The DOI matches its Crossref record; 108 of the 108 references it cites were found in a registry or an index.
Recent advances in biomedical engineering of nano-hydroxyapatite including dentistry, cancer treatment and bone repair
Abstract
Abstract Hydroxyapatite (HAp) has significant biological activity, degradability, and osteoconductivity. In recent decades, it has been widely used in dentistry, anti-tumour drug carriers, and orthopaedic repair. However, hydroxyapatite has limit features which are poor mechanical properties for directly inducing tooth enamel remineralization, particle size and morphology issues on drug delivery and brittleness for bone transplantation. This article summarizes the problems encountered in the preparation, application, and modification of hydroxyapatite in the above-mentioned fields and the current research progress, combining theory with experiment. Therefore, the greatest significance of this review is to comprehensively integrate and argue the forms and effects of nHA-based biomaterials, which provides a theoretical basis for the application of this material and help readers have clear insights into future research.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Bioinspired structural materials
Wegst, U. G. K., Bai, H., Saiz, E., Tomsia, A. P., & Ritchie, R. O. (2015) · Nature Materials · doi:10.1038/nmat4089 · Cited by 4,721
An overview of the recent developments in polylactide (PLA) research
Madhavan Nampoothiri, K., Nair, N. R., & John, R. P. (2010) · Bioresource Technology · doi:10.1016/j.biortech.2010.05.092 · Cited by 2,448
Poly-lactic acid synthesis for application in biomedical devices — A review
Lasprilla, A. J. R., Martinez, G. A. R., Lunelli, B. H., Jardini, A. L., & Filho, R. M. (2012) · Biotechnology Advances · doi:10.1016/j.biotechadv.2011.06.019 · Cited by 1,174
Biomimetic Systems for Hydroxyapatite Mineralization Inspired By Bone and Enamel
Palmer, L. C., Newcomb, C. J., Kaltz, S. R., Spoerke, E. D., & Stupp, S. I. (2008) · Chemical Reviews · doi:10.1021/cr8004422 · Cited by 1,090
Polylactic acid (PLA) controlled delivery carriers for biomedical applications
Tyler, B., Gullotti, D., Mangraviti, A., Utsuki, T., & Brem, H. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.06.018 · Cited by 1,050
Horiuchi, K., Amizuka, N., Takeshita, S., Takamatsu, H., Katsuura, M., Ozawa, H., Toyama, Y., Bonewald, L. F., & Kudo, A. (1999) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1999.14.7.1239 · Cited by 975
Kikuchi, M., Itoh, S., Ichinose, S., Shinomiya, K., & Tanaka, J. (2001) · Biomaterials · doi:10.1016/s0142-9612(00)00305-7 · Cited by 854
Fluoride toothpastes for preventing dental caries in children and adolescents
Marinho, V. C., Higgins, J., Logan, S., & Sheiham deceased, A. (2003) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002278 · Cited by 845
In vivo delivery, pharmacokinetics, biodistribution and toxicity of iron oxide nanoparticles
Arami, H., Khandhar, A., Liggitt, D., & Krishnan, K. M. (2015) · Chemical Society Reviews · doi:10.1039/c5cs00541h · Cited by 830
Mo, X. M., Xu, C. Y., Kotaki, M., & Ramakrishna, S. (2004) · Biomaterials · doi:10.1016/j.biomaterials.2003.08.042 · Cited by 803
Cited by
Bikiaris, N. D., Koumentakou, I., Samiotaki, C., Meimaroglou, D., Varytimidou, D., Karatza, A., Kalantzis, Z., Roussou, M., Bikiaris, R. D., & Papageorgiou, G. Z. (2023) · Polymers · doi:10.3390/polym15051196 · Cited by 279
Hydroxyapatite in Oral Care Products—A Review
Chen, L., Al-Bayatee, S., Khurshid, Z., Shavandi, A., Brunton, P., & Ratnayake, J. (2021) · Materials · doi:10.3390/ma14174865 · Cited by 105
Metadata
- Authors
- Du, M., Chen, J., Liu, K., Xing, H., & Song, C.
- Venue
- Composites Part B: Engineering
- Publisher
- Elsevier BV
- Published
- 2021-06
- Volume
- 215
- Pages
- 108790
- ISSN
- 1359-8368 (ISSN-L)
- OpenAlex
- W3138809674
- Cited by
- 268
- References
- 108
- FWCI
- 14.21
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Recent advances in biomedical engineering of nano-hydroxyapatite including dentistry, cancer treatment and bone repair. https://app.cochat.ai/papers/10.1016/j.compositesb.2021.108790
- The paper
- Du, M., Chen, J., Liu, K., Xing, H., & Song, C. (2021). Recent advances in biomedical engineering of nano-hydroxyapatite including dentistry, cancer treatment and bone repair. Composites Part B: Engineering. https://doi.org/10.1016/j.compositesb.2021.108790
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.