Randomized efficacy trial of two psychotherapies for depression in youth with inflammatory bowel disease
Open accessAbstract
Objective Pediatric inflammatory bowel disease (IBD) is associated with high rates of depression. This study compared the efficacy of cognitive behavioral therapy (CBT) to supportive nondirective therapy (SNDT) in treating youth with comorbid IBD and depression.Method Youth (51% female and 49% male; age 9-17 years, mean age 14.3 years) with depression and Crohn's disease (n = 161) or ulcerative colitis (n = 56) were randomly assigned to a 3-month course of CBT or SNDT. The primary outcome was comparative reduction in depressive symptom severity; secondary outcomes were depression remission, increase in depression response, and improved health-related adjustment and IBD activity.Results A total of 178 participants (82%) completed the 3-month intervention. Both psychotherapies resulted in significant reductions in total Children's Depression Rating Scale Revised score (37.3% for CBT and 31.9% for SNDT), but the difference between the 2 treatments was not significant (p = .16). There were large pre-post effect sizes for each treatment (d = 1.31 for CBT and d = 1.30 for SNDT). More than 65% of youth had a complete remission of depression at 3 months, with no difference between CBT and SNDT (67.8% and 63.2%, respectively). Compared to SNDT, CBT was associated with a greater reduction in IBD activity (p = .04) but no greater improvement on the Clinical Global Assessment Scale (p = .06) and health-related quality of life (IMPACT-III scale) (p = .07).Conclusion This is the first randomized controlled study to suggest improvements in depression severity, global functioning, quality of life, and disease activity in a physically ill pediatric cohort treated with psychotherapy. Clinical trial registration information-Reducing Depressive Symptoms in Physically Ill Youth; http://clinical trials.gov; NCT00534911.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Szigethy et al's 2014 trial comparing CBT with supportive non-directive therapy in participants with depression found no difference between treatments.
“However, Szigethy et al's 2014 trial comparing CBT with supportive non-directive therapy (SNDT) in participants with depression found no difference between treatments 29 .”
From A Systematic review of self-management interventions for children and adolescents with inflammatory bowel disease (2019) · cites this paper as [29]
The Results report no statistically significant difference between CBT and SNDT in depressive severity or remission. However, the Discussion states that CBT produced a significantly greater reduction in IBD activity, so the unqualified claim of no difference between treatments overstates the finding. (LLM, conf=0.88)
Experimental — accuracy not yet measuredSzigethy et al. 2014 compared CBT to supportive non-directive therapy and reported improvements over time but found no significant difference between the two conditions.
“Szigethy at al. 2014 compared CBT to supportive non-directive therapy reported improvements over time but found no significant difference between the two conditions 29 .”
From A Systematic review of self-management interventions for children and adolescents with inflammatory bowel disease (2019) · cites this paper as [29]
The Results and Discussion report improvement over time in both CBT and supportive non-directive therapy, with no significant between-treatment difference in depression severity. But the Discussion also reports a significant difference in reduced IBD activity favoring CBT, so the unqualified statement that there was no difference between conditions overstates the finding. (LLM, conf=0.88)
Experimental — accuracy not yet measuredMean CGAS scores posttreatment (CBT 65.83 versus SNDT 64.30) were consistent with minimal impairment on the CGAS scale.
“Mean CGAS scores posttreatment, (CBT 65.83 versus SNDT 64.30) were consistent with minimal impairment on the CGAS scale.”
From A Systematic review of self-management interventions for children and adolescents with inflammatory bowel disease (2019) · cites this paper as Szigethy et al (2014)
The Results section reports that posttreatment CGAS scores indicated minimal impairment and gives SNDT as 64.30. It gives the CBT mean as 65.82, however, rather than the claimed 65.83 (page unavailable in our copy). (LLM, conf=0.88)
Experimental — accuracy not yet measuredFive interventions were based on cognitive behavioural theory and aimed to improve psychological wellbeing.
“Five interventions were based on cognitive behavioural theory (CBT) and aimed to improve psychological wellbeing 28,29, 30,31, 32 .”
From A Systematic review of self-management interventions for children and adolescents with inflammatory bowel disease (2019) · cites this paper as [29]
Two CBT interventions measured disease activity as an outcome.
“Two CBT interventions measured disease activity as an outcome 28, 29 .”
From A Systematic review of self-management interventions for children and adolescents with inflammatory bowel disease (2019) · cites this paper as [29]
A positive effect favouring CBT in reducing disease activity was found over time in the larger trial (n=217) by Szigethy et al., 2014 but not the smaller trial (n=22) by Reigada et al.
“A positive effect favouring CBT in reducing disease activity was found over time in,the larger trial (n=217) by Szigethy et al., 2014 29 but not the smaller trial (n=22) by Reigada et al. 28 .”
From A Systematic review of self-management interventions for children and adolescents with inflammatory bowel disease (2019) · cites this paper as [29]
In a trial for participants with depression, Szigethy et al. 2014 found an improvement in both the CBT and SNDT groups but there were no differences between the groups in change over time and the trial did not include a usual care control group.
“In a trial for participants with depression, Szigethy et al. 2014 found an improvement in both the CBT and SNDT groups but there were no differences between the groups in change over time and the trial did not include a usual care control group 29,33 .”
From A Systematic review of self-management interventions for children and adolescents with inflammatory bowel disease (2019) · cites this paper as [29]
Five trials reported on psychosocial outcomes, all of which were evaluations of CBT interventions.
“Five trials reported on psychosocial outcomes, all of which were evaluations of CBT interventions 28-32 .”
From A Systematic review of self-management interventions for children and adolescents with inflammatory bowel disease (2019) · cites this paper as [29]
Both therapies showed an improvement in HRQoL.
“Both therapies showed an improvement in HRQoL”
From A Systematic review of self-management interventions for children and adolescents with inflammatory bowel disease (2019) · cites this paper as Szigethy et al (2014)
No significant difference between interventions on Children's Global Assessment Scale.
“No significant difference between interventions.”
From A Systematic review of self-management interventions for children and adolescents with inflammatory bowel disease (2019) · cites this paper as Szigethy et al (2014)
No significant differences were found between treatments in HRQoL.
“but no significant differences were found between treatments.”
From A Systematic review of self-management interventions for children and adolescents with inflammatory bowel disease (2019) · cites this paper as Szigethy et al (2014)
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
KAUFMAN, J., BIRMAHER, B., BRENT, D., RAO, U., FLYNN, C., MORECI, P., WILLIAMSON, D., & RYAN, N. (1997) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199707000-00021 · Cited by 10,148 · see citing works
Diagnostic and Statistical Manual of Mental Disorders ( DSM ‐ IV ‐ TR )
Segal, D. L. (2010) · Wiley eBooks · doi:10.1002/9780470479216.corpsy0271 · Cited by 4,683 · see citing works
Children’s Depression Inventory (CDI)
Kovacs, M. (2011) · Springer eBooks · doi:10.1007/978-0-387-79061-9_4285 · Cited by 3,885 · see citing works
A Children's Global Assessment Scale (CGAS)
Shaffer, D. (1983) · Archives of General Psychiatry · doi:10.1001/archpsyc.1983.01790100074010 · Cited by 3,716 · see citing works
Pediatric modification of the Montreal classification for inflammatory bowel disease
Levine, A., Griffiths, A. M., Markowitz, J. F., Wilson, D. C., Turner, D., Russell, R. K., Fell, J. M. E., Ruemmele, F. M., Walters, T. D., Sherlock, M. E., et al. (2010) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21493 · Cited by 1,518 · see citing works
Wampold, B. E., Mondin, G. W., Moody, M., Stich, F., Benson, K., & Ahn, H.-N. (1997) · Psychological Bulletin · doi:10.1037/0033-2909.122.3.203 · Cited by 1,091 · see citing works
Turner, D., Otley, A. R., Mack, D. R., Hyams, J. S., de Bruijne, J., Uusoue, K., Walters, T. D., Zachos, M., Mamula, P., Beaton, D., et al. (2007) · Gastroenterology · doi:10.1053/j.gastro.2007.05.029 · Cited by 1,073 · see citing works
Kappelman, M. D., Rifas‐Shiman, S. L., KLEINMAN, K. P., Ollendorf, D., Bousvaros, A., Grand, R. J., & Finkelstein, J. A. (2007) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2007.07.012 · Cited by 931 · see citing works
Self-citationTherapist Success and Its Determinants
Luborsky, L. B. (1985) · Archives of General Psychiatry · doi:10.1001/archpsyc.1985.01790290084010 · Cited by 766 · see citing works
Brent, D. A. (1997) · Archives of General Psychiatry · doi:10.1001/archpsyc.1997.01830210125017 · Cited by 753 · cited 8× · see citing works
“, history of abuse), it has been found to be more efficacious than CBT.(21,43) We cannot rule out factors common to both therapies (e.”
InfluentialIBD Working Group of the European Society for Paediatric Gastroenterology, H. A. N. (. (2005) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/01.mpg.0000163736.30261.82 · Cited by 702 · see citing works
Brain–Gut Interactions in Inflammatory Bowel Disease
Bonaz, B. L., & Bernstein, C. N. (2013) · Gastroenterology · doi:10.1053/j.gastro.2012.10.003 · Cited by 667 · see citing works
Children’s Depression Rating Scale – Revised (CDRS-R)
Keller, F., Grieb, J., Ernst, M., Spröber, N., Fegert, J. M., & Kölch, M. G. (2011) · Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie · doi:10.1024/1422-4917/a000090 · Cited by 453 · see citing works
Wang, P. S., Simon, G. E., Avorn, J., Azocar, F., Ludman, E. J., McCulloch, J., Petukhova, M. Z., & Kessler, R. C. (2007) · JAMA · doi:10.1001/jama.298.12.1401 · Cited by 408 · see citing works
A Conceptual and Methodological Analysis of the Nonspecifics Argument.
DeRubeis, R. J., Brotman, M. A., & Gibbons, C. J. (2005) · Clinical Psychology: Science and Practice · doi:10.1093/clipsy.bpi022 · Cited by 310 · see citing works
Sahler, O. J. Z., Fairclough, D. L., Phipps, S., Mulhern, R. K., Dolgin, M. J., Noll, R. B., Katz, E. R., Varni, J. W., Copeland, D. R., & Butler, R. W. (2005) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.73.2.272 · Cited by 282 · see citing works
Self-citationKennard, B. D., Silva, S. G., Vitiello, B., Curry, J. F., Kratochvil, C. J., Simons, A. D., Hughes, J. L., Feeny, N. C., Weller, E. B., SWEENEY, M., et al. (2006) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/01.chi.0000242228.75516.21 · Cited by 280 · see citing works
Otley, A. R., Smith, C., Nicholas, D. B., Munk, M., Avolio, J., Sherman, P. M., & Griffiths, A. M. (2002) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-200210000-00018 · Cited by 265 · see citing works
A meta-analytic review of the psychosocial adjustment of youth with inflammatory bowel disease
Greenley, R. N., Hommel, K. A., Nebel, J., Raboin, T., Li, S.-H., Simpson, P., & Mackner, L. (2010) · Journal of Pediatric Psychology · doi:10.1093/jpepsy/jsp120 · Cited by 259 · see citing works
Weisz, J. R., Thurber, C. A., Sweeney, L., Proffitt, V. D., & LeGagnoux, G. L. (1997) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.65.4.703 · Cited by 257 · see citing works
Self-citationPhillips, M. (1996) · Medical Entomology and Zoology · Cited by 216 · see citing works
Illness representations and matching labels with symptoms.
Baumann, L. J., Cameron, L. D., Zimmerman, R. S., & Leventhal, H. (1989) · Health Psychology · doi:10.1037//0278-6133.8.4.449 · Cited by 187 · see citing works
SZIGETHY, E., KENNEY, E., CARPENTER, J., HARDY, D. M., FAIRCLOUGH, D., BOUSVAROS, A., KELJO, D., WEISZ, J., BEARDSLEE, W. R., NOLL, R., et al. (2007) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/chi.0b013e3180f6341f · Cited by 183 · see citing works
Self-citationSzigethy, E., Levy‐Warren, A., Whitton, S. W., Bousvaros, A., Gauvreau, K., Leichtner, A. M., & Beardslee, W. R. (2004) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-200410000-00017 · Cited by 166 · see citing works
Self-citationIllness representations and matching labels with symptoms.
Baumann, L. J., Cameron, L. D., Zimmerman, R. S., et al. (1989) · Health Psychology · doi:10.1037/0278-6133.8.4.449 · Cited by 142 · see citing works
Goodhand, J., Greig, F. I. S., Koodun, Y., Mcdermott, A., Wahed, M., Langmead, L., & Rampton, D. (2012) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21846 · Cited by 131 · see citing works
Griffiths, A. M., Nicholas, D. B., Smith, C., Munk, M., Stephens, D., Durno, C. A., & Sherman, P. M. (1999) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-199904001-00009 · Cited by 118 · see citing works
Knowles, S. R., Wilson, J. L., Connell, W. R., & Kamm, M. A. (2011) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21650 · Cited by 113 · see citing works
Depression and Anxiety in Pediatric Inflammatory Bowel Disease and Cystic Fibrosis
Burke, P. M., MEYER, V., Kocoshis, S. A., Orenstein, D. M., Chandra, R., NORD, D. J., Sauer, J., & Cohen, E. E. W. (1989) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-198911000-00022 · Cited by 111 · see citing works
Otley, A. R., Griffiths, A. M., Hale, S., Kugathasan, S., Pfefferkorn, M. D., Mezoff, A. G., Rosh, J. R., Tolia, V. K., Markowitz, J. F., Mack, D. R., et al. (2006) · Inflammatory Bowel Diseases · doi:10.1097/00054725-200608000-00003 · Cited by 104 · see citing works
Self-citationKnowles, S. R., Monshat, K., & Castle, D. J. (2013) · Inflammatory Bowel Diseases · doi:10.1097/mib.0b013e318296ae5a · Cited by 102 · see citing works
Adjustment to inflammatory bowel disease: The relative influence of illness perceptions and coping
Dorrian, A., Dempster, M., & Adair, P. (2008) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20583 · Cited by 100 · see citing works
SZIGETHY, E., WHITTON, S. W., LEVY-WARREN, A., DeMaso, D. R., WEISZ, J., & BEARDSLEE, W. R. (2004) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/01.chi.0000142284.10574.1f · Cited by 92 · see citing works
Self-citationBarbe, R., Bridge, J. A., Birmaher, B. B., Kolko, D. J., & Brent, D. A. (2004) · The Journal of Clinical Psychiatry · doi:10.4088/jcp.v65n0113 · Cited by 88 · see citing works
Weisz, J. R., Thurber, C. A., Sweeney, L., Proffitt, V. D., & LeGagnoux, G. L. (1997) · Journal of Consulting and Clinical Psychology · doi:10.1037//0022-006x.65.4.703 · Cited by 88 · see citing works
Self-citationGray, W. N., Denson, L. A., Baldassano, R. N., & Hommel, K. A. (2011) · Inflammatory Bowel Diseases · doi:10.1002/ibd.21520 · Cited by 86 · see citing works
A Critical Assessment of Items on the Pediatric Crohn's Disease Activity Index
van der Zaag–Loonen, H. J., Griffiths, A. M., Merkus, M. P., & Derkx, H. H. F. (2003) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/00005176-200301000-00017 · Cited by 74 · see citing works
Giannakopoulos, G., Kazantzi, M. S., Dimitrakaki, C., Tsiantis, J., Kolaitis, G. A., & Tountas, Y. (2009) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-009-0005-z · Cited by 71 · see citing works
Depression subtypes in pediatric inflammatory bowel disease
Szigethy, E. M., Youk, A. O., Benhayon, D., Fairclough, D. L., Newara, M. C., Kirshner, M. A., Bujoreanu, S. I., Mrakotsky, C., Bousvaros, A., Srinath, A. I., et al. (2014) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000000262 · Cited by 65 · see citing works
Self-citationMrakotsky, C., Forbes, P. W., Bernstein, J. H., Grand, R. J., Bousvaros, A., Szigethy, E., & Waber, D. P. (2012) · Journal of the International Neuropsychological Society · doi:10.1017/s1355617712001014 · Cited by 53 · see citing works
Self-citationAssessing Secondary Control and its Association with Youth Depression Symptoms
Weisz, J. R., Francis, S. E. B., & Bearman, S. K. (2010) · Research on Child and Adolescent Psychopathology · doi:10.1007/s10802-010-9440-z · Cited by 52 · see citing works
Self-citationEstablishing Specificity in Psychotherapy Scientifically: Design and Evidence Issues
Wampold, B. E. (2005) · Clinical Psychology Science and Practice · doi:10.1093/clipsy.bpi025 · Cited by 50 · see citing works
Ryan, J. L., Mellon, M. W., Junger, K. W., Hente, E. A., Denson, L. A., Saeed, S. A., & Hommel, K. A. (2013) · Inflammatory Bowel Diseases · doi:10.1097/mib.0b013e3182a82b15 · Cited by 41 · see citing works
Appearance concern and depression in adolescent girls with systemic lupus erythematous
Ji, L., Lili, S., Wei, J., He, Y., Min, W., Xiao, J., & Hongmei, S. (2012) · Clinical Rheumatology · doi:10.1007/s10067-012-2071-8 · Cited by 37 · see citing works
Mikocka-Walus, A. A., Gordon, A. L., Stewart, B. J., & Andrews, J. M. (2012) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2011.06.006 · Cited by 34 · see citing works
Cognitive-Behavioral Therapy with Children and Adolescents
Ghuman, H. S., & Sarles, R. M. (2013) · Routledge eBooks · doi:10.4324/9780203777893-28 · Cited by 33 · see citing works
Verhoof, E., Maurice‐Stam, H., Heymans, H. S. A., & Grootenhuis, M. A. (2013) · Child and Adolescent Psychiatry and Mental Health · doi:10.1186/1753-2000-7-12 · Cited by 27 · see citing works
Thompson, R. D., Craig, A. E., Mrakotsky, C., Bousvaros, A., DeMaso, D. R., & Szigethy, E. (2012) · Comprehensive Psychiatry · doi:10.1016/j.comppsych.2012.04.006 · Cited by 26 · see citing works
Self-citationDepressive Symptoms in Inner-City Children With Asthma
Morrison, K. M., Goli, A., Wagoner, J. V., Brown, E. S., & Khan, D. A. (2002) · The Primary Care Companion For CNS Disorders · doi:10.4088/pcc.v04n0501 · Cited by 25 · see citing works
Developmental, emotional and behavioral co-morbidities across the chronic health condition spectrum
Blackman, J. A., & Conaway, M. R. (2013) · Journal of Pediatric Rehabilitation Medicine · doi:10.3233/prm-130240 · Cited by 24 · see citing works
Clinical Challenges and Complications of IBD
Regueiro, M. D., & Swoger, J. M. (2024) · CRC Press eBooks · doi:10.1201/9781003523017 · Cited by 9 · see citing works
Advances in inflammatory bowel diseases in children.
Michail, S. K., Ramsy, M., & Soliman, E. H. (2012) · PubMed · Cited by 8 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Evidence Base Update of Psychosocial Treatments for Child and Adolescent Depression
Weersing, V. R., Jeffreys, M., Do, M.-C. T., Schwartz, K. T. G., & Bolano, C. (2017) · Journal of Clinical Child & Adolescent Psychology · doi:10.1080/15374416.2016.1220310 · Cited by 505 · see citing works
Psychological interventions for parents of children and adolescents with chronic illness
Eccleston, C., Palermo, T. M., Fisher, E., & Law, E. (2012) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd009660.pub2 · Cited by 378 · see citing works
Oud, M., de Winter, L., Vermeulen-Smit, E., Bodden, D., Nauta, M., Stone, L., van den Heuvel, M., Taher, R. A., de Graaf, I., Kendall, T., et al. (2019) · European Psychiatry · doi:10.1016/j.eurpsy.2018.12.008 · Cited by 319 · see citing works
Psychological interventions for parents of children and adolescents with chronic illness
Law, E., Fisher, E., Eccleston, C., & Palermo, T. M. (2019) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd009660.pub4 · Cited by 207 · see citing works
Martín-Subero, M., Anderson, G., Kanchanatawan, B., Berk, M., & Maes, M. H. J. (2015) · CNS Spectrums · doi:10.1017/s1092852915000449 · Cited by 196 · see citing works
Abautret-Daly, Á., Dempsey, E., Parra‐Blanco, A., Medina, C., & Harkin, A. (2017) · Acta Neuropsychiatrica · doi:10.1017/neu.2017.3 · Cited by 185 · see citing works
Psychological Interventions for Irritable Bowel Syndrome and Inflammatory Bowel Diseases
Ballou, S., & Keefer, L. (2017) · Clinical and Translational Gastroenterology · doi:10.1038/ctg.2016.69 · Cited by 167 · see citing works
Psychological comorbidity in gastrointestinal diseases: Update on the brain-gut-microbiome axis
Person, H., & Keefer, L. (2021) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2020.110209 · Cited by 158 · see citing works
Etiology and Treatment of Pain and Psychosocial Issues in Patients With Inflammatory Bowel Diseases
Regueiro, M., Greer, J. B., & Szigethy, E. (2017) · Gastroenterology · doi:10.1053/j.gastro.2016.10.036 · Cited by 142 · see citing works
Self-citationBernstein, C. N., Zhang, L., Lix, L. M., Graff, L. A., Walker, J. R., Fisk, J. D., Patten, S. B., Hitchon, C. A., Bolton, J. M., Sareen, J., et al. (2018) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izy068 · Cited by 120 · see citing works
Brooks, A. J., Smith, P. J., Cohen, R., COLLINS, P. D., Douds, A. C., Forbes, V., Gaya, D. R., Johnston, B. T., McKiernan, P. J., Murray, C. D., et al. (2017) · Gut · doi:10.1136/gutjnl-2016-313000 · Cited by 118 · see citing works
Moore, D. A., Nunns, M., Shaw, L., Rogers, M., Walker, E., Ford, T. J., Garside, R., Ukoumunne, O. C., Titman, P., Shafran, R., et al. (2019) · Health Technology Assessment · doi:10.3310/hta23220 · Cited by 97 · see citing works
Ewais, T., Begun, J., Kenny, M. A., Rickett, K., Hay, K. E., Ajilchi, B., & Kisely, S. R. (2018) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2018.11.010 · Cited by 89 · see citing works
Depression and Anxiety Disorders in Patients With Inflammatory Bowel Disease
Hu, S., Chen, Y., Chen, Y., & Wang, C. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.714057 · Cited by 91 · see citing works
(2017) · Europe PMC (PubMed Central) · Cited by 86 · see citing works
Dietz, L. J., Weinberg, R. J., Brent, D. A., & Mufson, L. (2015) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2014.12.011 · Cited by 74 · see citing works
Levy, R. L., van Tilburg, M. A. L., Langer, S. L., Romano, J. M., Walker, L. S., Mancl, L. A., Murphy, T. B., Claar, R. L., Feld, S. I., Christie, D. L., et al. (2016) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000881 · Cited by 67 · see citing works
Stapersma, L., van den Brink, G., van der Ende, J., Bodelier, A., van Wering, H. V., Hurkmans, P., Mearin, M., Jong, A. E. V. D. M.-D., Escher, J., & Utens, E. M. W. J. (2019) · International Journal of Behavioral Medicine · doi:10.1007/s12529-019-09791-6 · Cited by 38 · see citing works
Gamwell, K. L., Baudino, M. N., Bakula, D. M., Sharkey, C. M., Roberts, C. M., Grunow, J. E., Jacobs, N. J., Gillaspy, S. R., Mullins, L. L., & Chaney, J. M. (2018) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izy011 · Cited by 64 · see citing works
Novel aspects of enteric serotonergic signaling in health and brain-gut disease
Colle, A. D., Israelyan, N., & Margolis, K. G. (2019) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00173.2019 · Cited by 66 · see citing works
van den Brink, G., Stapersma, L., Vlug, L. E., Rizopolous, D., Bodelier, A. G., van Wering, H., Hurkmans, P. C. W. M., Stuyt, R. J. L., Hendriks, D. M., van der Burg, J. A. T., et al. (2018) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.14832 · Cited by 61 · see citing works
Thabrew, H., Stasiak, K., Hetrick, S. E., Donkin, L., Huss, J. H., Highlander, A., Wong, S., & Merry, S. (2018) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012488.pub2 · Cited by 61 · see citing works
Resilience-based integrated IBD care is associated with reductions in health care use and opioids
Keefer, L., Gorbenko, K., Siganporia, T., Manning, L., Tse, S., Biello, A., Ungaro, R., Cohen, L. J., Cohen, B. L., & Dubinsky, M. C. (2022) · Clinical Gastroenterology and Hepatology · doi:10.1016/j.cgh.2021.11.013 · Cited by 49 · see citing works
Abdominal Pain in Inflammatory Bowel Diseases: A Clinical Challenge
Wils, P., Caron, B., D’Amico, F., Danese, S., & Peyrin‐Biroulet, L. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm11154269 · Cited by 48 · see citing works
Stapersma, L., van den Brink, G., van der Ende, J., Szigethy, E. M., Beukers, R., Korpershoek, T. A., Theuns-Valks, S. D. M., Hillegers, M. H. J., Escher, J. C., & Utens, E. M. W. J. (2018) · Journal of Pediatric Psychology · doi:10.1093/jpepsy/jsy029 · Cited by 46 · see citing works
Self-citationNarcotic Bowel Syndrome and Opioid-Induced Constipation
Szigethy, E., Schwartz, M. B., & Drossman, D. A. (2014) · Current Gastroenterology Reports · doi:10.1007/s11894-014-0410-4 · Cited by 45 · see citing works
Self-citationfor the CIHR Team “Defining the burden and managing the effects of psychiatric comorbidity in chronic immunoinflammatory disease”, Fiest, K. M., Bernstein, C. N., Walker, J. R., Graff, L. A., Hitchon, C. A., PESCHKEN, C. A., Zarychanski, R., Abou-Setta, A. M., Patten, S. B., et al. (2016) · BMC Research Notes · doi:10.1186/s13104-016-2204-2 · Cited by 46 · see citing works
Thabrew, H., Stasiak, K., Hetrick, S. E., Wong, S., Huss, J. H., & Merry, S. (2017) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd012488 · Cited by 45 · see citing works
Depression Screening in Pediatric Inflammatory Bowel Disease Clinics
Mackner, L. M., Whitaker, B. N., Maddux, M. H., Thompson, S., Hughes-Reid, C. L., Drovetta, M., & Reed, B. (2019) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000002499 · Cited by 41 · see citing works
Pediatric inflammatory bowel disease and depression: treatment implications
Keethy, D., Mrakotsky, C., & Szigethy, E. (2014) · Current Opinion in Pediatrics · doi:10.1097/mop.0000000000000129 · Cited by 40 · see citing works
Self-citationMaintaining mental health and function for the long run in cystic fibrosis
Smith, B. A., Georgiopoulos, A. M., & Quittner, A. L. (2016) · Pediatric Pulmonology · doi:10.1002/ppul.23522 · Cited by 39 · see citing works
Keerthy, D., Youk, A. O., Srinath, A. I., Malas, N., Bujoreanu, S. I., Bousvaros, A., Keljo, D. J., DeMaso, D. R., & Szigethy, E. (2016) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000001207 · Cited by 36 · see citing works
Self-citationModifiable Environmental Factors in Inflammatory Bowel Disease
Burke, K. E., Boumitri, C., & Ananthakrishnan, A. N. (2017) · Current Gastroenterology Reports · doi:10.1007/s11894-017-0562-0 · Cited by 36 · see citing works
van den Brink, G., Stapersma, L., Marroun, H. E., Henrichs, J., Szigethy, E., Utens, E. M. W. J., & Escher, J. C. (2016) · BMJ Open Gastroenterology · doi:10.1136/bmjgast-2015-000071 · Cited by 34 · see citing works
Self-citationEffect of 2 Psychotherapies on Depression and Disease Activity in Pediatric Crohnʼs Disease
Szigethy, E., Youk, A. O., Gonzalez-Heydrich, J., Bujoreanu, S. I., Weisz, J., Fairclough, D., Ducharme, P., Jones, N., Lotrich, F., Keljo, D., et al. (2015) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000000358 · Cited by 34 · see citing works
Self-citationStapersma, L., van den Brink, G., van der Ende, J., Szigethy, E., Groeneweg, M., de Bruijne, F. H., Hillegers, M. H. J., Escher, J. C., & Utens, E. M. W. J. (2019) · Journal of Clinical Psychology in Medical Settings · doi:10.1007/s10880-019-09649-9 · Cited by 33 · see citing works
Self-citationPrimary outcome reporting in adolescent depression clinical trials needs standardization
Monsour, A., Mew, E. J., Patel, S., Chee-A-Tow, A., Saeed, L., Santos, L., Courtney, D., Watson, P., Monga, S., Szatmári, P., et al. (2020) · BMC Medical Research Methodology · doi:10.1186/s12874-020-01019-6 · Cited by 32 · see citing works
Implementing psychological therapies for gastrointestinal disorders in pediatrics
Reed, B., Buzenski, J., & van Tilburg, M. A. L. (2020) · Expert Review of Gastroenterology & Hepatology · doi:10.1080/17474124.2020.1806055 · Cited by 32 · see citing works
Psychological Treatments for Depression in Adolescents: More Than Three Decades Later
Méndez, X., Sánchez-Hernández, Ó., Garber, J., Espada, J. P., & Orgilés, M. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph18094600 · Cited by 33 · see citing works
Mind–Body Interventions for Pediatric Inflammatory Bowel Disease
Yeh, A. M., Wren, A. A., & Golianu, B. J. (2017) · Children · doi:10.3390/children4040022 · Cited by 30 · see citing works
Hypnotherapy for Inflammatory Bowel Disease Across the Lifespan
Szigethy, E. (2015) · American Journal of Clinical Hypnosis · doi:10.1080/00029157.2015.1040112 · Cited by 31 · see citing works
Self-citationFeingold, J. H., Kaye‐Kauderer, H., Mendiolaza, M., Dubinsky, M. C., Keefer, L., & Gorbenko, K. O. (2021) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2021.110400 · Cited by 28 · see citing works
Systematic Review: Psychosocial Correlates of Pain in Pediatric Inflammatory Bowel Disease
Murphy, L. K., de la Vega, R., Kohut, S. A., Kawamura, J., Levy, R. L., & Palermo, T. M. (2020) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izaa115 · Cited by 27 · see citing works
Luo, H., Sun, Y., Li, Y., Lv, H., Sheng, L., Wang, L., & Qian, J. (2018) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2018.07.013 · Cited by 25 · see citing works
Evidence-Base Update of Psychosocial and Combination Treatments for Child and Adolescent Depression
Weersing, V. R., Goger, P., Schwartz, K. T. G., Baca, S. A., Angulo, F., & Kado-Walton, M. (2024) · Journal of Clinical Child & Adolescent Psychology · doi:10.1080/15374416.2024.2384022 · Cited by 24 · see citing works
Person, H., & Keefer, L. (2019) · Current Gastroenterology Reports · doi:10.1007/s11894-019-0683-8 · Cited by 24 · see citing works
Tran, L., & Mulligan, K. (2019) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izy299 · Cited by 22 · see citing works
van den Brink, G., Stapersma, L., Bom, A. S., Rizopolous, D., van der Woude, C. J., Stuyt, R. J. L., Hendriks, D. M., van der Burg, J. A. T., Beukers, R., Korpershoek, T. A., et al. (2019) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izz073 · Cited by 23 · see citing works
Managing Pain and Psychosocial Care in IBD: a Primer for the Practicing Gastroenterologist
Weaver, E. K., & Szigethy, E. (2020) · Current Gastroenterology Reports · doi:10.1007/s11894-020-0757-7 · Cited by 23 · see citing works
Self-citationVarni, J. W., Shulman, R. J., Self, M. M., Saeed, S. A., Zacur, G. M., Patel, A., Nurko, S., Neigut, D. A., Franciosi, J. P., Saps, M., et al. (2017) · Quality of Life Research · doi:10.1007/s11136-017-1702-6 · Cited by 23 · see citing works
Bullard, B. M., VanderVeen, B. N., McDonald, S. J., Cardaci, T. D., & Murphy, E. A. (2022) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00210.2022 · Cited by 21 · see citing works
Varni, J. W., Shulman, R. J., Self, M. M., Saeed, S. A., Patel, A., Nurko, S., Neigut, D. A., Saps, M., Zacur, G. M., Dark, C. V., et al. (2017) · Inflammatory Bowel Diseases · doi:10.1097/mib.0000000000001077 · Cited by 21 · see citing works
Varni, J. W., Shulman, R. J., Self, M. M., Saeed, S. A., Patel, A., Nurko, S., Neigut, D. A., Saps, M., Franciosi, J. P., Denham, J. M., et al. (2016) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000001428 · Cited by 21 · see citing works
Morey, A., & Loades, M. E. (2021) · Child and Adolescent Mental Health · doi:10.1111/camh.12421 · Cited by 20 · see citing works
Dermatological Manifestations in Pediatric Inflammatory Bowel Disease
Diaconescu, S., Strat, S., Balan, G. G., Anton, C., Ștefănescu, G., Ioniuc, I. K., & Stănescu, A. M. A. (2020) · Medicina · doi:10.3390/medicina56090425 · Cited by 19 · see citing works
Depression in Medically Ill Children and Adolescents
Malas, N., Plioplys, S., & Pao, M. (2019) · Child and Adolescent Psychiatric Clinics of North America · doi:10.1016/j.chc.2019.02.005 · Cited by 18 · see citing works
Reigada, L. C., Polokowski, A. R., Walder, D. J., Szigethy, E. M., Benkov, K. J., Bruzzese, J.-M., & Masia Warner, C. (2015) · Clinical Practice in Pediatric Psychology · doi:10.1037/cpp0000116 · Cited by 17 · see citing works
Self-citationViganò, C. A., Calzolari, R., Marinaccio, P. M., Bezzio, C., Furfaro, F., Ba, G., & Maconi, G. (2015) · Gastroenterology Research and Practice · doi:10.1155/2016/7803262 · Cited by 15 · see citing works
The immune-sleep crosstalk in inflammatory bowel disease
Eissa, N., Mujawar, Q. M., Alabdoulsalam, T., Zohni, S., & El‐Matary, W. (2020) · Sleep Medicine · doi:10.1016/j.sleep.2020.04.020 · Cited by 14 · see citing works
Mental Health Conditions and Unplanned Hospital Readmissions in Children
Doupnik, S. K., Lawlor, J. P., Zima, B. T., Coker, T. R., Bardach, N. S., Rehm, K. P., Gay, J. C., Hall, M., & Berry, J. G. (2018) · Journal of Hospital Medicine · doi:10.12788/jhm.2910 · Cited by 14 · see citing works
The Changing Phenotype of Inflammatory Bowel Disease
Moran, C. P., Sheehan, D., & Shanahan, F. (2016) · Gastroenterology Research and Practice · doi:10.1155/2016/1619053 · Cited by 14 · see citing works
Chronic Illness and Internalizing Symptomatology in a Transdiagnostic Clinical Sample of Youth
Wolock, E. R., Queen, A. H., Rodriguez, G. M., & Weisz, J. R. (2020) · Journal of Pediatric Psychology · doi:10.1093/jpepsy/jsaa028 · Cited by 13 · see citing works
Self-citationMurphy, L. K., Rights, J. D., Ricciuto, A., Church, P. C., & Ahola Kohut, S. (2020) · Frontiers in Pediatrics · doi:10.3389/fped.2020.00559 · Cited by 11 · see citing works
Depression Predicts Prolonged Length of Hospital Stay in Pediatric Inflammatory Bowel Disease
Patel, P. V., Pantell, M. S., Heyman, M. B., & Verstraete, S. G. (2019) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000002426 · Cited by 11 · see citing works
Psychological interventions for treatment of inflammatory bowel disease
Tiles-Sar, N., Neuser, J., de Sordi, D., Baltes, A., Preiß, J., Moser, G., & Timmer, A. (2025) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd006913.pub3 · Cited by 12 · see citing works
Brooks, A. J., Smith, P. J., & Lindsay, J. O. (2017) · Frontline Gastroenterology · doi:10.1136/flgastro-2016-100747 · Cited by 10 · see citing works
Applying new evidence standards to youth cognitive behavioral therapies – A review
Rith‐Najarian, L., Park, A. L., Wang, T. J., Etchison, A. I., Chavira, D. A., & Chorpita, B. F. (2016) · Behaviour Research and Therapy · doi:10.1016/j.brat.2016.12.011 · Cited by 6 · see citing works
Updates in Psychosomatic Medicine: 2014
Freudenreich, O., Huffman, J. C., Sharpe, M., Beach, S. R., Celano, C. M., Chwastiak, L., Cohen, M. A., Dickerman, A., Fitz-Gerald, M. J., Kontos, N. J., et al. (2015) · Psychosomatics · doi:10.1016/j.psym.2015.04.001 · Cited by 5 · see citing works
Sayegh, C. S., Chavannes, M., Moss, I. K., Featherstone, R. E., & Urquiza, I. (2023) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1002/jpn3.12060 · Cited by 4 · see citing works
Cognitive Behavioral Therapy with Youth: Essential Foundations and Elementary Practices
Friedberg, R. D., & Paternostro, J. (2019) · Autism and child psychopathology series · doi:10.1007/978-3-030-21683-2_7 · Cited by 4 · see citing works
Management of Pediatric Crohn’s Disease: an ECCO-ESPGHAN Guideline Update
Shouval, D. S., Hojsak, I., Miele, E., Sokollik, C., Turner, D., Kolho, K., Boneh, R. S., van Rheenen, P. F., Wine, E., Russell, R. K., et al. (2026) · Journal of Crohn s and Colitis · doi:10.1093/ecco-jcc/jjag084 · Cited by 3 · see citing works
Bjornstad, G. J., Sonthalia, S., Rouse, B., Freeman, L., Hessami, N., Dunne, J. H., & Axford, N. (2024) · Campbell Systematic Reviews · doi:10.1002/cl2.1376 · Cited by 3 · see citing works
Preventing internalising problems in preschoolers with chronic physical health conditions
Brown, A. M., Noone, K., Rapee, R. M., Kangas, M., Anderson, V. A., & Bayer, J. K. (2021) · Journal of Child Health Care · doi:10.1177/13674935211013192 · Cited by 3 · see citing works
Rea, K. E., Robbertz, A. S., Westbrook, A. L., Buzenski, J., & Reed, B. (2025) · Inflammatory Bowel Diseases · doi:10.1093/ibd/izaf061 · Cited by 2 · see citing works
Screening for Psychosocial and Family Risk in Pediatric Gastrointestinal Disorders
Cunningham, C., Cho, E., Shaffer, M. L., Bradford, M. C., & Palermo, T. M. (2016) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0000000000001426 · Cited by 2 · see citing works
Common psychological issues and management in patients with inflammatory bowel disease
Li, M., & Fan, Y. (2022) · World Chinese Journal of Digestology · doi:10.11569/wcjd.v30.i8.370 · Cited by 2 · see citing works
Martin, A., Joshi, P. T., Hulvershorn, L. A., Kim, Y. S., & Stringaris, A. K. (2015) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2015.09.011 · Cited by 1 · see citing works
Inflammatory Depressive Bowel Diseases: The New Era
Shemesh, E., & Gabbay, V. (2014) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2014.03.010
Enteral Nutrition in the Treatment of Inflammatory Bowel Disease
Bousvaros, A. (2014) · Springer eBooks · doi:10.1007/978-3-319-26890-3_6
Self-citationEditorial: anxiety and depression in inflammatory bowel disease – authors’ reply
Stapersma, L., van den Brink, G., Szigethy, E., Escher, J. C., & Utens, E. M. W. J. (2018) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.14928
Self-citationInflammatory bowel disease and cognitive behavioral therapy (CBT) in the young
Stapersma, L., Escher, J. C., & Utens, E. M. W. J. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-85757-4.00015-8
Inflammatory Bowel Disease: Interlinking Psychological Resilience and Anxiety
Chester, M. A., & Keefer, L. (2024) · Springer eBooks · doi:10.1007/978-3-031-32046-0_25-1
Inflammatory Bowel Disease: Interlinking Psychological Resilience and Anxiety
Chester, M. A., & Keefer, L. (2025) · Springer eBooks · doi:10.1007/978-3-031-73363-5_25
Lv, H., Steen, M., Porter, P., Zhou, H., & Huang, H. (2025) · Critical Public Health · doi:10.1080/09581596.2025.2545039
Yang, Y., Wang, Y., Zhang, S., Chen, G., Ji, S., Wang, X., & Li, S. (2026) · Frontiers in Medicine · doi:10.3389/fmed.2026.1868648
Does Stress Play a Role in My Disease? The Role of Stress and Psychiatric Issues in IBD
Szigethy, E. (2015) · Springer eBooks · doi:10.1007/978-3-319-14072-8_30
Self-citation
- Authors
- Szigethy, E., Bujoreanu, S. I., Youk, A. O., Weisz, J., Benhayon, D., Fairclough, D., Ducharme, P., Gonzalez-Heydrich, J., Keljo, D., Srinath, A., Bousvaros, A., Kirshner, M., Newara, M., Kupfer, D., & DeMaso, D. R.
- Affiliations
- University of Pittsburgh (US)
- Boston Children's Hospital (US)
- Harvard University (US)
- Colorado School of Public Health (US)
- Corresponding author
- Szigethy, Eva
- ORCID
- Venue
- Journal of the American Academy of Child & Adolescent Psychiatry
- Publisher
- Elsevier BV
- Published
- 2014-07
- Volume
- 53
- Issue
- 7
- Pages
- 726-735
- ISSN
- 0890-8567 (ISSN-L)
- PMC
- PMC4104185
- OpenAlex
- W2058706903
- Cited by
- 86
- References
- 51
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 3 · 2023: 2 · 2022: 3 · 2021: 5 · 2020: 10 · 2019: 12 · 2018: 10 · 2017: 10 · 2016: 11 · 2015: 8 · 2014: 5 · 2012: 1
- FWCI
- 13.37
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of the American Academy of Child & Adolescent Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Crohn's and Colitis Foundation of America
- Abbott Laboratories
- Pfizer
- AstraZeneca
- GlaxoSmithKline
- Biogen
- Tommy Fuss Fund
- Harvard University
- University of Pittsburgh
- Crohn's and Colitis Foundation
- Servier
- National Institutes of Health (UL1TR000005)
- National Institute of Mental Health (R01MH077770, MH077770)
- National Center for Advancing Translational Sciences
- Topics
- Social Sciences › Psychology › Clinical Psychology › Psychotherapy Techniques and Applications
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Keywords
- pediatric inflammatory bowel disease, depression, cognitive behavioral therapy, Crohn's disease, ulcerative colitis, comorbid depression, IBD activity, health-related quality of life, depression severity, depression remission
- MeSH terms
- Adolescent, Child, Depression, Female, Humans, Male, Psychotherapy, Inflammatory Bowel Diseases, Cognitive Behavioral Therapy, Treatment Outcome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
