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Intermittent fasting boosts sexual behavior by limiting the central availability of tryptophan and serotonin
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“A recent mechanistic study by Xie et al. demonstrated that IF boosts sexual behavior in animal models by limiting central availability of tryptophan and serotonin, neurotransmitters that can suppress libido when elevated [21].”
In the citing paper
“Recent mechanistic work by Xie et al. identified a novel pathway through which IF enhances sexual behavior: by limiting central nervous system availability of tryptophan (the precursor to serotonin), IF reduces brain serotonin levels [21].”
In the citing paper
“Since elevated serotonin can suppress libido and sexual behavior, this reduction may enhance sexual drive [21].”
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“This mechanism operates independently of gonadal hormone levels and represents a direct neurobiological effect of fasting on sexual motivation circuits.”
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Vallat, R. (2018) · Journal of Open Source Software · doi:10.21105/joss.01026 · Cited by 1,780
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Pfaus, J. G. (2009) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2009.01309.x · Cited by 678
Johnson, J. B., Summer, W., Cutler, R. G., Martin, B., Hyun, D.-H., Dixit, V. D., Pearson, M., Nassar, M., Tellejohan, R., Maudsley, S., et al. (2007) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.12.005 · Cited by 604
Rapamycin extends murine lifespan but has limited effects on aging
Neff, F., Flores-Dominguez, D., Ryan, D. P., Horsch, M., Schröder, S., Adler, T., Afonso, L. C., Aguilar-Pimentel, J. A., Becker, L., Garrett, L., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci67674 · Cited by 374
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Cited by
La Vignera, S., & Condorelli, R. A. (2026) · Nutrients · doi:10.3390/nu18111817 · Cited by 3
Metadata
- Authors
- Xie, K., Wang, C., Scifo, E., Pearson, B., Ryan, D., Henzel, K., Markert, A., Schaaf, K., Mi, X., Tian, X., Jia, J., Wang, M., Bonn, S., Schölling, M., Möhl, C., Bano, D., Zhou, Y., & Ehninger, D.
- ORCID
- Ehninger, Dan
- Venue
- Cell Metabolism
- Publisher
- Elsevier BV
- Published
- 2025-05
- Volume
- 37
- Issue
- 5
- Pages
- 1189-1205.e7
- ISSN
- 1550-4131
- Cited by
- 15
- References
- 6
- Language
- en
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- creativecommons.org/licenses/by/4.0/ (vor)
- Funders
- Shandong Province Natural Science Foundation (ZR2019ZD34)
- European Commission Marie Sklodowska-Curie Actions
- Helmholtz-Gemeinschaft
- National Natural Science Foundation of China (32071141, 32371211)
- Qingdao University
- European Commission
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- Xie, K., Wang, C., Scifo, E., Pearson, B., Ryan, D., Henzel, K., Markert, A., Schaaf, K., Mi, X., Tian, X., Jia, J., Wang, M., Bonn, S., Schölling, M., Möhl, C., Bano, D., Zhou, Y., & Ehninger, D. (2025). Intermittent fasting boosts sexual behavior by limiting the central availability of tryptophan and serotonin. Cell Metabolism. https://doi.org/10.1016/j.cmet.2025.03.001
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