The DOI matches its Crossref record; 100 of the 100 references it cites were found in a registry or an index.
Generation and maintenance of memory CD4+ T Cells
Open accessAbstract
Summary In the course of an immune response to an infectious microbe, pathogen-specific naïve CD4+ T cells proliferate extensively and differentiate into effector cells. Most of these cells die rapidly but a small fraction of effector cells persist as memory cells to confer enhanced protection against the same pathogen. Recent advances indicate that strong TCR stimulation during the primary response is essential for generation of long-lived memory CD4+ T cells. Memory cells appear to be derived equally from all subsets of effector cells, and memory cells can also acquire additional functional capabilities during the secondary response. Resting memory CD4+ cells are dependent on signals from contact with IL-7 and IL-15, but not MHC class II, for their survival and intermittent homeostatic proliferation.
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Cites
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Cited by
Lineage relationship and protective immunity of memory CD8 T cell subsets
Wherry, E. J., Teichgräber, V., Becker, T. C., Masopust, D., Kaech, S. M., Antia, R., von Andrian, U. H., & Ahmed, R. (2003) · Nature Immunology · doi:10.1038/ni889 · Cited by 1,864
The Influence of Age on T Cell Generation and TCR Diversity
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Progressive differentiation and selection of the fittest in the immune response
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Sleep Enhances the Human Antibody Response to Hepatitis A Vaccination
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Voehringer, D., Koschella, M., & Pircher, H. (2002) · Blood · doi:10.1182/blood-2002-02-0657 · Cited by 352
Metadata
- Authors
- van Leeuwen, E. M., Sprent, J., & Surh, C. D.
- Venue
- Current Opinion in Immunology
- Publisher
- Elsevier BV
- Published
- 2009-04
- Volume
- 21
- Issue
- 2
- Pages
- 167-172
- ISSN
- 0952-7915 (ISSN-L)
- OpenAlex
- W2076510057
- Cited by
- 300
- References
- 100
- FWCI
- 1.02
- Type
- journal article
- Language
- en
- Open access
- green
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- van Leeuwen, E. M., Sprent, J., & Surh, C. D. (2009). Generation and maintenance of memory CD4+ T Cells. Current Opinion in Immunology. https://doi.org/10.1016/j.coi.2009.02.005
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
