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Cited by 450

The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.

Mice Lacking the Type I Interferon Receptor Are Resistant to Listeria monocytogenes

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Auerbuch, Victoria, Brockstedt, Dirk G., Meyer-Morse, Nicole, O'Riordan, Mary, Portnoy, Daniel A.·2004·The Journal of Experimental Medicine
DOI 10.1084/jem.20040976
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Abstract

Listeria monocytogenes is a facultative intracellular pathogen that induces a cytosolic signaling cascade resulting in expression of interferon (IFN)-β. Although type I IFNs are critical in viral defense, their role in immunity to bacterial pathogens is much less clear. In this study, we addressed the role of type I IFNs by examining the infection of L. monocytogenes in BALB/c mice lacking the type I IFN receptor (IFN-α/βR−/−). During the first 24 h of infection in vivo, IFN-α/βR−/− and wild-type mice were similar in terms of L. monocytogenes survival. In addition, the intracellular fate of L. monocytogenes in macrophages cultured from IFN-α/βR−/− and wild-type mice was indistinguishable. However, by 72 h after inoculation in vivo, IFN-α/βR−/− mice were ∼1,000-fold more resistant to a high dose L. monocytogenes infection. Resistance was correlated with elevated levels of interleukin 12p70 in the blood and increased numbers of CD11b+ macrophages producing tumor necrosis factor α in the spleen of IFN-α/βR−/− mice. The results of this study suggest that L. monocytogenes might be exploiting an innate antiviral response to promote its pathogenesis.

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Metadata

Authors
Auerbuch, V., Brockstedt, D. G., Meyer-Morse, N., O'Riordan, M., & Portnoy, D. A.
Venue
The Journal of Experimental Medicine
Publisher
Rockefeller University Press
Published
2004-08-09
Volume
200
Issue
4
Pages
527-533
ISSN
  • 0022-1007 (ISSN-L)
  • 1540-9538
DOI
10.1084/jem.20040976
OpenAlex
W2113757071
Cited by
450
References
26
FWCI
8.45
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Mice Lacking the Type I Interferon Receptor Are Resistant to Listeria monocytogenes. https://app.cochat.ai/papers/10.1084/jem.20040976
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Auerbuch, V., Brockstedt, D. G., Meyer-Morse, N., O'Riordan, M., & Portnoy, D. A. (2004). Mice Lacking the Type I Interferon Receptor Are Resistant to Listeria monocytogenes. The Journal of Experimental Medicine. https://doi.org/10.1084/jem.20040976

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.