Akkermansia muciniphila gen. nov., sp. nov., a human intestinal mucin-degrading bacterium

Profiling of complex microbial populations by denaturing gradient gel electrophoresis analysis of polymerase chain reaction-amplified genes coding for 16S rRNA

Muyzer, G., de Waal, E. C., & Uitterlinden, A. G. (1993) · Applied and Environmental Microbiology · doi:10.1128/aem.59.3.695-700.1993 · Cited by 11,455 · see citing works

Nucleic acid techniques in bacterial systematics

Stackebrandt, E., & Goodfellow, M. (1991) · Wiley eBooks · Cited by 9,494 · see citing works

16S/23S rRNA sequencing

Lane, D. (1991) · Medical Entomology and Zoology · Cited by 7,944 · see citing works

ARB: a software environment for sequence data

Ludwig, W. (2004) · Nucleic Acids Research · doi:10.1093/nar/gkh293 · Cited by 6,649 · see citing works

Precise Measurement of the G+C Content of Deoxyribonucleic Acid by High-Performance Liquid Chromatography

MESBAH, M., PREMACHANDRAN, U., & Whitman, W. B. (1989) · International Journal of Systematic Bacteriology · doi:10.1099/00207713-39-2-159 · Cited by 4,534 · see citing works

Impact of Culture-Independent Studies on the Emerging Phylogenetic View of Bacterial Diversity

Hugenholtz, P., Goebel, B. M., & Pace, N. R. (1998) · Journal of Bacteriology · doi:10.1128/jb.180.18.4765-4774.1998 · Cited by 2,429 · see citing works

Commensal Host-Bacterial Relationships in the Gut

Hooper, L. V., & Gordon, J. I. (2001) · Science · doi:10.1126/science.1058709 · Cited by 2,362 · see citing works

Direct analysis of genes encoding 16S rRNA from complex communities reveals many novel molecular species within the human gut

Suau, A., Bonnet, R., Sutren, M., Godon, J.-J., Gibson, G. R., Collins, M. D., & Doré, J. (1999) · Applied and Environmental Microbiology · doi:10.1128/aem.65.11.4799-4807.1999 · Cited by 1,490 · see citing works

Temperature Gradient Gel Electrophoresis Analysis of 16S rRNA from Human Fecal Samples Reveals Stable and Host-Specific Communities of Active Bacteria

Zoetendal, E. G., Akkermans, A. D. L., & de Vos, W. M. (1998) · Applied and Environmental Microbiology · doi:10.1128/aem.64.10.3854-3859.1998 · Cited by 1,360 · see citing works

Sequence heterogeneities of genes encoding 16S rRNAs in Paenibacillus polymyxa detected by temperature gradient gel electrophoresis

Nübel, U., Engelen, B., Felske, A., Snaidr, J., Wieshuber, A., Amann, R., Ludwig, W., & Backhaus, H. (1996) · Journal of Bacteriology · doi:10.1128/jb.178.19.5636-5643.1996 · Cited by 1,356 · see citing works

Rapid silver staining and recovery of PCR products separated on polyacrylamide gels.

Cj, S., Neto, E. D., & Aj, S. (1994) · PubMed · Cited by 1,179 · see citing works

Human colonic biota studied by ribosomal DNA sequence analysis

Wilson, K. H., & Blitchington, R. B. (1996) · Applied and Environmental Microbiology · doi:10.1128/aem.62.7.2273-2278.1996 · Cited by 526 · see citing works

Fermentation of mucins and plant polysaccharides by anaerobic bacteria from the human colon

Salyers, A. A., West, S. E. H., Vercellotti, J. R., & Wilkins, T. D. (1977) · Applied and Environmental Microbiology · doi:10.1128/aem.34.5.529-533.1977 · Cited by 471 · see citing works

Growth adaptation to methotrexate of HT-29 human colon carcinoma cells is associated with their ability to differentiate into columnar absorptive and mucus-secreting cells.

Lesuffleur, T., Barbat, A., Dussaulx, E., & Zweibaum, A. (1990) · PubMed · Cited by 430 · see citing works

Assessment of microbial diversity in human colonic samples by 16S rDNA sequence analysis

Hold, G. L., Pryde, S. E., Russell, V. J., Furrie, E., & Flint, H. J. (2002) · FEMS Microbiology Ecology · doi:10.1111/j.1574-6941.2002.tb00904.x · Cited by 401 · see citing works

Roseburia intestinalis sp. nov., a novel saccharolytic, butyrate-producing bacterium from human faeces.

Duncan, S. H., Hold, G. L., Barcenilla, A., Stewart, C. S., & Flint, H. J. (2002) · INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY · doi:10.1099/00207713-52-5-1615 · Cited by 368 · see citing works

Growth of Syntrophic Propionate-Oxidizing Bacteria with Fumarate in the Absence of Methanogenic Bacteria

Stams, A. J. M., Dijk, J. B. V., Dijkema, C., & Plugge, C. M. (1993) · Applied and Environmental Microbiology · doi:10.1128/aem.59.4.1114-1119.1993 · Cited by 363 · see citing works

Mucin Degradation in Human Colon Ecosystems

Hoskins, L. C., & Boulding, E. T. (1981) · Journal of Clinical Investigation · doi:10.1172/jci110009 · Cited by 277 · see citing works

Analysis of 16S libraries of mouse gastrointestinal microflora reveals a large new group of mouse intestinal bacteria b bThe GenBank accession numbers for the clone sequences reported in this paper can be found in Table 1 T1 ; the accession number for isolate MIB-CB3 is AJ418059.

Salzman, N. H., de Jong, H., Paterson, Y. Y. W., Harmsen, H. J. M., Welling, G. W., & Bos, N. A. (2002) · Microbiology · doi:10.1099/00221287-148-11-3651 · Cited by 253 · see citing works

A molecular view of the intestinal ecosystem.

Vaughan, E. E., Schut, F., Heilig, H. G. H. J., Zoetendal, E. G., de Vos, W. M., & Akkermans, A. D. L. (2000) · PubMed · Cited by 250 · see citing works

Opitutus terrae gen. nov., sp. nov., to accommodate novel strains of the division 'Verrucomicrobia' isolated from rice paddy soil.

Chin, K., Liesack, W., & Janssen, P. H. (2001) · INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY · doi:10.1099/00207713-51-6-1965 · Cited by 223 · see citing works

Novel anaerobic ultramicrobacteria belonging to the Verrucomicrobiales lineage of bacterial descent isolated by dilution culture from anoxic rice paddy soil

Janssen, P. H., Schuhmann, A., Mörschel, E., & Rainey, F. A. (1997) · Applied and Environmental Microbiology · doi:10.1128/aem.63.4.1382-1388.1997 · Cited by 210 · see citing works

Anaerostipes caccae gen. nov., sp. nov., a New Saccharolytic, Acetate-utilising, Butyrate-producing Bacterium from Human Faeces

Schwiertz, A., Hold, G. L., Duncan, S. H., Gruhl, B., Collins, M. D., Lawson, P. A., Flint, H. J., & Blaut, M. (2002) · Systematic and Applied Microbiology · doi:10.1078/0723-2020-00096 · Cited by 194 · see citing works

Potential probiotic lactic acid bacteria Lactobacillus rhamnosus (HN001), Lactobacillus acidophilus (HN017) and Bifidobacterium lactis (HN019) do not degrade gastric mucin in vitro

Zhou, J. S., Gopal, P. K., & Gill, H. S. (2001) · International Journal of Food Microbiology · doi:10.1016/s0168-1605(00)00398-6 · Cited by 178 · see citing works

Verrucomicrobia div. nov., a new division of the Bacteria containing three new species of Prosthecobacter

Hedlund, B. P., Gosink, J. J., & Staley, J. T. (1997) · Antonie van Leeuwenhoek · doi:10.1023/a:1000348616863 · Cited by 177 · see citing works

Mucin degradation in human colon ecosystems

Miller, R. S., & Hoskins, L. C. (1981) · Gastroenterology · doi:10.1016/0016-5085(81)90503-5 · Cited by 166 · see citing works

Victivallis vadensis gen. nov., sp. nov., a sugar-fermenting anaerobe from human faeces

Zoetendal, E. G., Plugge, C. M., Akkermans, A. D. L., & de Vos, W. M. (2003) · INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY · doi:10.1099/ijs.0.02362-0 · Cited by 145 · see citing works

Reclassification of Eubacterium formicigenerans Holdeman and Moore 1974 as Dorea formicigenerans gen. nov., comb. nov., and description of Dorea longicatena sp. nov., isolated from human faeces.

Taras, D., Simmering, R., Collins, M. D., Lawson, P. A., & Blaut, M. (2002) · INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY · doi:10.1099/00207713-52-2-423 · Cited by 143 · see citing works

Inability ofLactobacillus caseiStrain GG,L. acidophilus, andBifidobacterium bifidumto Degrade Intestinal Mucus Glycoproteins

Embden, J. G. H. R.-V., Lieshout, L. M. C. V., Gosselink, M. J., & Marteau, P. R. (1995) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365529509096312 · Cited by 93 · see citing works

Campylobacter hominis sp. nov., from the human gastrointestinal tract.

Lawson, A., On, S. L. W., Logan, J. M. J., & Stanley, J. (2001) · INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY · doi:10.1099/00207713-51-2-651 · Cited by 87 · see citing works

Verrucomicrobium spinosum gen. nov., sp. nov.: a Fimbriated Prosthecate Bacterium

Schlesner, H. (1987) · Systematic and Applied Microbiology · doi:10.1016/s0723-2020(87)80010-3 · Cited by 83 · see citing works

Caloramator coolhaasii sp. nov., a glutamate-degrading, moderately thermophilic anaerobe.

Plugge, C. M., Zoetendal, E. G., & Stams, A. J. M. (2000) · INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY · doi:10.1099/00207713-50-3-1155 · Cited by 62 · see citing works

In VitroEffects of Mucin Fermentation on the Growth of Human Colonic Sulphate-Reducing Bacteria

Willis, C. L., Cummings, J. H., Neale, G., & Gibson, G. R. (1996) · Anaerobe · doi:10.1006/anae.1996.0015 · Cited by 55 · see citing works

Prosthecobacter fusiformis nov. gen. et sp., the fusiform caulobacter

Staley, J. T., de Bont, J. A. M., & de Jonge, K. (1976) · Antonie van Leeuwenhoek · doi:10.1007/bf00394132 · Cited by 50 · see citing works

Ruminococcus luti sp. nov., Isolated from a Human Faecal Sample

Simmering, R., Taras, D., Schwiertz, A., Blay, G. L., Gruhl, B., Lawson, P. A., Collins, M. D., & Blaut, M. (2002) · Systematic and Applied Microbiology · doi:10.1078/0723-2020-00112 · Cited by 44 · see citing works

Enterotypes of the human gut microbiome

MetaHIT Consortium (additional members), Arumugam, M., Raes, J., Pelletier, E., Le Paslier, D., Yamada, T., Mende, D. R., Fernandes, G. R., Tap, J., Bruls, T., et al. (2011) · Nature · doi:10.1038/nature09944 · Cited by 7,548 · see citing works

Cross-talk between <i>Akkermansia muciniphila</i> and intestinal epithelium controls diet-induced obesity

Everard, A., Belzer, C., Geurts, L., Ouwerkerk, J. P., Druart, C., Bindels, L. B., Guiot, Y., Derrien, M., Muccioli, G. G., Delzenne, N. M., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1219451110 · Cited by 4,511 · see citing works

Short Chain Fatty Acids (SCFAs)-Mediated Gut Epithelial and Immune Regulation and Its Relevance for Inflammatory Bowel Diseases

Parada Venegas, D., De la Fuente, M. K., Landskron, G., González, M. J., Quera, R., Dijkstra, G., Harmsen, H. J. M., Faber, K. N., & Hermoso, M. A. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.00277 · Cited by 3,820 · see citing works

Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism

Morrison, D. J., & Preston, T. (2016) · Gut Microbes · doi:10.1080/19490976.2015.1134082 · Cited by 3,781 · see citing works

Introduction to the human gut microbiota

Thursby, E., & Juge, N. (2017) · Biochemical Journal · doi:10.1042/bcj20160510 · Cited by 3,600 · see citing works

What is the Healthy Gut Microbiota Composition? A Changing Ecosystem across Age, Environment, Diet, and Diseases

Rinninella, E., Raoul, P., Cintoni, M., Franceschi, F., Miggiano, G. A. D., Gasbarrini, A., & Mele, M. C. (2019) · Microorganisms · doi:10.3390/microorganisms7010014 · Cited by 3,462 · see citing works

The pervasive effects of an antibiotic on the human gut microbiota, as revealed by deep 16S rRNA sequencing

Dethlefsen, L., Huse, S., Sogin, M. L., & Relman, D. A. (2008) · PLoS Biology · doi:10.1371/journal.pbio.0060280 · Cited by 2,361 · see citing works

A purified membrane protein from Akkermansia muciniphila or the pasteurized bacterium improves metabolism in obese and diabetic mice

Plovier, H., Everard, A., Druart, C., Depommier, C., Van Hul, M., Geurts, L., Chilloux, J., Ottman, N., Duparc, T., Lichtenstein, L., et al. (2017) · Nature Medicine · doi:10.1038/nm.4236 · Cited by 2,204 · see citing works

Prebiotic effects: metabolic and health benefits

Roberfroid, M. B., Gibson, G. R., Hoyles, L., McCartney, A. L., Rastall, R. A., Rowland, I. R., Wolvers, D. A. W., Watzl, B., Szajewska, H., Stahl, B., et al. (2010) · British Journal Of Nutrition · doi:10.1017/s0007114510003363 · Cited by 2,098 · see citing works

The first microbial colonizers of the human gut: composition, activities, and health implications of the infant gut microbiota

Milani, C., Duranti, S., Bottacini, F., Casey, E., Turroni, F., Mahony, J., Belzer, C., Delgado Palacio, S., Arboleya Montes, S., Mancabelli, L., et al. (2017) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00036-17 · Cited by 1,950 · see citing works

An increase in the <i>Akkermansia</i> spp. population induced by metformin treatment improves glucose homeostasis in diet-induced obese mice

Shin, N.-R., Lee, J.-C., Lee, H.-Y., Kim, M.-S., Whon, T. W., Lee, M.-S., & Bae, J.-W. (2014) · Gut · doi:10.1136/gutjnl-2012-303839 · Cited by 1,550 · see citing works

Human gut microbiome: Hopes, threats and promises

Cani, P. D. (2018) · Gut · doi:10.1136/gutjnl-2018-316723 · Cited by 1,386 · see citing works

Mucolytic Bacteria With Increased Prevalence in IBD Mucosa Augment In Vitro Utilization of Mucin by Other Bacteria

Png, C. W., Lindén, S. K., Gilshenan, K. S., Zoetendal, E. G., McSweeney, C. S., Sly, L. I., McGuckin, M. A., & Florin, T. H. J. (2010) · American Journal of Gastroenterology · doi:10.1038/ajg.2010.281 · Cited by 1,364 · see citing works

Alterations of the human gut microbiome in multiple sclerosis

Jangi, S., Gandhi, R., Cox, L. M., Li, N., von Glehn, F., Yan, R., Patel, B., Mazzola, M. A., Liu, S., Glanz, B. L., et al. (2016) · Nature Communications · doi:10.1038/ncomms12015 · Cited by 1,307 · see citing works

Phylogenetic distribution of three pathways for propionate production within the human gut microbiota

Reichardt, N., Duncan, S. H., Young, P., Belenguer, Á., Leitch, E. C. M., Scott, K. P., Flint, H. J., & Louis, P. (2014) · The ISME Journal · doi:10.1038/ismej.2014.14 · Cited by 1,302 · see citing works

Akkermansia muciniphila: paradigm for next-generation beneficial microorganisms

Cani, P. D., Depommier, C., Derrien, M., Everard, A., & de Vos, W. M. (2022) · Nature Reviews Gastroenterology &amp; Hepatology · doi:10.1038/s41575-022-00631-9 · Cited by 1,192 · see citing works

The first 1000 cultured species of the human gastrointestinal microbiota

Rajilić-Stojanović, M., & de Vos, W. M. (2014) · FEMS Microbiology Reviews · doi:10.1111/1574-6976.12075 · Cited by 1,182 · see citing works

Parabacteroides distasonis Alleviates Obesity and Metabolic Dysfunctions via Production of Succinate and Secondary Bile Acids

Wang, K., Liao, M., Zhou, N., Bao, L., Ma, K., Zheng, Z., Wang, Y., Liu, C., Wang, W., Wang, J., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2018.12.028 · Cited by 1,166 · see citing works

A critical assessment of the “sterile womb” and “in utero colonization” hypotheses: implications for research on the pioneer infant microbiome

Perez-Muñoz, M. E., Arrieta, M.-C., Ramer-Tait, A. E., & Walter, J. (2017) · Microbiome · doi:10.1186/s40168-017-0268-4 · Cited by 1,096 · see citing works

Composition of the adult digestive tract bacterial microbiome based on seven mouth surfaces, tonsils, throat and stool samples

Segata, N., Haake, S. K., Mannon, P., Lemon, K. P., Waldron, L., Gevers, D., Huttenhower, C., & Izard, J. (2012) · Genome Biology · doi:10.1186/gb-2012-13-6-r42 · Cited by 1,076 · see citing works

Next-Generation Beneficial Microbes: The Case of Akkermansia muciniphila

Cani, P. D., & de Vos, W. M. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.01765 · Cited by 1,058 · see citing works

Genetic determinants of the gut microbiome in UK twins

Goodrich, J. K., Davenport, E. R., Beaumont, M., Jackson, M. A., Knight, R., Ober, C., Spector, T. D., Bell, J. T., Clark, A. G., & Ley, R. E. (2016) · Cell Host &amp; Microbe · doi:10.1016/j.chom.2016.04.017 · Cited by 1,048 · see citing works

The influence of diet on the gut microbiota

Scott, K. P., Gratz, S. W., Sheridan, P. O., Flint, H. J., & Duncan, S. H. (2013) · Pharmacological Research · doi:10.1016/j.phrs.2012.10.020 · Cited by 1,052 · see citing works

Akkermansia muciniphila and its role in regulating host functions

Derrien, M., Belzer, C., & de Vos, W. M. (2017) · Microbial Pathogenesis · doi:10.1016/j.micpath.2016.02.005 · Cited by 1,044 · see citing works

Microbial Regulation of Host Physiology by Short-chain Fatty Acids

van der Hee, B., & Wells, J. M. (2021) · Trends in Microbiology · doi:10.1016/j.tim.2021.02.001 · Cited by 988 · see citing works

Indoleacrylic Acid Produced by Commensal Peptostreptococcus Species Suppresses Inflammation

Wlodarska, M., Luo, C., Kolde, R., d'Hennezel, E. B., Annand, J. W., Heim, C. E., Krastel, P., Schmitt, E. K., Omar, A. S., Creasey, E. A., et al. (2017) · Cell Host & Microbe · doi:10.1016/j.chom.2017.06.007 · Cited by 890 · see citing works

Culturing the human microbiota and culturomics

Lagier, J., Dubourg, G., Million, M., Cadoret, F., Bilen, M., Fenollar, F., Levasseur, A., Rolain, J., Fournier, P., & Raoult, D. (2018) · Nature Reviews Microbiology · doi:10.1038/s41579-018-0041-0 · Cited by 882 · see citing works

Carbohydrate metabolism in Bifidobacteria

Pokusaeva, K., Fitzgerald, G. F., & van Sinderen, D. (2011) · Genes & Nutrition · doi:10.1007/s12263-010-0206-6 · Cited by 855 · see citing works

Microbiota and diabetes: an evolving relationship

Tilg, H., & Moschen, A. R. (2014) · Gut · doi:10.1136/gutjnl-2014-306928 · Cited by 853 · see citing works

Akkermansia muciniphila-derived extracellular vesicles influence gut permeability through the regulation of tight junctions

Chelakkot, C., Choi, Y., Kim, D., Park, H. T., Ghim, J., Kwon, Y., Jeon, J., Kim, M.-S., Jee, Y., Gho, Y. S., et al. (2018) · Experimental & Molecular Medicine · doi:10.1038/emm.2017.282 · Cited by 859 · see citing works

Mucin glycan foraging in the human gut microbiome

Tailford, L. E., Crost, E. H., Kavanaugh, D. W., & Juge, N. (2015) · Frontiers in Genetics · doi:10.3389/fgene.2015.00081 · Cited by 851 · see citing works

The Rebirth of Culture in Microbiology through the Example of Culturomics To Study Human Gut Microbiota

Lagier, J., Hugon, P., Khelaifia, S., Fournier, P., Scola, B. L., & Raoult, D. (2015) · Clinical Microbiology Reviews · doi:10.1128/cmr.00014-14 · Cited by 839 · see citing works

Gut Microbiome Metagenomics Analysis Suggests a Functional Model for the Development of Autoimmunity for Type 1 Diabetes

Brown, C. T., Davis-Richardson, A. G., Giongo, A., Gano, K. A., Crabb, D. B., Mukherjee, N., Casella, G., Drew, J. C., Ilonen, J., Knip, M., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0025792 · Cited by 778 · see citing works

High-Fat, Western-Style Diet, Systemic Inflammation, and Gut Microbiota: A Narrative Review

Malesza, I. J., Malesza, M., Walkowiak, J., Mussin, N. M., Walkowiak, D., Aringazina, R. A., Bartkowiak-Wieczorek, J., & Mądry, E. (2021) · Cells · doi:10.3390/cells10113164 · Cited by 807 · see citing works

Interplay between the human gut microbiome and host metabolism

Visconti, A., Le Roy, C. I., Rosa, F., Rossi, N., Martin, T. C., Mohney, R. P., Li, W., de Rinaldis, E., Bell, J. T., Venter, J. C., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-12476-z · Cited by 782 · see citing works

<i>Akkermansia Muciniphila</i> Protects Against Atherosclerosis by Preventing Metabolic Endotoxemia-Induced Inflammation in <i>Apoe</i> ^−/− Mice

Li, J., Lin, S., Vanhoutte, P. M., Woo, C. W., & Xu, A. (2016) · Circulation · doi:10.1161/circulationaha.115.019645 · Cited by 775 · see citing works

Gut microbiome analysis as a tool towards targeted non-invasive biomarkers for early hepatocellular carcinoma

Ren, Z., Li, A., Jiang, J., Zhou, L., Yu, Z., Lu, H., Xie, H., Chen, X., Shao, L., Zhang, R., et al. (2018) · Gut · doi:10.1136/gutjnl-2017-315084 · Cited by 770 · see citing works

Mechanisms and consequences of intestinal dysbiosis

Weiss, G. A., & Hennet, T. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2509-x · Cited by 775 · see citing works

Negative Effects of a High-Fat Diet on Intestinal Permeability: A Review

Rohr, M., Narasimhulu, C. A., Rudeski-Rohr, T., & Parthasarathy, S. (2019) · Advances in Nutrition · doi:10.1093/advances/nmz061 · Cited by 766 · see citing works

Short-chain fatty acids in diseases

Zhang, D., Jian, Y., Zhang, Y., Li, Y., Gu, L.-T., Sun, H.-H., Liu, M., Zhou, H., Wang, Y., & Xu, Z. (2023) · Cell Communication and Signaling · doi:10.1186/s12964-023-01219-9 · Cited by 763 · see citing works

Microbes inside—from diversity to function: the case of Akkermansia

Belzer, C., & de Vos, W. M. (2012) · The ISME Journal · doi:10.1038/ismej.2012.6 · Cited by 715 · see citing works

<i>Akkermansia muciniphila</i> is a promising probiotic

Zhang, T., Li, Q., Cheng, L., Buch, H., & Zhang, F. (2019) · Microbial Biotechnology · doi:10.1111/1751-7915.13410 · Cited by 708 · see citing works

Intestinal Integrity and <i>Akkermansia muciniphila</i> , a Mucin-Degrading Member of the Intestinal Microbiota Present in Infants, Adults, and the Elderly

Collado, M. C., Derrien, M., Isolauri, E., de Vos, W. M., & Salminen, S. (2007) · Applied and Environmental Microbiology · doi:10.1128/aem.01477-07 · Cited by 706 · see citing works

Dietary Polyphenols Promote Growth of the Gut Bacterium <i>Akkermansia muciniphila</i> and Attenuate High-Fat Diet–Induced Metabolic Syndrome

Roopchand, D. E., Carmody, R. N., Kuhn, P., Moskal, K., Rojas-Silva, P., Turnbaugh, P. J., & Raskin, I. (2015) · Diabetes · doi:10.2337/db14-1916 · Cited by 678 · see citing works

Diets that differ in their FODMAP content alter the colonic luminal microenvironment

Halmos, E. P., Christophersen, C. T., Bird, A. R., Shepherd, S. J., Gibson, P. R., & Muir, J. G. (2015) · Gut · doi:10.1136/gutjnl-2014-307264 · Cited by 681 · see citing works

Genomic characterization of the uncultured Bacteroidales family S24-7 inhabiting the guts of homeothermic animals

Ormerod, K. L., Wood, D., Lachner, N., Gellatly, S. L., Daly, J. N., Parsons, J. D., Dal’Molin, C. G. D. O., Palfreyman, R. W., Nielsen, L. K., Cooper, M. A., et al. (2016) · Microbiome · doi:10.1186/s40168-016-0181-2 · Cited by 675 · see citing works

High-throughput diversity and functionality analysis of the gastrointestinal tract microbiota

Zoetendal, E. G., Rajilić-Stojanović, M. D., & de Vos, W. M. (2008) · Gut · doi:10.1136/gut.2007.133603 · Cited by 672 · see citing works

The Mucin Degrader Akkermansia muciniphila Is an Abundant Resident of the Human Intestinal Tract

Derrien, M., Collado, M. C., Amor, K. B., Salminen, S., & de Vos, W. M. (2007) · Applied and Environmental Microbiology · doi:10.1128/aem.01226-07 · Cited by 659 · see citing works

Butyrate-producingClostridiumcluster XIVa species specifically colonize mucins in anin vitrogut model

den Abbeele, P. V., Belzer, C., Goossens, M., Kleerebezem, M., de Vos, W. M., Thas, O., Weirdt, R. D., Kerckhof, F., & de Wiele, T. V. (2012) · The ISME Journal · doi:10.1038/ismej.2012.158 · Cited by 639 · see citing works

Shaping the Future of Probiotics and Prebiotics

Cunningham, M., Azcarate-Peril, M. A., Barnard, A., Benoit, V., Grimaldi, R., Guyonnet, D., Holscher, H. D., Hunter, K., Manurung, S., Obis, D., et al. (2021) · Trends in Microbiology · doi:10.1016/j.tim.2021.01.003 · Cited by 637 · see citing works

Interactions and competition within the microbial community of the human colon: links between diet and health

Flint, H. J., Duncan, S. H., Scott, K. P., & Louis, P. (2007) · Environmental Microbiology · doi:10.1111/j.1462-2920.2007.01281.x · Cited by 632 · see citing works

Recovery of ethanol-induced <i>Akkermansia muciniphila</i> depletion ameliorates alcoholic liver disease

Grander, C., Adolph, T. E., Wieser, V., Lowe, P., Wrzosek, L., Gyongyosi, B., Ward, D. V., Grabherr, F., Gerner, R. R., Pfister, A., et al. (2018) · Gut · doi:10.1136/gutjnl-2016-313432 · Cited by 618 · see citing works

The Potential of Gut Commensals in Reinforcing Intestinal Barrier Function and Alleviating Inflammation

Hiippala, K., Jouhten, H., Ronkainen, A., Hartikainen, A., Kainulainen, V., Jalanka, J., & Satokari, R. M. (2018) · Nutrients · doi:10.3390/nu10080988 · Cited by 599 · see citing works

Impact of Bacterial Metabolites on Gut Barrier Function and Host Immunity: A Focus on Bacterial Metabolism and Its Relevance for Intestinal Inflammation

Gasaly, N., de Vos, P., & Hermoso, M. A. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.658354 · Cited by 592 · see citing works

Modulation of Mucosal Immune Response, Tolerance, and Proliferation in Mice Colonized by the Mucin-Degrader Akkermansia muciniphila

Derrien, M., van Baarlen, P., Hooiveld, G. J. E. J., Norin, E. L., Müller, M. M., & de Vos, W. M. (2011) · Frontiers in Microbiology · doi:10.3389/fmicb.2011.00166 · Cited by 582 · see citing works

Microbial Ecology along the Gastrointestinal Tract

Hillman, E. T., Lu, H., Yao, T., & Nakatsu, C. H. (2017) · Microbes and Environments · doi:10.1264/jsme2.me17017 · Cited by 586 · see citing works

<i>Akkermansia muciniphila</i> induces intestinal adaptive immune responses during homeostasis

Ansaldo, E., Slayden, L. C., Ching, K. L., Koch, M. A., Wolf, N. K., Plichta, D. R., Brown, E. M., Graham, D. B., Xavier, R. J., Moon, J. J., et al. (2019) · Science · doi:10.1126/science.aaw7479 · Cited by 566 · see citing works

Role of Intestinal Microbiota in the Bioavailability and Physiological Functions of Dietary Polyphenols

Kawabata, K., Yoshioka, Y., & Terao, J. (2019) · Molecules · doi:10.3390/molecules24020370 · Cited by 563 · see citing works

Akkermansia muciniphila Adheres to Enterocytes and Strengthens the Integrity of the Epithelial Cell Layer

Reunanen, J., Kainulainen, V., Huuskonen, L., Ottman, N., Belzer, C., Huhtinen, H., de Vos, W. D., & Satokari, R. (2015) · Applied and Environmental Microbiology · doi:10.1128/aem.04050-14 · Cited by 510 · see citing works

Gut microbiota, obesity and diabetes

Patterson, E., Ryan, P. M., Cryan, J. F., Dinan, T. G., Ross, R. P., Fitzgerald, G. F., & Stanton, C. (2016) · Postgraduate Medical Journal · doi:10.1136/postgradmedj-2015-133285 · Cited by 552 · see citing works

Diabetes, obesity and gut microbiota

Everard, A., & Cani, P. D. (2013) · Best Practice & Research Clinical Gastroenterology · doi:10.1016/j.bpg.2013.03.007 · Cited by 546 · see citing works

Microbial pathways in colonic sulfur metabolism and links with health and disease

Carbonero, F., Benefiel, A. C., Alizadeh-Ghamsari, A. H., & Gaskins, H. R. (2012) · Frontiers in Physiology · doi:10.3389/fphys.2012.00448 · Cited by 544 · see citing works

Extracellular vesicles derived from gut microbiota, especially Akkermansia muciniphila, protect the progression of dextran sulfate sodium-induced colitis

Kang, C.-S., Ban, M., Choi, E.-J., Moon, H.-G., Jeon, J.-S., Kim, D.-K., Park, S.-K., Jeon, S. G., Roh, T.-Y., Myung, S.-J., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0076520 · Cited by 543 · see citing works

Polysaccharide Degradation by the Intestinal Microbiota and Its Influence on Human Health and Disease

Cockburn, D. W., & Koropatkin, N. M. (2016) · Journal of Molecular Biology · doi:10.1016/j.jmb.2016.06.021 · Cited by 542 · see citing works

The Microbiota of the Gut in Preschool Children With Normal and Excessive Body Weight

Karlsson, C., Önnerfält, J., Xu, J., Molin, G., Ahrné, S., & Thorngren‐Jerneck, K. (2012) · Obesity · doi:10.1038/oby.2012.110 · Cited by 536 · see citing works

Administration of Akkermansia muciniphila Ameliorates Dextran Sulfate Sodium-Induced Ulcerative Colitis in Mice

Bian, X., Wu, W., Yang, L., Lv, L., Wang, Q., Li, Y., Ye, J., Fang, D., Wu, J., Jiang, X., et al. (2019) · Frontiers in Microbiology · doi:10.3389/fmicb.2019.02259 · Cited by 529 · see citing works

The gut microbiota influences anticancer immunosurveillance and general health

Routy, B., Gopalakrishnan, V., Daillère, R., Zitvogel, L., Wargo, J. A., & Kroemer, G. (2018) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-018-0006-2 · Cited by 523 · see citing works

Commensal Akkermansia muciniphila Exacerbates Gut Inflammation in Salmonella Typhimurium-Infected Gnotobiotic Mice

Ganesh, B. P., Klopfleisch, R., Loh, G., & Blaut, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0074963 · Cited by 522 · see citing works

Pili-like proteins of Akkermansia muciniphila modulate host immune responses and gut barrier function

Ottman, N., Reunanen, J., Meijerink, M., Pietilä, T. E., Kainulainen, V., Klievink, J., Huuskonen, L., Aalvink, S., Skurnik, M., Boeren, S. A., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0173004 · Cited by 522 · see citing works

Human genetic variation and the gut microbiome in disease

Hall, A. B., Tolonen, A. C., & Xavier, R. J. (2017) · Nature Reviews Genetics · doi:10.1038/nrg.2017.63 · Cited by 517 · see citing works

Genome-guided design of a defined mouse microbiota that confers colonization resistance against Salmonella enterica serovar Typhimurium

Brugiroux, S., Beutler, M., Pfann, C., Garzetti, D., Ruscheweyh, H., Ring, D., Diehl, M., Herp, S., Loetscher, Y., Hussain, S., et al. (2016) · Nature Microbiology · doi:10.1038/nmicrobiol.2016.215 · Cited by 463 · see citing works

The Enteric Network: Interactions between the Immune and Nervous Systems of the Gut

Yoo, B. B., & Mazmanian, S. K. (2017) · Immunity · doi:10.1016/j.immuni.2017.05.011 · Cited by 479 · see citing works

Differential Modulation by Akkermansia muciniphila and Faecalibacterium prausnitzii of Host Peripheral Lipid Metabolism and Histone Acetylation in Mouse Gut Organoids

Lukovac, S., Belzer, C., Pellis, L., Keijser, B. J. F., de Vos, W. M., Montijn, R. C., & Roeselers, G. (2014) · mBio · doi:10.1128/mbio.01438-14 · Cited by 476 · see citing works

The Planctomycetes, Verrucomicrobia, Chlamydiae and sister phyla comprise a superphylum with biotechnological and medical relevance

Wagner, M., & Horn, M. (2006) · Current Opinion in Biotechnology · doi:10.1016/j.copbio.2006.05.005 · Cited by 466 · see citing works

Fight them or feed them: How the intestinal mucus layer manages the gut microbiota

Schroeder, B. O. (2019) · Gastroenterology report · doi:10.1093/gastro/goy052 · Cited by 464 · see citing works

Interactions of Intestinal Bacteria with Components of the Intestinal Mucus

Sicard, J.-F., Bihan, G. L., Vogeleer, P., Jacques, M., & Harel, J. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00387 · Cited by 460 · see citing works

The gut microbiota and its relationship to diet and obesity

Clarke, S. F., Murphy, E. F., Nilaweera, K. N., Ross, R. P., Shanahan, F., O’Toole, P. W., & Cotter, P. D. (2012) · Gut Microbes · doi:10.4161/gmic.20168 · Cited by 458 · see citing works

Tracking heavy water (D 2 O) incorporation for identifying and sorting active microbial cells

Berry, D., Mader, E., Lee, T. K., Woebken, D., Wang, Y., Zhu, D., Palatinszky, M., Schintlmeister, A., Schmid, M. C., Hanson, B. T., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1420406112 · Cited by 455 · see citing works

Akkermansia muciniphila in the Human Gastrointestinal Tract: When, Where, and How?

Geerlings, S. Y., Kostopoulos, I., de Vos, W. M., & Belzer, C. (2018) · Microorganisms · doi:10.3390/microorganisms6030075 · Cited by 452 · see citing works

Update of the list of QPS‐recommended biological agents intentionally added to food or feed as notified to EFSA 13: suitability of taxonomic units notified to EFSA until September 2020

(BIOHAZ), E. P. O. B. H., Koutsoumanis, K., Allende, A., Álvarez‐Ordóñez, A., Bolton, D., Bover‐Cid, S., Chemaly, M., Davies, R., Cesare, A. D., Hilbert, F., et al. (2021) · EFSA Journal · doi:10.2903/j.efsa.2021.6377 · Cited by 443 · see citing works

Role of the intestinal microbiome in health and disease: from correlation to causation

de Vos, W. M., & de Vos, E. A. (2012) · Nutrition Reviews · doi:10.1111/j.1753-4887.2012.00505.x · Cited by 440 · see citing works

Microbial Metabolic Networks at the Mucus Layer Lead to Diet-Independent Butyrate and Vitamin B 12 Production by Intestinal Symbionts

Belzer, C., Chia, L. W., Aalvink, S., Chamlagain, B., Piironen, V. I., Knol, J., & de Vos, W. M. (2017) · mBio · doi:10.1128/mbio.00770-17 · Cited by 439 · see citing works

A next generation probiotic, Akkermansia muciniphila

Zhai, Q., Feng, S., Narbad, A., & Chen, W. (2018) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2018.1517725 · Cited by 437 · see citing works

The Genome of Akkermansia muciniphila, a Dedicated Intestinal Mucin Degrader, and Its Use in Exploring Intestinal Metagenomes

van Passel, M. W. J., Kant, R., Zoetendal, E. G., Plugge, C. M., Derrien, M., Malfatti, S., Chain, P., Woyke, T., Palva, A., de Vos, W. M., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016876 · Cited by 425 · see citing works

Function of Akkermansia muciniphila in obesity: interactions with lipid metabolism, immune response and gut systems

Xu, Y., Wang, N., Tan, H.-Y., Li, S., Zhang, C., & Feng, Y. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.00219 · Cited by 420 · see citing works

Mucins and the Microbiome

Hansson, G. C. (2020) · Annual Review of Biochemistry · doi:10.1146/annurev-biochem-011520-105053 · Cited by 417 · see citing works

Akkermansia muciniphila and Gut Immune System: A Good Friendship That Attenuates Inflammatory Bowel Disease, Obesity, and Diabetes

Rodrigues, V. F., Elias‐Oliveira, J., Pereira, Í. S., Pereira, J. A., Barbosa, S. C., Machado, M. S. G., & Carlos, D. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.934695 · Cited by 420 · see citing works

The interaction among gut microbes, the intestinal barrier and short chain fatty acids

Ma, J., Piao, X., Mahfuz, S. U., Long, S., & Wang, J. (2021) · Animal nutrition · doi:10.1016/j.aninu.2021.09.012 · Cited by 409 · see citing works

Responses of gut microbiota to diet composition and weight loss in lean and obese mice

Ravussin, Y., Koren, O., Spor, A., LeDuc, C., Gutman, R., Stombaugh, J., Knight, R., Ley, R. E., & Leibel, R. L. (2012) · Obesity · doi:10.1038/oby.2011.111 · Cited by 406 · see citing works

A comprehensive repertoire of prokaryotic species identified in human beings

Hugon, P., Dufour, J.-C., Colson, P., Fournier, P., Sallah, K., & Raoult, D. (2015) · The Lancet Infectious Diseases · doi:10.1016/s1473-3099(15)00293-5 · Cited by 406 · see citing works

The gut-bone axis: How bacterial metabolites bridge the distance

Zaiss, M. M., Jones, R. M., Schett, G., & Pacifici, R. (2019) · Journal of Clinical Investigation · doi:10.1172/jci128521 · Cited by 403 · see citing works

NLRP6 Protects Il10 Mice from Colitis by Limiting Colonization of Akkermansia muciniphila

Seregin, S. S., Golovchenko, N., Schaf, B., Chen, J., Pudlo, N. A., Mitchell, J., Baxter, N. T., Zhao, L., Schloss, P. D., Martens, E. C., et al. (2017) · Cell Reports · doi:10.1016/j.celrep.2017.03.080 · Cited by 386 · see citing works

Gut microbiota-mediated inflammation in obesity: a link with gastrointestinal cancer

Cani, P. D., & Jordan, B. F. (2018) · Nature Reviews Gastroenterology &amp; Hepatology · doi:10.1038/s41575-018-0025-6 · Cited by 383 · see citing works

Gut microbiota, enteroendocrine functions and metabolism

Cani, P. D., Everard, A., & Duparc, T. (2013) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2013.09.008 · Cited by 378 · see citing works

A library of human gut bacterial isolates paired with longitudinal multiomics data enables mechanistic microbiome research

Poyet, M., Groussin, M., Gibbons, S. M., Ávila-Pacheco, J., Jiang, X., Kearney, S. M., Perrotta, A. R., Berdy, B. M., Zhao, S., Lieberman, T. D., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0559-3 · Cited by 365 · see citing works

Immune regulation by microbiome metabolites

Kim, C. H. (2018) · Immunology · doi:10.1111/imm.12930 · Cited by 375 · see citing works

<scp>Meta‐Analysis</scp> of Gut Dysbiosis in Parkinson's Disease

Nishiwaki, H., Ito, M., Ishida, T., Hamaguchi, T., Maeda, T., Kashihara, K., Tsuboi, Y., Ueyama, J., Shimamura, T., Mori, H., et al. (2020) · Movement Disorders · doi:10.1002/mds.28119 · Cited by 370 · see citing works

Strain-Specific Anti-inflammatory Properties of Two Akkermansia muciniphila Strains on Chronic Colitis in Mice

Zhai, R., Xue, X., Zhang, L., Yang, X., Zhao, L., & Zhang, C. (2019) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2019.00239 · Cited by 368 · see citing works

Exercise, diet and stress as modulators of gut microbiota: Implications for neurodegenerative diseases

Gubert, C., Kong, G., Renoir, T., & Hannan, A. J. (2019) · Neurobiology of Disease · doi:10.1016/j.nbd.2019.104621 · Cited by 372 · see citing works

Characterization of the rumen microbiota of pre-ruminant calves using metagenomic tools.

Li, R. W., Connor, E., Li, C.-J., Baldwin, R., & Sparks, M. E. (2012) · Environmental Microbiology · doi:10.1111/j.1462-2920.2011.02543.x · Cited by 353 · see citing works

Correspondence

Derrien, M., Vaughan, E. E., Plugge, C. M., & de Vos, W. M. (2015)

Mucin utilisation and host interactions of the novel intestinal microbe Akkermansia muciniphila

Derrien, M. (2007) · doi:10.18174/2279 · Cited by 25 · see citing works

Akkermansia biwaensis sp. nov., an anaerobic mucin-degrading bacterium isolated from human faeces

Kobayashi, Y., Kawahara, T., Inoue, S., & Kohda, N. (2023) · INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY · doi:10.1099/ijsem.0.005697 · Cited by 30 · see citing works

Comparative Genomics and Physiology of Akkermansia muciniphila Isolates from Human Intestine Reveal Specialized Mucosal Adaptation

Ouwerkerk, J. P., Tytgat, H. L. P., Elzinga, J., Koehorst, J., Van den Abbeele, P., Henrissat, B., Gueimonde, M., Cani, P. D., Van de Wiele, T., Belzer, C., et al. (2022) · Microorganisms · doi:10.3390/microorganisms10081605 · Cited by 23 · see citing works

The Genome of Akkermansia muciniphila, a Dedicated Intestinal Mucin Degrader, and Its Use in Exploring Intestinal Metagenomes

van Passel, M. W. J., Kant, R., Zoetendal, E. G., Plugge, C. M., Derrien, M., Malfatti, S., Chain, P., Woyke, T., Palva, A., de Vos, W. M., et al. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016876 · Cited by 425 · see citing works