Pediatric inflammatory bowel disease and depression: treatment implications
Open accessAbstract
PURPOSE OF REVIEW: Depression in pediatric inflammatory bowel disease is increasingly recognized to be a heterogeneous condition with diverse underlying predisposing and precipitating factors. Although there is a growing awareness regarding the benefits of integrating behavioral health into medical care, the way psychiatric treatments can best target different aspects of depression and related dysfunction has not been systematically explored. RECENT FINDINGS: This review discusses neurobiological risk factors for depression in inflammatory bowel disease including inflammation, associated anti-inflammatory treatment with corticosteroids, pain, and sleep disturbance, as well as psychosocial factors including reactions to illness, illness perception, and disease and environmental stressors with an emphasis on how these factors can influence treatment decisions. Empirically supported psychosocial and psychopharmacological interventions are discussed within this context. SUMMARY: Understanding the diverse pathways that can lead to depression in youths with inflammatory bowel disease can lead to the development of more targeted interventions and better integration of psychosocial care into the medical treatment of inflammatory bowel disease.
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Patients with IBD and comorbid depression and/or anxiety may be less likely to adhere to medical care procedures and therapeutic schemes, resulting in unnecessary escalation in therapy and complications.
“patients with IBD and co-morbid depression and/or anxiety may be less likely to adhere to medical care procedures and therapeutic schemes, resulting in unnecessary escalation in therapy and complications [50,51,52].”
From Association between Childhood Onset Inflammatory Bowel Disease and Psychiatric Comorbidities in Adulthood (2023) · cites this paper as [50]
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Tyring, S., Gottlieb, A., Papp, K., Gordon, K., Leonardi, C., Wang, A., Lalla, D., Woolley, M., Jahreis, A., Zitnik, R., et al. (2006) · The Lancet · doi:10.1016/s0140-6736(05)67763-x · Cited by 1,069 · cited 1× · see citing works
“In adults with IBD, reduced IBD activity and tumor necrosis factor (TNF)-alpha after infliximab treatment for their IBD had the added benefit of improving depression [18].”
BackgroundEpidemiology of pediatric inflammatory bowel disease: A systematic review of international trends
Benchimol, E. I., Fortinsky, K. J., Gozdyra, P., van den Heuvel, M., Limbergen, J. V., & Griffiths, A. M. (2010) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21349 · Cited by 953 · see citing works
Brain–Gut Interactions in Inflammatory Bowel Disease
Bonaz, B. L., & Bernstein, C. N. (2013) · Gastroenterology · doi:10.1053/j.gastro.2012.10.003 · Cited by 667 · see citing works
Depression and anxiety in inflammatory bowel disease: A review of comorbidity and management
Graff, L. A., Walker, J. R., & Bernstein, C. N. (2009) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20873 · Cited by 586 · see citing works
Ford, A. C., Talley, N. J., Schoenfeld, P. S., Quigley, E. M. M., & Moayyedi, P. (2009) · Gut · doi:10.1136/gut.2008.163162 · Cited by 582 · see citing works
A role for synaptic plasticity in the adolescent development of executive function
Selemon, L. D. (2013) · Translational Psychiatry · doi:10.1038/tp.2013.7 · Cited by 439 · cited 1× · see citing works
“developmental period is one of particular psychiatric vulnerability; it represents a time of brain maturation and neuroplasticity as well as development of behavioral repertoires which may lend themselves to behavioral intervention [7].”
BackgroundWagner, K. D. (2003) · JAMA · doi:10.1001/jama.290.8.1033 · Cited by 413 · see citing works
Fuller-Thomson, E., & Sulman, J. (2006) · Inflammatory Bowel Diseases · doi:10.1097/00054725-200608000-00005 · Cited by 292 · see citing works
Elsenbruch, S. (2010) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2010.11.010 · Cited by 280 · see citing works
A meta-analytic review of the psychosocial adjustment of youth with inflammatory bowel disease
Greenley, R. N., Hommel, K. A., Nebel, J., Raboin, T., Li, S.-H., Simpson, P., & Mackner, L. (2010) · Journal of Pediatric Psychology · doi:10.1093/jpepsy/jsp120 · Cited by 259 · cited 2× · see citing works
“It is important tonote thatnotallyouthwith IBD becomedepressed, particularly during IBD remission [2,80].”
BackgroundThe evolutionary significance of depression in Pathogen Host Defense (PATHOS-D)
Raison, C. L., & Miller, A. H. (2013) · Molecular Psychiatry · doi:10.1038/mp.2012.2 · Cited by 253 · see citing works
Corticosteroid-related central nervous system side effects
Ciriaco, M., Ventrice, P., Russo, G., Scicchitano, M., Mazzitello, G., Scicchitano, F., & Russo, E. (2013) · Journal of Pharmacology and Pharmacotherapeutics · doi:10.4103/0976-500x.120975 · Cited by 247 · see citing works
Anglin, R., Yuan, Y., Moayyedi, P., Tse, F., Armstrong, D., & Leontiadis, G. I. (2014) · American Journal of Gastroenterology · doi:10.1038/ajg.2014.82 · Cited by 234 · cited 1× · see citing works
“, nausea, pain, diarrhea, and risk of gastrointestinal bleeding) that need to be particularly monitored [73,74].”
Wagner, K. D., Jonas, J. M., Findling, R. L., Ventura, D., & Saikali, K. G. (2006) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/01.chi.0000192250.38400.9e · Cited by 210 · see citing works
Psychosocial Issues in Pediatric Inflammatory Bowel Disease
Mackner, L. M., Greenley, R. N., Szigethy, E., Herzer, M., Deer, K., & Hommel, K. A. (2013) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e3182841263 · Cited by 189 · see citing works
Self-citationSZIGETHY, E., KENNEY, E., CARPENTER, J., HARDY, D. M., FAIRCLOUGH, D., BOUSVAROS, A., KELJO, D., WEISZ, J., BEARDSLEE, W. R., NOLL, R., et al. (2007) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/chi.0b013e3180f6341f · Cited by 183 · see citing works
Self-citationKappelman, M. D., Long, M. D., Martin, C., DeWalt, D. A., Kinneer, P. M., Chen, W., Lewis, J. D., & Sandler, R. S. (2014) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2013.10.019 · Cited by 178 · see citing works
Szigethy, E., Levy‐Warren, A., Whitton, S. W., Bousvaros, A., Gauvreau, K., Leichtner, A. M., & Beardslee, W. R. (2004) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-200410000-00017 · Cited by 166 · see citing works
Self-citationAbuse, Trauma, and GI Illness: Is There a Link?
Drossman, D. A. (2010) · The American Journal of Gastroenterology · doi:10.1038/ajg.2010.453 · Cited by 157 · see citing works
Gray, W. N., Denson, L. A., Baldassano, R. N., & Hommel, K. A. (2012) · Journal of Pediatric Psychology · doi:10.1093/jpepsy/jsr092 · Cited by 143 · see citing works
Ali, T., Madhoun, M. F., Orr, W. C., & Rubin, D. T. (2013) · Inflammatory Bowel Diseases · doi:10.1097/mib.0b013e3182a0ea54 · Cited by 141 · see citing works
Nicholas, D. B., Otley, A., Smith, C., Avolio, J., Munk, M., & Griffiths, A. M. (2007) · Health and Quality of Life Outcomes · doi:10.1186/1477-7525-5-28 · Cited by 140 · see citing works
The Complex Role of Sleep in Adolescent Depression
Clarke, G. N., & Harvey, A. G. (2012) · Child and Adolescent Psychiatric Clinics of North America · doi:10.1016/j.chc.2012.01.006 · Cited by 139 · see citing works
Goodhand, J., Greig, F. I. S., Koodun, Y., Mcdermott, A., Wahed, M., Langmead, L., & Rampton, D. (2012) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21846 · Cited by 131 · see citing works
Cognitive Behavior Therapy for Pediatric Functional Abdominal Pain: A Randomized Controlled Trial
van der Veek, S., Derkx, B., Benninga, M. A., Boer, F., & de Haan, E. (2013) · PEDIATRICS · doi:10.1542/peds.2013-0242 · Cited by 127 · see citing works
Quality of Life in Children with Crohn's Disease
Rabbett, H., Elbadri, A., Thwaites, R., Northover, H., Dady, I. M., Firth, D., Hillier, V. F., Miller, V., & Thomas, A. G. (1996) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-199612000-00003 · Cited by 123 · see citing works
Wilkinson, P. O., Croudace, T. J., & Goodyer, I. M. (2013) · BMC Psychiatry · doi:10.1186/1471-244x-13-250 · Cited by 121 · see citing works
Werkstetter, K. J., Ullrich, J., Schatz, S. B., Prell, C., Koletzko, B. V., & Koletzko, S. (2012) · Journal of Crohn s and Colitis · doi:10.1016/j.crohns.2011.11.017 · Cited by 121 · see citing works
Antidepressants and inflammatory bowel disease: a systematic review.
Mikocka‐Walus, A. A., Turnbull, D. A., Moulding, N., Wilson, I. G., Andrews, J. M., & Holtmann, G. (2006) · Clinical Practice and Epidemiology in Mental Health · doi:10.1186/1745-0179-2-24 · Cited by 120 · see citing works
Mussell, M., cker, U. B., Nagel, N., & Singer, M. V. (2004) · European Journal of Gastroenterology & Hepatology · doi:10.1097/00042737-200412000-00007 · Cited by 117 · see citing works
Knowles, S. R., Wilson, J. L., Connell, W. R., & Kamm, M. A. (2011) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21650 · Cited by 113 · see citing works
Depression and Anxiety in Pediatric Inflammatory Bowel Disease and Cystic Fibrosis
Burke, P. M., MEYER, V., Kocoshis, S. A., Orenstein, D. M., Chandra, R., NORD, D. J., Sauer, J., & Cohen, E. E. W. (1989) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-198911000-00022 · Cited by 111 · see citing works
Pain management in patients with inflammatory bowel disease: insights for the clinician
Srinath, A. I., Walter, C., Newara, M. C., & Szigethy, E. M. (2012) · Therapeutic Advances in Gastroenterology · doi:10.1177/1756283x12446158 · Cited by 111 · see citing works
Self-citationPsychotherapy for inflammatory bowel disease: a review and update
McCombie, A. M., Mulder, R. T., & Gearry, R. B. (2013) · Journal of Crohn s and Colitis · doi:10.1016/j.crohns.2013.02.004 · Cited by 105 · see citing works
Knowles, S. R., Monshat, K., & Castle, D. J. (2013) · Inflammatory Bowel Diseases · doi:10.1097/mib.0b013e318296ae5a · Cited by 102 · see citing works
Shepanski, M. A., Hurd, L. B., Culton, K., Markowitz, J. E., Mamula, P., & Baldassano, R. N. (2005) · Inflammatory Bowel Diseases · doi:10.1097/00054725-200502000-00010 · Cited by 97 · see citing works
Tricyclic Antidepressants for Management of Residual Symptoms in Inflammatory Bowel Disease
Iskandar, H. N., Cassell, B., Kanuri, N., Gyawali, C. P., Gutierrez, A., Dassopoulos, T., Ciorba, M. A., & Sayuk, G. S. (2014) · Journal of Clinical Gastroenterology · doi:10.1097/mcg.0000000000000049 · Cited by 96 · see citing works
Piche, T., Ducrotté, P., Sabate, J. M., Coffin, B., Zerbib, F., Dapoigny, M., Hua, M., Marine-barjoan, E., Dainese, R., & Hébuterne, X. (2010) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2010.01502.x · Cited by 95 · see citing works
Strategies to improve quality of life in adolescents with inflammatory bowel disease
Karwowski, C., Keljo, D. J., & Szigethy, E. (2009) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20919 · Cited by 89 · see citing works
Self-citationBryant, R. V., van Langenberg, D. R., Holtmann, G., & Andrews, J. M. (2011) · Journal of Gastroenterology and Hepatology · doi:10.1111/j.1440-1746.2011.06624.x · Cited by 87 · see citing works
Szigethy, E., Bujoreanu, S. I., Youk, A. O., Weisz, J., Benhayon, D., Fairclough, D., Ducharme, P., Gonzalez-Heydrich, J., Keljo, D., Srinath, A., et al. (2014) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2014.04.014 · Cited by 86 · see citing works
Self-citationStructure of major depressive disorder in adolescents and adults in the US general population
Lamers, F., Burstein, M., He, J.-P., Avenevoli, S., Angst, J., & Merikangas, K. R. (2012) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.111.098079 · Cited by 82 · see citing works
Knowles, S. R., Cook, S. I., & Tribbick, D. (2013) · Journal of Crohn s and Colitis · doi:10.1016/j.crohns.2013.02.022 · Cited by 74 · see citing works
Kinnucan, J. A. R., Rubin, D. T., & Ali, T. (2013) · Europe PMC (PubMed Central) · Cited by 73 · see citing works
Engelmann, G., Erhard, D., Petersen, M., Parzer, P., Schlarb, A. A., Resch, F., Brunner, R., Hoffmann, G. F., Lenhartz, H., & Richterich, A. (2015) · Child Psychiatry & Human Development · doi:10.1007/s10578-014-0471-5 · Cited by 72 · see citing works
Quality of care in inflammatory bowel disease: A review and discussion
Kappelman, M. D., Palmer, L. B., Boyle, B. M., & Rubin, D. T. (2009) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21028 · Cited by 70 · see citing works
The Overlap of Functional Abdominal Pain in Pediatric Crohn’s Disease
Zimmerman, L. A., Srinath, A. I., Goyal, A., Bousvaros, A., Ducharme, P., Szigethy, E., & Nurko, S. (2013) · Inflammatory Bowel Diseases · doi:10.1097/mib.0b013e3182802a0a · Cited by 65 · see citing works
Self-citationDepression subtypes in pediatric inflammatory bowel disease
Szigethy, E. M., Youk, A. O., Benhayon, D., Fairclough, D. L., Newara, M. C., Kirshner, M. A., Bujoreanu, S. I., Mrakotsky, C., Bousvaros, A., Srinath, A. I., et al. (2014) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000000262 · Cited by 65 · see citing works
Self-citationKaminski, A., Kamper, A., Thaler, K. J., Chapman, A. L., & Gartlehner, G. (2011) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd008013.pub2 · Cited by 63 · see citing works
Kast, R. E. (2003) · General Hospital Psychiatry · doi:10.1016/s0163-8343(03)00093-8 · Cited by 62 · see citing works
Nicholas, D. B., Swan, S. R., Gerstle, T. J., Allan, T., & Griffiths, A. M. (2008) · Health and Quality of Life Outcomes · doi:10.1186/1477-7525-6-114 · Cited by 59 · see citing works
Reigada, L. C., Bruzzese, J., Benkov, K. J., Levy, J., Waxman, A. R., Petkova, E., & Warner, C. M. (2011) · Journal for Specialists in Pediatric Nursing · doi:10.1111/j.1744-6155.2011.00292.x · Cited by 58 · see citing works
Predictors of Depression in Youth With Crohn Disease
Clark, J. G., Srinath, A. I., Youk, A. O., Kirshner, M. A., McCarthy, F. N., Keljo, D. J., Bousvaros, A., DeMaso, D. R., & Szigethy, E. (2013) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000000277 · Cited by 56 · see citing works
Self-citationBenhayon, D., Youk, A. O., McCarthy, F. N., Davis, S., Keljo, D. J., Bousvaros, A., Fairclough, D. L., Kupfer, D. J., Buysse, D. J., & Szigethy, E. (2013) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e31829641df · Cited by 56 · see citing works
Self-citationWojtowicz, A. A., Greenley, R. N., Gumidyala, A. P., Rosen, A., & Williams, S. E. (2014) · Journal of Crohn s and Colitis · doi:10.1016/j.crohns.2014.02.011 · Cited by 54 · see citing works
Crohn’s disease remission on bupropion
Kane, S. V., Altschuler, E. L., & Kast, R. E. (2003) · Gastroenterology · doi:10.1016/j.gastro.2003.02.004 · Cited by 52 · see citing works
Mrakotsky, C., Forbes, P. W., Bernstein, J. H., Grand, R. J., Bousvaros, A., Szigethy, E., & Waber, D. P. (2012) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617712001014 · Cited by 52 · see citing works
Self-citationCognitive functioning and depressive symptoms in adolescents with inflammatory bowel disease
Castaneda, A. E. (2013) · World Journal of Gastroenterology · doi:10.3748/wjg.v19.i10.1611 · Cited by 48 · see citing works
Profile of depression in adolescents with inflammatory bowel disease: Implications for treatment
Szigethy, E., Craig, A. E., Iobst, E. A., Grand, R. J., Keljo, D. J., DeMaso, D. R., & Noll, R. B. (2008) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20693 · Cited by 43 · see citing works
Self-citationThompson, R. D., Craig, A. E., Crawford, E. A., Fairclough, D. L., Gonzalez–Heydrich, J., Bousvaros, A., Noll, R. B., DeMaso, D. R., & Szigethy, E. (2012) · Journal of Clinical Psychology in Medical Settings · doi:10.1007/s10880-012-9301-8 · Cited by 43 · see citing works
Self-citationRyan, J. L., Mellon, M. W., Junger, K. W., Hente, E. A., Denson, L. A., Saeed, S. A., & Hommel, K. A. (2013) · Inflammatory Bowel Diseases · doi:10.1097/mib.0b013e3182a82b15 · Cited by 41 · see citing works
Strategies for Quantifying the Relationship between Medications and Suicidal Behaviour
Gibbons, R. D., & Mann, J. J. (2011) · Drug Safety · doi:10.2165/11589350-000000000-00000 · Cited by 39 · see citing works
Open Trial of Bupropion SR in Adolescent Major Depression
Glod, C. A., Lynch, A., Flynn, E., Berkowitz, C., & Baldessarini, R. J. (2003) · Journal of Child and Adolescent Psychiatric Nursing · doi:10.1111/j.1744-6171.2003.00123.x · Cited by 37 · see citing works
Antidepressant Drugs and the Risk of Suicide in Children and Adolescents
Isacsson, G., & Rich, C. L. (2014) · Pediatric Drugs · doi:10.1007/s40272-013-0061-1 · Cited by 37 · see citing works
Case study: Longitudinal treatment of adolescents with depression and inflammatory bowel disease
SZIGETHY, E., CARPENTER, J., BAUM, E., KENNEY, E., BAPTISTA-NETO, L., BEARDSLEE, W. R., & DeMASO, D. R. (2006) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/01.chi.0000198591.45949.a4 · Cited by 33 · see citing works
Self-citationPredictors of Abdominal Pain in Depressed Pediatric Inflammatory Bowel Disease Patients
Srinath, A. I., Goyal, A., Zimmerman, L. A., Newara, M. C., Kirshner, M. A., McCarthy, F. N., Keljo, D. J., Binion, D. G., Bousvaros, A., DeMaso, D. R., et al. (2014) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000104 · Cited by 33 · see citing works
Self-citationDepression Treatment in Patients With General Medical Conditions: Results From the CO-MED Trial
Morris, D. W., Budhwar, N., Husain, M. M., Wisniewski, S. R., Kurian, B. T., Luther, J., Kerber, K. A., Rush, A. J., & Trivedi, M. H. (2012) · The Annals of Family Medicine · doi:10.1370/afm.1316 · Cited by 32 · see citing works
When independent healthcare behaviors develop in adolescents with inflammatory bowel disease
van Groningen, J. T., Ziniel, S. I., Arnold, J. H., & Fishman, L. N. (2012) · Inflammatory Bowel Diseases · doi:10.1002/ibd.22937 · Cited by 30 · see citing works
Depressive Symptoms in Youth with Inflammatory Bowel Disease Compared with a Community Sample
Reed, B., Lobato, D. J., Hagin, S., McQuaid, E. L., Seifer, R., Kopel, S. J., Boergers, J., Nassau, J. H., Suorsa, K. I., Bancroft, B., et al. (2014) · Inflammatory Bowel Diseases · doi:10.1097/01.mib.0000442678.62674.b7 · Cited by 30 · see citing works
Thompson, R. D., Craig, A. E., Mrakotsky, C., Bousvaros, A., DeMaso, D. R., & Szigethy, E. (2012) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2012.04.006 · Cited by 26 · see citing works
Self-citationPsychoneuroimmunologic factors in inflammatory bowel disease
Mackner, L. M., Clough-Paabo, E., PAJER, K. A., Lourie, A., & Crandall, W. (2010) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21430 · Cited by 25 · see citing works
Schoultz, M., Atherton, I., Hubbard, G., & Watson, A. J. M. (2013) · Trials · doi:10.1186/1745-6215-14-431 · Cited by 20 · see citing works
Choe, C. J., Emslie, G. J., & Mayes, T. L. (2012) · Child and Adolescent Psychiatric Clinics of North America · doi:10.1016/j.chc.2012.07.002 · Cited by 20 · see citing works
BIOMARKERS IN PEDIATRIC DEPRESSION
Rao, U. (2013) · Depression and Anxiety · doi:10.1002/da.22171 · Cited by 18 · see citing works
Hypnosis as an Adjuvant Treatment for Children With Inflammatory Bowel Disease
Shaoul, R. R., Sukhotnik, I., & Mogilner, J. G. (2009) · Journal of Developmental & Behavioral Pediatrics · doi:10.1097/dbp.0b013e3181a7eeb0 · Cited by 16 · see citing works
O’Donovan, A. (2014) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000000292 · Cited by 8 · see citing works
McLafferty, L. P., Craig, A. E., Levine, A., Jones, N. P., Becker, A., & Szigethy, E. (2011) · Inflammatory Bowel Diseases · doi:10.1093/ibd/17.supplement1.s54a · Cited by 7 · see citing works
Self-citationSalazar, G. (2014) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000000332 · Cited by 4 · see citing works
Corticosteroids, inflammation, and memory in pediatric Crohn's disease.
Mrakotsky, C., Waber, D. P., Bousvaros, A., & Grand, R. J. (2011) · Inflammatory Bowel Diseases · doi:10.1093/ibd/17.supplement1.s9 · Cited by 1 · see citing works
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Brooks, A. J., Rowse, G., Ryder, A., Peach, E. J., Corfe, B. M., & Lobo, A. J. (2016) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.13645 · Cited by 98 · see citing works
Ferro, M. A. (2015) · Epidemiology and Psychiatric Sciences · doi:10.1017/s2045796015000700 · Cited by 85 · see citing works
Inflammatory Bowel Disease in Childhood and Adolescence
Däbritz, J., Gerner, P., Enninger, A., Claßen, M., & Radke, M. H. (2017) · Deutsches Ärzteblatt international · doi:10.3238/arztebl.2017.0331 · Cited by 79 · see citing works
Morshedzadeh, N., Shahrokh, S., Aghdaei, H. A., Pourhoseingholi, M. A., Chaleshi, V., Hekmatdoost, A., Karimi, S., Zali, M. R., & Mirmiran, P. (2019) · Complementary Therapies in Medicine · doi:10.1016/j.ctim.2019.07.012 · Cited by 65 · see citing works
Pediatric Inflammatory Bowel Disease
Fuller, M. K. (2019) · Surgical Clinics of North America · doi:10.1016/j.suc.2019.08.008 · Cited by 64 · see citing works
Qualter, P., Rouncefield‐Swales, A., Bray, L., Blake, L., Allen, S. J., Probert, C. S., Crook, K., & Carter, B. (2020) · Quality of Life Research · doi:10.1007/s11136-020-02653-9 · Cited by 55 · see citing works
Xu, Z., Tang, H., Huang, F., Qiao, Z., Wang, X., Yang, C., & Deng, Q. (2020) · Frontiers in Microbiology · doi:10.3389/fmicb.2020.615404 · Cited by 46 · see citing works
Zhan, X., Peng, W., Wang, Z., Liu, X., Dai, W., Quanxi, M., & Hu, X. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/2042163 · Cited by 44 · see citing works
Youth and Parent Illness Appraisals and Adjustment in Pediatric Inflammatory Bowel Disease
Roberts, C. M., Gamwell, K. L., Baudino, M. N., Perez, M. N., Delozier, A. M., Sharkey, C. M., Grant, D. M., Grunow, J. E., Jacobs, N. J., Tung, J., et al. (2019) · Journal of Developmental and Physical Disabilities · doi:10.1007/s10882-019-09678-0 · Cited by 40 · see citing works
van den Brink, G., Stapersma, L., Marroun, H. E., Henrichs, J., Szigethy, E., Utens, E. M. W. J., & Escher, J. C. (2016) · BMJ Open Gastroenterology · doi:10.1136/bmjgast-2015-000071 · Cited by 34 · see citing works
Self-citationMind–Body Interventions for Pediatric Inflammatory Bowel Disease
Yeh, A. M., Wren, A. A., & Golianu, B. J. (2017) · Children · doi:10.3390/children4040022 · Cited by 30 · see citing works
Roberts, C. M., Baudino, M. N., Gamwell, K. L., Edwards, C. S., Traino, K. A., Tung, J., Grunow, J. E., Jacobs, N. J., Mullins, L. L., & Chaney, J. M. (2020) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000002939 · Cited by 29 · see citing works
Yamamoto, M., Shanmuganathan, M., Hart, L., Pai, N., & Britz‐McKibbin, P. (2021) · Metabolites · doi:10.3390/metabo11040245 · Cited by 25 · see citing works
Sălcudean, A., Nan, A. G., Bodo, C. R., Cosma, M. C., Strete, E. G., & Lica, M. M. (2023) · Diagnostics · doi:10.3390/diagnostics13111868 · Cited by 24 · see citing works
Food-Related Quality of Life in Children and Adolescents With Crohn’s Disease
Brown, S., Whelan, K., Frampton, C., Wall, C. L., Gearry, R. B., & Day, A. S. (2022) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izac010 · Cited by 24 · see citing works
Abdo, S. A., Wadie, W., Abdelsalam, R. M., & Khattab, M. M. (2019) · Inflammation · doi:10.1007/s10753-019-01068-0 · Cited by 22 · see citing works
Shen, C., Yang, A. C., Hung, J.-H., Hu, L., Chiang, Y.-Y., & Tsai, S. (2016) · Journal of Psychosomatic Obstetrics & Gynecology · doi:10.3109/0167482x.2015.1124852 · Cited by 21 · see citing works
Improving Care in Pediatric Inflammatory Bowel Disease
Egberg, M. D., Kappelman, M. D., & Gulati, A. (2018) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2018.07.013 · Cited by 20 · see citing works
Dermatological Manifestations in Pediatric Inflammatory Bowel Disease
Diaconescu, S., Strat, S., Balan, G. G., Anton, C., Ștefănescu, G., Ioniuc, I. K., & Stănescu, A. M. A. (2020) · Medicina · doi:10.3390/medicina56090425 · Cited by 19 · see citing works
Tempchin, J., Storch, B., & Reigada, L. C. (2021) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2021.110558 · Cited by 19 · see citing works
Depression in Medically Ill Children and Adolescents
Malas, N., Plioplys, S., & Pao, M. (2019) · Child and Adolescent Psychiatric Clinics of North America · doi:10.1016/j.chc.2019.02.005 · Cited by 18 · see citing works
Relation between inflammatory bowel disease, depression, and inpatient outcomes in the United States
Ali, H., Pamarthy, R., Bolick, N. L., Lambert, K., & Naseer, M. (2022) · Baylor University Medical Center Proceedings · doi:10.1080/08998280.2022.2028344 · Cited by 17 · see citing works
Roberts, C. M., Gamwell, K. L., Baudino, M. N., Edwards, C. S., Jacobs, N. J., Tung, J., Grunow, J. E., Mullins, L. L., & Chaney, J. M. (2022) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0000000000002420 · Cited by 17 · see citing works
Depression Predicts Prolonged Length of Hospital Stay in Pediatric Inflammatory Bowel Disease
Patel, P. V., Pantell, M. S., Heyman, M. B., & Verstraete, S. G. (2019) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000002426 · Cited by 11 · see citing works
AL-Aamri, H., Al‐Huseini, S., Chan, M. F., Saadi, A. A., Al‐Sibani, N., Al-Dughaishi, Z., & Al‐Alawi, M. (2021) · Oman Medical Journal · doi:10.5001/omj.2022.48 · Cited by 10 · see citing works
Chronisch entzündliche Darmerkrankungen – die biopsychosoziale Realität im Kindes- und Jugendalter
Krohn, K., Pfeifer, M., Manzey, P., & Koletzko, S. (2020) · Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz · doi:10.1007/s00103-020-03166-z · Cited by 8 · see citing works
Patient, Parent, and Provider Perceptions of Barriers to Pediatric Inflammatory Bowel Disease Care
Dotson, J. L., Bricker, J. B., Chisolm, D. J., & Mackner, L. M. (2023) · JPGN Reports · doi:10.1097/pg9.0000000000000386 · Cited by 7 · see citing works
The association of sleep with inflammatory bowel disease in children and adolescents
Manhart, A.-K., Hellmann, S. M., Hamelmann, E. H., & Schlarb, A. A. (2016) · Somnologie - Schlafforschung und Schlafmedizin · doi:10.1007/s11818-016-0067-3 · Cited by 7 · see citing works
Wong, J. J., Maddux, M. H., & Park, K. T. (2018) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000001947 · Cited by 7 · see citing works
Wang, C., Bai, C., Mao, C., Leng, X., Wang, F., & Guo, X. (2022) · Journal of Clinical Laboratory Analysis · doi:10.1002/jcla.24488 · Cited by 6 · see citing works
Edwards, C. S., Baudino, M. N., Roberts, C. M., Basile, N. L., Dattilo, T. M., Gamwell, K. L., Jacobs, N. J., Edwards, D. S., Tung, J., Parker, C. V., et al. (2023) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1002/jpn3.12056 · Cited by 4 · see citing works
Nakamura, A., Jimbo, K., Suzuki, M., Hibio, M., Nagata, M., Arai, N., Miyata, E., Kudo, T., Hoshino, E., & Shoji, H. (2025) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izaf034 · Cited by 3 · see citing works
Edwards, C. S., Roberts, C. M., Baudino, M. N., Basile, N. L., Gamwell, K. L., Jacobs, N. J., Tung, J., Grunow, J. E., Mullins, L. L., & Chaney, J. M. (2022) · Journal of Clinical Psychology in Medical Settings · doi:10.1007/s10880-022-09886-5 · Cited by 3 · see citing works
Depression Screening Scores and Allergy and Gastrointestinal Medication Use in Adolescents
Harris, K. R., Saikumar, P., Sunkoj, Y., Vancuren, T., Olufowote, B., & Dedeaux, J. A. (2022) · Current Drug Safety · doi:10.2174/1574886317666220826170140 · Cited by 3 · see citing works
Gastrointestinal Ostomies in Children: A Primer for the Pediatrician
Mullin, K. T., Rentea, R. M., Appleby, M., & Reeves, P. T. (2024) · Pediatrics in Review · doi:10.1542/pir.2023-006195 · Cited by 2 · see citing works
Psychological Aspects of Inflammatory Bowel Disease in Children and Adolescents
Plevinsky, J. M., & Hommel, K. A. (2023) · Springer eBooks · doi:10.1007/978-3-031-14744-9_50 · Cited by 2 · see citing works
Health Care Maintenance in Pediatric Inflammatory Bowel Disease
Mitchel, E. B., & Grossman, A. B. (2023) · Gastroenterology Clinics of North America · doi:10.1016/j.gtc.2023.05.009 · Cited by 1 · see citing works
Psychische Gesundheit von Kindern und Jugendlichen mit chronisch entzündlichen Darmerkrankungen
Lenhartz, H. (2022) · Arthritis und Rheuma · doi:10.1055/a-1958-6998
Baker, M. E., Grice, J. W., Gamwell, K. L., Roberts, C. M., & Chaney, J. M. (2026) · Open Journal of Applied Sciences · doi:10.4236/ojapps.2026.165087
Markovinović, A., Ma, C., Shaheen, A., Coward, S. B., & Kaplan, G. G. (2026) · Journal of the Canadian Association of Gastroenterology · doi:10.1093/jcag/gwag015
- Authors
- Keethy, D., Mrakotsky, C., & Szigethy, E.
- Affiliations
- Boston Children's Hospital (US)
- University of Pittsburgh (US)
- Corresponding author
- Szigethy, Eva
- Venue
- Current Opinion in Pediatrics
- Published
- 2014-10
- Volume
- 26
- Issue
- 5
- Pages
- 561-567
- ISSN
- 1040-8703 (ISSN-L)
- PMC
- PMC4229361
- OpenAlex
- W2319115568
- Cited by
- 40
- References
- 79
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 1 · 2023: 5 · 2022: 8 · 2021: 3 · 2020: 5 · 2019: 6 · 2018: 2 · 2017: 2 · 2016: 4 · 2015: 1
- FWCI
- 0.31
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Current Opinion in Pediatrics (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health (R01MH077770)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (K23HD058466)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Inflammatory Bowel Disease
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- pediatric inflammatory bowel disease, depression, neurobiological risk factors, inflammation, corticosteroids, pain, sleep disorders, psychosocial factors, illness perception, psychopharmacological interventions, psychosocial interventions, behavioral health integration, adolescents
- MeSH terms
- Adolescent, Antidepressive Agents, Child, Child, Preschool, Combined Modality Therapy, Depression, Humans, Inflammation, Psychophysiologic Disorders, Psychotherapy, Risk Factors, Sleep Wake Disorders, Inflammatory Bowel Diseases, Abdominal Pain
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