The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Recognition of viruses by cytoplasmic sensors
Open accessAbstract
Summary of recent advances The immune response to virus infection is initiated when pathogen recognition receptors (PRRs) of the host cell recognize specific non-self motifs within viral products to trigger intracellular signaling events that induce innate immunity, the front line of defense against microbial infection. The replication program of all viruses includes a cytosolic phase of genome amplification and/or mRNA metabolism and viral protein expression. Cytosolic recognition of viral infection by specific PRRs takes advantage of the dependence of viruses on the cytosolic component of their replication programs. Such PRR-PAMP interactions lead to PRR-dependent non-self recognition and the downstream induction of type I interferons and proinflammatory cytokines. These factors serve to induce innate immune programs and drive the maturation of adaptive immunity and inflammation for the control of infection. Recent studies have focused on identifying the particular viral ligands recognized as non-self by cytosolic PRRs, and on defining the nature of the PRRs and their signaling pathways involved in immunity. The RIG-I-like receptors, RIG-I and MDA5, have been defined as essential PRRs for host detection of a variety of RNA viruses. Novel PRRs and their signaling pathways involved in detecting DNA viruses through non-self recognition of viral DNA are also being elucidated. Moreover, studies to identify the PRRs and signaling factors of the host cell that mediate inflammatory signaling through inflammasome activation following virus infection are currently underway and have already revealed specific NOD-like receptors (NLRs) as inflammatory triggers. This review summarizes recent progress and current areas of focus in pathogen recognition and immune triggering by cytosolic PRRs.
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Cites
Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses
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Cited by
Genetic Analysis of Psoriasis Consortium & the Wellcome Trust Case Control Consortium 2 (2010) · Nature Genetics · doi:10.1038/ng.694 · Cited by 1,047
Developing mRNA-vaccine technologies
Schlake, T., Thess, A., Fotin-Mleczek, M., & Kallen, K.-J. (2012) · RNA Biology · doi:10.4161/rna.22269 · Cited by 622
SARS-CoV-2 Disrupts Splicing, Translation, and Protein Trafficking to Suppress Host Defenses
Banerjee, A. K., Blanco, M. R., Bruce, E. A., Honson, D. D., Chen, L. M., Chow, A., Bhat, P., Ollikainen, N., Quinodoz, S. A., Loney, C., et al. (2020) · Cell · doi:10.1016/j.cell.2020.10.004 · Cited by 583
Nucleic acid recognition by the innate immune system
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Pattern recognition receptors and central nervous system repair
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Metadata
- Authors
- Wilkins, C., & Gale, M.
- Venue
- Current Opinion in Immunology
- Publisher
- Elsevier BV
- Published
- 2010-02
- Volume
- 22
- Issue
- 1
- Pages
- 41-47
- ISSN
- 0952-7915 (ISSN-L)
- OpenAlex
- W2145990658
- Cited by
- 430
- References
- 10
- FWCI
- 3.35
- Type
- journal article
- Language
- en
- Open access
- green
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