Cited by 705Neutrophil, Myeloperoxidase and Oxidative MechanismsRedox biology and oxidative stressNitric Oxide and Endothelin Effects

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NADPH oxidase

Babior, Bernard M·2004·Current Opinion in Immunology

DOI 10.1016/j.coi.2003.12.001

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Abstract

NADPH oxidase is an enzyme that catalyzes the production of superoxide from oxygen and NADPH. It is a complex enzyme consisting of two membrane-bound components and three components in the cytosol, plus rac 1 or rac 2. Activation of the oxidase involves the phosphorylation of one of the cytosolic components. Recent crystallography data indicate that the tail of this cytosolic component lies in a groove between two Src homology 3 domains and, when phosphorylated, the tail leaves the groove and is replaced by the tail of one of the membrane-bound components. Chronic granulomatous disease is an inherited immune deficiency caused by the absence of one of the components of the oxidase. The most important recent advances in the field have been the crystallographic analysis of the oxidase and the use of antifungal agents in the prophylaxis of chronic granulomatous disease.

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“The major sources of ROS are NADPH oxidase (nicotinamide adenine dinucleotide phosphate-oxidase) and myeloperoxidase in leukocytes, xanthine oxidase in the myocardium, and mitochondrial electron transport chain of cardiomyocytes after ischemia-reperfusion (Akhlaghi and Bandy, 2009; Babior, 2004; Landmesser et al., 200…”
Background
Hypercholesterolemic diet induces hepatic steatosis and alterations in mRNA expression of NADPH oxidase in rat livers
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“When p47PHOX is phosphorylated, it binds to p22PHOX, an interaction that is probably responsible for activating the oxidase (38).”
Background
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“One of the main sources of ROS generation is NADPH oxidase, which is composed of two membrane-bound elements (gp91 and p22), three cytosolic components (p67, p47, and p40), and a low-molecular-weight G protein (either rac 2 or rac 1) (4).”
Background
JAK2 is necessary and sufficient for interferon-γ-induced transcription of the gene encoding gp91PHOX
Kakar, R., Kautz, B., & Eklund, E. A. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0704429 · Cited by 30
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Tanaka, K., Kanno, T., Yanagisawa, Y., Yasutake, K., Inoue, S., Hirayama, N., & Ikeda, J. (2014) · PLoS ONE · doi:10.1371/journal.pone.0087728 · Cited by 29
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Gene therapy of inherited immunodeficiencies
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Binding of Pleomorphic Adenoma Gene-like 2 to the Tumor Necrosis Factor (TNF)-α-responsive Region of the NCF2 Promoter Regulates p67 Expression and NADPH Oxidase Activity
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“A key source of cellular ROS is nicotinamide adenine dinucleotide phosphate (NADPH) oxidases (NOX), which are a class of membrane-bound multimeric enzyme complexes that catalyze the reduction of molecular oxygen to superoxide (Babior, 2004; Bedard & Krause, 2007).”
Background
Opportunities and Challenges for Nanotherapeutics for the Aging Population
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“V-ATPase promotes an acidic environment (pH 4.5) (Marshansky and Futai, 2008), oxidase complexes produce reactive oxygen species (ROS) and superoxide (O2 −) (Babior, 2004; Minakami and Sumimoto, 2006).”
BackgroundInfluential
The Presence of p47phox in Liver Parenchymal Cells is a Key Mediator in the Pathogenesis of Alcoholic Liver Steatosis
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Li, X. J., Fieschi, F., Paclet, M., Grünwald, D., Campion, Y., Gaudin, P., Morel, F., & Stasia, M. J. (2006) · Journal of Leukocyte Biology · doi:10.1189/jlb.0905541 · Cited by 28
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“A major mechanism induced by activation of the AngII/AT1 axis is production of superoxide derived from NADPH-oxidase complex activation, which generates high levels of superoxide in cells responsible for the inflammatory response, such as microglial cells, and lower levels of superoxide in tissue resident cells such a…”
Background

Authors: Babior, B. M.
Affiliations: Scripps Research Institute (US)
Corresponding author: Babior, Bernard M
Venue: Current Opinion in Immunology
Publisher: Elsevier BV
Published: 2004-02
Volume: 16
Issue: 1
Pages: 42-47
ISSN: 0952-7915 (ISSN-L)
DOI: 10.1016/j.coi.2003.12.001
OpenAlex: W4242182607
Cited by: 705
References: 63
Citations by year: 2026: 7 · 2025: 8 · 2024: 25 · 2023: 20 · 2022: 28 · 2021: 24 · 2020: 34 · 2019: 22 · 2018: 21 · 2017: 26 · 2016: 29 · 2015: 29 · 2014: 53 · 2013: 40 · 2012: 42
FWCI: 2.15
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Current Opinion in Immunology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01ai044434-05)
National Institute of Allergy and Infectious Diseases (AI44434, R01AI028479, AI-24227, AI28479)
Topics: Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Health Sciences › Medicine › Physiology (medical) › Nitric Oxide and Endothelin Effects
Keywords: NADPH oxidase, superoxide production, Rac1, Rac2, Src homology 3 domain, chronic granulomatous disease, antifungal prophylaxis, crystal structure
MeSH terms: Granulomatous Disease, Chronic, Humans, Models, Molecular, Crystallography, X-Ray, src Homology Domains, NADPH Oxidases, Protein Subunits

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