Using the Children's Depression Inventory in youth with inflammatory bowel disease: support for a physical illness-related factor
Open accessAbstract
The objective of the present investigation was to evaluate the factor structure of the Children's Depression Inventory (CDI) in adolescents with inflammatory bowel disease (IBD) to better understand the CDI's psychometric properties in a medically complicated population. An exploratory factor analysis was performed on CDI data collected from a clinical sample of 191 youth with IBD, aged 11 to 17 years. Exploratory factor analysis with quartimax rotation yielded 3 factors: mood, behavioral/motivational, and somatic complaints. Only the somatic factor (ie, fatigue, sleep, decreased appetite, and worry about aches and pain) showed a significant positive correlation with IBD severity. The CDI holds promise as a brief measure for the assessment of depressive features psychometrically independent of IBD severity and common steroid treatments as well as of nongastrointestinal specific somatic complaints in a sample of adolescents with IBD. Continued work in this area of research appears promising in honing the assessment of depressive and somatic symptoms in youths with IBD.
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There are a myriad of mental health screening measures used, and few have been validated in an IBD population.
“there are a myriad of mental health screening measures used, and it is notable that few have been validated in an IBD population (38, 86).”
From Controversies Revisited: A Systematic Review of the Comorbidity of Depression and Anxiety with Inflammatory Bowel Diseases (2016) · cites this paper as [86]
There was tremendous variability in measurement of anxiety and depression; 16 scales were used across the 66 unique studies examined in this systematic review and only two appear to have been validated in individuals with IBD.
“there was tremendous variability in measurement of anxiety and depression; 16 scales (5 for both anxiety and depression; 6 for depression alone; and 5 for anxiety alone) were used across the 66 unique studies examined in this systematic review and only two appear to have been validated in individuals with IBD (38, 86).”
From Controversies Revisited: A Systematic Review of the Comorbidity of Depression and Anxiety with Inflammatory Bowel Diseases (2016) · cites this paper as [86]
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Cites
From inflammation to sickness and depression: when the immune system subjugates the brain
Dantzer, R., O'Connor, J. C., Freund, G. G., Johnson, R. W., & Kelley, K. W. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2297 · Cited by 7,395 · see citing works
Depression among children with chronic medical problems: A meta-analysis
Bennett, D. S. (1994) · Journal of Pediatric Psychology · doi:10.1093/jpepsy/19.2.149 · Cited by 322 · see citing works
SZIGETHY, E., WHITTON, S. W., LEVY-WARREN, A., DeMaso, D. R., WEISZ, J., & BEARDSLEE, W. R. (2004) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/01.chi.0000142284.10574.1f · Cited by 92 · see citing works
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Mikocka-Walus, A., Knowles, S. R., Keefer, L., & Graff, L. (2016) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000620 · Cited by 567 · see citing works
Szigethy, E., Bujoreanu, S. I., Youk, A. O., Weisz, J., Benhayon, D., Fairclough, D., Ducharme, P., Gonzalez-Heydrich, J., Keljo, D., Srinath, A., et al. (2014) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2014.04.014 · Cited by 86 · see citing works
Self-citationPediatric inflammatory bowel disease and depression: treatment implications
Keethy, D., Mrakotsky, C., & Szigethy, E. (2014) · Current Opinion in Pediatrics · doi:10.1097/mop.0000000000000129 · Cited by 40 · see citing works
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- Authors
- Thompson, R. D., Craig, A. E., Mrakotsky, C., Bousvaros, A., DeMaso, D. R., & Szigethy, E.
- Affiliations
- Children's Hospital of Pittsburgh (US)
- Duke Medical Center (US)
- Boston Children's Hospital (US)
- Corresponding author
- Szigethy, Eva
- Venue
- Comprehensive Psychiatry
- Publisher
- Elsevier BV
- Published
- 2012-11
- Volume
- 53
- Issue
- 8
- Pages
- 1194-1199
- ISSN
- 0010-440X (ISSN-L)
- PMC
- PMC4017927
- OpenAlex
- W2020683179
- Cited by
- 26
- References
- 3
- Citations by year
- 2026: 1 · 2022: 1 · 2021: 4 · 2020: 1 · 2019: 1 · 2018: 4 · 2017: 1 · 2016: 5 · 2014: 6 · 2013: 2
- FWCI
- 3.43
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Comprehensive Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- National Institutes of Health (7k23mh064604-04)
- National Institute of Mental Health (K-23 MH064604)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Social Sciences › Decision Sciences › Management Science and Operations Research › Psychometric Methodologies and Testing
- Keywords
- Children's Depression Inventory, inflammatory bowel disease, adolescents, depression, somatic symptoms, factor structure, fatigue, sleep, appetite, corticosteroid therapy, psychometric properties
- MeSH terms
- Adolescent, Adrenal Cortex Hormones, Affect, Child, Colitis, Ulcerative, Crohn Disease, Depressive Disorder, Female, Humans, Male, Motivation, Personality Inventory, Psychometrics, Psychophysiologic Disorders, Severity of Illness Index, Statistics as Topic, Reproducibility of Results, Comorbidity
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