Uniform polydimethylsiloxane beads coated with polydopamine and their potential biomedical applications
Abstract
Based on oil-in-water emulsion, uniform poly(dimethylsiloxane) (PDMS) beads were prepared using a simple fluidic device and then modified with polydopamine (PDA) to improve cell attachment. The size of the PDMS beads could be easily tuned by changing the flow rates of the discontinuous and continuous phases, and PDMS concentration in oil phase. The PDA-coated PDMS beads exhibited a dark and rough surface, whereas the pristine PDMS beads had a clear and smooth surface. The PDA layer at the surface of the PDMS beads was found to provide a favorable environment for cell culture due to its hydrophilic property. The PDA-coated PDMS beads can potentially be employed as filler materials for tissue engineering.
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Such targeted modification makes the biphasic interface of material more stable and versatile for diverse requirements from bone tissue repair.
“Such targeted modification makes the biphasic interface of material more stable and versatile for diverse requirements from bone tissue repair [97].”
From Polydopamine-Assisted Surface Modification for Bone Biosubstitutes (2016) · cites this paper as [97]
PDA-assisted surface modification uses PDA as a biocompatible surface modifier to interact with organic and inorganic components on the interface of bone bio-substitutes.
“PDA-assisted surface modification uses PDA as a biocompatible surface modifier to interact with organic and inorganic components on the interface of bone bio-substitutes.”
From Polydopamine-Assisted Surface Modification for Bone Biosubstitutes (2016) · cites this paper as [97]
Cites
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Injectable biodegradable materials for orthopedic tissue engineering
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Polydopamine-Assisted Surface Modification for Bone Biosubstitutes
Huang, S., Liang, N., Hu, Y., Zhou, X., & Abidi, N. (2016) · BioMed Research International · doi:10.1155/2016/2389895 · Cited by 97 · see citing works
“The PDA coating layer on poly(dimethylsiloxane) (PDMS) can enhance the cytoaffinity of PDMS based bone cement where NIH3T3 fibroblast cells can attach more readily to the material substrate which further improves the cell proliferation [96].”
Background
- Authors
- Jun, D.-R., Moon, S.-K., & Choi, S.-W.
- Affiliations
- Catholic University of Korea (KR)
- Corresponding author
- Choi, Sung-Wook
- ORCID
- Choi, Sung-Wook
- Venue
- Colloids and Surfaces B: Biointerfaces
- Publisher
- Elsevier BV
- Published
- 2014-09
- Volume
- 121
- Pages
- 395-399
- ISSN
- 0927-7765 (ISSN-L)
- OpenAlex
- W1973782589
- Cited by
- 33
- References
- 3
- Citations by year
- 2026: 2 · 2025: 3 · 2024: 3 · 2023: 5 · 2022: 4 · 2021: 2 · 2020: 3 · 2018: 2 · 2017: 1 · 2016: 5 · 2015: 3
- FWCI
- 1.18
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Colloids and Surfaces B Biointerfaces (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Ministry of Education, Science and Technology (2011-0023064)
- National Research Foundation of Korea
- Topics
- Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
- Physical Sciences › Engineering › Biomedical Engineering › Microfluidic and Capillary Electrophoresis Applications
- Keywords
- polydopamine coating, oil-in-water emulsions, fluidic devices, bead size control, cell attachment, hydrophilicity, tissue engineering scaffolds, fillers
- MeSH terms
- Animals, Dimethylpolysiloxanes, Indoles, Microscopy, Fluorescence, Microspheres, Particle Size, Polymers, Staining and Labeling, Spectroscopy, Fourier Transform Infrared, Coated Materials, Biocompatible, Biomedical Technology, NIH 3T3 Cells, Cell Proliferation, Mice
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