The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
A new eye on NLR proteins: focused on clarity or diffused by complexity?
Open accessAbstract
The nucleotide-binding domain leucine-rich repeat proteins (NLRs) represent the major class of intracellular innate immune receptors in plants and animals. Understanding their functions is a major challenge in immunology. This review highlights recent efforts toward elucidating NLR functions in human and plants. We compare unconventional aspects of NLR proteins across the two kingdoms. We review recent advances describing P-loop independent activation, nuclear-cytoplasmic trafficking, oligomerization and multimerization requirements for signaling, and for expanded functions beyond pathogen recognition by several NLR proteins.
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Cites
Sterile inflammation: sensing and reacting to damage
Chen, G. Y., & Nuñez, G. (2010) · Nature Reviews Immunology · doi:10.1038/nri2873 · Cited by 3,051
The Inflammasome NLRs in Immunity, Inflammation, and Associated Diseases
Davis, B. K., Wen, H., & Ting, J. P.-Y. (2011) · Annual Review of Immunology · doi:10.1146/annurev-immunol-031210-101405 · Cited by 1,618
Travassos, L. H., Carneiro, L. A. M., Ramjeet, M., Hussey, S., Kim, Y.-G., Magalhães, J. G., Yuan, L., Soares, F., Chea, E., Le Bourhis, L., et al. (2010) · Nature Immunology · doi:10.1038/ni.1823 · Cited by 1,306
NLR family member NLRC5 is a transcriptional regulator of MHC class I genes
Meissner, T. B., Li, A., Biswas, A., Lee, K.-H., Liu, Y.-J., Bayir, E., Iliopoulos, D., van den Elsen, P. J., & Kobayashi, K. S. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1008684107 · Cited by 447
Cited by
Pivoting the Plant Immune System from Dissection to Deployment
Dangl, J. L., Horvath, D. M., & Staskawicz, B. J. (2013) · Science · doi:10.1126/science.1236011 · Cited by 1,252
Self-citationPtdIns4P on dispersed trans-Golgi network mediates NLRP3 inflammasome activation
Chen, J., & Chen, Z. J. (2018) · Nature · doi:10.1038/s41586-018-0761-3 · Cited by 692
The plant hypersensitive response: concepts, control and consequences
Balint‐Kurti, P. (2019) · Molecular Plant Pathology · doi:10.1111/mpp.12821 · Cited by 630
Transcriptional networks in plant immunity
Tsuda, K., & Somssich, I. E. (2015) · New Phytologist · doi:10.1111/nph.13286 · Cited by 552
Homeostasis-altering molecular processes as mechanisms of inflammasome activation
Liston, A., & Masters, S. L. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2016.151 · Cited by 459
Metadata
- Authors
- Bonardi, V., Cherkis, K., Nishimura, M. T., & Dangl, J. L.
- Venue
- Current Opinion in Immunology
- Publisher
- Elsevier BV
- Published
- 2012-02
- Volume
- 24
- Issue
- 1
- Pages
- 41-50
- ISSN
- 0952-7915 (ISSN-L)
- OpenAlex
- W2140767747
- Cited by
- 161
- References
- 4
- FWCI
- 0.95
- Type
- journal article
- Language
- en
- Open access
- green
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- Bonardi, V., Cherkis, K., Nishimura, M. T., & Dangl, J. L. (2012). A new eye on NLR proteins: focused on clarity or diffused by complexity? Current Opinion in Immunology. https://doi.org/10.1016/j.coi.2011.12.006
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