A hydrophobic layer prepared by cyclic grafting of polydimethylsiloxane on magnesium: improved corrosion resistance and biocompatibility
Open accessAbstract
Magnesium and its alloys have been widely studied as absorbable coronary stent materials. However, the rapid corrosion rate in the intravascular environment inhibits the application of magnesium-based stents. In order to endow magnesium-based stent with appropriate degradation rate and biocompatibility, a hydrophobic layer was constructed by in situ cyclic grafting 4,4′-diphenylmethane diisocyanate and aminopropyl-terminated polydimethylsiloxane on pure magnesium. SEM-EDS, X-ray photoelectron spectroscopy and water contact angle were detected to analyze the chemical composition of the layer. The amino groups were confirmed to be introduced on the surface which provide a platform for subsequent modification. The contact angle value of the modified surface is 132.1°, indicating a hydrophilic surface. The electrochemical measurements and immersion tests demonstrated that the hydrophobic layer significantly improved the anti-corrosion ability of the substrate. Besides, the biocompatibility of the hydrophobic surface was examined by platelet adhesion, cytocompatibility in vitro and subcutaneous implantation in vivo. Immunological and histological results indicated that the hydrophobic layer had excellent biocompatibility. Therefore, the presented study might be a promising method for the surface modification of biomedical magnesium-based stent.
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Increased hydrophobicity reduces attachment of water molecules to the coating surface, and the densified network structure blocks penetration of corrosive ions like Cl−.
“This structural modification is critical for corrosion protection45,46, as increased hydrophobicity reduces the attachment of water molecules to the coating surface, and the densified network structure effectively blocks the penetration of corrosive ions like Cl⁻.”
From Intelligence-responsive wettability switch coating on magnesium implants for treating osteoporotic fracture (2026) · cites this paper as [45]
The Surface wettability and Immersion degradation sections (pages not provided) say the hydrophobic layer limits contact with the corrosive environment and reduces corrosion, supporting the water-contact part of the claim. They do not describe a densified network structure or show that it blocks penetration of Cl⁻ ions. (LLM, conf=0.86)
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“This structural modi fi cation is critical for corrosion protection 45,46 , asincreased hydrophobicity reduces the attachment of water molecules to the coating surface, and the densi fi ed network structure effectively blocks the penetration of corrosive ions like Cl ⁻ .”
Self-citation
- Authors
- Shen, X., Zhang, H., Li, X., Li, P., Zhao, Y., Wang, Y., & Wang, J.
- Affiliations
- Panzhihua University (CN)
- Third People's Hospital of Chengdu (CN)
- Southwest Jiaotong University (CN)
- Sichuan University (CN)
- Corresponding author
- Zhang, Hao
- Wang, Jin
- Venue
- Regenerative Biomaterials
- Publisher
- Oxford University Press (OUP)
- Published
- 2022-01-01
- Volume
- 9
- Pages
- rbac068-rbac068
- ISSN
- 2056-3418 (ISSN-L)
- 2056-3426
- PMC
- PMC9566967
- OpenAlex
- W4298006004
- Cited by
- 21
- References
- 53
- Citations by year
- 2026: 3 · 2025: 9 · 2024: 3 · 2023: 6
- FWCI
- 1.13
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Locations
- Regenerative Biomaterials (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (52101286)
- Sichuan Science and Technology Program (2022NSFSC2011)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Magnesium Alloys: Properties and Applications
- Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
- Physical Sciences › Materials Science › Surfaces, Coatings and Films › Surface Modification and Superhydrophobicity
- Keywords
- hydrophobic surface modification, 4,4'-diphenylmethane diisocyanate, corrosion resistance, biocompatibility, platelet adhesion, cytocompatibility, subcutaneous implantation
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