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Cited by 115Barrier Structure and Function StudiesDrug Transport and Resistance MechanismsNeurogenesis and neuroplasticity mechanisms

‘Sealing off the CNS’: cellular and molecular regulation of blood–brain barriergenesis

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Siegenthaler, Julie A, Sohet, Fabien, Daneman, Richard·2013·Current Opinion in Neurobiology
DOI 10.1016/j.conb.2013.06.006PMC PMC4061913
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Abstract

From their initial ingression into the neural tube to the established, adult vascular plexus, blood vessels within the CNS are truly unique. Covered by a virtually continuous layer of perivascular cells and astrocytic endfeet and connected by specialized cell-cell junctional contacts, mature CNS blood vessels simultaneously provide nutritive blood flow and protect the neural milieu from potentially disruptive or harmful molecules and cells flowing through the vessel lumen. In this review we will discuss how the CNS vasculature acquires blood-brain barrier (BBB) properties with a specific focus on recent work identifying the cell types and molecular pathways that orchestrate barriergenesis.

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  • In contrast to leaky capillary endothelium in peripheral organs, the BBB endothelium is sealed by TJs and has a low rate of bulk-flow transcytosis.

    “In contrast to leaky capillary endothelium in peripheral organs (391), the BBB endothelium is sealed by TJs (492, 590, 682) and has low rate of bulk-flow transcytosis (538, 682).”

    From Blood-Brain Barrier: From Physiology to Disease and Back (2019) · cites this paper as [538]

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Authors
Siegenthaler, J. A., Sohet, F., & Daneman, R.
Affiliations
  • University of Colorado Denver (US)
  • University of California, San Francisco (US)
Corresponding author
  • Siegenthaler, Julie A
  • Daneman, Richard
ORCID
Venue
Current Opinion in Neurobiology
Publisher
Elsevier BV
Published
2013-12
Volume
23
Issue
6
Pages
1057-1064
ISSN
0959-4388 (ISSN-L)
DOI
10.1016/j.conb.2013.06.006
PMC
PMC4061913
OpenAlex
W2045482803
Cited by
115
References
5
Citations by year
2026: 4 · 2025: 2 · 2024: 10 · 2023: 8 · 2022: 11 · 2021: 9 · 2020: 12 · 2019: 9 · 2018: 9 · 2017: 13 · 2016: 8 · 2015: 10 · 2014: 9 · 2013: 1
FWCI
0.90
Type
journal article
Language
en
Open access
Licence
Locations
  • Current Opinion in Neurobiology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Neurological Disorders and Stroke (R00NS070920)
Topics
  • Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
  • Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
  • Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Keywords
blood-brain barrier, perivascular cells, astrocytic endfeet, cell-cell contact, blood vessel development, neural tube, vascular plexus
MeSH terms
Animals, Blood-Brain Barrier, Brain, Humans, Neurogenesis

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