Superoxide Production and Expression of Nox Family Proteins in Human Atherosclerosis
Abstract
Background — NAD(P)H oxidases are important sources of superoxide in the vasculature, the activity of which is associated with risk factors for human atherosclerosis. This study was designed to investigate the localization of superoxide production and the expression of the Nox family of NAD(P)H oxidase proteins (gp91phox, Nox1, and Nox4) in nonatherosclerotic and atherosclerotic human coronary arteries. Methods and Results — In coronary artery segments from explanted human hearts, we examined intracellular superoxide production with dihydroethidium. In nonatherosclerotic coronary arteries, superoxide was present homogenously throughout the intima, media, and adventitia. In atherosclerotic arteries, there was an additional intense area of superoxide in the plaque shoulder, which is rich in macrophages and α-actin–positive cells. p22phox colocalized with gp91phox mainly in macrophages, whereas Nox4 was found only in nonphagocytic vascular cells. Expression of gp91phox and p22phox mRNA was associated with the severity of atherosclerosis. gp91phox correlated with the plaque macrophage content, whereas Nox4 correlated with the content of α-actin–positive cells. Nox1 expression was low both in human coronary arteries and isolated vascular cells. Conclusions — Several Nox proteins, including gp91phox and Nox4, may contribute to increased intracellular oxidative stress in human coronary atherosclerosis in a cell-specific manner and thus may be involved in the genesis and progression of human coronary atherosclerotic disease.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In Parkinson's patients, MitoQ showed no difference in motor function compared with placebo, but the trial established that administration of MitoQ to humans for 1 yr is safe.
“Although Parkinson’s patients taking MitoQ showed no difference in motor function compared with those on placebo treatment, this trial did establish that administration of MitoQ to humans for 1 yr is safe (874).”
From Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation (2019) · cites this paper as [874]
Cites
Stary, H. C., Chandler, A. B., Dinsmore, R. E., Fuster, V., Glagov, S. K., Insull, W., Rosenfeld, M. E., Schwartz, C. J., Wagner, W. D., & Wissler, R. W. (1995) · Circulation · doi:10.1161/01.cir.92.5.1355 · Cited by 3,506 · see citing works
NAD(P)H Oxidase: Role in Cardiovascular Biology and Disease
Griendling, K. K., Sorescu, D., & Ushio-Fukai, M. (2000) · Circulation Research · doi:10.1161/01.res.86.5.494 · Cited by 2,886 · see citing works
Self-citationBABIOR, B. M. (1999) · Blood · doi:10.1182/blood.v93.5.1464 · Cited by 2,147 · see citing works
Heitzer, T., Schlinzig, T., Krohn, K., Meinertz, T., & Münzel, T. (2001) · Circulation · doi:10.1161/hc4601.099485 · Cited by 1,961 · see citing works
Cell transformation by the superoxide-generating oxidase Mox1
Suh, Y.-A., Arnold, R. S., Lassegue, B., Shi, J., Xu, X., Sorescu, D., Chung, A. B., Griendling, K. K., & Lambeth, J. D. (1999) · Nature · doi:10.1038/43459 · Cited by 1,480 · see citing works
Self-citationIdentification of Renox, an NAD(P)H oxidase in kidney
Geiszt, M., Kopp, J. B., Várnai, P., & Leto, T. L. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.130135897 · Cited by 840 · see citing works
Lassègue, B., Sorescu, D., Szöcs, K., Yin, Q., Akers, M., Zhang, Y., Grant, S. L., Lambeth, J. D., & Griendling, K. K. (2001) · Circulation Research · doi:10.1161/hh0901.090299 · Cited by 839 · see citing works
Self-citationRole of Superoxide in Angiotensin II–Induced but Not Catecholamine-Induced Hypertension
Laursen, J. B., Rajagopalan, S., Galis, Z. S., Tarpey, M. M., Freeman, B. Α., & Harrison, D. G. (1997) · Circulation · doi:10.1161/01.cir.95.3.588 · Cited by 820 · see citing works
Cheng, G. C., Loree, H. M., Kamm, R. D., Fishbein, M. C., & Lee, R. T. (1993) · Circulation · doi:10.1161/01.cir.87.4.1179 · Cited by 795 · see citing works
Miller, F. J., Gutterman, D. D., Rios, C., Heistad, D. D., & Davidson, B. L. (1998) · Circulation Research · doi:10.1161/01.res.82.12.1298 · Cited by 623 · see citing works
Görlach, A., Brandes, R. P., Nguyen, K., Amidi, M., Dehghani, F., & Busse, R. (2000) · Circulation Research · doi:10.1161/01.res.87.1.26 · Cited by 598 · see citing works
Vascular Superoxide Production by NAD(P)H Oxidase
Guzik, T. J., West, N. E. J., Black, E., McDonald, D., Ratnatunga, C., Pillai, R. G., & Channon, K. M. (2000) · Circulation Research · doi:10.1161/01.res.86.9.e85 · Cited by 584 · see citing works
p47phox is required for atherosclerotic lesion progression in ApoE–/– mice
Barry-Lane, P. A., Patterson, C., van der Merwe, M., Hu, Z., Holland, S. M., Yeh, E. T. H., & Runge, M. S. (2001) · Journal of Clinical Investigation · doi:10.1172/jci200111927 · Cited by 489 · see citing works
Upregulation of Nox-Based NAD(P)H Oxidases in Restenosis After Carotid Injury
Szöcs, K., Lassegue, B. P., Sorescu, D., Hilenski, L. L., Valppu, L., Couse, T. L., Wilcox, J. N., Quinn, M. T., Lambeth, J. D., & Griendling, K. K. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/hq0102.102189 · Cited by 444 · see citing works
Self-citationLambeth, J. D., Cheng, G., Arnold, R. S., & Edens, W. A. (2000) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(00)01658-3 · Cited by 355 · see citing works
Self-citationWang, H. D., Xu, S., Johns, D. G., Du, Y., Quinn, M. T., Cayatte, A. J., & Cohen, R. A. (2001) · Circulation Research · doi:10.1161/hh0901.089987 · Cited by 342 · see citing works
Self-citationInvestigation Into the Sources of Superoxide in Human Blood Vessels
Berry, C., Hamilton, C., Brosnan, M. J., Magill, F. G., Berg, G. A., McMurray, J. J. V., & Dominiczak, A. F. (2000) · Circulation · doi:10.1161/01.cir.101.18.2206 · Cited by 305 · see citing works
Expression of NADH/NADPH Oxidase p22 phox in Human Coronary Arteries
Azumi, H., Inoue, N., Takeshita, S., Rikitake, Y., Kawashima, S., Hayashi, Y., Itoh, H., & Yokoyama, M. (1999) · Circulation · doi:10.1161/01.cir.100.14.1494 · Cited by 256 · see citing works
Kirk, E. A., Dinauer, M. C., Rosen, H., Chait, A., Heinecke, J. W., & LeBoeuf, R. C. (2000) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.20.6.1529 · Cited by 171 · see citing works
Hsich, E., Segal, B. H., Pagano, P. J., Rey, F. E., Paigen, B., Deleonardis, J., Hoyt, R. F., Holland, S. M., & Finkel, T. (2000) · Circulation · doi:10.1161/01.cir.101.11.1234 · Cited by 158 · see citing works
Topological Mapping of Neutrophil Cytochrome b Epitopes with Phage-display Libraries
Burritt, J. B., Quinn, M. T., Jutila, M. A., Bond, C. W., & Jesaitis, A. J. (1995) · Journal of Biological Chemistry · doi:10.1074/jbc.270.28.16974 · Cited by 157 · see citing works
Self-citationJesaitis, A. J., Buescher, E. S., Harrison, D. J., Quinn, M. T., Parkos, C. A., Livesey, S. A., & Linner, J. G. (1990) · Journal of Clinical Investigation · doi:10.1172/jci114509 · Cited by 142 · see citing works
Self-citationde Souza, H. P., Laurindo, F. R. M., Ziegelstein, R. C., Berlowitz, C. O., & Zweier, J. L. (2001) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.2001.280.2.h658 · Cited by 71 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Increased oxidative stress in obesity and its impact on metabolic syndrome
Furukawa, S., Fujita, T., Shimabukuro, M., Iwaki, M., Yamada, Y., Nakajima, Y., Nakayama, O., Makishima, M., Matsuda, M., & Shimomura, I. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21625 · Cited by 5,508 · see citing works
NOX enzymes and the biology of reactive oxygen
Lambeth, J. D. (2004) · Nature Reviews Immunology · doi:10.1038/nri1312 · Cited by 3,125 · see citing works
Self-citationEndothelial Nitric Oxide Synthase in Vascular Disease: From Marvel to Menace
Förstermann, U., & Münzel, T. (2006) · Circulation · doi:10.1161/circulationaha.105.602532 · Cited by 1,957 · see citing works
Roles of vascular oxidative stress and nitric oxide in the pathogenesis of atherosclerosis
Förstermann, U., Xia, N., & Li, H. (2017) · Circulation Research · doi:10.1161/circresaha.116.309326 · Cited by 1,519 · see citing works
Endothelial Function: A Critical Determinant in Atherosclerosis?
Landmesser, U., Hornig, B., & Drexler, H. (2004) · Circulation · doi:10.1161/01.cir.0000129501.88485.1f · Cited by 851 · see citing works
Zhao, H., Kalivendi, S., Zhang, H., Joseph, J., Nithipatikom, K., Vásquez-Vivar, J., & Kalyanaraman, B. (2003) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(03)00142-4 · Cited by 803 · see citing works
Cucoranu, I., Clempus, R., Dikalova, A., Phelan, P. J., Ariyan, S., Dikalov, S., & Sorescu, D. (2005) · Circulation Research · doi:10.1161/01.res.0000187457.24338.3d · Cited by 786 · see citing works
Self-citationEndothelial cell superoxide generation: regulation and relevance for cardiovascular pathophysiology
Li, J.-M., & Shah, A. M. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00124.2004 · Cited by 773 · see citing works
Babior, B. M. (2004) · Current Opinion in Immunology · doi:10.1016/j.coi.2003.12.001 · Cited by 705 · see citing works
The vascular NAD(P)H oxidases as therapeutic targets in cardiovascular diseases
Cai, H., Griendling, K. K., & Harrison, D. G. (2003) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(03)00233-5 · Cited by 687 · see citing works
Self-citationTarpey, M. M., Wink, D. A., & Grisham, M. B. (2004) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00361.2003 · Cited by 673 · see citing works
NADPH Oxidases in Cardiovascular Health and Disease
Cave, A. C., Brewer, A. C., Narayanapanicker, A., Ray, R., Grieve, D. J., Walker, S., & Shah, A. M. (2006) · Antioxidants & Redox Signaling · doi:10.1089/ars.2006.8.691 · Cited by 630 · see citing works
Touyz, R. M., Chen, X., Tabet, F., Yao, G., He, G., Quinn, M. T., Pagano, P. J., & Schiffrin, E. L. (2002) · Circulation Research · doi:10.1161/01.res.0000020404.01971.2f · Cited by 590 · see citing works
Self-citationOxidative stress in vascular disease: causes, defense mechanisms and potential therapies
Förstermann, U. (2008) · Nature Clinical Practice Cardiovascular Medicine · doi:10.1038/ncpcardio1211 · Cited by 576 · see citing works
Zhao, H., Joseph, J., Fales, H. M., Sokoloski, E. A., Levine, R. L., Vasquez-Vivar, J., & Kalyanaraman, B. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0501719102 · Cited by 576 · see citing works
Sources of Vascular Nitric Oxide and Reactive Oxygen Species and Their Regulation
Tejero, J., Shiva, S., & Gladwin, M. T. (2019) · Physiological Reviews · doi:10.1152/physrev.00036.2017 · Cited by 541 · see citing works
Nox4 as the Major Catalytic Component of an Endothelial NAD(P)H Oxidase
Ago, T., Kitazono, T., Ooboshi, H., Iyama, T., Han, Y. H., Takada, J., Wakisaka, M., Ibayashi, S., Utsumi, H., & Iida, M. (2004) · Circulation · doi:10.1161/01.cir.0000105680.92873.70 · Cited by 497 · see citing works
Dermal Wound Healing Is Subject to Redox Control
Roy, S., Khanna, S., Nallu, K., Hunt, T. K., & Sen, C. K. (2006) · Molecular Therapy · doi:10.1016/j.ymthe.2005.07.684 · Cited by 472 · see citing works
Quinn, M. T., & Gauss, K. A. (2004) · Journal of Leukocyte Biology · doi:10.1189/jlb.0404216 · Cited by 480 · see citing works
Self-citationIs oxidative stress a therapeutic target in cardiovascular disease?
Münzel, T., Gori, T., Bruno, R. M., & Taddei, S. (2010) · European Heart Journal · doi:10.1093/eurheartj/ehq396 · Cited by 470 · see citing works
Association of Nitrotyrosine Levels With Cardiovascular Disease and Modulation by Statin Therapy
Shishehbor, M. H., Aviles, R. J., Brennan, M.-L., Fu, X., Goormastic, M., Pearce, G. L., Gokce, N., Keaney, J. F., Penn, M. S., Sprecher, D. L., et al. (2003) · JAMA · doi:10.1001/jama.289.13.1675 · Cited by 464 · see citing works
Inoguchi, T., Sonta, T., Tsubouchi, H., Etoh, T., Kakimoto, M., Sonoda, N., Sato, N., Sekiguchi, N., Kobayashi, K., Sumimoto, H., et al. (2003) · Journal of the American Society of Nephrology · doi:10.1097/01.asn.0000077407.90309.65 · Cited by 435 · see citing works
NADPH oxidase in brain injury and neurodegenerative disorders
Ma, M. W., Wang, J., Zhang, Q., Wang, R., Dhandapani, K. M., Vadlamudi, R. K., & Brann, D. W. (2017) · Molecular Neurodegeneration · doi:10.1186/s13024-017-0150-7 · Cited by 432 · see citing works
Nitric oxide, tetrahydrobiopterin, oxidative stress, and endothelial dysfunction in hypertension
Schulz, E., Jansen, T., Wenzel, P., Daiber, A., & Münzel, T. (2008) · Antioxidants & Redox Signaling · doi:10.1089/ars.2007.1989 · Cited by 430 · see citing works
The NOX toolbox: validating the role of NADPH oxidases in physiology and disease
Altenhöfer, S., Kleikers, P. W. M., Radermacher, K. A., Scheurer, P., Rob Hermans, J. J., Schiffers, P., Ho, H., Wingler, K., & Schmidt, H. H. H. W. (2012) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-012-1010-9 · Cited by 371 · see citing works
NADPH Oxidase 1 Plays a Key Role in Diabetes Mellitus–Accelerated Atherosclerosis
Gray, S. P., Di Marco, E., Okabe, J., Szyndralewiez, C., Heitz, F., Montezano, A. C., de Haan, J. B., Koulis, C., El-Osta, A., Andrews, K. L., et al. (2013) · Circulation · doi:10.1161/circulationaha.112.132159 · Cited by 386 · see citing works
Thomas, S. R., Witting, P. K., & Drummond, G. R. (2008) · Antioxidants & Redox Signaling · doi:10.1089/ars.2008.2027 · Cited by 383 · see citing works
Oxidative stress in the pathology and treatment of systemic lupus erythematosus
Perl, A. (2013) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2013.147 · Cited by 358 · see citing works
Janaszak-Jasiecka, A., Płoska, A., Wierońska, J. M., Dobrucki, L. W., & Kalinowski, L. (2023) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-023-00423-2 · Cited by 358 · see citing works
Decreased blood pressure in NOX1‐deficient mice
Gavazzi, G., Banfi, B., Deffert, C., Fiette, L., Schappi, M., Herrmann, F., & Krause, K.-H. (2006) · FEBS Letters · doi:10.1016/j.febslet.2005.12.049 · Cited by 321 · see citing works
Judkins, C. P., Diep, H., Broughton, B. R. S., Mast, A. E., Hooker, E. U., Miller, A. A., Selemidis, S., Dusting, G. J., Sobey, C. G., & Drummond, G. R. (2010) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00799.2009 · Cited by 299 · see citing works
Vallet, P., Charnay, Y., Steger, K., Ogier-Denis, E., Kovari, E., Herrmann, F., Michel, J.-P., & Szanto, I. (2005) · Neuroscience · doi:10.1016/j.neuroscience.2004.12.038 · Cited by 291 · see citing works
Uncoupling of endothelial NO synthase in atherosclerosis and vascular disease
Li, H., & Förstermann, U. (2013) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2013.01.006 · Cited by 285 · see citing works
Guzik, T. J., Chen, W., Gongora, M. C., Guzik, B., Lob, H. E., Mangalat, D., Hoch, N., Dikalov, S., Rudzinski, P., Kapelak, B., et al. (2008) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2008.07.063 · Cited by 281 · see citing works
Coronary Artery Superoxide Production and Nox Isoform Expression in Human Coronary Artery Disease
Guzik, T. J., Sadowski, J., Guzik, B., Jopek, A., Kapelak, B., Przybyłowski, P., Wierzbicki, K., Korbut, R., Harrison, D. G., & Channon, K. M. (2006) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.0000196651.64776.51 · Cited by 278 · see citing works
TENFREYHAUS, H., HUNTGEBURTH, M., WINGLER, K., SCHNITKER, J., BAUMER, A., VANTLER, M., BEKHITE, M., WARTENBERG, M., SAUER, H., & ROSENKRANZ, S. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2006.01.022 · Cited by 259 · see citing works
Basuroy, S., Bhattacharya, S., Leffler, C. W., & Parfenova, H. (2009) · American Journal of Physiology-Cell Physiology · doi:10.1152/ajpcell.00381.2008 · Cited by 254 · see citing works
The contribution of Nox4 to NADPH oxidase activity in mouse vascular smooth muscle
ELLMARK, S., DUSTING, G., NGTANGFUI, M., GUZZOPERNELL, N., & DRUMMOND, G. (2005) · Cardiovascular Research · doi:10.1016/j.cardiores.2004.10.026 · Cited by 213 · see citing works
Rustenhoven, J., Aalderink, M., Scotter, E. L., Oldfield, R. L., Bergin, P. S., Mee, E. W., Graham, E. S., Faull, R. L. M., Curtis, M. A., Park, T. I.-H., et al. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0503-0 · Cited by 201 · see citing works
Sex steroids as inflammatory regulators
Gilliver, S. C. (2010) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2009.12.015 · Cited by 198 · see citing works
New insights on oxidative stress in the artery wall
STOCKER, R., & KEANEY, J. F. (2005) · Journal of Thrombosis and Haemostasis · doi:10.1111/j.1538-7836.2005.01370.x · Cited by 188 · see citing works
Ismail, S., Sturrock, A., Wu, P., Cahill, B., Norman, K., Huecksteadt, T., Sanders, K., Kennedy, T., & Hoidal, J. (2009) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.90488.2008 · Cited by 177 · see citing works
Vendrov, A. E., Hakim, Z. S., Madamanchi, N. R., Rojas, M., Madamanchi, C., & Runge, M. S. (2007) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.107.152629 · Cited by 173 · see citing works
ROS-induced ROS release in vascular biology: redox-redox signaling
Zinkevich, N. S., & Gutterman, D. D. (2011) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.01271.2010 · Cited by 163 · see citing works
Therapeutic potential of nadph oxidase 1/4 inhibitors
Teixeira, G., Szyndralewiez, C., Molango, S., Carnesecchi, S., Heitz, F., Wiesel, P., & Wood, J. M. (2017) · British Journal of Pharmacology · doi:10.1111/bph.13532 · Cited by 163 · see citing works
The nox4 inhibitor gkt137831 attenuates hypoxia-induced pulmonary vascular cell proliferation
Green, D. E., Murphy, T. C., Kang, B.-Y., Kleinhenz, J. M., Szyndralewiez, C., Page, P., Sutliff, R. L., & Hart, C. M. (2012) · American Journal of Respiratory Cell and Molecular Biology · doi:10.1165/rcmb.2011-0418oc · Cited by 146 · see citing works
FOXO3A regulates peroxiredoxin III expression in human cardiac fibroblasts
Chiribau, C. B., Cheng, L., Cucoranu, I. C., Yu, Y.-S., Clempus, R. E., & Sorescu, D. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m710610200 · Cited by 140 · see citing works
Self-citationLangbein, H., Brunssen, C., Hofmann, A., Cimalla, P., Brux, M., Bornstein, S. R., Deussen, A., Koch, E., & Morawietz, H. (2016) · European Heart Journal · doi:10.1093/eurheartj/ehv564 · Cited by 133 · see citing works
Calcium and 1,25‐Dihydroxyvitamin D<sub>3</sub> Regulation of Adipokine Expression
Sun, X., & Zemel, M. B. (2007) · Obesity · doi:10.1038/oby.2007.540 · Cited by 137 · see citing works
Nox2 B-loop peptide, Nox2ds, specifically inhibits the NADPH oxidase Nox2
Csányi, G., Cifuentes-Pagano, E., Al Ghouleh, I., Ranayhossaini, D. J., Egaña, L., Lopes, L. R., Jackson, H. M., Kelley, E. E., & Pagano, P. J. (2011) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2011.04.025 · Cited by 131 · see citing works
Phagocytic NADPH Oxidase Overactivity Underlies Oxidative Stress in Metabolic Syndrome
Fortuño, A., San José, G., Moreno, M. U., Beloqui, O., Díez, J., & Zalba, G. (2006) · Diabetes · doi:10.2337/diabetes.55.01.06.db05-0751 · Cited by 128 · see citing works
Differential effects of diabetes on the expression of the gp91phox homologues nox1 and nox4
Wendt, M. C., Daiber, A., Kleschyov, A. L., Mülsch, A., Sydow, K., Schulz, E., Chen, K., Keaney, J. F., Lassègue, B., Walter, U., et al. (2005) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2005.03.020 · Cited by 122 · see citing works
Self-citationTong, X.-K., Nicolakakis, N., Fernandes, P., Ongali, B., Brouillette, J., Quirion, R., & Hamel, E. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.06.003 · Cited by 122 · see citing works
Douglas, G., Bendall, J. K., Crabtree, M. J., Tatham, A. L., Carter, E. E., Hale, A. B., & Channon, K. M. (2012) · Cardiovascular Research · doi:10.1093/cvr/cvs026 · Cited by 111 · see citing works
NOX signaling in molecular cardiovascular mechanisms involved in the blood pressure homeostasis
Santillo, M., Colantuoni, A., Mondola, P., Guida, B., & Damiano, S. (2015) · Frontiers in Physiology · doi:10.3389/fphys.2015.00194 · Cited by 95 · see citing works
Xu, H., Goettsch, C., Xia, N., Horke, S., Morawietz, H., Förstermann, U., & Li, H. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.01.023 · Cited by 89 · see citing works
The Quest for Selective Nox Inhibitors and Therapeutics: Challenges, Triumphs and Pitfalls
Cifuentes-Pagano, E., Meijles, D. N., & Pagano, P. J. (2014) · Antioxidants & Redox Signaling · doi:10.1089/ars.2013.5620 · Cited by 84 · see citing works
Endothelial NADPH oxidase 4 protects ApoE-/- mice from atherosclerotic lesions
Craige, S. M., Kant, S., Reif, M., Chen, K., Pei, Y., Angoff, R., Sugamura, K., Fitzgibbons, T., & Keaney, J. F. (2015) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2015.07.004 · Cited by 85 · see citing works
Yoshida, L. S., & Tsunawaki, S. (2008) · International Immunopharmacology · doi:10.1016/j.intimp.2008.05.004 · Cited by 68 · see citing works
Baldus, S., Müllerleile, K., Chumley, P., Steven, D., Rudolph, V., Lund, G. K., Staude, H.-J., Stork, A., Köster, R., Kähler, J., et al. (2006) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2006.07.010 · Cited by 63 · see citing works
NADPH oxidase 4 promotes cardiac microvascular angiogenesis after hypoxia/reoxygenation in vitro
Wang, J., Hong, Z., Zeng, C., Yu, Q., & Wang, H. (2014) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2014.01.027 · Cited by 48 · see citing works
Zhang, G., Zhang, F., Muh, R., Yi, F., Chalupsky, K., Cai, H., & Li, P.-L. (2007) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00632.2006 · Cited by 42 · see citing works
Di Marco, E., Gray, S. P., Chew, P., Kennedy, K., Cooper, M. E., Schmidt, H. H. H. W., & Jandeleit-Dahm, K. A. M. (2016) · Clinical Science · doi:10.1042/cs20160249 · Cited by 37 · see citing works
Gole, H. K. A., Tharp, D. L., & Bowles, D. K. (2014) · PLoS ONE · doi:10.1371/journal.pone.0105337 · Cited by 36 · see citing works
Sobey, C. G., Judkins, C. P., Rivera, J., Lewis, C. V., Diep, H., Lee, H. W., Kemp-Harper, B. K., Broughton, B. R. S., Selemidis, S., Gaspari, T. A., et al. (2015) · Free Radical Research · doi:10.3109/10715762.2014.992893 · Cited by 33 · see citing works
Liu, X.-H., Zhang, Q.-Y., Pan, L.-L., Liu, S.-Y., Xu, P., Luo, X.-L., Zou, S.-L., Xin, H., Qu, L.-F., & Zhu, Y.-Z. (2016) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2016.02.031 · Cited by 31 · see citing works
Csányi, G., & Pagano, P. J. (2013) · International Journal of Hypertension · doi:10.1155/2013/842827 · Cited by 20 · see citing works
Endothelial NADPH oxidase 2: when does it matter in atherosclerosis?
Haendeler, J., Eckers, A., Lukosz, M., Unfried, K., & Altschmied, J. (2012) · Cardiovascular Research · doi:10.1093/cvr/cvs106 · Cited by 15 · see citing works
- Authors
- Sorescu, D., Weiss, D., Lassègue, B., Clempus, R. E., Szöcs, K., Sorescu, G. P., Valppu, L., Quinn, M. T., Lambeth, J. D., Vega, J. D., Taylor, W. R., & Griendling, K. K.
- Affiliations
- Emory University (US)
- From the Department of Medicine (D.S., D.W., B.L., R.E.C., K.S., G.P.S., L.V., W.R.T., K.K.G.), Division of Cardiology, Department of Pathology and Laboratory Medicine (J.D.L.), and Department of Surgery (J.D.V.), Emory University, Atlanta, Ga, and the Department of Veterinary Molecular Biology (M.T.Q.), Montana State University, Bozeman, Mont.
- Venue
- Circulation
- Published
- 2002-03-26
- Volume
- 105
- Issue
- 12
- Pages
- 1429-1435
- ISSN
- 0009-7322 (ISSN-L)
- 1524-4539
- OpenAlex
- W2102202839
- Cited by
- 847
- References
- 23
- Citations by year
- 2026: 7 · 2025: 18 · 2024: 13 · 2023: 23 · 2022: 12 · 2021: 19 · 2020: 21 · 2019: 20 · 2018: 18 · 2017: 32 · 2016: 37 · 2015: 36 · 2014: 37 · 2013: 46 · 2012: 56
- FWCI
- 33.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Circulation (publishedVersion)
- PubMed (publishedVersion)
- Funders
- American Heart Association
- National Institutes of Health
- Topics
- Health Sciences › Medicine › Physiology › Nitric Oxide and Endothelin Effects
- Life Sciences › Immunology and Microbiology › Immunology › Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Life Sciences › Immunology and Microbiology › Immunology › Atherosclerosis and Cardiovascular Diseases
- Keywords
- superoxide production, NADPH oxidase, gp91phox, p22phox, NOX4, NOX1, coronary artery disease, plaque macrophages, oxidative stress, plaque shoulder, human coronary arteries
- MeSH terms
- NADPH Oxidase 2, NADPH Oxidase 4, Arteriosclerosis, Cells, Cultured, Coronary Artery Disease, Coronary Vessels, Endothelium, Vascular, Female, Fibroblasts, Fluorescent Antibody Technique, Fluorescent Dyes, Heart Failure, Humans, Isoenzymes, Male, Membrane Glycoproteins, Middle Aged, Muscle, Smooth, Vascular, NADH, NADPH Oxidoreductases, NADPH Dehydrogenase, Phosphoproteins, RNA, Messenger, Superoxides, Polymerase Chain Reaction, NADPH Oxidases, Membrane Transport Proteins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review