Cited by 138Neuroscience and Neuropharmacology ResearchEpilepsy research and treatmentNeural dynamics and brain function

Plasticity of Hippocampal Excitatory-Inhibitory Balance: Missing the Synaptic Control in the Epileptic Brain

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Bonansco, Christian, Fuenzalida, Marco·2016·Neural Plasticity

Abstract

Synaptic plasticity is the capacity generated by experience to modify the neural function and, thereby, adapt our behaviour. Long-term plasticity of glutamatergic and GABAergic transmission occurs in a concerted manner, finely adjusting the excitatory-inhibitory (E/I) balance. Imbalances of E/I function are related to several neurological diseases including epilepsy. Several evidences have demonstrated that astrocytes are able to control the synaptic plasticity, with astrocytes being active partners in synaptic physiology and E/I balance. Here, we revise molecular evidences showing the epileptic stage as an abnormal form of long-term brain plasticity and propose the possible participation of astrocytes to the abnormal increase of glutamatergic and decrease of GABAergic neurotransmission in epileptic networks.

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Research works printed but not linked: 2

  1. [1]Gastaut H. Letter: Epileptic seizures Developmental Medicine and Child Neurology 1973 15 5 688 689 2-s2.0-0015678860 4765238
  2. [25]Dhir A. UNIT 9.37 Pentylenetetrazol (PTZ) kindling model of epilepsy Current Protocols in Neuroscience 2012 chapter 9 Hoboken, NJ, USA John Wiley & Sons 10.1002/0471142301.ns0937s58 23042503 · DOI

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Authors
Bonansco, C., & Fuenzalida, M.
Affiliations
University of Valparaíso (CL)
Corresponding author
  • Bonansco, Christian
  • Fuenzalida, Marco
Venue
Neural Plasticity
Publisher
Wiley
Published
2016
Volume
2016
Pages
1-13
ISSN
  • 1687-5443 (ISSN-L)
  • 2090-5904
OpenAlex
W2283621784
Cited by
138
References
168
Citations by year
2026: 10 · 2025: 10 · 2024: 13 · 2023: 23 · 2022: 17 · 2021: 15 · 2020: 20 · 2019: 16 · 2018: 9 · 2017: 4 · 2016: 1
FWCI
1.10
Type
journal article
Language
en
Open access
Locations
  • Neural Plasticity (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Fondo Nacional de Desarrollo Científico y Tecnológico (1130491, 1130614)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
excitation-inhibition balance, synaptic plasticity, epilepsy, astrocytes, long-term plasticity, glutamatergic neurotransmission, GABAergic neurotransmission, epileptic networks, astrocyte-neuron interaction
MeSH terms
Animals, Astrocytes, Brain, Epilepsy, gamma-Aminobutyric Acid, Hippocampus, Humans, Synaptic Transmission, Neuronal Plasticity, Synapses, Glutamic Acid

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