The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Reduction of the “burst release” of copper ions from copper-based intrauterine devices by organic inhibitors
Open accessAbstract
Background The copper intrauterine device is a contraceptive method that is based on the release of copper ions from a copper wire. Immediately after insertion, the dissolution of copper in the uterine fluid is markedly higher ("burst release") than that necessary for contraception action, leading to a variety of harmful effects.Study design Pretreatments with organic compounds [thiourea (TU) and purine (PU), 10(-4)-10(-2) M concentration range, 1- and 3-h immersion times] were tested. The dissolution of copper with and without pretreatments in TU and PU solutions was analyzed by conventional electrochemical techniques and surface analysis.Results Pretreatments in PU solutions reduced the initial corrosion rate of copper in simulated uterine solutions, with inhibitory efficiencies that depend on the PU concentration and on the immersion time assayed. Inhibitory efficiency values higher than 98% for pretreatments with ≥10(-3) M PU were found. Conversely, after TU pretreatments, a high copper release was measured.Conclusions It was concluded that 10(-3) M PU pretreatment is a promising strategy able to reduce the "burst release" of copper and to ensure contraceptive action.
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Cites
Department of economic and social affairs
United Nations Department of Economic and Social Affairs (2025) · Energy Statistics Pocketbook · doi:10.18356/9789211069280c001 · Cited by 689
Intrauterine device insertion during the postpartum period: a systematic review
Kapp, N., & Curtis, K. M. (2009) · Contraception · doi:10.1016/j.contraception.2009.03.024 · Cited by 278
Ortiz, M. E., & Croxatto, H. B. (2007) · Contraception · doi:10.1016/j.contraception.2007.01.020 · Cited by 254
Attitudes and beliefs about the intrauterine device among teenagers and young women
Fleming, K. L., Sokoloff, A., & Raine, T. R. (2010) · Contraception · doi:10.1016/j.contraception.2010.02.020 · Cited by 150
de Chialvo, M. R. G., Salvarezza, R. C., MOLL, D. V. V., et al. (1985) · Electrochimica Acta · doi:10.1016/0013-4686(85)80012-8 · Cited by 139
Copper containing, framed intra-uterine devices for contraception
Kulier, R., O'Brien, P., Helmerhorst, F. M., et al. (2007) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd005347.pub3 · Cited by 118
Intrauterine devices: mechanisms of action, safety, and efficacy
Mishell, D. R. (1998) · Contraception · doi:10.1016/s0010-7824(98)00082-1 · Cited by 100
Inhibition of copper corrosion in sodium nitrate solutions with nontoxic inhibitors
Scendo, M. (2008) · Corrosion Science · doi:10.1016/j.corsci.2008.02.015 · Cited by 94
O'Brien, P., Kulier, R., Helmerhorst, F. M., Usher-Patel, M., & d’Arcangues, C. (2008) · Contraception · doi:10.1016/j.contraception.2007.12.011 · Cited by 91
Influence of pH and oxygen on copper corrosion in simulated uterine fluid
Mora, N., Cano, E., Mora, E., et al. (2002) · Biomaterials · doi:10.1016/s0142-9612(01)00154-5 · Cited by 85
Cited by
Zinc as a non-hormonal contraceptive: a better alternative to the copper intrauterine device (IUD)
Shankie-Williams, K., Lindsay, L., Murphy, C., & Dowland, S. (2022) · doi:10.1101/2022.03.24.485705 · Cited by 3
Metadata
- Authors
- Alvarez, F., Schilardi, P. L., & de Mele, M. F. L.
- Affiliations
- Consejo Nacional de Investigaciones Científicas y Técnicas (AR)
- Venue
- Contraception
- Publisher
- Elsevier BV
- Published
- 2012-01
- Volume
- 85
- Issue
- 1
- Pages
- 91-98
- ISSN
- 0010-7824 (ISSN-L)
- OpenAlex
- W2114346301
- Semantic Scholar
- 2d70fc0ffedfb9042fe31129a44936508ad4a1af
- Cited by
- 32
- References
- 49
- Citations by year
- 2026: 2 · 2025: 2 · 2024: 1 · 2023: 1 · 2022: 5 · 2021: 2 · 2019: 4 · 2018: 2 · 2017: 2 · 2016: 3 · 2015: 5 · 2014: 1 · 2013: 2
- FWCI
- 0.94
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Contraception (publishedVersion)
- PubMed (publishedVersion)
- CONICET Digital (CONICET) (submittedVersion, cc-by-nc-nd)
- Funders
- Consejo Nacional de Investigaciones Científicas y Técnicas
- Universidad Nacional de La Plata (11/I129, 11/X532)
- Topics
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Health and Contraception
- Physical Sciences › Materials Science › Materials Chemistry › Corrosion Behavior and Inhibition
- Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Antimicrobial agents and applications
- Keywords
- copper intrauterine device, burst release, copper ion release, corrosion inhibition, purines, thiourea, uterine fluid, corrosion rate, pretreatment, contraceptive devices
- MeSH terms
- Copper, Corrosion, Intrauterine Devices, Copper, Purines, Thiourea, Electrochemical Techniques
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- Alvarez, F., Schilardi, P. L., & de Mele, M. F. L. (2012). Reduction of the “burst release” of copper ions from copper-based intrauterine devices by organic inhibitors. Contraception. https://doi.org/10.1016/j.contraception.2011.05.011
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