The DOI matches its Crossref record; 50 of the 51 references it cites were found in a registry or an index.
Safety aspects of next generation probiotics
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“Computational tools can be applied to mitigate risks associated with NGPs by enabling whole-genome sequence analysis, early detection of antibiotic resistance genes, virulence-related traits, the potential for horizontal gene transfer, and other potentially negative metabolic characteristics, thus speeding up strain selection and regulatory assessment [140,161].”
From Current Concepts in Probiotic Safety and Efficacy (2026) · cites this paper as [140]
In the citing paper
“Another class of probiotics, NGPs (e.g., specifically commensal gut bacteria such as Bacteroides, Clostridium, and Akkermansia), require greater safety consideration than traditional probiotics because they lack a “safe use history” and have a more “ambiguous” potential to cause infectious diseases [140].”
From Current Concepts in Probiotic Safety and Efficacy (2026) · cites this paper as [140]
Citations
Cites
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Flagged first, then by citations
1 of the 51 references couldn’t be matched to a known paper.
Research works printed but not linked: 2
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Cited by
Sorted by citations
Gut microbes and metabolites as modulators of blood-brain barrier integrity and brain health
Parker, A., Fonseca, S., & Carding, S. R. (2019) · Gut Microbes · doi:10.1080/19490976.2019.1638722 · Cited by 745
“There is increasing interest in exploring the beneficial features of next-generation probiotics or live therapeutic products which include species not traditionally considered as probiotics, such as Akkermansia muciniphila,(187) Faecalibacterium prausnitzii,(188) species of the genus Bacteroides,(189) and genetically…”
BackgroundHelmy, Y. A., Taha-Abdelaziz, K., Hawwas, H. A. E.-H., Ghosh, S. B., Alkafaas, S. S., Moawad, M. M. M., Saied, E. M., Kassem, I. I., & Mawad, A. M. M. (2023) · Antibiotics · doi:10.3390/antibiotics12020274 · Cited by 253
“prausnitzii have been related to its potential health benefits [177].”
BackgroundInfluentialNext-generation probiotics: the upcoming biotherapeutics
Al-Fakhrany, O. M., & Elekhnawy, E. (2024) · Molecular Biology Reports · doi:10.1007/s11033-024-09398-5 · Cited by 208
“Most of these microbes have metabolic activities that make them challenging to use in large-scale food production [73, 74].”
BackgroundPerraudeau, F., McMurdie, P., Bullard, J., Cheng, A., Cutcliffe, C., Deo, A., Eid, J., Gines, J., Iyer, M., Justice, N., et al. (2020) · BMJ Open Diabetes Research & Care · doi:10.1136/bmjdrc-2020-001319 · Cited by 186
Probiotics-based foods and beverages as future foods and their overall safety and regulatory claims
Koirala, S., & Anal, A. K. (2021) · Future Foods · doi:10.1016/j.fufo.2021.100013 · Cited by 181
Metadata
- Authors
- Saarela, M. H.
- Affiliations
- VTT Technical Research Centre of Finland (FI)
- Corresponding author
- Saarela, Maria H
- ORCID
- Saarela, Maria H
- Venue
- Current Opinion in Food Science
- Publisher
- Elsevier BV
- Published
- 2019-12
- Volume
- 30
- Pages
- 8-13
- ISSN
- 2214-7993 (ISSN-L)
- OpenAlex
- W2889616411
- Cited by
- 118
- References
- 51
- Citations by year
- 2026: 10 · 2025: 13 · 2024: 18 · 2023: 18 · 2022: 22 · 2021: 19 · 2020: 11 · 2019: 7
- FWCI
- 0.93
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Food Science (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Probiotics and Fermented Foods
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Keywords
- next-generation probiotics, probiotic safety assessment, gut microbiota, Bacteroides, Clostridium, Faecalibacterium, Akkermansia, antibiotic resistance genes, probiotic supplements, health-promoting properties
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