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Cited by 1,012Neurobiology of Language and BilingualismAdvanced Neuroimaging Techniques and ApplicationsFunctional Brain Connectivity Studies

The neural architecture of the language comprehension network: converging evidence from lesion and connectivity analyses.

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Turken, And U., Dronkers, Nina F.·2011·Frontiers in System Neuroscience
DOI 10.3389/fnsys.2011.00001PMC PMC3039157
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Abstract

While traditional models of language comprehension have focused on the left posterior temporal cortex as the neurological basis for language comprehension, lesion and functional imaging studies indicate the involvement of an extensive network of cortical regions. However, the full extent of this network and the white matter pathways that contribute to it remain to be characterized. In an earlier voxel-based lesion-symptom mapping analysis of data from aphasic patients (Dronkers et al., 2004), several brain regions in the left hemisphere were found to be critical for language comprehension: the left posterior middle temporal gyrus, the anterior part of Brodmann's area 22 in the superior temporal gyrus (anterior STG/BA22), the posterior superior temporal sulcus (STS) extending into Brodmann's area 39 (STS/BA39), the orbital part of the inferior frontal gyrus (BA47), and the middle frontal gyrus (BA46). Here, we investigated the white matter pathways associated with these regions using diffusion tensor imaging from healthy subjects. We also used resting-state functional magnetic resonance imaging data to assess the functional connectivity profiles of these regions. Fiber tractography and functional connectivity analyses indicated that the left MTG, anterior STG/BA22, STS/BA39, and BA47 are part of a richly interconnected network that extends to additional frontal, parietal, and temporal regions in the two hemispheres. The inferior occipito-frontal fasciculus, the arcuate fasciculus, and the middle and inferior longitudinal fasciculi, as well as transcallosal projections via the tapetum were found to be the most prominent white matter pathways bridging the regions important for language comprehension. The left MTG showed a particularly extensive structural and functional connectivity pattern which is consistent with the severity of the impairments associated with MTG lesions and which suggests a central role for this region in language comprehension.

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  • The inferior fronto-occipital (IFOF) and uncinate (UF) fasciculi are crucial for the ventral intra-hemispheric transfer of information between the frontal cortex and the occipital, temporal and parietal cortices.

    “Both inferior fronto-occipital (IFOF) and uncinate (UF) fasciculi are crucial for the ventral intra-hemispheric transfer of information between the frontal cortex and the occipital, temporal and parietal cortices”

    From Cortical Terminations of the Inferior Fronto-Occipital and Uncinate Fasciculi: Anatomical Stem-Based Virtual Dissection (2016) · cites this paper as Turken and Dronkers, 2011

    The Introduction describes the inferior occipito-frontal fasciculus as a pathway from frontal cortex to temporal, parietal, and occipital cortices. It describes the uncinate fasciculus more narrowly, as connecting the temporal pole with inferior frontal regions; the Results also associate it with the anterior superior temporal gyrus. These passages do not establish that both tracts are crucial for information transfer to all three posterior cortical regions. Page numbers are unavailable in our copy. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

  • Knowing the cortical terminations of the IFOF and UF is fundamental for understanding their role in mediating language semantics.

    “knowing their cortical terminations is fundamental for understanding their role in mediating language semantics”

    From Cortical Terminations of the Inferior Fronto-Occipital and Uncinate Fasciculi: Anatomical Stem-Based Virtual Dissection (2016) · cites this paper as Turken and Dronkers, 2011

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Research works printed but not linked: 124

  1. Achard S. Salvador R. Whitcher B. Suckling J. Bullmore E. (2006). A resilient, low-frequency, small-world human brain functional network with highly connected association cortical hubs. J. Neurosci. 26, 63– 72 10.1523/JNEUROSCI.3874-05.2006 16399673 PMC6674299 · DOI · Paper page
  2. Alexander M. P. Hiltbrunner B. Fischer R. S. (1989). Distributed anatomy of transcortical sensory aphasia. Arch. Neurol. 46, 885– 892 2757529
  3. Anwander A. Tittgemeyer M. von Cramon D. Y. Friederici A. D. Knosche T. R. (2007). Connectivity-based parcellation of Broca's area. Cereb. Cortex 17, 816– 825 16707738
  4. Ashburner J. Friston K. J. (2005). Unified segmentation. Neuroimage 26, 839– 851 10.1016/j.neuroimage.2005.02.018 15955494 · DOI · Paper page
  5. Basser P. J. (1995). Inferring microstructural features and the physiological state of tissues from diffusion-weighted images. NMR Biomed. 8, 333– 344 10.1002/nbm.1940080707 8739270 · DOI
  6. Basser P. J. Mattiello J. LeBihan D. (1994). MR diffusion tensor spectroscopy and imaging. Biophys. J. 66, 259– 267 8130344 PMC1275686
  7. Basser P. J. Pajevic S. Pierpaoli C. Duda J. Aldroubi A. (2000). In vivo fiber tractography using DT-MRI data. Magn. Reson. Med. 44, 625– 632 11025519
  8. Bates E. Wilson S. M. Saygin A. P. Dick F. Sereno M. I. Knight R. T. Dronkers N. F. (2003). Voxel-based lesion-symptom mapping. Nat. Neurosci. 6, 448– 450 12704393
  9. Behzadi Y. Restom K. Liau J. Liu T. T. (2007). A component based noise correction method (CompCor) for BOLD and perfusion based fMRI. Neuroimage 37, 90– 101 10.1016/j.neuroimage.2007.04.042 17560126 PMC2214855 · DOI · Paper page
  10. Binder J. R. (2003). “Wernicke aphasia: a disorder of central language processing’, in Neurological Foundations of Cognitive Neuroscience, ed. D'Esposito M. E. (Cambridge: The MIT Press), 75– 238
  11. Binder J. R. Desai R. H. Graves W. W. Conant L. L. (2009). Where is the semantic system? A critical review and meta-analysis of 120 functional neuroimaging studies. Cereb. Cortex 19, 2767– 2796 10.1093/cercor/bhp055 19329570 PMC2774390 · DOI · Paper page
  12. Binder J. R. Frost J. A. Hammeke T. A. Cox R. W. Rao S. M. Prieto T. (1997). Human brain language areas identified by functional magnetic resonance imaging. J. Neurosci. 17, 353– 362 8987760 PMC6793702
  13. Biswal B. B. Mennes M. Zuo X. N. Gohel S. Kelly C. Smith S. M. Beckmann C. F. Adelstein J. S. Buckner R. L. Colcombe S. Dogonowski A. M. Ernst M. Fair D. Hampson M. Hoptman M. J. Hyde J. S. Kiviniemi V. J. Kotter R. Li S. J. Lin C. P. Lowe M. J. Mackay C. Madden D. J. Madsen K. H. Margulies D. S. Mayberg H. S. McMahon K. Monk C. S. Mostofsky S. H. Nagel B. J. Pekar J. J. Peltier S. J. Petersen S. E. Riedl V. Rombouts S. A. Rypma B. Schlaggar B. L. Schmidt S. Seidler R. D. Siegle G. J. Sorg C. Teng G. J. Veijola J. Villringer A. Walter M. Wang L. Weng X. C. Whitfield-Gabrieli S. Williamson P. Windischberger C. Zang Y. F. Zhang H. Y. Castellanos F. X. Milham M. P. (2010). Toward discovery science of human brain function. Proc. Natl. Acad. Sci. U.S.A. 107, 4734– 4739 20176931 PMC2842060
  14. Boatman D. Gordon B. Hart J. Selnes O. Miglioretti D. Lenz F. (2000). Transcortical sensory aphasia: revisited and revised. Brain 123(Pt 8), 1634– 1642 10908193
  15. Bogen J. E. Bogen G. M. (1976). Wernicke's region-where is it? Ann. N. Y. Acad. Sci. 280, 834– 843 1070943
  16. Bookheimer S. (2002). Functional MRI of language: new approaches to understanding the cortical organization of semantic processing. Annu. Rev. Neurosci. 25, 151– 188 12052907
  17. Brauer J. Anwander A. Friederici A. D. (2010). Neuroanatomical prerequisites for language functions in the maturing brain. Cereb. Cortex 41, 1484– 1492 20566580
  18. Burgel U. Amunts K. Hoemke L. Mohlberg H. Gilsbach J. M. Zilles K. (2006). White matter fiber tracts of the human brain: three-dimensional mapping at microscopic resolution, topography and intersubject variability. Neuroimage 29, 1092– 1105 10.1016/j.neuroimage.2005.08.040 16236527 · DOI
  19. Caplan D. Hildebrandt N. Makris N. (1996). Location of lesions in stroke patients with deficits in syntactic processing in sentence comprehension. Brain 119(Pt 3), 933– 949 10.1093/brain/119.3.933 8673503 · DOI
  20. Caplan D. Waters G. Kennedy D. Alpert N. Makris N. Dede G. Michaud J. Reddy A. (2007). A study of syntactic processing in aphasia II: neurological aspects. Brain Lang. 101, 151– 177 10.1016/j.bandl.2006.06.226 16997366 · DOI
  21. Catani M. Allin M. P. Husain M. Pugliese L. Mesulam M. M. Murray R. M. Jones D. K. (2007). Symmetries in human brain language pathways correlate with verbal recall. Proc. Natl. Acad. Sci. U.S.A. 104, 17163– 17168 17939998 PMC2040413
  22. Catani M. Howard R. J. Pajevic S. Jones D. K. (2002). Virtual in vivo interactive dissection of white matter fasciculi in the human brain. Neuroimage 17, 77– 94 10.1006/nimg.2002.1136 12482069 · DOI · Paper page
  23. Catani M. Mesulam M. (2008a). The arcuate fasciculus and the disconnection theme in language and aphasia: history and current state. Cortex 44, 953– 961 10.1016/j.cortex.2008.04.002 18614162 PMC2740371 · DOI
  24. Catani M. Mesulam M. (2008b). What is a disconnection syndrome? Cortex 44, 911– 913 10.1016/j.cortex.2008.05.001 18603236 · DOI
  25. Catani M. Thiebaut de Schotten M. (2008). A diffusion tensor imaging tractography atlas for virtual in vivo dissections. Cortex 44, 1105– 1132 10.1016/j.cortex.2008.05.004 18619589 · DOI · Paper page
  26. Conturo T. E. Lori N. F. Cull T. S. Akbudak E. Snyder A. Z. Shimony J. S. McKinstry R. C. Burton H. Raichle M. E. (1999). Tracking neuronal fiber pathways in the living human brain. Proc. Natl. Acad. Sci. U.S.A. 96, 10422– 10427 10468624 PMC17904
  27. Damasio A. R. (1989). Time-locked multiregional retroactivation: a systems-level proposal for the neural substrates of recall and recognition. Cognition 33, 25– 62 10.1016/0010-0277(89)90005-X 2691184 · DOI · Paper page
  28. Damasio A. R. (1991). “Signs of aphasia,” in Acquired Aphasia, 2nd Edn ed. Sarno M. T. (San Diego, CA: Academic Press), 27– 43
  29. Damasio A. R. (1992). Aphasia. N. Engl. J. Med. 326, 531– 539 1732792
  30. Damasio A. R. Damasio H. (2002). Principles of Behavioral and Cognitive Neurology, 2nd Edn. New York: Oxford University Press
  31. Damoiseaux J. S. Rombouts S. A. Barkhof F. Scheltens P. Stam C. J. Smith S. M. Beckmann C. F. (2006). Consistent resting-state networks across healthy subjects. Proc. Natl. Acad. Sci. U.S.A. 103, 13848– 13853 16945915 PMC1564249
  32. Dancause N. Barbay S. Frost S. B. Plautz E. J. Chen D. Zoubina E. V. Stowe A. M. Nudo R. J. (2005). Extensive cortical rewiring after brain injury. J. Neurosci. 25, 10167– 10179 16267224 PMC6725801
  33. De Witt Hamer P. C. Moritz-Gasser S. Gatignol P. Duffau H. (2010). Is the human left middle longitudinal fascicle essential for language? A brain electrostimulation study. Hum. Brain Mapp. 20578169 PMC6870476
  34. DeArmond S. J. Fusco M. M. Dewey M. M. (1989). Structure of the Human Brain: A Photographic Atlas. New York: Oxford University Press
  35. Demb J. B. Desmond J. E. Wagner A. D. Vaidya C. J. Glover G. H. Gabrieli J. D. (1995). Semantic encoding and retrieval in the left inferior prefrontal cortex: a functional MRI study of task difficulty and process specificity. J. Neurosci. 15, 5870– 5878 7666172 PMC6577672
  36. Demonet J. F. Chollet F. Ramsay S. Cardebat D. Nespoulous J. L. Wise R. Rascol A. Frackowiak R. (1992). The anatomy of phonological and semantic processing in normal subjects. Brain 115(Pt 6), 1753– 1768 10.1093/brain/115.6.1753 1486459 · DOI
  37. Dosenbach N. U. Fair D. A. Miezin F. M. Cohen A. L. Wenger K. K. Dosenbach R. A. Fox M. D. Snyder A. Z. Vincent J. L. Raichle M. E. Schlaggar B. L. Petersen S. E. (2007). Distinct brain networks for adaptive and stable task control in humans. Proc. Natl. Acad. Sci. U.S.A. 104, 11073– 11078 17576922 PMC1904171
  38. Dronkers N. F. (2000). The pursuit of brain–language relationships. Brain Lang. 71, 59– 61 10.1006/brln.1999.2212 10716807 · DOI
  39. Dronkers N. Pinker S. Damasio A. R. (2000a). “Language and the aphasias,” in Principles in Neural Science, 4th Edn. eds Kandel E. R. Schwartz J. Jessell T. (New York: McGraw-Hill), 1169– 1187
  40. Dronkers N. F. Redfern B. B. Knight R. T. (2000b). “The neural architecture of language disorders,” in The New Cognitive Neurosciences, ed. Gazzaniga M. S. (Cambridge: The MIT Press), 949– 958
  41. Duffau H. (2008). The anatomo-functional connectivity of language revisited. New insights provided by electrostimulation and tractography. Neuropsychologia 46, 927– 934 10.1016/j.neuropsychologia.2007.10.025 18093622 · DOI
  42. Duffau H. Gatignol P. Mandonnet E. Peruzzi P. Tzourio-Mazoyer N. Capelle L. (2005). New insights into the anatomo-functional connectivity of the semantic system: a study using cortico-subcortical electrostimulations. Brain 128, 797– 810 10.1093/brain/awh423 15705610 · DOI
  43. Duffau H. Gatignol P. Moritz-Gasser S. Mandonnet E. (2009). Is the left uncinate fasciculus essential for language? A cerebral stimulation study. J. Neurol. 256, 382– 389 10.1007/s00415-009-0053-9 19271103 · DOI
  44. Duffau H. Peggy Gatignol S. T. Mandonnet E. Capelle L. Taillandier L. (2008). Intraoperative subcortical stimulation mapping of language pathways in a consecutive series of 115 patients with grade II glioma in the left dominant hemisphere. J. Neurosurg. 109, 461– 471 10.3171/JNS/2008/109/9/0461 18759577 · DOI
  45. Fernandez-Miranda J. C. Rhoton A. L. Jr. Alvarez-Linera J. Kakizawa Y. Choi C. de Oliveira E. P. (2008). Three-dimensional microsurgical and tractographic anatomy of the white matter of the human brain. Neurosurgery 62, 989– 1026; discussion 1026– 1028 18695585
  46. Fillard P. Pennec X. Arsigny V. Ayache N. (2007). Clinical DT-MRI estimation, smoothing, and fiber tracking with log-Euclidean metrics. IEEE Trans. Med. Imaging 26, 1472– 1482 18041263
  47. Fox M. D. Snyder A. Z. Vincent J. L. Corbetta M. Van Essen D. C. Raichle M. E. (2005). The human brain is intrinsically organized into dynamic, anticorrelated functional networks. Proc. Natl. Acad. Sci. U.S.A. 102, 9673– 9678 15976020 PMC1157105
  48. Frey S. Campbell J. S. Pike G. B. Petrides M. (2008). Dissociating the human language pathways with high angular resolution diffusion fiber tractography. J. Neurosci. 28, 11435– 11444 10.1523/JNEUROSCI.2388-08.2008 18987180 PMC6671318 · DOI · Paper page
  49. Friederici A. D. (2002). Towards a neural basis of auditory sentence processing. Trends Cogn. Sci. 6, 78– 84 15866191
  50. Friederici A. D. (2009). Pathways to language: fiber tracts in the human brain. Trends Cogn. Sci. 13, 175– 181 19223226
  51. Gabrieli J. D. Poldrack R. A. Desmond J. E. (1998). The role of left prefrontal cortex in language and memory. Proc. Natl. Acad. Sci. U.S.A. 95, 906– 913 9448258 PMC33815
  52. Geschwind N. (1965a). Disconnexion syndromes in animals and man. I. Brain 88, 237– 294 10.1093/brain/88.2.237 5318481 · DOI
  53. Geschwind N. (1965b). Disconnexion syndromes in animals and man. II. Brain 88, 585– 644 10.1093/brain/88.3.585 5318824 · DOI
  54. Geschwind N. (1970). The organization of language and the brain. Science 170, 940– 944 10.1126/science.170.3961.940 5475022 · DOI
  55. Geschwind N. (1972). Language and the brain. Sci. Am. 226, 76– 83 5014017
  56. Glasser M. F. Rilling J. K. (2008). DTI tractography of the human brain's language pathways. Cereb. Cortex 18, 2471– 2482 10.1093/cercor/bhn011 18281301 · DOI
  57. Goodglass H. (1993). Understanding Aphasia. San Diego: Academic Press
  58. Hagmann P. Jonasson L. Maeder P. Thiran J. P. Wedeen V. J. Meuli R. (2006). Understanding diffusion MR imaging techniques: from scalar diffusion-weighted imaging to diffusion tensor imaging and beyond. Radiographics 26(Suppl. 1), S205– S223 17050517
  59. Hampson M. Peterson B. S. Skudlarski P. Gatenby J. C. Gore J. C. (2002). Detection of functional connectivity using temporal correlations in MR images. Hum. Brain Mapp. 15, 247– 262 10.1002/hbm.10022 11835612 PMC6872035 · DOI · Paper page
  60. Hart J. Jr. Gordon B. (1990). Delineation of single-word semantic comprehension deficits in aphasia, with anatomical correlation. Ann. Neurol. 27, 226– 231 2327733
  61. He B. J. Snyder A. Z. Vincent J. L. Epstein A. Shulman G. L. Corbetta M. (2007). Breakdown of functional connectivity in frontoparietal networks underlies behavioral deficits in spatial neglect. Neuron 53, 905– 918 10.1016/j.neuron.2007.02.013 17359924 · DOI
  62. Heiss W. D. Thiel A. Kessler J. Herholz K. (2003). Disturbance and recovery of language function: correlates in PET activation studies. Neuroimage 20(Suppl. 1), S42– S49 14597295
  63. Hickok G. Poeppel D. (2004). Dorsal and ventral streams: a framework for understanding aspects of the functional anatomy of language. Cognition 92, 67– 99 10.1016/j.cognition.2003.10.011 15037127 · DOI · Paper page
  64. Hillis A. E. Boatman D. Hart J. Gordon B. (1999). Making sense out of jargon: a neurolinguistic and computational account of jargon aphasia. Neurology 53, 1813– 1824 10563633
  65. Hua K. Oishi K. Zhang J. Wakana S. Yoshioka T. Zhang W. Akhter K. D. Li X. Huang H. Jiang H. van Zijl P. Mori S. (2009). Mapping of functional areas in the human cortex based on connectivity through association fibers. Cereb. Cortex 19, 1889– 1895 10.1093/cercor/bhn215 19068488 PMC2705697 · DOI
  66. Hua K. Zhang J. Wakana S. Jiang H. Li X. Reich D. S. Calabresi P. A. Pekar J. J. van Zijl P. C. Mori S. (2008). Tract probability maps in stereotaxic spaces: analyses of white matter anatomy and tract-specific quantification. Neuroimage 39, 336– 347 10.1016/j.neuroimage.2007.07.053 17931890 PMC2724595 · DOI
  67. Jung-Beeman M. (2005). Bilateral brain processes for comprehending natural language. Trends Cogn. Sci. 9, 512– 518 16214387
  68. Just M. A. Carpenter P. A. Keller T. A. Eddy W. F. Thulborn K. R. (1996). Brain activation modulated by sentence comprehension. Science 274, 114– 116 10.1126/science.274.5284.114 8810246 · DOI
  69. Kaiser M. Martin R. Andras P. Young M. P. (2007). Simulation of robustness against lesions of cortical networks. Eur. J. Neurosci. 25, 3185– 3192 17561832
  70. Kaplan E. Naeser M. A. Martin P. I. Ho M. Wang Y. Baker E. Pascual-Leone A. (2010). Horizontal portion of arcuate fasciculus fibers track to pars opercularis, not pars triangularis, in right and left hemispheres: a DTI study. Neuroimage 52, 436– 444 10.1016/j.neuroimage.2010.04.247 20438853 PMC2909757 · DOI
  71. Kelly C. Uddin L. Q. Shehzad Z. Margulies D. S. Castellanos F. X. Milham M. P. Petrides M. (2010). Broca's region: linking human brain functional connectivity data and non-human primate tracing anatomy studies. Eur. J. Neurosci. 32, 383– 398 20662902 PMC3111969
  72. Kertesz A. Harlock W. Coates R. (1979). Computer tomographic localization, lesion size, and prognosis in aphasia and nonverbal impairment. Brain Lang. 8, 34– 50 10.1016/0093-934X(79)90038-5 476474 · DOI
  73. Kertesz A. Lau W. K. Polk M. (1993). The structural determinants of recovery in Wernicke's aphasia. Brain Lang. 44, 153– 164 10.1006/brln.1993.1010 8428309 · DOI
  74. Kertesz A. Sheppard A. MacKenzie R. (1982). Localization in transcortical sensory aphasia. Arch. Neurol. 39, 475– 478 7103795
  75. Kier E. L. Staib L. H. Davis L. M. Bronen R. A. (2004). MR imaging of the temporal stem: anatomic dissection tractography of the uncinate fasciculus, inferior occipitofrontal fasciculus, and Meyer's loop of the optic radiation. AJNR Am. J. Neuroradiol. 25, 677– 691 15140705 PMC7974480
  76. Koyama M. S. Kelly C. Shehzad Z. Penesetti D. Castellanos F. X. Milham M. P. (2010). Reading networks at rest. Cereb. Cortex 10, 2549– 2559 20139150 PMC2981020
  77. Lawes I. N. Barrick T. R. Murugam V. Spierings N. Evans D. R. Song M. Clark C. A. (2008). Atlas-based segmentation of white matter tracts of the human brain using diffusion tensor tractography and comparison with classical dissection. Neuroimage 39, 62– 79 10.1016/j.neuroimage.2007.06.041 17919935 · DOI
  78. Lowe M. J. Mock B. J. Sorenson J. A. (1998). Functional connectivity in single and multislice echoplanar imaging using resting-state fluctuations. Neuroimage 7, 119– 132 10.1006/nimg.1997.0315 9558644 · DOI · Paper page
  79. Makris N. Kennedy D. N. McInerney S. Sorensen A. G. Wang R. Caviness V. S. Jr. Pandya D. N. (2005). Segmentation of subcomponents within the superior longitudinal fascicle in humans: a quantitative, in vivo, DT-MRI study. Cereb. Cortex 15, 854– 869 15590909
  80. Makris N. Pandya D. N. (2009). The extreme capsule in humans and rethinking of the language circuitry. Brain Struct. Funct. 213, 343– 358 19104833 PMC3777634
  81. Marsh E. B. Hillis A. E. (2006). Recovery from aphasia following brain injury: the role of reorganization. Prog. Brain Res. 157, 143– 156 10.1016/S0079-6123(06)57009-8 17046670 · DOI
  82. Martino J. Brogna C. Robles S. G. Vergani F. Duffau H. (2010). Anatomic dissection of the inferior fronto-occipital fasciculus revisited in the lights of brain stimulation data. Cortex 46, 691– 699 10.1016/j.cortex.2009.07.015 19775684 · DOI · Paper page
  83. Mesulam M. (2005). Imaging connectivity in the human cerebral cortex: the next frontier? Ann. Neurol. 57, 5– 7 15622538
  84. Mesulam M. (2009). Defining neurocognitive networks in the BOLD new world of computed connectivity. Neuron 62, 1– 3 10.1016/j.neuron.2009.04.001 19376059 · DOI
  85. Mesulam M. M. (1990). Large-scale neurocognitive networks and distributed processing for attention, language, and memory. Ann. Neurol. 28, 597– 613 2260847
  86. Mesulam M. M. (1998). From sensation to cognition. Brain 121(Pt 6), 1013– 1052 10.1093/brain/121.6.1013 9648540 · DOI · Paper page
  87. Mori S. Kaufmann W. E. Davatzikos C. Stieltjes B. Amodei L. Fredericksen K. Pearlson G. D. Melhem E. R. Solaiyappan M. Raymond G. V. Moser H. W. van Zijl P. C. (2002). Imaging cortical association tracts in the human brain using diffusion-tensor-based axonal tracking. Magn. Reson. Med. 47, 215– 223 11810663
  88. Mori S. Oishi K. Jiang H. Jiang L. Li X. Akhter K. Hua K. Faria A. V. Mahmood A. Woods R. Toga A. W. Pike G. B. Neto P. R. Evans A. Zhang J. Huang H. Miller M. I. van Zijl P. Mazziotta J. (2008). Stereotaxic white matter atlas based on diffusion tensor imaging in an ICBM template. Neuroimage 40, 570– 582 10.1016/j.neuroimage.2007.12.035 18255316 PMC2478641 · DOI
  89. Naeser M. A. Alexander M. P. Helm-Estabrooks N. Levine H. L. Laughlin S. A. Geschwind N. (1982). Aphasia with predominantly subcortical lesion sites: description of three capsular/putaminal aphasia syndromes. Arch. Neurol. 39, 2– 14 6976780
  90. Naeser M. A. Helm-Estabrooks N. Haas G. Auerbach S. Srinivasan M. (1987). Relationship between lesion extent in “Wernicke's area” on computed tomographic scan and predicting recovery of comprehension in Wernicke's aphasia. Arch. Neurol. 44, 73– 82 3800725
  91. Nomura E. M. Gratton C. Visser R. M. Kayser A. Perez F. D'Esposito M. (2010). Double dissociation of two cognitive control networks in patients with focal brain lesions. Proc. Natl. Acad. Sci. U.S.A. 107, 12017– 12022 20547857 PMC2900657
  92. Oishi K. Zilles K. Amunts K. Faria A. Jiang H. Li X. Akhter K. Hua K. Woods R. Toga A. W. Pike G. B. Rosa-Neto P. Evans A. Zhang J. Huang H. Miller M. I. van Zijl P. C. Mazziotta J. Mori S. (2008). Human brain white matter atlas: identification and assignment of common anatomical structures in superficial white matter. Neuroimage 43, 447– 457 10.1016/j.neuroimage.2008.07.009 18692144 PMC2586008 · DOI
  93. Parker G. J. Luzzi S. Alexander D. C. Wheeler-Kingshott C. A. Ciccarelli O. Lambon Ralph M. A. (2005). Lateralization of ventral and dorsal auditory-language pathways in the human brain. Neuroimage 24, 656– 666 10.1016/j.neuroimage.2004.08.047 15652301 · DOI
  94. Petrides M. Pandya D. N. (1988). Association fiber pathways to the frontal cortex from the superior temporal region in the rhesus monkey. J. Comp. Neurol. 273, 52– 66 2463275
  95. Petrides M. Pandya D. N. (2006). Efferent association pathways originating in the caudal prefrontal cortex in the macaque monkey. J. Comp. Neurol. 498, 227– 251 16856142
  96. Poldrack R. A. Wagner A. D. Prull M. W. Desmond J. E. Glover G. H. Gabrieli J. D. (1999). Functional specialization for semantic and phonological processing in the left inferior prefrontal cortex. Neuroimage 10, 15– 35 10.1006/nimg.1999.0441 10385578 · DOI · Paper page
  97. Powell H. W. Parker G. J. Alexander D. C. Symms M. R. Boulby P. A. Wheeler-Kingshott C. A. Barker G. J. Noppeney U. Koepp M. J. Duncan J. S. (2006). Hemispheric asymmetries in language-related pathways: a combined functional MRI and tractography study. Neuroimage 32, 388– 399 10.1016/j.neuroimage.2006.03.011 16632380 · DOI
  98. Price C. J. (2000). The anatomy of language: contributions from functional neuroimaging. J. Anat. 197(Pt 3), 335– 359 10.1046/j.1469-7580.2000.19730335.x 11117622 PMC1468137 · DOI
  99. Rilling J. K. Glasser M. F. Preuss T. M. Ma X. Zhao T. Hu X. Behrens T. E. (2008). The evolution of the arcuate fasciculus revealed with comparative DTI. Nat. Neurosci. 11, 426– 428 18344993
  100. Rilling J. K. Seligman R. A. (2002). A quantitative morphometric comparative analysis of the primate temporal lobe. J. Hum. Evol. 42, 505– 533 11969295
  101. Saur D. Kreher B. W. Schnell S. Kummerer D. Kellmeyer P. Vry M. S. Umarova R. Musso M. Glauche V. Abel S. Huber W. Rijntjes M. Hennig J. Weiller C. (2008). Ventral and dorsal pathways for language. Proc. Natl. Acad. Sci. U.S.A. 105, 18035– 18040 19004769 PMC2584675
  102. Saur D. Schelter B. Schnell S. Kratochvil D. Kupper H. Kellmeyer P. Kummerer D. Kloppel S. Glauche V. Lange R. Mader W. Feess D. Timmer J. Weiller C. (2010). Combining functional and anatomical connectivity reveals brain networks for auditory language comprehension. Neuroimage 49, 3187– 3197 10.1016/j.neuroimage.2009.11.009 19913624 · DOI
  103. Schmahmann J. D. Pandya D. N. (2006). Fiber Pathways of the Brain. Oxford; NY: Oxford University Press
  104. Schmahmann J. D. Pandya D. N. (2007). Cerebral white matter-historical evolution of facts and notions concerning the organization of the fiber pathways of the brain. J. Hist. Neurosci. 16, 237– 267 17620190
  105. Schmahmann J. D. Pandya D. N. (2008). Disconnection syndromes of basal ganglia, thalamus, and cerebrocerebellar systems. Cortex 44, 1037– 1066 10.1016/j.cortex.2008.04.004 18614161 PMC3738020 · DOI
  106. Schmahmann J. D. Pandya D. N. Wang R. Dai G. D'Arceuil H. E. de Crespigny A. J. Wedeen V. J. (2007). Association fibre pathways of the brain: parallel observations from diffusion spectrum imaging and autoradiography. Brain 130, 630– 653 10.1093/brain/awl359 17293361 · DOI · Paper page
  107. Seltzer B. Pandya D. N. (1984). Further observations on parieto-temporal connections in the rhesus monkey. Exp. Brain Res. 55, 301– 312 6745368
  108. Seltzer B. Pandya D. N. (1994). Parietal, temporal, and occipital projections to cortex of the superior temporal sulcus in the rhesus monkey: a retrograde tracer study. J. Comp. Neurol. 343, 445– 463 8027452
  109. Shehzad Z. Kelly A. M. Reiss P. T. Gee D. G. Gotimer K. Uddin L. Q. Lee S. H. Margulies D. S. Roy A. K. Biswal B. B. Petkova E. Castellanos F. X. Milham M. P. (2009). The resting brain: unconstrained yet reliable. Cereb. Cortex 19, 2209– 2229 10.1093/cercor/bhn256 19221144 PMC3896030 · DOI
  110. Thompson-Schill S. L. D'Esposito M. Aguirre G. K. Farah M. J. (1997). Role of left inferior prefrontal cortex in retrieval of semantic knowledge: a reevaluation. Proc. Natl. Acad. Sci. U.S.A. 94, 14792– 14797 9405692 PMC25116
  111. Ture U. Yasargil M. G. Friedman A. H. Al-Mefty O. (2000). Fiber dissection technique: lateral aspect of the brain. Neurosurgery 47, 417– 426; discussion 426– 417 10942015
  112. Turken A. Whitfield-Gabrieli S. Bammer R. Baldo J. V. Dronkers N. F. Gabrieli J. D. (2008). Cognitive processing speed and the structure of white matter pathways: convergent evidence from normal variation and lesion studies. Neuroimage 42, 1032– 1044 10.1016/j.neuroimage.2008.03.057 18602840 PMC2630965 · DOI · Paper page
  113. Tyler L. K. Marslen-Wilson W. (2008). Fronto-temporal brain systems supporting spoken language comprehension. Philos. Trans. R. Soc. Lond., B, Biol. Sci. 363, 1037– 1054 17827104 PMC2494576
  114. Tzourio-Mazoyer N. Landeau B. Papathanassiou D. Crivello F. Etard O. Delcroix N. Mazoyer B. Joliot M. (2002). Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain. Neuroimage 15, 273– 289 10.1006/nimg.2001.0978 11771995 · DOI · Paper page
  115. Van Dijk K. R. Hedden T. Venkataraman A. Evans K. C. Lazar S. W. Buckner R. L. (2010). Intrinsic functional connectivity as a tool for human connectomics: theory, properties, and optimization. J. Neurophysiol. 103, 297– 321 10.1152/jn.00783.2009 19889849 PMC2807224 · DOI · Paper page
  116. Vernooij M. W. Smits M. Wielopolski P. A. Houston G. C. Krestin G. P. van der Lugt A. (2007). Fiber density asymmetry of the arcuate fasciculus in relation to functional hemispheric language lateralization in both right- and left-handed healthy subjects: a combined fMRI and DTI study. Neuroimage 35, 1064– 1076 10.1016/j.neuroimage.2006.12.041 17320414 · DOI · Paper page
  117. Vigneau M. Beaucousin V. Herve P. Y. Duffau H. Crivello F. Houde O. Mazoyer B. Tzourio-Mazoyer N. (2006). Meta-analyzing left hemisphere language areas: phonology, semantics, and sentence processing. Neuroimage 30, 1414– 1432 10.1016/j.neuroimage.2005.11.002 16413796 · DOI · Paper page
  118. Vincent J. L. Patel G. H. Fox M. D. Snyder A. Z. Baker J. T. Van Essen D. C. Zempel J. M. Snyder L. H. Corbetta M. Raichle M. E. (2007). Intrinsic functional architecture in the anaesthetized monkey brain. Nature 447, 83– 86 10.1038/nature05758 17476267 · DOI · Paper page
  119. Wakana S. Caprihan A. Panzenboeck M. M. Fallon J. H. Perry M. Gollub R. L. Hua K. Zhang J. Jiang H. Dubey P. Blitz A. van Zijl P. Mori S. (2007). Reproducibility of quantitative tractography methods applied to cerebral white matter. Neuroimage 36, 630– 644 10.1016/j.neuroimage.2007.02.049 17481925 PMC2350213 · DOI · Paper page
  120. Wakana S. Jiang H. Nagae-Poetscher L. M. van Zijl P. C. Mori S. (2004). Fiber tract-based atlas of human white matter anatomy. Radiology 230, 77– 87 10.1148/radiol.2301021640 14645885 · DOI
  121. Ward N. S. (2005). Plasticity and the functional reorganization of the human brain. Int. J. Psychophysiol. 58, 158– 161 10.1016/j.ijpsycho.2005.02.009 16181695 · DOI
  122. Wedeen V. J. Wang R. P. Schmahmann J. D. Benner T. Tseng W. Y. Dai G. Pandya D. N. Hagmann P. D'Arceuil H. de Crespigny A. J. (2008). Diffusion spectrum magnetic resonance imaging (DSI) tractography of crossing fibers. Neuroimage 41, 1267– 1277 10.1016/j.neuroimage.2008.03.036 18495497 · DOI
  123. Xiang H. D. Fonteijn H. M. Norris D. G. Hagoort P. (2010). Topographical functional connectivity pattern in the perisylvian language networks. Cereb. Cortex 20, 549– 560 10.1093/cercor/bhp119 19546155 · DOI
  124. Zhang W. Olivi A. Hertig S. J. van Zijl P. Mori S. (2008 Neuroimage 42, 771– 777 10.1016/j.neuroimage.2008.04.241 18554930 PMC2585359 · DOI

Cited by

Sorted by citations

Authors
Turken, A. U., & Dronkers, N. F.
Affiliations
VA Northern California Health Care System (US)
Corresponding author
Dronkers, Nina F.
ORCID
Dronkers, Nina F.
Venue
Frontiers in System Neuroscience
Publisher
Frontiers Media SA
Published
2011
Volume
5
Pages
1-1
ISSN
1662-5137 (ISSN-L)
DOI
10.3389/fnsys.2011.00001
PMC
PMC3039157
OpenAlex
W2150009200
Cited by
1,012
References
16
Citations by year
2026: 25 · 2025: 36 · 2024: 45 · 2023: 45 · 2022: 54 · 2021: 78 · 2020: 59 · 2019: 69 · 2018: 56 · 2017: 80 · 2016: 77 · 2015: 91 · 2014: 98 · 2013: 103 · 2012: 78
FWCI
48.25
Type
journal article
Language
en
Open access
Licence
cc-by
Locations
  • Frontiers in Systems Neuroscience (publishedVersion, cc-by)
  • PubMed Central (publishedVersion)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
U.S. Department of Veterans Affairs
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neurobiology of Language and Bilingualism
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
Keywords
language comprehension, anterior superior temporal gyrus, posterior superior temporal sulcus, inferior frontal gyrus, white matter tracts, fiber tractography, functional connectivity, arcuate fasciculus, voxel-based lesion-symptom mapping, aphasia, left hemisphere

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