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The landscape of cell–cell communication through single-cell transcriptomics
Open accessAbstract
Cell-cell communication is a fundamental process that shapes biological tissue. Historically, studies of cell-cell communication have been feasible for one or two cell types and a few genes. With the emergence of single-cell transcriptomics, we are now able to examine the genetic profiles of individual cells at unprecedented scale and depth. The availability of such data presents an exciting opportunity to construct a more comprehensive description of cell-cell communication. This review discusses the recent explosion of methods that have been developed to infer cell-cell communication from non-spatial and spatial single-cell transcriptomics, two promising technologies which have complementary strengths and limitations. We propose several avenues to propel this rapidly expanding field forward in meaningful ways.
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“Although many ligand-receptor (LR) interactions have been experimentally validated, a considerable proportion remains completely uncharacterised, reflecting the challenge to resolve intercellular communications networks [5], particularly within complex and heterogeneous tissue environments.”
From Quantitative profiling of lifespan-dependent cell-cell communication potential reveals dynamic ligand-receptor network shifts across mouse tissues (2026) · cites this paper as [5]
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Inference and analysis of cell-cell communication using CellChat
Jin, S., Guerrero-Juarez, C. F., Zhang, L., Chang, I., Ramos, R., Kuan, C.-H., Myung, P., Plikus, M. V., & Nie, Q. (2021) · Nature Communications · doi:10.1038/s41467-021-21246-9 · Cited by 8,409
Self-citationVisualization and analysis of gene expression in tissue sections by spatial transcriptomics
Ståhl, P. L., Salmén, F., Vickovic, S., Lundmark, A., Navarro, J. F., Magnusson, J., Giacomello, S., Asp, M., Westholm, J. O., Huss, M., et al. (2016) · Science · doi:10.1126/science.aaf2403 · Cited by 3,834
Efremova, M., Vento-Tormo, M., Teichmann, S. A., & Vento-Tormo, R. (2020) · Nature Protocols · doi:10.1038/s41596-020-0292-x · Cited by 3,449
Simultaneous epitope and transcriptome measurement in single cells
Stoeckius, M., Hafemeister, C., Stephenson, W., Houck-Loomis, B., Chattopadhyay, P. K., Swerdlow, H., Satija, R., & Smibert, P. (2017) · Nature Methods · doi:10.1038/nmeth.4380 · Cited by 3,098
Slide-seq: A scalable technology for measuring genome-wide expression at high spatial resolution
Rodriques, S. G., Stickels, R. R., Goeva, A., Martin, C. A., Murray, E., Vanderburg, C. R., Welch, J., Chen, L. M., Chen, F., & Macosko, E. Z. (2019) · Science · doi:10.1126/science.aaw1219 · Cited by 2,424
Single-cell reconstruction of the early maternal–fetal interface in humans
Vento-Tormo, R., Efremova, M., Botting, R. A., Turco, M. Y., Vento-Tormo, M., Meyer, K. B., Park, J.-E., Stephenson, E., Polański, K., Goncalves, A., et al. (2018) · Nature · doi:10.1038/s41586-018-0698-6 · Cited by 2,358
Single-cell chromatin accessibility reveals principles of regulatory variation
Buenrostro, J. D., Wu, B., Litzenburger, U. M., Ruff, D., Gonzales, M. L., Snyder, M. P., Chang, H. Y., & Greenleaf, W. J. (2015) · Nature · doi:10.1038/nature14590 · Cited by 2,308
NicheNet: Modeling intercellular communication by linking ligands to target genes
Browaeys, R., Saelens, W., & Saeys, Y. (2020) · Nature Methods · doi:10.1038/s41592-019-0667-5 · Cited by 2,192
Transcriptome-scale super-resolved imaging in tissues by RNA seqFISH
Eng, C.-H. L., Lawson, M., Zhu, Q., Dries, R., Koulena, N., Takei, Y., Yun, J., Cronin, C., Karp, C., Yuan, G.-C., et al. (2019) · Nature · doi:10.1038/s41586-019-1049-y · Cited by 1,754
A comparison of single-cell trajectory inference methods
Saelens, W., Cannoodt, R., Todorov, H., & Saeys, Y. (2019) · Nature Biotechnology · doi:10.1038/s41587-019-0071-9 · Cited by 1,670
Flagged first, then by citations
Research works printed but not linked: 3
- Cheng, 2020, Inferring microenvironmental regulation of gene expression from single-cell RNA sequencing data using scMLnet with an application to COVID-19, Briefings Bioinf, 1
- Armingol, 2020, Inferring the spatial code of cell-cell interactions and communication across a whole animal body Graphical abstract, bioRxiv, 2020
- Cabello-Aguilar, 2020, SingleCellSignalR: inference of intercellular networks from single-cell transcriptomics, Nucleic Acids Res, 1
Cited by
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Items 101–200 of 200
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Liu, S., Zhang, Y., Peng, J., & Shang, X. (2023) · Briefings in Functional Genomics · doi:10.1093/bfgp/elac056 · Cited by 9
Wu, D., Gaskins, J., Sekula, M. N., & Datta, S. (2023) · Genes · doi:10.3390/genes14071368 · Cited by 8
Qi, J., Zhu, H., Li, Y., Guan, X., He, Y., Ren, G., Guo, Q., Liu, L., Gu, Y., Dong, X., et al. (2023) · Small Methods · doi:10.1002/smtd.202300730 · Cited by 8
Can the Tumor Microenvironment Alter Ion Channels? Unraveling Their Role in Cancer
Gentile, R., Feudi, D., Sallicandro, L., & Biagini, A. (2025) · Cancers · doi:10.3390/cancers17071244 · Cited by 7
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Mircea, M., & Semrau, S. (2021) · Biochemical Society Transactions · doi:10.1042/bst20210135 · Cited by 9
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Jena, S. G., Verma, A., & Engelhardt, B. E. (2024) · BMC Bioinformatics · doi:10.1186/s12859-024-05912-5 · Cited by 7
Chen, T., Zhan, X., Zhu, J., Zhou, C., Huang, C., Wu, S., Yao, Y., Zhang, B., Feng, S., Chen, J., et al. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.113276 · Cited by 6
Zajac, N., Zhang, Q., Bratus-Neuenschwander, A., Qi, W., Bolck, H. A., Karakulak, T., Oltra, T. C., Moch, H., Kahraman, A., & Rehrauer, H. (2025) · NAR Genomics and Bioinformatics · doi:10.1093/nargab/lqaf089 · Cited by 10
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Meng-Lin, K., Ung, C. Y., Zhang, C., Weisskittel, T., Wiśniewski, P., Zhang, Z. M., Tan, S.-H., Yeo, K. S., Zhu, S., Correia, C., et al. (2023) · Biomolecules · doi:10.3390/biom13060895 · Cited by 6
Kyaw, W., Chai, R. C. C., Khoo, W. H., Goldstein, L. D., Croucher, P. I., Murray, J. M., & Phan, T. G. (2023) · Bioinformatics · doi:10.1093/bioinformatics/btad765 · Cited by 6
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Zhou, Z., Zhang, Y., Xu, Z., Tang, X., Chen, X., Guan, J., & Zhang, Z. (2024) · Frontiers in Genetics · doi:10.3389/fgene.2023.1241834 · Cited by 5
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Stairley, R. A., Trouten, A. M., Li, S., Roddy, P. L., DeLeon‐Pennell, K. Y., Lee, K., Sucov, H. M., Liu, C., & Tao, G. (2024) · Antioxidants · doi:10.3390/antiox13070769 · Cited by 5
Hou, S., Ma, W., & Zhou, X. (2025) · Nature Communications · doi:10.1038/s41467-025-66272-z · Cited by 6
Analyzing network diversity of cell–cell interactions in COVID-19 using single-cell transcriptomics
Wang, X., Almet, A. A., & Nie, Q. H. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.948508 · Cited by 5
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Swenson, C., Pillai, K. S., Carlos, A. J., & Moellering, R. E. (2023) · Israel Journal of Chemistry · doi:10.1002/ijch.202200104 · Cited by 3
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Kim, H., Choi, E., Shim, Y., & Kwon, J. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26157110 · Cited by 3
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Hameed, S. A., Kölch, W., Brennan, D. J., & Zhernovkov, V. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.04.16.589574 · Cited by 3
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Zhang, C., Hu, Y., & Gao, L. (2023) · Scientific Reports · doi:10.1038/s41598-023-42883-8 · Cited by 3
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Hameed, S. A., Kölch, W., Brennan, D. J., & Zhernovkov, V. (2025) · Scientific Reports · doi:10.1038/s41598-025-98463-5 · Cited by 3
Yang, C., Cheng, D., Wang, S., Wang, B., Li, Y., Wang, G., Wang, X., Shi, C., Tian, Y., Zhu, K., et al. (2025) · Journal of Cancer · doi:10.7150/jca.110981 · Cited by 1
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Lin, Q., Lv, X., Qiu, Q., Mei, L., Chen, L., Song, S., Liu, W. X., Jiang, X., Huang, M., Shen, L., et al. (2025) · Frontiers in Pediatrics · doi:10.3389/fped.2025.1596643 · Cited by 1
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Tong, Y., Hong, R., Li, M., Yang, N., Deng, W., Tang, H., Zeng, T., & Liu, R. (2025) · Briefings in Bioinformatics · doi:10.1093/bib/bbaf568 · Cited by 1
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Jin, Z., Tang, Z., Li, X., Zhang, K., Xie, Z., & Zhang, N. (2026) · Genome biology · doi:10.1186/s13059-026-04043-9 · Cited by 2
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Kotah, J. M., Trombetta-Lima, M., Dragt, E. C., Voulgaroglou, A., Brouwer, N., Holtman, I. R., Kooistra, S. M., & Eggen, B. J. L. (2026) · Glia · doi:10.1002/glia.70210 · Cited by 2
Yi, Z., Liu, Y., Wang, J., Hu, C., & Man, Y. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.05.23.541910 · Cited by 1
Ji, B., Wang, X., Wang, X., Xu, L., & Peng, S. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.02.28.582416 · Cited by 1
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Wei, B., Troendle, E. P., Simpson, D. A., & Stitt, A. W. (2026) · PLoS ONE · doi:10.1371/journal.pone.0345045
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Tan, F., Xuan, Y., Long, L., Yu, Y., Zhang, C., Liang, P., Wang, Y., Chen, M., Wen, J., & Chen, G. (2023) · BMC Genomics · doi:10.1186/s12864-023-09615-8
Basto, E., Wajid, B., Read, J. F., Armitage, J. D., Waithman, J., Small, M., & Bosco, A. (2025) · bioRxiv · doi:10.1101/2024.05.01.591681
Wang, S., Zhang, B., Lou, Z., Hu, Y., Wang, J., Wang, J., Chen, Z., & Yin, S. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e35478
Wang, J., Jin, A., Pan, H., Zheng, R., Wu, C., & Li, M. (2024) · ACM International Conference on Bioinformatics, Computational Biology, and Health Informatics (ACM-BCB) · doi:10.1145/3698587.3701352
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Al-Tal, M. K. F., Liu, X., & Zhou, J. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.01.691666
Wang, Z., Li, J., Xie, L., Wang, Y., Wang, T., Chen, J., Shang, X., Li, X., Liu, Z., & Hu, J. (2026) · Briefings in Bioinformatics · doi:10.1093/bib/bbag371
Soelter, T. M., Howton, T. C., Clark, A. D., Oza, V. H., & Lasseigne, B. N. (2024) · Figshare · doi:10.6084/m9.figshare.26730970
Tan, F., Xuan, Y., Long, L., Yu, Y., Zhang, C., Liang, P., Wang, Y., Chen, M., Wen, J., & Chen, G. (2023) · Figshare · doi:10.6084/m9.figshare.24077045
Liu, Z., Sun, D., & Wang, C. (2022) · Figshare · doi:10.6084/m9.figshare.21351415
Soelter, T. M., Howton, T. C., Clark, A. D., Oza, V. H., & Lasseigne, B. N. (2024) · Figshare · doi:10.6084/m9.figshare.26730961
Liu, Z., Sun, D., & Wang, C. (2022) · Figshare · doi:10.6084/m9.figshare.21351412
Soelter, T. M., Howton, T. C., Clark, A. D., Oza, V. H., & Lasseigne, B. N. (2024) · Figshare · doi:10.6084/m9.figshare.26730964
Tan, F., Xuan, Y., Long, L., Yu, Y., Zhang, C., Liang, P., Wang, Y., Chen, M., Wen, J., & Chen, G. (2023) · Figshare · doi:10.6084/m9.figshare.24077048
Tan, F., Xuan, Y., Long, L., Yu, Y., Zhang, C., Liang, P., Wang, Y., Chen, M., Wen, J., & Chen, G. (2023) · Figshare · doi:10.6084/m9.figshare.24077039
Soelter, T. M., Howton, T. C., Clark, A. D., Oza, V. H., & Lasseigne, B. N. (2024) · Figshare · doi:10.6084/m9.figshare.26730967
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Yu, X., Qian, J., & Wang, J. (2026) · Methods in molecular biology · doi:10.1007/978-1-0716-5408-8_10
Yi, Z., Liu, Y., Wang, J., Deng, C., Jin, Y., Qu, Y., Hu, C., & Man, Y. (2026) · Bone Research · doi:10.1038/s41413-026-00585-7
Agarwal, V., Ralph, S. J., Bhatnagar, N., Haywood, A., Singh, M., Malik, M. Z., Iqbal, S., & Cheesman, M. J. (2026) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2026.147732
Liu, G., Yang, J., Li, H., Deng, L., Jiang, L., Tan, Y., Zhu, J., Li, J., & Wang, Y. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1916056
Han, Y., Liu, Q., Ao, F., Huang, J., & Lin, H. (2026) · Frontiers in Immunology · doi:10.3389/fimmu.2026.1879293
Stromal-myeloid-lymphoid crosstalk in immune evasion and immunotherapy resistance in solid tumors
Raza, B., Usama, M., Cai, Q., Iqbal, Z., & Ji, S. (2026) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2026.105643
Zhong, S., Xie, G., & Zhang, Z. (2026) · Genes · doi:10.3390/genes17101261
Chen, D., Zhao, H., Zhao, H., & Wang, J. (2026) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2026.154761
Metadata
- Authors
- Almet, A. A., Cang, Z., Jin, S., & Nie, Q.
- Affiliations
- University of California, Irvine (US)
- Corresponding author
- Nie, Qing
- Venue
- Current Opinion in Systems Biology
- Publisher
- Elsevier BV
- Published
- 2021-06
- Volume
- 26
- Pages
- 12-23
- ISSN
- 2452-3100 (ISSN-L)
- PMC
- PMC8104132
- OpenAlex
- W3146817258
- Cited by
- 197
- References
- 54
- Citations by year
- 2026: 34 · 2025: 38 · 2024: 37 · 2023: 49 · 2022: 30 · 2021: 9
- FWCI
- 3.36
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Current Opinion in Systems Biology (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by-nc-nd)
- Funders
- Simons Foundation (594598)
- National Science Foundation (DMS1763272)
- National Institutes of Health (U01AR073159)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Single-cell and spatial transcriptomics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gene Regulatory Network Analysis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bioinformatics and Genomic Networks
- Keywords
- intercellular communication, single-cell transcriptomics, spatial transcriptomics, cell-to-cell communication, tissue organization
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