. (2006) · Immunity & Ageing · doi:10.1186/1742-4933-3-5 · Cited by 77 · see citing works

Inactivation of Transcription Factor Gene <i>ACE2</i> in the Fungal Pathogen <i>Candida glabrata</i> Results in Hypervirulence

Kamran, M., Calcagno, A.-M., Findon, H., Bignell, E., Jones, M. D., Warn, P., Hopkins, P., Denning, D. W., Butler, G., Rogers, T., et al. (2004) · Eukaryotic Cell · doi:10.1128/ec.3.2.546-552.2004 · Cited by 75 · see citing works

Tethering of Apoptotic Cells to Phagocytes through Binding of CD47 to Src Homology 2 Domain-Bearing Protein Tyrosine Phosphatase Substrate-1

Tada, K., Tanaka, M., Hanayama, R., Miwa, K., Shinohara, A., Iwamatsu, A., & Nagata, S. (2003) · The Journal of Immunology · doi:10.4049/jimmunol.171.11.5718 · Cited by 70 · see citing works

Eating the dead to keep atherosclerosis at bay

Brophy, M. L., Dong, Y., Wu, H., Rahman, H. N. A., Song, K., & Chen, H. (2017) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2017.00002 · Cited by 68 · see citing works

Differential Effects of p38, MAPK, PI3K or Rho Kinase Inhibitors on Bacterial Phagocytosis and Efferocytosis by Macrophages in COPD

Bewley, M. A., Belchamber, K. B. R., Chana, K. K., Budd, R. C., Donaldson, G., Wedzicha, J. A., Brightling, C. E., Kilty, I., Donnelly, L. E., Barnes, P. J., et al. (2016) · PLOS ONE · doi:10.1371/journal.pone.0163139 · Cited by 64 · see citing works

TREM2 Regulates the Removal of Apoptotic Cells and Inflammatory Processes during the Progression of NAFLD

Liebold, I., Meyer, S., Heine, M., Kuhl, A., Witt, J., Eissing, L., Fischer, A., Koop, A., Kluwe, J., Schulze zur Wiesch, J., et al. (2023) · Cells · doi:10.3390/cells12030341 · Cited by 55 · see citing works

Immunization with an Apoptotic Cell-Binding Protein Recapitulates the Nephritis and Sequential Autoantibody Emergence of Systemic Lupus Erythematosus

Levine, J. S., Subang, R., Nasr, S. H., Fournier, S., Lajoie, G., Wither, J., & Rauch, J. (2006) · The Journal of Immunology · doi:10.4049/jimmunol.177.9.6504 · Cited by 51 · see citing works

Secondary necrosis of apoptotic neutrophils induced by the human cathelicidin LL-37 is not proinflammatory to phagocytosing macrophages

Li, H.-N., Barlow, P. G., Bylund, J., Mackellar, A., Björstad, Å., Conlon, J., Hiemstra, P. S., Haslett, C., Gray, M., Simpson, A. J., et al. (2009) · Journal of Leukocyte Biology · doi:10.1189/jlb.0209050 · Cited by 49 · see citing works