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Cited by 11Hearing, Cochlea, Tinnitus, GeneticsAutism Spectrum Disorder ResearchHearing Loss and Rehabilitation

Auditory brainstem responses in adults with autism spectrum disorder

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Fujihira, H., Itoi, C., Furukawa, S., Kato, N., Kashino, M.·2021·Clinical Neurophysiology Practice
DOI 10.1016/j.cnp.2021.04.004PMC PMC8249870
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Abstract

OBJECTIVE: To investigate possible differences in the auditory peripheral and brainstem functions between adults with autism spectrum disorder (ASD) and neurotypical (NT) adults. METHODS: Click-evoked auditory brainstem responses (ABRs) were obtained from 17 high-functioning ASD adults (aged 21-38 years) and 20 NT adults (aged 22-36 years). A relatively large number of stimulus presentations (6000) were adopted, and ABRs by horizontal and vertical electrode montages were evaluated, in order to allow precise evaluations of early ABR components. RESULTS: Waves I, II, III, and V were identified in the vertical electrode montage, and wave I and the summating potential (SP) in electrocochleograms were identified in the horizontal electrode montage. There were no significant group differences in the wave I, II, III, and V latencies or the interpeak latencies (IPLs) in the vertical electrode montage. In the horizontal montage, the ASD adults exhibited significantly shortened SP latencies compared with the NT adults, whereas there was no significant group difference in the wave I latency. CONCLUSION: The ASD adults may have the abnormalities of processing more in the peripheral auditory system than in the brainstem. SIGNIFICANCE: The current study suggests that the peripheral abnormality is associated with ASD.

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Cited by

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Authors
Fujihira, H., Itoi, C., Furukawa, S., Kato, N., & Kashino, M.
Affiliations
  • Japan Society for the Promotion of Science (JP)
  • Chuo University (JP)
  • NTT (Japan) (JP)
  • SHOWA Medical University (JP)
Corresponding author
Fujihira, H.
ORCID
Venue
Clinical Neurophysiology Practice
Publisher
Elsevier BV
Published
2021
Volume
6
Pages
179-184
ISSN
2467-981X (ISSN-L)
DOI
10.1016/j.cnp.2021.04.004
PMC
PMC8249870
OpenAlex
W3168726488
Cited by
11
References
3
Citations by year
2026: 1 · 2025: 4 · 2024: 4 · 2023: 2
FWCI
0.84
Type
journal article
Language
en
Open access
Licence
Locations
  • Clinical Neurophysiology Practice (publishedVersion, cc-by-nc-nd)
  • PubMed Central (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • Institutional Repositories DataBase (IRDB) (submittedVersion, cc-by-nc-nd)
  • Kyushu University Institutional Repository (QIR) (Kyushu University) (submittedVersion, cc-by-nc-nd)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Japan Society for the Promotion of Science
Topics
  • Life Sciences › Neuroscience › Sensory Systems › Hearing, Cochlea, Tinnitus, Genetics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Autism Spectrum Disorder Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Hearing Loss and Rehabilitation
Keywords
autism spectrum disorder, auditory brainstem response, click-evoked ABR, electrocochleography, summating potential, wave I latency, interpeak latency, peripheral auditory system, high-functioning adults, electrode montage

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