The Effect of Retarded Growth Upon the Length of Life Span and Upon the Ultimate Body Size
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Rats on a restricted diet lived about 33% longer than it was known before.
“In 1935, Clive McCay and coworkers published a seminal paper in which they reported that rats on a restricted diet lived about 33% longer than it was known before (McCay et al. 1935).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as McCay et al. 1935
Dietary restriction and related regimens extend lifespan and healthspan.
“While dietary restriction and related regimens extend lifespan and healthspan, a key question is whether they have a ‘rejuvenating’ effect and reverse ageing features in already old individuals.”
From Ageing and rejuvenation of tissue stem cells and their niches (2023) · cites this paper as [206]
Alterations in the diet, particularly dietary restriction, have long been used to delay the ageing process.
“Alterations in the diet, particularly dietary restriction, have long been used to delay the ageing process206,207.”
From Ageing and rejuvenation of tissue stem cells and their niches (2023) · cites this paper as [206]
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Nutrition modulation of human aging: The calorie restriction paradigm
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Villareal, D. T., Kotyk, J. J., Armamento‐Villareal, R. C., Kenguva, V., Seaman, P., Shahar, A., Wald, M. J., Kleerekoper, M., & Fontana, L. (2011) · Aging Cell · doi:10.1111/j.1474-9726.2010.00643.x · Cited by 51 · see citing works
Katsimpardi, L., Kuperwasser, N., Camus, C., Moigneu, C., Chiche, A., Tolle, V., Li, H., Kokovay, E., & Lledo, P. (2020) · Aging Cell · doi:10.1111/acel.13038 · Cited by 47 · see citing works
The Geroscience Hypothesis: Is It Possible to Change the Rate of Aging?
Austad, S. N. (2016) · Advances in Geroscience · doi:10.1007/978-3-319-23246-1_1 · Cited by 43 · see citing works
Radler, M. E., Wright, B. J., Walker, F. R., Hale, M. W., & Kent, S. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2014.11.014 · Cited by 31 · see citing works
Exercise and food restriction in rats
Holloszy, J. O. (1992) · The Journal of Nutrition · doi:10.1093/jn/122.suppl_3.774 · Cited by 30 · see citing works
Intermittent Fasting: Myths, Fakes and Truth on This Dietary Regimen Approach
Brogi, S., Tabanelli, R., Puca, S., & Calderone, V. (2024) · Foods · doi:10.3390/foods13131960 · Cited by 26 · see citing works
- Authors
- McCay, C. M., Crowell, M. F., & Maynard, L. A.
- Affiliations
- Cornell University (US)
- Venue
- The Journal of Nutrition
- Publisher
- Elsevier BV
- Published
- 1935-07
- Volume
- 10
- Issue
- 1
- Pages
- 63-79
- ISSN
- 0022-3166 (ISSN-L)
- OpenAlex
- W1901983160
- Cited by
- 2,264
- References
- 3
- Citations by year
- 2026: 28 · 2025: 54 · 2024: 57 · 2023: 65 · 2022: 56 · 2021: 80 · 2020: 83 · 2019: 84 · 2018: 66 · 2017: 73 · 2016: 80 · 2015: 77 · 2014: 82 · 2013: 94 · 2012: 84
- FWCI
- 10.50
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Journal of Nutrition (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Life Sciences › Agricultural and Biological Sciences › Animal Science and Zoology › Animal Nutrition and Physiology
- Keywords
- growth retardation, lifespan, delayed maturation, rats, growth potential, sex differences in aging, organ size, heart size, liver size, kidney size, hair diameter, aging
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