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Cited by 222Neuroscience and Neuropharmacology ResearchNeural dynamics and brain functionMemory and Neural Mechanisms

Long-term plasticity at inhibitory synapses

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Castillo, Pablo E, Chiu, Chiayu Q, Carroll, Reed C·2011·Current Opinion in Neurobiology
DOI 10.1016/j.conb.2011.01.006PMC PMC3092861
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Abstract

Experience-dependent modifications of neural circuits and function are believed to heavily depend on changes in synaptic efficacy such as LTP/LTD. Hence, much effort has been devoted to elucidating the mechanisms underlying these forms of synaptic plasticity. Although most of this work has focused on excitatory synapses, it is now clear that diverse mechanisms of long-term inhibitory plasticity have evolved to provide additional flexibility to neural circuits. By changing the excitatory/inhibitory balance, GABAergic plasticity can regulate excitability, neural circuit function and ultimately, contribute to learning and memory, and neural circuit refinement. Here we discuss recent advancements in our understanding of the mechanisms and functional relevance of GABAergic inhibitory synaptic plasticity.

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Authors
Castillo, P. E., Chiu, C. Q., & Carroll, R. C.
Affiliations
Albert Einstein College of Medicine (US)
Corresponding author
Castillo, Pablo E
ORCID
Venue
Current Opinion in Neurobiology
Publisher
Elsevier BV
Published
2011-04
Volume
21
Issue
2
Pages
328-338
ISSN
0959-4388 (ISSN-L)
DOI
10.1016/j.conb.2011.01.006
PMC
PMC3092861
OpenAlex
W1972638494
Cited by
222
References
9
Citations by year
2026: 5 · 2025: 8 · 2024: 6 · 2023: 13 · 2022: 14 · 2021: 10 · 2020: 27 · 2019: 11 · 2018: 17 · 2017: 11 · 2016: 18 · 2015: 14 · 2014: 19 · 2013: 29 · 2012: 12
FWCI
2.07
Type
journal article
Language
en
Open access
Licence
Locations
  • Current Opinion in Neurobiology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute on Drug Abuse (R01DA017392)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords
inhibitory plasticity, long-term plasticity, GABAergic synapses, long-term potentiation, long-term depression, excitation-inhibition balance, neural circuit refinement, learning and memory, neuronal excitability
MeSH terms
Animals, Humans, Neuronal Plasticity, Synapses

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