Cited by 35Magnesium Alloys: Properties and ApplicationsHydrogels: synthesis, properties, applicationsTitanium Alloys Microstructure and Properties

Biomimetic hydrogel coatings for improving the corrosion resistance, hemocompatibility, and endothelial cell growth of the magnesium alloy

Chen, Jie, Xu, Ruiting, Meng, Lingjie, Yan, Fei, Wang, Lingtao, Xu, Yi, Zhang, Qiuyang, Zhai, Wanli +1 more·2025·Colloids and Surfaces B: Biointerfaces

Abstract

The fast biodegradation and poor biocompatibility of Mg alloys in physiological environments are still the main problems restricting their application in cardiovascular stents. In this study, the hydrogel coatings (SBMA-AAM) with different proportions of methacryloyl ethyl sulfobetaine (SBMA) and acrylamide (AAM) were built on the surface of AZ31B magnesium alloy through ultraviolet (UV) polymerization. The corrosion degradation behavior, hemocompatibility, and endothelial cell (EC) growth performance of the samples were studied in detail. The findings revealed that the uniform and dense SBMA-AAM coatings could significantly enhance the corrosion resistance. In addition, the hydrogel coatings showed excellent hydrophilicity, which increased the albumin adsorption while inhibiting the fibrinogen adsorption, and thus reduced the platelet adhesion and activation and hemolysis rate, accordingly significantly enhancing their anticoagulant performance. Furthermore, SBMA-AAM hydrogel coating promoted the EC adhesion and proliferation and the vascular endothelial growth factor (VEGF) and nitric oxide (NO) secretion of ECs, which is conducive to promoting endothelialization. When the concentration ratio of SBMA and AAM was 1: 2, the modified magnesium alloy showed the best corrosion resistance and biocompatibility. Therefore, the SBMA-AAM hydrogel coating could effectively regulate the corrosion degradation performance and biocompatibility of Mg alloys, laying a foundation for the application of Mg alloys in cardiovascular stents.

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Crossref · 10.1016/j.colsurfb.2024.114204

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Authors
Chen, J., Xu, R., Meng, L., Yan, F., Wang, L., Xu, Y., Zhang, Q., Zhai, W., & Pan, C.
Affiliations
  • Huai'an University (CN)
  • Changzhou University (CN)
Corresponding author
  • Chen, Jie
  • Pan, Changjiang
Venue
Colloids and Surfaces B: Biointerfaces
Publisher
Elsevier BV
Published
2025-01
Volume
245
Pages
114204
ISSN
0927-7765 (ISSN-L)
OpenAlex
W4402184232
Cited by
34
References
59
Citations by year
2026: 11 · 2025: 20 · 2024: 3
FWCI
3.21
Type
journal article
Language
en
Open access
closed
Locations
  • Colloids and Surfaces B Biointerfaces (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Natural Science Research of Jiangsu Higher Education Institutions of China
  • Jiangsu Province Natural Science Foundation
  • National Natural Science Foundation of China
Topics
  • Physical Sciences › Materials Science › Biomaterials › Magnesium Alloys: Properties and Applications
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
  • Physical Sciences › Materials Science › Materials Chemistry › Titanium Alloys Microstructure and Properties
Keywords
magnesium alloys, hydrogel coating, AZ31B, acrylamide, UV photopolymerization, corrosion resistance, hemocompatibility, endothelialization, cardiovascular stents, biodegradation, platelet adhesion, hemolysis, endothelial cell proliferation, vascular endothelial growth factor, nitric oxide
MeSH terms
Alloys, Cell Adhesion, Cells, Cultured, Corrosion, Hemolysis, Humans, Magnesium, Materials Testing, Platelet Adhesiveness, Surface Properties, Coated Materials, Biocompatible, Hydrogels, Biomimetic Materials, Vascular Endothelial Growth Factor A, Endothelial Cells, Cell Proliferation, Human Umbilical Vein Endothelial Cells

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