Iron deficiency on neuronal function

Muñoz, Pablo; Humeres, Alexis

doi:10.1007/s10534-012-9550-x

Cited by 92Iron Metabolism and DisordersNeurological diseases and metabolismTrace Elements in Health

Iron deficiency on neuronal function

Open access

Muñoz, Pablo, Humeres, Alexis·2012·BioMetals

DOI 10.1007/s10534-012-9550-x

Open this paper in CoChat — free account

Abstract

Because of the intrinsic ability of iron to catalyze the formation of reactive oxygen species, it has been associated with oxidative stress and neurodegenerative diseases. However, iron deficiency (ID) also negatively impacts various functions of the brain, suggesting that iron plays an important physiological role in neuronal processes such as myelination, synaptogenesis, behavior and synaptic plasticity (SP). ID not only produces changes in the hippocampus, striatum, amygdale or prefrontal cortex, it also affects the interaction among these systems. In both humans and rodents, the perturbations of these structures are associated to cognitive deficits. These cognitive alterations have been well correlated with changes in neural plasticity, the possible cellular substrate of memory and learning. Given that SP is strongly affected by early ID and the lasting-neurological consequences remain even after ID has been corrected, it is important to prevent ID as well as to seek effective therapeutic interventions that reduce or reverse the long-term effects of the ID in the nervous system. This review will give an overview of the literature on the effects of iron deficit in neuronal functions such as behavior, neurotransmission and SP. We also discuss our recent data about the possible oxidative effect of iron on the mechanisms involved in neural plasticity.

Integrity signals

Registry

Crossref · 10.1007/s10534-012-9550-x

Cites

76 of 76 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Iron deficiency induces alterations in the electrophysiological properties of neural circuitry and neurotransmitter systems in preclinical studies.
“Iron is thought to be important for synaptic function as iron deficiency has been shown in a large set of preclinical studies to induce alterations in the electrophysiological properties of neural circuitry and neurotransmitter systems [88].”
From Vitamins and Minerals for Energy, Fatigue and Cognition: A Narrative Review of the Biochemical and Clinical Evidence (2020) · cites this paper as [88]

Arzneimittelforschung
Miletzki, B., & Gleiter, C. H. (2005) · Bundesgesundheitsblatt - Gesundheitsforschung - Gesundheitsschutz · doi:10.1007/s00103-005-1024-7 · Cited by 9,401 · see citing works
The hippocampal-VTA loop: controlling the entry of information into long-term memory
Lisman, J. E., & Grace, A. A. (2005) · Neuron · doi:10.1016/j.neuron.2005.05.002 · Cited by 1,983 · see citing works
Learning induces long-term potentiation in the hippocampus
Whitlock, J. R., Heynen, A. J., Shuler, M. G., & Bear, M. F. (2006) · Science · doi:10.1126/science.1128134 · Cited by 1,913 · see citing works
The Haber–Weiss reaction and mechanisms of toxicity
Kehrer, J. P. (2000) · Toxicology · doi:10.1016/s0300-483x(00)00231-6 · Cited by 1,418 · see citing works
Prefrontal executive and cognitive functions in rodents: neural and neurochemical substrates
Dalley, J. W., Cardinal, R. N., & Robbins, T. W. (2004) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2004.09.006 · Cited by 1,329 · see citing works
A review of studies on the effect of iron deficiency on cognitive development in children
Grantham-McGregor, S., & Ani, C. (2001) · The Journal of Nutrition · doi:10.1093/jn/131.2.649s · Cited by 1,293 · see citing works
Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons
Feng, J., Zhou, Y., Campbell, S. L., Le, T., Li, E., Sweatt, J. D., Silva, A. J., & Fan, G. (2010) · Nature Neuroscience · doi:10.1038/nn.2514 · Cited by 1,019 · see citing works
Long-lasting neural and behavioral effects of iron deficiency in infancy
Lozoff, B., Beard, J., Connor, J., Felt, B., Georgieff, M., & Schallert, T. (2006) · Nutrition Reviews · doi:10.1301/nr.2006.may.s34-s43 · Cited by 975 · see citing works
Poorer Behavioral and Developmental Outcome More Than 10 Years After Treatment for Iron Deficiency in Infancy
Lozoff, B., Jiménez, E., Hagen, J. W., Mollen, E., & Wolf, A. W. (2000) · PEDIATRICS · doi:10.1542/peds.105.4.e51 · Cited by 894 · see citing works
Competition among multiple memory systems: converging evidence from animal and human brain studies
Poldrack, R. A., & Packard, M. G. (2003) · Neuropsychologia · doi:10.1016/s0028-3932(02)00157-4 · Cited by 880 · see citing works
Iron Deficiency and Brain Development
Lozoff, B., & Georgieff, M. (2006) · Seminars in Pediatric Neurology · doi:10.1016/j.spen.2006.08.004 · Cited by 711 · see citing works
I <scp>RON</scp> S <scp>TATUS AND</scp> N <scp>EURAL</scp> F <scp>UNCTIONING</scp>
Beard, J. L., & Connor, J. R. (2003) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.23.020102.075739 · Cited by 669 · see citing works
Reactive Oxygen Species in the Regulation of Synaptic Plasticity and Memory
Massaad, C. A., & Klann, E. (2011) · Antioxidants & Redox Signaling · doi:10.1089/ars.2010.3208 · Cited by 635 · see citing works
Oligodendrocytes and myelination: The role of iron
Todorich, B., Pasquini, J. M., Garcia, C. I., Paez, P. M., & Connor, J. R. (2008) · Glia · doi:10.1002/glia.20784 · Cited by 615 · see citing works
Dopaminergic modulation of limbic and cortical drive of nucleus accumbens in goal-directed behavior
Goto, Y., & Grace, A. A. (2005) · Nature Neuroscience · doi:10.1038/nn1471 · Cited by 576 · see citing works
Iron Deficiency and Child Development
Lozoff, B. (2007) · Food and Nutrition Bulletin · doi:10.1177/15648265070284s409 · Cited by 450 · see citing works
Divalent metal transporter 1 (DMT1) contributes to neurodegeneration in animal models of Parkinson's disease
Salazar, J., Mena, N., Hunot, S., Prigent, A., Alvarez-Fischer, D., Arredondo, M., Duyckaerts, C., Sazdovitch, V., Zhao, L., Garrick, L. M., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804373105 · Cited by 409 · see citing works
Increased Iron and Free Radical Generation in Preclinical Alzheimer Disease and Mild Cognitive Impairment
Smith, M. A., Zhu, X., Tabaton, M., Liu, G., McKeel, D. W., Cohen, M. L., Wang, X., Siedlak, S. L., Dwyer, B. E., Hayashi, T., et al. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-1239 · Cited by 400 · see citing works
Anatomical Substrates for Glutamate‐Dopamine Interactions
Sesack, S., Carr, D. B., Omelchenko, N., & Pinto, A. (2003) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1300.066 · Cited by 348 · see citing works
In vivo NMR studies of the glutamate neurotransmitter flux and neuroenergetics: implications for brain function
Rothman, D. L., Behar, K. L., Hyder, F., & Shulman, R. G. (2003) · Annual Review of Physiology · doi:10.1146/annurev.physiol.65.092101.142131 · Cited by 337 · see citing works
Iron deficiency decreases dopamine D1 and D2 receptors in rat brain
Erikson, K. M., Jones, B. C., Hess, E. J., Zhang, Q., & Beard, J. L. (2001) · Pharmacology Biochemistry and Behavior · doi:10.1016/s0091-3057(01)00563-9 · Cited by 334 · see citing works
Why Iron Deficiency Is Important in Infant Development
Beard, J. L. (2008) · The Journal of Nutrition · doi:10.1093/jn/138.12.2534 · Cited by 316 · see citing works
Effects of iron supplementation and anthelmintic treatment on motor and language development of preschool children in Zanzibar: double blind, placebo controlled study
Stoltzfus, R. J., Kvalsvig, J. D., Chwaya, H. M., Montresor, A., Albonico, M., Tielsch, J. M., Savioli, L., & Pollitt, E. (2001) · BMJ · doi:10.1136/bmj.323.7326.1389 · Cited by 307 · see citing works
Long-term brain and behavioral consequences of early iron deficiency
Georgieff, M. (2011) · Nutrition Reviews · doi:10.1111/j.1753-4887.2011.00432.x · Cited by 303 · see citing works
Iron deficiency in infancy and neurocognitive functioning at 19 years: evidence of long-term deficits in executive function and recognition memory
Lukowski, A. F., Koss, M., Burden, M. J., Jonides, J. J., Nelson, C. A., Kaciroti, N., Jiménez, E., & Lozoff, B. (2010) · Nutritional Neuroscience · doi:10.1179/147683010x12611460763689 · Cited by 303 · see citing works
NMDA Receptor-Nitric Oxide Transmission Mediates Neuronal Iron Homeostasis via the GTPase Dexras1
Cheah, J. H., Kim, S. F., Hester, L. D., Clancy, K. W., Patterson, S. E., Papadopoulos, V., & Snyder, S. H. (2006) · Neuron · doi:10.1016/j.neuron.2006.07.011 · Cited by 285 · see citing works
Iron Deficiency Alters Dopamine Transporter Functioning in Rat Striatum
Erikson, K. M., Jones, B. C., & Beard, J. L. (2000) · Journal of Nutrition · doi:10.1093/jn/130.11.2831 · Cited by 273 · see citing works
Iron deficiency alters auditory recognition memory in newborn infants of diabetic mothers
Siddappa, A. M., Georgieff, M. K., Wewerka, S., Worwa, C., Nelson, C. A., & Deregnier, R.-A. (2004) · Pediatric Research · doi:10.1203/01.pdr.0000127021.38207.62 · Cited by 269 · see citing works
Iron in fetal and neonatal nutrition
Rao, R., & Georgieff, M. (2006) · Seminars in Fetal and Neonatal Medicine · doi:10.1016/j.siny.2006.10.007 · Cited by 269 · see citing works
Postnatal ontogenesis of hippocampal CA1 area in rats. I. Development of dendritic arborisation in pyramidal neurons
Pokorny, J., & Yamamoto, T. (1981) · Brain Research Bulletin · doi:10.1016/0361-9230(81)90075-7 · Cited by 265 · see citing works
Sources and Targets of Reactive Oxygen Species in Synaptic Plasticity and Memory
Kishida, K. T., & Klann, E. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.9.233 · Cited by 264 · see citing works
Early Iron Deficiency Has Brain and Behavior Effects Consistent with Dopaminergic Dysfunction1–3
Lozoff, B. (2011) · Journal of Nutrition · doi:10.3945/jn.110.131169 · Cited by 260 · see citing works
Identification of Cysteines Involved in S-Nitrosylation, S-Glutathionylation, and Oxidation to Disulfides in Ryanodine Receptor Type 1
Aracena-Parks, P., Goonasekera, S. A., Gilman, C. P., Dirksen, R. T., Hidalgo, C., & Hamilton, S. L. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m600876200 · Cited by 254 · see citing works
Sources and Targets of Reactive Oxygen Species in Synaptic Plasticity and Memory
Kishida, K. T., & Klann, E. (2006) · Antioxidants and Redox Signaling · doi:10.1089/ars.2007.9.ft-8 · Cited by 245 · see citing works
stathmin, a Gene Enriched in the Amygdala, Controls Both Learned and Innate Fear
Shumyatsky, G. P., Malleret, G., Shin, R.-M., Takizawa, S., Tully, K., Tsvetkov, E., Zakharenko, S. S., Joseph, J., Vronskaya, S., Yin, D., et al. (2005) · Cell · doi:10.1016/j.cell.2005.08.038 · Cited by 235 · see citing works
Persistent neurochemical and behavioral abnormalities in adulthood despite early iron supplementation for perinatal iron deficiency anemia in rats
FELT, B., BEARD, J., SCHALLERT, T., SHAO, J., ALDRIDGE, J., CONNOR, J., GEORGIEFF, M., & LOZOFF, B. (2006) · Behavioural Brain Research · doi:10.1016/j.bbr.2006.04.001 · Cited by 224 · see citing works
Long-term plasticity at inhibitory synapses
Castillo, P. E., Chiu, C. Q., & Carroll, R. C. (2011) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2011.01.006 · Cited by 222 · see citing works
Perinatal iron deficiency alters apical dendritic growth in hippocampal CA1 pyramidal neurons
Jorgenson, L. A., Wobken, J. D., & Georgieff, M. K. (2003) · Developmental Neuroscience · doi:10.1159/000075667 · Cited by 209 · see citing works
β-Adrenergic Receptor Activation Facilitates Induction of a Protein Synthesis-Dependent Late Phase of Long-Term Potentiation
Gelinas, J. N., & Nguyen, P. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.4175-04.2005 · Cited by 205 · see citing works
Neuralized1 Activates CPEB3: A Function for Nonproteolytic Ubiquitin in Synaptic Plasticity and Memory Storage
Pavlopoulos, E., Trifilieff, P., Chevaleyre, V., Fioriti, L., Zairis, S., Pagano, A., Malleret, G., & Kandel, E. R. (2011) · Cell · doi:10.1016/j.cell.2011.09.056 · Cited by 189 · see citing works
Iron Is Essential for Neuron Development and Memory Function in Mouse Hippocampus
Carlson, E. S., Tkáč, I., Magid, R., O’Connor, M. B., Andrews, N. C., Schallert, T. J., Gunshin, H., Georgieff, M., & Petryk, A. (2009) · Journal of Nutrition · doi:10.3945/jn.108.096354 · Cited by 185 · see citing works
Recent Evidence from Human and Animal Studies Regarding Iron Status and Infant Development
Beard, J. (2007) · Journal of Nutrition · doi:10.1093/jn/137.2.524s · Cited by 164 · see citing works
Fetal iron deficiency disrupts the maturation of synaptic function and efficacy in area CA1 of the developing rat hippocampus
Jorgenson, L. A., Sun, M., O'Connor, M., & Georgieff, M. K. (2005) · Hippocampus · doi:10.1002/hipo.20128 · Cited by 162 · see citing works
Ryanodine Receptors Contribute to cGMP-Induced Late-Phase LTP and CREB Phosphorylation in the Hippocampus
Lü, Y.-F., & Hawkins, R. D. (2002) · Journal of Neurophysiology · doi:10.1152/jn.2002.88.3.1270 · Cited by 153 · see citing works
Iron deficiency: Differential effects on monoamine transporters
Burhans, M. S., Dailey, C., Beard, Z., Wiesinger, J. A., Murray‐Kolb, L. E., Jones, B. C., & Beard, J. L. (2005) · Nutritional Neuroscience · doi:10.1080/10284150500047070 · Cited by 143 · see citing works
Iron Deficiency in Young Children in Low-Income Countries and New Approaches for Its Prevention
Lutter, C. K. (2008) · Journal of Nutrition · doi:10.3945/jn.108.095406 · Cited by 132 · see citing works
Iron Mediates N-Methyl-d-aspartate Receptor-dependent Stimulation of Calcium-induced Pathways and Hippocampal Synaptic Plasticity
Muñoz, P., Humeres, A., Elgueta, C., Kirkwood, A., Hidalgo, C., & Núñez, M. T. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.213785 · Cited by 128 · see citing works
Hippocampal long-term potentiation, memory, and longevity in mice that overexpress mitochondrial superoxide dismutase
Hu, D., Cao, P., Thiels, E., Chu, C. T., Wu, G., Oury, T. D., & Klann, E. (2006) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2006.10.003 · Cited by 127 · see citing works
Gestational and Neonatal Iron Deficiency Alters Apical Dendrite Structure of CA1 Pyramidal Neurons in Adult Rat Hippocampus
Brunette, K. E., Tran, P. V., Wobken, J. D., Carlson, E. S., & Georgieff, M. (2010) · Developmental Neuroscience · doi:10.1159/000314341 · Cited by 122 · see citing works
Potential Adaptive Function for Altered Long-Term Potentiation Mechanisms in Aging Hippocampus
Boric, K., Muñoz, P., Gallagher, M., & Kirkwood, A. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.2036-08.2008 · Cited by 115 · see citing works
Gestational and Lactational Iron Deficiency Alters the Developing Striatal Metabolome and Associated Behaviors in Young Rats1
Ward, K. L., Tkáč, I., Jing, Y., Felt, B. T., Beard, J., Connor, J. R., Schallert, T. J., Georgieff, M., & Rao, R. (2007) · Journal of Nutrition · doi:10.1093/jn/137.4.1043 · Cited by 115 · see citing works
Selective localization of polyribosomes beneath developing synapses: A quantitative analysis of the relationships between polyribosomes and developing synapses in the hippocampus and dentate gyrus
Steward, O., & Falk, P. M. (1991) · The Journal of Comparative Neurology · doi:10.1002/cne.903140311 · Cited by 114 · see citing works
Ferritin and iron levels in children with autistic disorder
Hergüner, S., Keleşoğlu, F. M., Tanıdır, C., & Çöpür, M. (2012) · European Journal of Pediatrics · doi:10.1007/s00431-011-1506-6 · Cited by 112 · see citing works
Early-Life Iron Deficiency Anemia Alters Neurotrophic Factor Expression and Hippocampal Neuron Differentiation in Male Rats2
Tran, P. V., Carlson, E. S., Fretham, S. J. B., & Georgieff, M. (2008) · Journal of Nutrition · doi:10.3945/jn.108.091553 · Cited by 101 · see citing works
Comparative study of the formation of oxidative damage marker 8-hydroxy-2′-deoxyguanosine (8-OHdG) adduct from the nucleoside 2′-deoxyguanosine by transition metals and suspensions of particulate matter in relation to metal content and redox reactivity
Valavanidis, A., Vlahoyianni, T., & Fiotakis, K. (2005) · Free Radical Research · doi:10.1080/10715760500188671 · Cited by 93 · see citing works
Calcium release by ryanodine receptors mediates hydrogen peroxide-induced activation of ERK and CREB phosphorylation in N2a cells and hippocampal neurons
Kemmerling, U., Muñoz, P., Müller, M., Sánchez, G., Aylwin, M. L., Klann, E., Carrasco, M. A., & Hidalgo, C. (2006) · Cell Calcium · doi:10.1016/j.ceca.2006.10.001 · Cited by 86 · see citing works
Dissociating the long-term effects of fetal/neonatal iron deficiency on three types of learning in the rat.
Schmidt, A., Waldow, K. J., Grove, W. M., Salinas, J. A., & Georgieff, M. (2007) · Behavioral Neuroscience · doi:10.1037/0735-7044.121.3.475 · Cited by 80 · see citing works
Perinatal nutritional iron deficiency permanently impairs hippocampus-dependent trace fear conditioning in rats
McEchron, M. D., Cheng, A. Y. T., Liu, H., Connor, J. R., & Gilmartin, M. R. (2005) · Nutritional Neuroscience · doi:10.1080/10284150500162952 · Cited by 78 · see citing works
Iron Deficiency: Beyond Anemia
Yadav, D. K., & Chandra, J. (2010) · The Indian Journal of Pediatrics · doi:10.1007/s12098-010-0129-7 · Cited by 76 · see citing works
Fetal and neonatal iron deficiency causes volume loss and alters the neurochemical profile of the adult rat hippocampus
Rao, R., Tkáč, I., Schmidt, A. T., & Georgieff, M. (2011) · Nutritional Neuroscience · doi:10.1179/1476830511y.0000000001 · Cited by 74 · see citing works
In vivo effect of chronic hypoxia on the neurochemical profile of the developing rat hippocampus
Raman, L., Tkáč, I., Ennis, K., Georgieff, M., Rolf Gruetter, A., & Rao, R. (2005) · Developmental Brain Research · doi:10.1016/j.devbrainres.2005.02.013 · Cited by 73 · see citing works
Effects of iron deficiency on neonatal behavior at different stages of pregnancy
Hernández‐Martínez, C., Canals, J., Aranda, N., Ribot, B., Escribano, J., & Arija, V. (2011) · Early Human Development · doi:10.1016/j.earlhumdev.2010.12.006 · Cited by 66 · see citing works
Effect of iron on the activation of the MAPK/ERK pathway in PC12 neuroblastoma cells
Muñoz, P., Zavala, G., Castillo, K., Aguirre, P., Hidalgo, C., & Núñez, M. T. (2006) · Biological Research · doi:10.4067/s0716-97602006000100021 · Cited by 66 · see citing works
Impaired cognition, sensorimotor gating, and hippocampal long-term depression in mice lacking the prostaglandin E2 EP2 receptor
Savonenko, A. V., Muñoz, P., Melnikova, T., Wang, Q., Liang, X., BREYER, R. M., Montine, T. J., Kirkwood, A., & Andreasson, K. I. (2009) · Experimental Neurology · doi:10.1016/j.expneurol.2009.01.016 · Cited by 65 · see citing works
Myoglobin and cytochrome response during repair of iron deficiency in the rat.
Dallman, P. R., & Schwartz, H. C. (1965) · Journal of Clinical Investigation · doi:10.1172/jci105269 · Cited by 64 · see citing works
Hippocampus specific iron deficiency alters competition and cooperation between developing memory systems
Carlson, E. S., Fretham, S. J. B., Unger, E. L., O’Connor, M. B., Petryk, A., Schallert, T. J., Rao, R., Tkáč, I., & Georgieff, M. (2010) · Journal of Neurodevelopmental Disorders · doi:10.1007/s11689-010-9049-0 · Cited by 50 · see citing works
Developmental and Neurophysiologic Deficits in Iron Deficiency in Children
Madan, N., Rusia, U., Sikka, M., Sharma, S., & Shankar, N. (2010) · The Indian Journal of Pediatrics · doi:10.1007/s12098-010-0192-0 · Cited by 48 · see citing works
Developmental regulation of the late phase of long-term potentiation (L-LTP) and metaplasticity in hippocampal area CA1 of the rat
Cao, G., & Harris, K. M. (2011) · Journal of Neurophysiology · doi:10.1152/jn.00780.2011 · Cited by 47 · see citing works
Effect of Latent Iron Deficiency on 5‐Hydroxytryptamine Metabolism in Rat Brain
Shukla, A., Agarwal, K. N., Chansuria, J. P. N., & Taneja, V. (1989) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1989.tb02515.x · Cited by 46 · see citing works
Effects of Iron Deficiency Anemia on Cognitive Function in Children
Ağaoğlu, L., Torun, O., Ünüvar, E., Sefil, Y., & Demir, D. (2011) · Arzneimittelforschung · doi:10.1055/s-0031-1296691 · Cited by 45 · see citing works
Increased Hippocampal Expression of the Divalent Metal Transporter 1 (DMT1) mRNA Variants 1B and +IRE and DMT1 Protein After NMDA-Receptor Stimulation or Spatial Memory Training
Haeger, P. A., Álvarez, Á., Leal, N. R., Adasme, T., Núñez, M. T., & Hidalgo, C. (2009) · Neurotoxicity Research · doi:10.1007/s12640-009-9096-z · Cited by 30 · see citing works
Effects of gestational iron deficiency on fear conditioning in juvenile and adult rats
Gewirtz, J. C., Hamilton, K. L., Babu, M. A., Wobken, J. D., & Georgieff, M. (2008) · Brain Research · doi:10.1016/j.brainres.2008.08.079 · Cited by 28 · see citing works
Cellular iron concentrations directly affect the expression levels of norepinephrine transporter in PC12 cells and rat brain tissue
Beard, J. L., Wiesinger, J. A., & Jones, B. C. (2006) · Brain Research · doi:10.1016/j.brainres.2006.03.071 · Cited by 22 · see citing works
Perinatal Nutritional Iron Deficiency Impairs Hippocampus-Dependent Trace Eyeblink Conditioning in Rats
McEchron, M. D., Alexander, D. N., Gilmartin, M. R., & Paronish, M. D. (2007) · Developmental Neuroscience · doi:10.1159/000110502 · Cited by 19 · see citing works
Early Iron Deficiency Enhances Stimulus-response Learning of Adult Rats in the Context of Competing Spatial Information
Schmidt, A. T., Álvarez, G., Grove, W. M., Rao, R. B., & Georgieff, M. K. (2011) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2011.07.014 · Cited by 16 · see citing works
Perinatal Nutritional Iron Deficiency Impairs Noradrenergic-Mediated Synaptic Efficacy in the CA1 Area of Rat Hippocampus ,
McEchron, M. D., Goletiani, C. J., & Alexander, D. N. (2010) · Journal of Nutrition · doi:10.3945/jn.109.114702 · Cited by 15 · see citing works

Flagged first, then by citations

1 of the 77 references couldn’t be matched to a known paper.

Sorted by citations

Oxidative Stress and the Pathogenesis of Alzheimer's Disease
Zhao, Y., & Zhao, B. (2013) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2013/316523 · Cited by 855 · see citing works
Vitamins and Minerals for Energy, Fatigue and Cognition: A Narrative Review of the Biochemical and Clinical Evidence
Tardy, A.-L., Pouteau, E., Marquez, D., Yilmaz, C., & Scholey, A. (2020) · Nutrients · doi:10.3390/nu12010228 · Cited by 541 · see citing works
Physiology of Iron Metabolism
Waldvogel‐Abramowski, S., Waeber, G., Gassner, C., Buser, A. S., Frey, B. M., Favrat, B., & Tissot, J. (2014) · Transfusion Medicine and Hemotherapy · doi:10.1159/000362888 · Cited by 263 · see citing works
Molecular Mechanisms and Genetics of Oxidative Stress in Alzheimer’s Disease
Cioffi, F., Adam, R. H. I., & Broersen, K. (2019) · Journal of Alzheimer s Disease · doi:10.3233/jad-190863 · Cited by 204 · see citing works
The Effects of Nutritional Interventions on the Cognitive Development of Preschool-Age Children: A Systematic Review
Roberts, M., Tolar-Peterson, T., Reynolds, A., Wall, C., Reeder, N., & Méndez, G. R. (2022) · Nutrients · doi:10.3390/nu14030532 · Cited by 243 · see citing works
An overview of liposomal nano-encapsulation techniques and its applications in food and nutraceutical
Subramani, T., & Ganapathyswamy, H. (2020) · Journal of Food Science and Technology · doi:10.1007/s13197-020-04360-2 · Cited by 187 · see citing works
Ferrous iron formation following the co-aggregation of ferric iron and the Alzheimer's disease peptide β-amyloid (1–42)
Everett, J. L., Céspedes, E., Shelford, L. R., Exley, C., Collingwood, J. F., Dobson, J., van der Laan, G., Jenkins, C., Arenholz, E., & Telling, N. D. (2014) · Journal of The Royal Society Interface · doi:10.1098/rsif.2014.0165 · Cited by 152 · see citing works
Oxidative Stress in Age-Related Neurodegenerative Diseases: An Overview of Recent Tools and Findings
Korovesis, D., Rubio‐Tomás, T., & Tavernarakis, N. (2023) · Antioxidants · doi:10.3390/antiox12010131 · Cited by 132 · see citing works
Increased Iron Deposition on Brain Quantitative Susceptibility Mapping Correlates with Decreased Cognitive Function in Alzheimer’s Disease
Du, L., Zhao, Z., Cui, A., Zhu, Y., Zhang, L., Liu, J., Shi, S., Fu, C., Han, X., Gao, W., et al. (2018) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.8b00194 · Cited by 129 · see citing works
Nanoscale synchrotron X-ray speciation of iron and calcium compounds in amyloid plaque cores from Alzheimer's disease subjects
Everett, J. L., Collingwood, J. F., Tjhin, V. T., Brooks, J., Lermyte, F., Plascencia‐Villa, G., Hands-Portman, I., Dobson, J., Perry, G. L., & Telling, N. D. (2018) · Nanoscale · doi:10.1039/c7nr06794a · Cited by 116 · see citing works
Iron deficiency and iron deficiency anemia in women
Coad, J. E., & Pedley, K. C. (2014) · Scandinavian Journal of Clinical and Laboratory Investigation · doi:10.3109/00365513.2014.936694 · Cited by 97 · see citing works
Anemia of Inflammation with An Emphasis on Chronic Kidney Disease
Begum, S., & Latunde-Dada, G. O. (2019) · Nutrients · doi:10.3390/nu11102424 · Cited by 77 · see citing works
Efecto de la anemia en el desarrollo infantil: consecuencias a largo plazo
Zavaleta, N., & Astete-Robilliard, L. (2017) · Revista Peruana de Medicina Experimental y Salud Pública · doi:10.17843/rpmesp.2017.344.3346 · Cited by 69 · see citing works
Evidence of Redox-Active Iron Formation Following Aggregation of Ferrihydrite and the Alzheimer’s Disease Peptide β-Amyloid
Everett, J. L., Céspedes, E., Shelford, L. R., Exley, C., Collingwood, J. F., Dobson, J., van der Laan, G., Jenkins, C., Arenholz, E., & Telling, N. D. (2014) · Inorganic Chemistry · doi:10.1021/ic402406g · Cited by 67 · see citing works
The prevalence of vitamin D deficiency in iron-deficient and normal children under the age of 24 months
Jin, H. J., Lee, J. H., & Kim, M. K. (2013) · Blood Research · doi:10.5045/br.2013.48.1.40 · Cited by 65 · see citing works
Iron Pathophysiology in Alzheimer’s Diseases
Wang, T., Xu, S.-F., Fan, Y.-G., Li, L.-B., & Guo, C. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-981-13-9589-5_5 · Cited by 64 · see citing works
Magnetic susceptibility of brain iron is associated with childhood spatial IQ
Carpenter, K. L. H., Li, W., Wei, H., Wu, B. H., Xiao, X., Liu, C., Worley, G., & EGGER, H. L. (2016) · NeuroImage · doi:10.1016/j.neuroimage.2016.02.028 · Cited by 63 · see citing works
Copper Enhances Zinc-Induced Neurotoxicity and the Endoplasmic Reticulum Stress Response in a Neuronal Model of Vascular Dementia
Tanaka, K., & Kawahara, M. (2017) · Frontiers in Neuroscience · doi:10.3389/fnins.2017.00058 · Cited by 58 · see citing works
Adverse effects of iron deficiency anemia on pregnancy outcome and offspring development and intervention of three iron supplements
Zhang, Q., Lu, X., Zhang, M., Yang, C.-Y., Lv, S., Li, S., Zhong, C., & Geng, S. (2021) · Scientific Reports · doi:10.1038/s41598-020-79971-y · Cited by 57 · see citing works
Association Between Dietary Iron Intake and Serum Ferritin and Severe Headache or Migraine
Meng, S., Zhou, H., Li, X., Wang, M., Kang, L., Fu, J., Li, X., Li, X., & Zhao, Y. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.685564 · Cited by 55 · see citing works
Iron stored in ferritin is chemically reduced in the presence of aggregating Aβ(1-42)
Everett, J. L., Brooks, J., Lermyte, F., O’Connor, P. B., Sadler, P. J., Dobson, J., Collingwood, J. F., & Telling, N. D. (2020) · Scientific Reports · doi:10.1038/s41598-020-67117-z · Cited by 55 · see citing works
Can Nutrients and Dietary Supplements Potentially Improve Cognitive Performance Also in Esports?
Szot, M., Karpęcka-Gałka, E., Dróżdź, R., & Frączek, B. (2022) · Healthcare · doi:10.3390/healthcare10020186 · Cited by 56 · see citing works
Overdosing on iron: Elevated iron and degenerative brain disorders
D’Mello, S. R., & Kindy, M. S. (2020) · Experimental Biology and Medicine · doi:10.1177/1535370220953065 · Cited by 49 · see citing works
In vitro bioaccessibility and bioavailability of iron from fenugreek, baobab and moringa
Khoja, K. K., Aslam, M. F., Sharp, P., & Latunde-Dada, G. O. (2020) · Food Chemistry · doi:10.1016/j.foodchem.2020.127671 · Cited by 49 · see citing works
Developmental variation in regional brain iron and its relation to cognitive functions in childhood
Hect, J. L., Daugherty, A. M., Hermez, K., & Thomason, M. E. (2018) · Developmental Cognitive Neuroscience · doi:10.1016/j.dcn.2018.05.004 · Cited by 46 · see citing works
A Nanoparticulate Ferritin-Core Mimetic Is Well Taken Up by HuTu 80 Duodenal Cells and Its Absorption in Mice Is Regulated by Body Iron
Latunde-Dada, G. O., Pereira, D. I. A., Tempest, B., Ilyas, H., Flynn, A. C., Aslam, M. F., Simpson, R. J., & Powell, J. J. (2014) · Journal of Nutrition · doi:10.3945/jn.114.201715 · Cited by 42 · see citing works
Lysosomal iron modulates NMDA receptor-mediated excitation via small GTPase, Dexras1
White, R. S., Bhattacharya, A. K., Chen, Y., Byrd, M., McMullen, M. F., Siegel, S. J., Carlson, G. C., & Kim, S. F. (2016) · Molecular Brain · doi:10.1186/s13041-016-0220-8 · Cited by 42 · see citing works
Role of oxidative stress in various diseases: Relevance of dietary antioxidants
Kumar, V., Khan, A. A., Tripathi, A., Dixit, P. K., & Bajaj, U. K. (2015) · The Journal of Phytopharmacology · doi:10.31254/phyto.2015.4213 · Cited by 40 · see citing works
Anemia and Mild Cognitive Impairment in the German General Population
Jokisch, M., Winkler, A., Weimar, C., Dürig, J., Broecker‐Preuss, M., Dragano, N., Moebus, S., Jöckel, K., Erbel, R., Eisele, L., et al. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-150434 · Cited by 35 · see citing works
An explanation of the pathophysiology of adverse neurodevelopmental outcomes in iron deficiency
Bakoyiannis, I., Gkioka, E., Daskalopoulou, A., Κορού, Λ.-Μ., Perrea, D. N., & Pergialiotis, V. (2015) · Reviews in the Neurosciences · doi:10.1515/revneuro-2015-0012 · Cited by 35 · see citing works
Diet, Exercise, Lifestyle, and Mental Distress among Young and Mature Men and Women: A Repeated Cross-Sectional Study
Begdache, L., Sadeghzadeh, S., Derose, G., & Abrams, C. (2020) · Nutrients · doi:10.3390/nu13010024 · Cited by 35 · see citing works
Neurocognitive Function Is Associated With Serum Iron Status in Early Adolescents
Ji, X., Cui, N., & Liu, J. (2017) · Biological Research For Nursing · doi:10.1177/1099800417690828 · Cited by 33 · see citing works
Tremor-Dominant in Parkinson Disease: The Relevance to Iron Metabolism and Inflammation
Lian, T., Guo, P. F., Zuo, L.-J., Hu, Y., Yu, S., Yu, Q.-J., Jin, Z. Y., Wang, R., Li, L., & Zhang, W. (2019) · Frontiers in Neuroscience · doi:10.3389/fnins.2019.00255 · Cited by 31 · see citing works
Single‐Vesicle Electrochemistry Following Repetitive Stimulation Reveals a Mechanism for Plasticity Changes with Iron Deficiency
Wang, Y., Gu, C., & Ewing, A. G. (2022) · Angewandte Chemie International Edition · doi:10.1002/anie.202200716 · Cited by 28 · see citing works
Effect of Insulin Receptor-Knockdown on the Expression Levels of Blood–Brain Barrier Functional Proteins in Human Brain Microvascular Endothelial Cells
Nagano, H., Ito, S., Masuda, T., & Ohtsuki, S. (2021) · Pharmaceutical Research · doi:10.1007/s11095-021-03131-8 · Cited by 28 · see citing works
Quantitative susceptibility mapping reveals brain iron deficiency in children with attention-deficit/hyperactivity disorder: a whole-brain analysis
Chen, Y., Su, S., Dai, Y., Zou, M., Lin, L., Qian, L., Zhou, Q., Zhang, H., Liu, M., Zhao, J., et al. (2022) · European Radiology · doi:10.1007/s00330-021-08516-2 · Cited by 26 · see citing works
Iron Deficiency Reduces Synapse Formation in the Drosophila Clock Circuit
Rudisill, S. S., Martin, B. R., Mankowski, K. M., & Tessier, C. R. (2018) · Biological Trace Element Research · doi:10.1007/s12011-018-1442-7 · Cited by 25 · see citing works
Parkinson’s Disease and the Metal–Microbiome–Gut–Brain Axis: A Systems Toxicology Approach
Forero-Rodríguez, L. J., Josephs‐Spaulding, J., Flor, S., Pinzón, A. M., & Kaleta, C. (2021) · Antioxidants · doi:10.3390/antiox11010071 · Cited by 22 · see citing works
The influence of combined magnesium and vanadate administration on the level of some elements in selected rat organs: V–Mg interactions and the role of iron-essential protein (DMT-1) in the mechanism underlying altered tissues iron level
Ścibior, A., Adamczyk, A., Gołębiowska, D., Niedźwiecka, I., & Fornal, E. (2014) · Metallomics · doi:10.1039/c3mt00363a · Cited by 20 · see citing works
Relevance of biometals during neuronal differentiation and myelination: in vitro and in vivo studies
Chin-Chan, M., Montes, S., Blanco-Álvarez, V. M., Aguirre‐Alarcón, H., Rodríguez, I. H., & Bautista, E. (2022) · BioMetals · doi:10.1007/s10534-022-00380-x · Cited by 19 · see citing works
Naotaifang extract treatment results in increased ferroportin expression in the hippocampus of rats subjected to cerebral ischemia
Liao, J., Xia, X., Wang, G., Shi, Y., & Ge, J. (2015) · Molecular Medicine Reports · doi:10.3892/mmr.2015.3309 · Cited by 18 · see citing works
Iron chelator Deferoxamine protects human neuroblastoma cell line SH-SY5Y from 6-Hydroxydopamine-induced apoptosis and autophagy dysfunction
Rakshit, J., Priyam, A., Gowrishetty, K. K., Mishra, S., & Bandyopadhyay, J. (2019) · Journal of Trace Elements in Medicine and Biology · doi:10.1016/j.jtemb.2019.126406 · Cited by 17 · see citing works
Red Cell Distribution Width, Anemia, and Brain Volumetric Outcomes Among Middle-Aged Adults
Beydoun, M. A., Hossain, S. A., MacIver, P. H., Srinivasan, D., Beydoun, H. A., Maldonado, A. I., Katzel, L. I., Davatzikos, C. A., Gullapalli, R. P., Seliger, S. L., et al. (2021) · Journal of Alzheimer s Disease · doi:10.3233/jad-201386 · Cited by 17 · see citing works
Impact of Iron Intake and Reserves on Cognitive Function in Young University Students
Benedicto, C. M. D., Albasanz, J. L., Bermejo, L. M., Castro‐Vázquez, L., Sánchez-Melgar, A., Martı́n, M., & García, R. M. M. (2024) · Nutrients · doi:10.3390/nu16162808 · Cited by 15 · see citing works
Prenatal Ethanol Exposure Misregulates Genes Involved in Iron Homeostasis Promoting a Maladaptation of Iron Dependent Hippocampal Synaptic Transmission and Plasticity
de la Fuente-Ortega, E., Plaza-Briceño, W., Vargas-Robert, S., & Haeger, P. A. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01312 · Cited by 15 · see citing works
Bioavailability of iron multi-amino acid chelate preparation in mice and human duodenal HuTu 80 cells
Kajarabille, N., Brown, C., Cucliciu, A., Thapaliya, G., & Latunde-Dada, G. O. (2017) · British Journal Of Nutrition · doi:10.1017/s0007114517000186 · Cited by 15 · see citing works
Nutrigenomics and neurological disorders: exploring diet-brain interactions for cognitive health
Waheed, A., Ghaffar, M., Mustafa, S., Abbas, A., Khan, S. I., Waheed, A., & Naz, H. (2024) · Neurogenetics · doi:10.1007/s10048-024-00791-7 · Cited by 13 · see citing works
Naotaifang extract treatment results in increased ferroportin expression in the hippocampus of rats subjected to cerebral ischemia
Liao, J., Xia, X., Wang, G., Shi, Y., & Ge, J. (2015) · Molecular Medicine Reports · doi:10.3892/mmr.2015.4630 · Cited by 13 · see citing works
Exploring the links among brain iron accumulation, cognitive performance, and dietary intake in older adults: A longitudinal MRI study
Zachariou, V., Pappas, C. A., Bauer, C. E., Seago, E. R., & Gold, B. T. (2024) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2024.10.006 · Cited by 12 · see citing works
Label-Free In Situ Chemical Characterization of Amyloid Plaques in Human Brain Tissues
Everett, J. L., Brooks, J., Tjhin, V. T., Lermyte, F., Hands-Portman, I., Plascencia‐Villa, G., Perry, G. L., Sadler, P. J., O’Connor, P. B., Collingwood, J. F., et al. (2024) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.3c00756 · Cited by 11 · see citing works
Alterations of Iron Level in the Bilateral Basal Ganglia Region in Patients With Middle Cerebral Artery Occlusion
Du, L., Zhao, Z., Liu, X., Chen, Y., Gao, W., Wang, Y., Liu, J., Liu, B., & Ma, G. (2021) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.608058 · Cited by 11 · see citing works
Iron Intake and Human Health
Latunde-Dada, G. O. (2024) · Nutrients · doi:10.3390/nu16020206 · Cited by 12 · see citing works
Single‐Vesicle Electrochemistry Following Repetitive Stimulation Reveals a Mechanism for Plasticity Changes with Iron Deficiency
Wang, Y., Gu, C., & Ewing, A. G. (2022) · Angewandte Chemie · doi:10.1002/ange.202200716 · Cited by 8 · see citing works
Fermented Goat Milk Consumption Enhances Brain Molecular Functions during Iron Deficiency Anemia Recovery
Moreno‐Fernández, J., López‐Aliaga, I., García‐Burgos, M., Alférez, M. J. M., & Díaz‐Castro, J. (2019) · Nutrients · doi:10.3390/nu11102394 · Cited by 8 · see citing works
Examining the Role of a Functional Deficiency of Iron in Lysosomal Storage Disorders with Translational Relevance to Alzheimer’s Disease
LeVine, S. M. (2023) · Cells · doi:10.3390/cells12222641 · Cited by 8 · see citing works
A Review of the Association Between Dietary Intake and Brain Iron Levels in Older Adults: Preliminary Findings and Future Directions
Zachariou, V., Bauer, C. E., Pappas, C. A., & Gold, B. T. (2024) · Nutrients · doi:10.3390/nu16234193 · Cited by 7 · see citing works
Brain Iron Alteration in Pediatric Tourette Syndrome: A Quantitative Susceptibility Mapping Study
Lin, L., Ruan, Z., Li, Y. B., Qiu, H., Deng, C., Qian, L., Cui, W., Tang, W., Yang, Z., Cheng, Y., et al. (2025) · European Journal of Neurology · doi:10.1111/ene.70054 · Cited by 7 · see citing works
Body mass index modifies the relationship between dietary iron intake and depressive symptoms among adults: A national population-based cohort
Tian, S., Wu, L., Zheng, H., Zhong, X., Yu, X., & Wu, W. (2023) · Journal of Affective Disorders · doi:10.1016/j.jad.2023.08.105 · Cited by 7 · see citing works
Iron Bioavailability: A Comparative Study of Plant-Based and Animal-Based Burgers
Li, S., Luo, M., Wong, S., Zhang, Y., Xiao, H., & McClements, D. J. (2025) · Food Biophysics · doi:10.1007/s11483-025-09945-y · Cited by 6 · see citing works
Gut: The gate and key to brain
Zhang, X., & Yang, Y. (2025) · Chinese Medical Journal · doi:10.1097/cm9.0000000000003767 · Cited by 6 · see citing works
Preventing complications by persistence with iron replacement therapy: a comprehensive literature review
Serati, M., & Torella, M. (2018) · Current Medical Research and Opinion · doi:10.1080/03007995.2018.1552850 · Cited by 8 · see citing works
Iron Deficiency Anemia Is Associated with Proprioceptive Deficit in Adult Women: a Cross-Sectional Case–Control Study
Harrabi, M. A., Fendri, T., Turki, M., Ayed, R., Chaari, F., Mezghani, I., Kallel, C., Ayadi, F. M., & Sahli, S. (2023) · Biological Trace Element Research · doi:10.1007/s12011-023-03603-5 · Cited by 6 · see citing works
Vitamin D Status in Children with Iron Deficiency and/or Anemia
Qader, E. A., & Alkhateeb, N. E. (2016) · DOAJ (DOAJ: Directory of Open Access Journals) · doi:10.22038/ijp.2016.7482 · Cited by 6 · see citing works
Involvement of Free Radicals in the Development and Progression of Alzheimer’s Disease
Rosales‐Hernández, M. C., Rodríguez, M. H., Wejebe, J. E. M., & Correa‐Basurto, J. (2016) · InTech eBooks · doi:10.5772/64708 · Cited by 5 · see citing works
Serum levels of trace elements in children born after assisted reproductive technology
Xia, X.-R., Jiang, S., Zhang, Y., Hu, Y., Yi, H., Liu, J., Zhao, N., Chen, J., Gao, L., Cui, Y., et al. (2018) · Clinica Chimica Acta · doi:10.1016/j.cca.2018.09.032 · Cited by 5 · see citing works
Assessing the Impact of Serum Ferritin on Life Skills in Children with ADHD
Okuyucu, M., Kavakcı, M., Terzioğlu, M., Gökler, M. E., & Tarakçıoğlu, M. C. (2025) · Children · doi:10.3390/children12080972 · Cited by 3 · see citing works
Imbalances of key parameters needed for energy-yielding processes in the serum of tramadol-treated male rats
Abazid, H., Jaffal, S. M., & Abu‐Samak, M. (2022) · Journal of Applied Pharmaceutical Science · doi:10.7324/japs.2022.120417 · Cited by 3 · see citing works
Mechanistic insight into the binding between Ferritin and Serotonin: Possible implications in neurodegenerative diseases
Anjum, F., Shahwan, M. J., Alhumaydhi, F. A., Sharaf, S. E., Abdulmonem, W. A., Shafie, A., Bilgrami, A. L., Shamsi, A., & Ashraf, G. M. (2022) · Journal of Molecular Liquids · doi:10.1016/j.molliq.2022.118618 · Cited by 3 · see citing works
Presenilin mutations disrupt iron homeostasis to promote ferroptosis mediated neurodegeneration in Caenorhabditis elegans
Ryan, K. C., Laboy, J. T., Ashraf, R., Ashkavand, Z., Jayasinghe, I., & Norman, K. R. (2025) · Redox Biology · doi:10.1016/j.redox.2025.103910 · Cited by 2 · see citing works
Brain Derived Neurotrophic Growth Factor and Cognitive Function in Children with Iron Deficiency Anemia
Nassar, M. F. (2014) · Journal of Advances in Medicine and Medical Research · doi:10.9734/bjmmr/2014/9552 · Cited by 2 · see citing works
Regulation of trace elements and redox status in striatum of adult rats by long-term aerobic exercise depends on iron uptakes
Wu, H.-B., & Xiao, D.-S. (2017) · Neuroscience Letters · doi:10.1016/j.neulet.2017.01.070 · Cited by 2 · see citing works
Nutritional Status on the Cognitive Development of Early Childhood (5-6 Years) at TKQ/TPQ Al hafiz Medan
Maimunah, R., Yunita, W., & Ramadhani, Y. (2024) · International Journal of Public Health Excellence (IJPHE) · doi:10.55299/ijphe.v3i2.747 · Cited by 1 · see citing works
Regional high iron deposition is linked with cognitive impairments in peritoneal dialysis: a quantitative susceptibility mapping study
Li, D., Yin, Y., Jiang, S., Yin, J., Yu, L., Feng, N., Sun, Z., Chen, Z., Xu, H., Zhou, Y., et al. (2025) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2025.1660734 · Cited by 1 · see citing works
Baseline CSF ferritin levels were associated with trajectories of depressive symptoms among older people without dementia
Wang, Q., Ye, X., & Lin, Y. (2025) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2025.1516388 · Cited by 1 · see citing works
Brain-derived neurotrophic factor levels and anemia in elementary school children
Juhaina, E., Flora, R., Sitorus, R. J., Zulkarnain, M., Faisya, A. F., Fajar, N. A., & Nurlaili, N. (2019) · Jurnal Aisyah Jurnal Ilmu Kesehatan · doi:10.30604/jika.v5i1.234 · Cited by 1 · see citing works
Essential trace metals and their function in brain development
Grabrucker, A. M. (2020) · Elsevier eBooks · doi:10.1016/b978-0-12-821132-8.00004-5 · Cited by 1 · see citing works
The Effect of Hemoglobin, Folate, Vitamin B12, and 25 (OH) Vitamin D3 Levels on Function, Disability, Pain, and Balance in Patients with Post-Stroke Hemiplegia
Okçu, M., Tuncay, F., Koçak, F. A., DOĞRU, Y. G., Güngör, Z. K., & Kaya, S. S. (2022) · Fiziksel Tıp ve Rehabilitasyon Bilimleri Dergisi · doi:10.31609/jpmrs.2021-87387 · Cited by 1 · see citing works
Factores sociodemográficos asociados a la anemia en niños menores de 60 meses
Román-Lazarte, V., Roman, L. Á., Sanga, H., & Tarqui, L. (2022) · Revista Médica Basadrina · doi:10.33326/26176068.2022.2.1550 · Cited by 1 · see citing works
Investigation into the molecular complexity of Alzheimer's disease : an amyloid-β centered approach
Cioffi, F. (2019) · doi:10.3990/1.9789036548410
EFFECTS OF IRON DEFICIENCY AND IRON DEFICIENCY ANEMIA ON VISUAL EVOKED POTENTIAL IN WOMEN
Moghaddam, A. H., Heydari, M., Ebrahim, H., & Iranmanesh, F. (2014) · Zahedan Journal of Research in Medical Sciences
Identification and analysis of genetic and chemical modulators of iron metabolism
Hawula, Z. J. (2021) · Queensland University of Technology · doi:10.5204/thesis.eprints.225904
ANEMIA POR DEFICIENCIA DE HIERRO EN NIÑOS MENORES DE 36 MESES
Tena, J. A. D., Horna-Rubio, A. J., Salinas, M. V., & Ponce, S. K. M. (2021) · Revista Iberoamericana de la Educación · doi:10.31876/ie.vi.83
Mudança dos hábitos alimentares de crianças e adolescentes durante a pandemia e insegurança alimentar
Rodrigues, B. L., Rodrigues, T. P. H., Rossignolo, S. C. D. O., & Pietro, L. (2023) · Brazilian Journal of Health Review · doi:10.34119/bjhrv6n4-306
Neuroeducación: Comprendiendo el cerebro para mejorar el aprendizaje
López, U. E. N. M., Vizuete, K. H. A., Vizuete, S. M. A., Vizuete, C. A. A., de Octubre, E. 1., Trávez, R. G. V., Maná, U. E. L., Alcívar, E. Y. P., & de Mayo, C. T. E. 1. (2024) · doi:10.16921/naciones.60
Brain and Nutrition
Hatipoğlu, A. (2024) · doi:10.69860/nobel.9786053359371.7
Nutrition and Neurodevelopment
Román, C., Cannavale, C. N., & Khan, N. A. (2025) · Oxford University Press eBooks · doi:10.1093/oxfordhb/9780197677131.013.31
Assessment of dietary heme and non-heme iron intake among pharmacy student population
Petrovičova, O. D., Zrnić-Ćirić, M., & Todorović, V. (2024) · Hrana i ishrana · doi:10.5937/hraish2401036d
The Impact of Nutrition, Genetics, Environment, and Common Issues on Adolescent Growth and Development
Hernández‐Ramírez, S., & Guzmán-Ramos, K. R. (2026) · Advances in experimental medicine and biology · doi:10.1007/978-981-95-7000-3_6 · Cited by 1 · see citing works
Association between dietary iron intake from natural food sources and the likelihood of abdominal aortic calcification in US adults: a population-based study
Liang, D., Liu, C. A., & Zhang, X. (2026) · Food, Nutrition and Health. · doi:10.1007/s44403-026-00060-5
Clinical significance of oral iron absorption test in the differential diagnosis of microcytic anemia
Ożga, A., Siwiec, A., Morawska, M., Jakubik, M., Kiżewska, M., Szymczyk, K., Dargacz, A., Szczepańska, D., Kozikowska, J., Owczarzak, M., et al. (2026) · Humanities & Social Sciences Reviews · doi:10.18510/hssr.2026.1421
Ferroptosis–neuroinflammation interplay: mechanistic pathways and therapeutic opportunities in central nervous system disorders
Dinislam, K., Kataev, V. A., Ajmal, M. R., Amer, A. S., Prasad, P., & Zuberi, A. (2026) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2026.1874307
Hippocampal Volume Mediates the Association Between Serum Ferritin and Cognition in Non‐Dialysis End‐Stage Renal Disease Patients
Si, J., Zhu, M., & Mingzhe, D. (2026) · Brain and Behavior · doi:10.1002/brb3.71777

Authors: Muñoz, P., & Humeres, A.
Affiliations: University of Valparaíso (CL)
University of Chile (CL)
Corresponding author: Muñoz, Pablo
ORCID: Muñoz, Pablo
Venue: BioMetals
Publisher: Springer Science and Business Media LLC
Published: 2012-05-26
Volume: 25
Issue: 4
Pages: 825-835
ISSN: 0966-0844 (ISSN-L)
1572-8773
DOI: 10.1007/s10534-012-9550-x
OpenAlex: W2008448431
Cited by: 92
References: 77
Citations by year: 2026: 5 · 2025: 8 · 2024: 10 · 2023: 5 · 2022: 10 · 2021: 8 · 2020: 7 · 2019: 9 · 2018: 6 · 2017: 5 · 2016: 4 · 2015: 5 · 2014: 8 · 2013: 2
FWCI: 3.17
Type: journal article
Language: en
Open access: green
repositorio.uchile.cl
Licence: cc-by-nc-nd
www.springer.com/tdm (tdm)
Locations: BioMetals (publishedVersion)
PubMed (publishedVersion)
Universidad de Chile (submittedVersion, cc-by-nc-nd)
Topics: Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
Keywords: iron deficiency, neuronal function, synaptic plasticity, oxidative stress, reactive oxygen species, neurodegenerative diseases, cognitive impairment, neuroplasticity, neurotransmission, myelination, synaptogenesis, hippocampus, prefrontal cortex, striatum, amygdala, iron deficiency anemia
MeSH terms: Iron Deficiencies, Animals, Cognition Disorders, Hippocampus, Humans, Iron, Neuronal Plasticity, Synapses, Calcium Signaling

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Iron deficiency on neuronal function

Abstract

Integrity signals

Claims the paper makes

Claims other papers make about this one

Cites

Cited by

Related

Record

About these checks