Effect of Ficus carica L. leaves extract loaded gold nanoparticles against cisplatin-induced acute kidney injury
Abstract
Background Cisplatin (CisPt) is one of the most widely used and highly effective drugs for the treatment of various solid tumors, unfortunately acute kidney injury (AKI) is considered one of its side effects through several mechanisms including production of reactive oxygen species (ROS), pro-inflammatory and pro-fibrotic cytokines. Due to the poor effect of AKI therapy, the use of nanoparticles loaded with natural extracts for delivering to the kidney molecules are desirable.Aim This study aims to investigate the effectiveness of different concentrations of gold nanoparticles (Au-NPs) as a carrier for Ficus carica L. (Fig) leaves extract against CisPt induced AKI.Methods Seventy male albino rats were used and divided into seven groups. After the experimental period, blood was withdrawn, serum was separated for determination of urea, creatinine, homocystein (Hcy) and folic acid while reduced glutathione (GSH), nitric oxide (NO), malondialdehyde (MDA), total antioxidant capacity (TAC) and hydroxyproline content (Hyp) were evaluated in kidney tissue homogenate.Results CisPt induced AKI in rats and results in a significant increase in the levels of serum urea, creatinine, Hcy and kidney Hyp, lipid peroxidation along with a significant reduction of kidney GSH, NO and TAC compared to the control rats. Treatment with Au-NPs and Fig extract particularly in a ratio of (3:2) respectively was shown to improve renal functions with efficient capacity in scavenging ROS and reduced AKI severity.Conclusion Au-NPs enhanced the anti-oxidative properties of the Fig extract in targeting kidney damaged tissue and reduced oxidative toxicity induced by CisPt.
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Ficus carica extract transported by gold nanoparticles reduces toxicity caused by cisplatin-induced oxidative stress.
“For example, an extract from Ficus carica, a plant native to the Mediterranean region transported by gold nanoparticles has been shown to reduce toxicity caused by cis-platin-induced oxidative stress (El-Sayed et al. 2019).”
From Reactive Oxygen Species, Toxicity, Oxidative Stress, and Antioxidants: Chronic Diseases and Aging (2023) · cites this paper as El-Sayed et al. 2019
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- Authors
- El-Sayed, S. M., El-Naggar, M. E., Hussein, J., Medhat, D., & El-Banna, M.
- Affiliations
- National Research Centre (EG)
- Venue
- Colloids and Surfaces B: Biointerfaces
- Publisher
- Elsevier BV
- Published
- 2019-12
- Volume
- 184
- Pages
- 110465
- ISSN
- 0927-7765 (ISSN-L)
- OpenAlex
- W2972414237
- Cited by
- 56
- References
- 40
- Citations by year
- 2026: 4 · 2025: 4 · 2024: 8 · 2023: 13 · 2022: 9 · 2021: 6 · 2020: 12
- FWCI
- 4.97
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Colloids and Surfaces B Biointerfaces (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Pathology and Forensic Medicine › Chemotherapy-induced organ toxicity mitigation
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and biological activities of Ficus species
- Health Sciences › Medicine › Nephrology › Acute Kidney Injury Research
- Keywords
- Ficus carica, fig leaf extract, gold nanoparticles, cisplatin, acute kidney injury, nephrotoxicity, oxidative stress, reactive oxygen species, lipid peroxidation, antioxidant activity, renal function, homocysteine, folic acid, nitric oxide, glutathione, total antioxidant capacity, hydroxyproline, nanoparticle drug delivery
- MeSH terms
- Animals, Cisplatin, Creatinine, Glutathione, Gold, Homocysteine, Liver, Male, Malondialdehyde, Phytotherapy, Plant Extracts, Plant Leaves, Ficus, Rats, Metal Nanoparticles, Acute Kidney Injury
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