The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Type I Interferon Production Enhances Susceptibility to Listeria monocytogenes Infection
Open accessAbstract
Numerous bacterial products such as lipopolysaccharide potently induce type I interferons (IFNs); however, the contribution of this innate response to host defense against bacterial infection remains unclear. Although mice deficient in either IFN regulatory factor (IRF)3 or the type I IFN receptor (IFNAR)1 are highly susceptible to viral infection, we show that these mice exhibit a profound resistance to infection caused by the Gram-positive intracellular bacterium Listeria monocytogenes compared with wild-type controls. Furthermore, this enhanced bacterial clearance is accompanied by a block in L. monocytogenes–induced splenic apoptosis in IRF3- and IFNAR1-deficient mice. Thus, our results highlight the disparate roles of type I IFNs during bacterial versus viral infections and stress the importance of proper IFN modulation in host defense.
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Cites
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Functional Role of Type I and Type II Interferons in Antiviral Defense
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Self-citationImmune Response in Mice that Lack the Interferon-γ Receptor
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IRF3 Mediates a TLR3/TLR4-Specific Antiviral Gene Program
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Self-citationInterferons α and β as Immune Regulators—A New Look
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Cited by
Type I interferons in infectious disease
McNab, F., Mayer-Barber, K., Sher, A., Wack, A., & O'Garra, A. (2015) · Nature Reviews Immunology · doi:10.1038/nri3787 · Cited by 2,780
Interferon-inducible antiviral effectors
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Type I IFNs mediate development of postinfluenza bacterial pneumonia in mice
Shahangian, A., Chow, E. K., Tian, X., Kang, J. R., Ghaffari, A., Liu, S. Y., Belperio, J. A., Cheng, G., & Deng, J. C. (2009) · Journal of Clinical Investigation · doi:10.1172/jci35412 · Cited by 479
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Metadata
- Authors
- O'Connell, R. M., Saha, S. K., Vaidya, S. A., Bruhn, K. W., Miranda, G. A., Zarnegar, B., Perry, A. K., Nguyen, B. O., Lane, T. F., Taniguchi, T., Miller, J. F., & Cheng, G.
- Venue
- The Journal of Experimental Medicine
- Publisher
- Rockefeller University Press
- Published
- 2004-08-09
- Volume
- 200
- Issue
- 4
- Pages
- 437-445
- ISSN
- 0022-1007 (ISSN-L)
- 1540-9538
- OpenAlex
- W2110864354
- Cited by
- 489
- References
- 34
- FWCI
- 9.01
- Type
- journal article
- Language
- en
- Open access
- bronze
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- O'Connell, R. M., Saha, S. K., Vaidya, S. A., Bruhn, K. W., Miranda, G. A., Zarnegar, B., Perry, A. K., Nguyen, B. O., Lane, T. F., Taniguchi, T., Miller, J. F., & Cheng, G. (2004). Type I Interferon Production Enhances Susceptibility to Listeria monocytogenes Infection. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.20040712
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