The DOI matches its Crossref record; 70 of the 72 references it cites were found in a registry or an index.
Lesion analysis of the brain areas involved in language comprehension
Open accessAbstract
The cortical regions of the brain traditionally associated with the comprehension of language are Wernicke's area and Broca's area. However, recent evidence suggests that other brain regions might also be involved in this complex process. This paper describes the opportunity to evaluate a large number of brain-injured patients to determine which lesioned brain areas might affect language comprehension. Sixty-four chronic left hemisphere stroke patients were evaluated on 11 subtests of the Curtiss-Yamada Comprehensive Language Evaluation - Receptive (CYCLE-R; Curtiss, S., & Yamada, J. (1988). Curtiss-Yamada Comprehensive Language Evaluation. Unpublished test, UCLA). Eight right hemisphere stroke patients and 15 neurologically normal older controls also participated. Patients were required to select a single line drawing from an array of three or four choices that best depicted the content of an auditorily-presented sentence. Patients' lesions obtained from structural neuroimaging were reconstructed onto templates and entered into a voxel-based lesion-symptom mapping (VLSM; Bates, E., Wilson, S., Saygin, A. P., Dick, F., Sereno, M., Knight, R. T., & Dronkers, N. F. (2003). Voxel-based lesion-symptom mapping. Nature Neuroscience, 6(5), 448-450.) analysis along with the behavioral data. VLSM is a brain-behavior mapping technique that evaluates the relationships between areas of injury and behavioral performance in all patients on a voxel-by-voxel basis, similar to the analysis of functional neuroimaging data. Results indicated that lesions to five left hemisphere brain regions affected performance on the CYCLE-R, including the posterior middle temporal gyrus and underlying white matter, the anterior superior temporal gyrus, the superior temporal sulcus and angular gyrus, mid-frontal cortex in Brodmann's area 46, and Brodmann's area 47 of the inferior frontal gyrus. Lesions to Broca's and Wernicke's areas were not found to significantly alter language comprehension on this particular measure. Further analysis suggested that the middle temporal gyrus may be more important for comprehension at the word level, while the other regions may play a greater role at the level of the sentence. These results are consistent with those seen in recent functional neuroimaging studies and offer complementary data in the effort to understand the brain areas underlying language comprehension.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Although BA46 is typically viewed as a middle frontal region, its ventral aspect lies in IFG and participates in language processes (51–53) and has been implicated in the genesis of AVHs (26,54).”
From Elevated functional connectivity along a corticostriatal loop and the mechanism of auditory/verbal hallucinations in patients with schizophrenia (2011) · cites this paper as [53]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Co-Planar Stereotaxic Atlas of the Human Brain
Talairach, J., & Tournoux, P. (1988) · Medical Entomology and Zoology · Cited by 11,798
Co-planar stereotaxic atlas of the human brain
Laitinen, L. (1989) · Clinical Neurology and Neurosurgery · doi:10.1016/0303-8467(89)90128-5 · Cited by 7,565
Berti, A. (1992) · Neuropsychologia · doi:10.1016/0028-3932(92)90076-x · Cited by 4,190
Imaging Cognition II: An Empirical Review of 275 PET and fMRI Studies
Cabeza, R., & Nyberg, L. (2000) · Journal of Cognitive Neuroscience · doi:10.1162/08989290051137585 · Cited by 3,598
Gazzaniga, M. S., & Bizzi, E. (2000) · Cited by 2,547
Towards a neural basis of auditory sentence processing
Friederici, A. D. (2002) · Trends in Cognitive Sciences · doi:10.1016/s1364-6613(00)01839-8 · Cited by 2,231
Hickok, G., & Poeppel, D. (2004) · Cognition · doi:10.1016/j.cognition.2003.10.011 · Cited by 2,212
Hécaen, H. (1983) · Neuropsychologia · doi:10.1016/0028-3932(83)90089-1 · Cited by 1,697
A neural basis for lexical retrieval
Damásio, H., Grabowski, T. J., Tranel, D., Hichwa, R. D., & Damásio, A. R. (1996) · Nature · doi:10.1038/380499a0 · Cited by 1,587
Voxel-based lesion-symptom mapping
Bates, E., Wilson, S. M., Saygin, A. P., Dick, F., Sereno, M. I., Knight, R. T., & Dronkers, N. F. (2003) · Nature Neuroscience · doi:10.1038/nn1050 · Cited by 1,457
Self-citation
Flagged first, then by citations
2 of the 72 references couldn’t be matched to a known paper.
Research works printed but not linked: 7
- Broca, 1864, Sur les mots aphemie, aphasie et aphrasie; Lettre a M. le Professeur Trousseau, Gazette des Hopitaux, 23
- Dronkers, 1995, Lesion localization in chronic Wernicke's aphasia, Brain and Language, 51, 62
- Dronkers, 1998, Brain regions associated with conduction aphasia and echoic rehearsal, Journal of the International Neuropsychological Society, 4, 23
- Dronkers, 1992, The role of Broca's area in Broca's aphasia, Journal of Clinical and Experimental Neuropsychology, 14, 52
- Dronkers, 1994, A reconsideration of the brain areas involved in the disruption of morphosyntactic comprehension, Brain and Language, 47, 461
- Dronkers, 1996, Cortical areas underlying the comprehension of grammar, Working Papers from the Center for Aphasia and Related Disorders, 1
- Frey, 1987, Defining functional areas with averaged CT scans, Society for Neuroscience Abstracts, 13, 1266
Cited by
Sorted by citations
Binder, J. R., Desai, R. H., Graves, W. W., & Conant, L. L. (2009) · Cerebral Cortex · doi:10.1093/cercor/bhp055 · Cited by 4,060
The neurobiology of semantic memory
Binder, J. R., & Desai, R. H. (2011) · Trends in Cognitive Sciences · doi:10.1016/j.tics.2011.10.001 · Cited by 2,114
Meta-analyzing left hemisphere language areas: phonology, semantics, and sentence processing.
Vigneau, M., Beaucousin, V., Hervé, P. Y., Duffau, H., Crivello, F., Houdé, O., Mazoyer, B., & Tzourio-Mazoyer, N. (2006) · NeuroImage · doi:10.1016/j.neuroimage.2005.11.002 · Cited by 1,851
A cortical network for semantics: (de)constructing the N400
Lau, E. F., Phillips, C., & Poeppel, D. (2008) · Nature reviews. Neuroscience · doi:10.1038/nrn2532 · Cited by 1,779
Turken, A. U., & Dronkers, N. F. (2011) · Frontiers in System Neuroscience · doi:10.3389/fnsys.2011.00001 · Cited by 1,012
Self-citation
Metadata
- Authors
- Dronkers, N. F., Wilkins, D. P., Van Valin, R. D., Redfern, B. B., & Jaeger, J. J.
- Affiliations
- VA Northern California Health Care System (US)
- University at Buffalo, State University of New York (US)
- Corresponding author
- Dronkers, Nina F
- Venue
- Cognition
- Publisher
- Elsevier BV
- Published
- 2004-05
- Volume
- 92
- Issue
- 1-2
- Pages
- 145-177
- ISSN
- 0010-0277 (ISSN-L)
- OpenAlex
- W2125711977
- Cited by
- 1,035
- References
- 72
- Citations by year
- 2026: 20 · 2025: 41 · 2024: 38 · 2023: 38 · 2022: 92 · 2021: 53 · 2020: 85 · 2019: 54 · 2018: 37 · 2017: 64 · 2016: 52 · 2015: 68 · 2014: 52 · 2013: 57 · 2012: 56
- FWCI
- 13.96
- Type
- journal article
- Language
- en
- Open access
- green
- hdl.handle.net
- Licence
- Locations
- Cognition (publishedVersion)
- PubMed (publishedVersion)
- MPG.PuRe (Max Planck Society) (submittedVersion, other-oa)
- Funders
- National Science Foundation (9207484)
- U.S. Department of Veterans Affairs
- National Institute on Deafness and Other Communication Disorders (2 R01DC00216, R01DC000216)
- National Institute of Neurological Disorders and Stroke (P01 NS177786, P01 NS 40813, P01NS040813)
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
- Social Sciences › Psychology › Developmental and Educational Psychology › Reading and Literacy Development
- Social Sciences › Psychology › Developmental and Educational Psychology › Language Development and Disorders
- Keywords
- language comprehension, receptive language, stroke, lesion-symptom mapping, Wernicke's area, Broca's area, left hemisphere, right hemisphere, middle temporal gyrus, superior temporal sulcus, angular gyrus, Brodmann area 46
- MeSH terms
- Aged, Aphasia, Brain, Female, Humans, Functional Laterality, Male, Middle Aged, Neuropsychological Tests, Speech Perception
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
