The DOI matches its Crossref record; 112 of the 112 references it cites were found in a registry or an index.
Why does obesity cause diabetes?
Open accessAbstract
The accumulation of an excessive amount of body fat can cause type 2 diabetes, and the risk of type 2 diabetes increases linearly with an increase in body mass index. Accordingly, the worldwide increase in the prevalence of obesity has led to a concomitant increase in the prevalence of type 2 diabetes. The cellular and physiological mechanisms responsible for the link between obesity and type 2 diabetes are complex and involve adiposity-induced alterations in β cell function, adipose tissue biology, and multi-organ insulin resistance, which are often ameliorated and can even be normalized with adequate weight loss.
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“It has also been shown to reduce both quality of life and life expectancy (2).”
From The Benefits of Exercise Training in Combination With Weight Loss Therapies (2025) · cites this paper as [2]
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Cites
Obesity is associated with macrophage accumulation in adipose tissue
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Adipose Expression of Tumor Necrosis Factor-α: Direct Role in Obesity-Linked Insulin Resistance
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β-Cell Deficit and Increased β-Cell Apoptosis in Humans With Type 2 Diabetes
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Cited by
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Gastaldelli, A., Cusi, K., Fernández Landó, L., Bray, R., Brouwers, B., & Rodríguez, Á. (2022) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(22)00070-5 · Cited by 513
Self-citationThe Role of Obesity in Type 2 Diabetes Mellitus—An Overview
Chandrasekaran, P., & Weiskirchen, R. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25031882 · Cited by 582
Obesity, Inflammation, and Immune System in Osteoarthritis
Nedunchezhiyan, U., Varughese, I., Sun, A. R., Wu, X., Crawford, R., & Prasadam, I. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.907750 · Cited by 507
Neeland, I. J., Lim, S., Tchernof, A., Gastaldelli, A., Rangaswami, J., Ndumele, C. E., Powell-Wiley, T. M., & Després, J.-P. (2024) · Nature Reviews Disease Primers · doi:10.1038/s41572-024-00563-5 · Cited by 463
Self-citationTirzepatide for Obesity Treatment and Diabetes Prevention
Jastreboff, A. M., le Roux, C. W., Stefanski, A., Aronne, L. J., Halpern, B., Wharton, S., Wilding, J. P. H., Perreault, L., Zhang, S., Battula, R., et al. (2025) · New England Journal of Medicine · doi:10.1056/nejmoa2410819 · Cited by 462
Metadata
- Authors
- Klein, S., Gastaldelli, A., Yki-Järvinen, H., & Scherer, P. E.
- Affiliations
- Washington University in St. Louis (US)
- Istituto di Fisiologia Clinica (IT)
- The University of Texas Southwestern Medical Center (US)
- Corresponding author
- Klein, Samuel
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2022-01
- Volume
- 34
- Issue
- 1
- Pages
- 11-20
- ISSN
- 1550-4131 (ISSN-L)
- PMC
- PMC8740746
- OpenAlex
- W4206513048
- Cited by
- 939
- References
- 112
- Citations by year
- 2026: 196 · 2025: 329 · 2024: 249 · 2023: 112 · 2022: 51
- FWCI
- 29.48
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 368 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cell Metabolism (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Sigrid Juséliuksen Säätiö
- Inventiva Pharma
- National Institutes of Health (R01-DK099110, DK20579, RC2-DK118620, UL1TR002345, DK56341, R01-DK55758)
- Academy of Finland
- Eli Lilly and Company
- Gilead Sciences
- Janssen Pharmaceuticals
- Merck
- Novo Nordisk
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pancreatic function and diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- obesity, type 2 diabetes, body mass index, beta-cell dysfunction, adipose tissue, insulin resistance, weight loss, diabetes pathogenesis
- MeSH terms
- Adipose Tissue, Diabetes Mellitus, Type 2, Humans, Insulin Resistance, Obesity, Adiposity
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