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Cited by 472

The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.

Natural killer cells as an initial defense against pathogens

Open access
Lodoen, Melissa B, Lanier, Lewis L·2006·Current Opinion in Immunology
DOI 10.1016/j.coi.2006.05.002
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Abstract

Natural killer (NK) cells serve as a crucial first line of defense against tumors and a diverse range of pathogens. Recognition of infection by NK cells is accomplished by the activation of receptors on the NK cell surface, which initiate NK cell effector functions. Many of the receptors and ligands involved in NK cell antimicrobial activity have been identified, and we are beginning to appreciate how they function during infection. In addition, NK cells are activated by cytokines (e.g. interleukin 12 and type I interferons), which are products of activated macrophages and dendritic cells. In response to these activating stimuli, NK cells secrete cytokines and chemokines and lyse target cells. Recent studies have focused on the mechanisms by which NK cells recognize and respond to viruses, parasites and bacteria, and on the unique role of NK cells in innate immunity to infection.

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Crossref · 10.1016/j.coi.2006.05.002

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Metadata

Authors
Lodoen, M. B., & Lanier, L. L.
Venue
Current Opinion in Immunology
Publisher
Elsevier BV
Published
2006-08
Volume
18
Issue
4
Pages
391-398
ISSN
0952-7915 (ISSN-L)
DOI
10.1016/j.coi.2006.05.002
OpenAlex
W2022230965
Cited by
472
References
46
FWCI
1.93
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Natural killer cells as an initial defense against pathogens. https://app.cochat.ai/papers/10.1016/j.coi.2006.05.002
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Lodoen, M. B., & Lanier, L. L. (2006). Natural killer cells as an initial defense against pathogens. Current Opinion in Immunology. https://doi.org/10.1016/j.coi.2006.05.002

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.